Published in J Am Chem Soc on September 21, 2005
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Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood. Cancer Res (1991) 1.70
Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology (2005) 1.17
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Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38
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Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (2013) 6.43
Physical plasticity of the nucleus in stem cell differentiation. Proc Natl Acad Sci U S A (2007) 4.30
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Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci (2008) 3.86
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol (2006) 3.78
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Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (2013) 2.42
Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol (2008) 2.39
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Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water. Science (2009) 2.30
Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys J (2005) 2.19
Polymer vesicles in vivo: correlations with PEG molecular weight. J Control Release (2003) 2.07
Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics. Nat Mater (2004) 2.07
Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol (2014) 2.01
Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophys J (2006) 1.96
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Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing. Biophys J (2003) 1.77
Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods Cell Biol (2007) 1.74
Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73
Cooperativity in forced unfolding of tandem spectrin repeats. Biophys J (2003) 1.70
Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J Control Release (2006) 1.69
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. J Cell Biol (2012) 1.65
Species- and cell type-specific interactions between CD47 and human SIRPalpha. Blood (2005) 1.63
Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Mol Pharm (2006) 1.61
Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophys J (2005) 1.56
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles. J Control Release (2004) 1.55
How deeply cells feel: methods for thin gels. J Phys Condens Matter (2010) 1.51
Unfolding a linker between helical repeats. J Mol Biol (2005) 1.48
Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains. Biophys J (2003) 1.46
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Targeted worm micelles. Biomacromolecules (2004) 1.45
Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci Signal (2008) 1.42
Matrix strains induced by cells: Computing how far cells can feel. Cell Mol Bioeng (2009) 1.41
Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nat Mater (2009) 1.40
Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm Res (2007) 1.38
Conformational changes and signaling in cell and matrix physics. Curr Biol (2009) 1.33
Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells Mol Dis (2010) 1.31
Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules (2004) 1.30
Patterning, prestress, and peeling dynamics of myocytes. Biophys J (2004) 1.29
Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proc Natl Acad Sci U S A (2011) 1.28
Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood (2006) 1.22
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Topographical pattern dynamics in passive adhesion of cell membranes. Biophys J (2004) 1.21
Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry (2009) 1.21
Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. J Biol Chem (2006) 1.20
Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. Integr Biol (Camb) (2012) 1.20
Adhesion-contractile balance in myocyte differentiation. J Cell Sci (2004) 1.20
Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology (2005) 1.17
The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials (2011) 1.17
Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Curr Biol (2013) 1.17
Molecular extensibility of mini-dystrophins and a dystrophin rod construct. J Mol Biol (2005) 1.13
Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding. J Biol Chem (2004) 1.11
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken) (2010) 1.08
Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Curr Opin Cell Biol (2008) 1.08
Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A (2013) 1.06
Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix. Biophys J (2011) 1.06
Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods Cell Biol (2007) 1.05
Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophys J (2009) 1.05
Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation (2013) 1.04
Stem cells, microenvironment mechanics, and growth factor activation. Curr Opin Cell Biol (2009) 1.04
Protein unfolding accounts for the unusual mechanical behavior of fibrin networks. Acta Biomater (2011) 1.04
Polymersome delivery of siRNA and antisense oligonucleotides. J Control Release (2008) 1.04
Endothelial targeting of antibody-decorated polymeric filomicelles. ACS Nano (2011) 1.03
Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophys J (2011) 1.03
Visualizing worm micelle dynamics and phase transitions of a charged diblock copolymer in water. J Phys Chem B (2005) 1.02
Nuclear mechanics and methods. Methods Cell Biol (2007) 1.01
Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy. Oncotarget (2013) 1.00
Influence of lateral association on forced unfolding of antiparallel spectrin heterodimers. J Biol Chem (2004) 1.00
Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling. Blood Cells Mol Dis (2006) 0.99
Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells. Blood (2003) 0.98
Curvature-coupled hydration of Semicrystalline Polymer Amphiphiles yields flexible Worm Micelles but favors rigid Vesicles: polycaprolactone-based block copolymers. Macromolecules (2010) 0.96
Dissipative particle dynamics simulations of polymersomes. J Phys Chem B (2005) 0.95
Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers. Biomacromolecules (2007) 0.95
Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophys J (2013) 0.90
Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells. Proc Natl Acad Sci U S A (2011) 0.90
Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles. Adv Mater (2011) 0.89
Stem cells feel the difference. Nat Methods (2010) 0.89
Key roles for chain flexibility in block copolymer membranes that contain pores or make tubes. Nano Lett (2005) 0.88
Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes. Blood (2002) 0.87
Preparation of collagen-coated gels that maximize in vitro myogenesis of stem cells by matching the lateral elasticity of in vivo muscle. Methods Mol Biol (2010) 0.87
Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation. Eur J Cell Biol (2011) 0.86
Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase. Biomacromolecules (2009) 0.85
Domain unfolding in neurofilament sidearms: effects of phosphorylation and ATP. FEBS Lett (2002) 0.84
Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers. J Phys Chem B (2005) 0.84
Developmental biology: holding it together in the eye. Nature (2004) 0.84
Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics. Biomech Model Mechanobiol (2012) 0.83
Curvature-driven molecular demixing in the budding and breakup of mixed component Worm-like Micelles. Soft Matter (2010) 0.83
RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. PLoS One (2013) 0.83
Mechanical force in T cell receptor signal initiation. Front Immunol (2012) 0.83
Grafting short peptides onto polybutadiene-block-poly(ethylene oxide): a platform for self-assembling hybrid amphiphiles. Angew Chem Int Ed Engl (2006) 0.82
Post-translational regulation of expression and conformation of an immunoglobulin domain in yeast surface display. Biotechnol Bioeng (2006) 0.82
Matrix elasticity in vitro controls muscle stem cell fate in vivo. Stem Cell Res Ther (2010) 0.81
gamma-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion. J Cell Sci (2005) 0.81
Self-assembly: towards precision micelles. Nature (2004) 0.80
Physical plasticity of the nucleus and its manipulation. Methods Cell Biol (2010) 0.80
Polymer Vesicles with a Red Cell-like Surface Charge: Microvascular Imaging and in vivo Tracking with Near-Infrared Fluorescence. Macromol Rapid Commun (2009) 0.80
Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH. Langmuir (2013) 0.80