Published in Biophys J on February 19, 2013
The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue. J Cell Sci (2014) 1.04
Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proc Natl Acad Sci U S A (2014) 1.03
Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells. Sci Rep (2015) 0.85
Volume regulation and shape bifurcation in the cell nucleus. J Cell Sci (2015) 0.83
Activation of autophagy via Ca(2+)-dependent AMPK/mTOR pathway in rat notochordal cells is a cellular adaptation under hyperosmotic stress. Cell Cycle (2015) 0.81
Derivation and osmotolerance characterization of three immortalized tilapia (Oreochromis mossambicus) cell lines. PLoS One (2014) 0.80
Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Ann Biomed Eng (2015) 0.77
A Case for the Nuclear Membrane as a Mechanotransducer. Cell Mol Bioeng (2016) 0.77
Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophys J (2016) 0.76
Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis. Cell Mol Bioeng (2016) 0.75
Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity. Elife (2016) 0.75
ATR-mediated regulation of nuclear and cellular plasticity. DNA Repair (Amst) (2016) 0.75
Cell-biological studies of osmotic shock response in Streptomyces. J Bacteriol (2016) 0.75
Actomyosin and vimentin cytoskeletal networks regulate nuclear shape, mechanics and chromatin organization. Sci Rep (2017) 0.75
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature (2000) 14.91
Differences in the localization and morphology of chromosomes in the human nucleus. J Cell Biol (1999) 6.35
Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell (1997) 5.62
Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47
Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature (2008) 4.92
Physical plasticity of the nucleus in stem cell differentiation. Proc Natl Acad Sci U S A (2007) 4.30
Simulations of the erythrocyte cytoskeleton at large deformation. II. Micropipette aspiration. Biophys J (1998) 2.79
The analysis of cell images. Ann N Y Acad Sci (1966) 2.72
Contact pressures in the human hip joint measured in vivo. Proc Natl Acad Sci U S A (1986) 2.09
Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks. Chromosome Res (2006) 2.07
The effects of osmotic stress on the viscoelastic and physical properties of articular chondrocytes. Biophys J (2002) 1.95
The chondrocyte: a cell under pressure. Br J Rheumatol (1994) 1.69
Cis- and trans-acting factors regulating transcription of the BGT1 gene in response to hypertonicity. Am J Physiol (1998) 1.66
Regulation of matrix synthesis rates by the ionic and osmotic environment of articular chondrocytes. J Cell Physiol (1993) 1.64
Electrical dimension of the nuclear envelope. Physiol Rev (2001) 1.41
Hyper-osmotic stress induces volume change and calcium transients in chondrocytes by transmembrane, phospholipid, and G-protein pathways. J Biomech (2001) 1.37
Effect of static load on matrix synthesis rates in the intervertebral disc measured in vitro by a new perfusion technique. J Orthop Res (1995) 1.29
Chondrocyte intracellular calcium, cytoskeletal organization, and gene expression responses to dynamic osmotic loading. Am J Physiol Cell Physiol (2006) 1.29
Hypo-osmotic stress induces calcium-dependent actin reorganization in articular chondrocytes. Osteoarthritis Cartilage (2003) 1.26
Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels. J Biomech (2000) 1.18
Regulatory volume decrease (RVD) by isolated and in situ bovine articular chondrocytes. J Cell Physiol (2001) 1.17
The volume and morphology of chondrocytes within non-degenerate and degenerate human articular cartilage. Osteoarthritis Cartilage (2003) 1.13
Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose. Histochem J (2000) 1.04
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med (2004) 1.03
The effects of osmotic stress on the structure and function of the cell nucleus. J Cell Biochem (2010) 1.03
Roles of chromatin insulator proteins in higher-order chromatin organization and transcription regulation. Nucleus (2011) 1.02
Dynamic osmotic loading of chondrocytes using a novel microfluidic device. J Biomech (2004) 1.02
Nonlinear osmotic properties of the cell nucleus. Ann Biomed Eng (2008) 1.00
Adaptive cellular response to osmotic stress in pig articular chondrocytes. Tissue Cell (1995) 0.98
The effect of continuous mechanical pressure upon the turnover of articular cartilage proteoglycans in vitro. Clin Orthop Relat Res (1982) 0.97
A real-time DNase assay (ReDA) based on PicoGreen fluorescence. Nucleic Acids Res (2003) 0.96
Effects of mechanical and osmotic pressure on the rate of glycosaminoglycan synthesis in the human adult femoral head cartilage: an in vitro study. J Orthop Res (1986) 0.96
In vitro method for measuring synthesis rates in the intervertebral disc. J Orthop Res (1986) 0.95
Dependence of zonal chondrocyte water transport properties on osmotic environment. Cell Mol Bioeng (2008) 0.95
Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture. Biorheology (2003) 0.92
Role of tyrosine kinase activity in cardiac slow delayed rectifier channel modulation by cell swelling. Pflugers Arch (1997) 0.91
Adaptation of articular chondrocytes to changes in osmolality. Biorheology (2003) 0.90
Analysis of DNA breaks, DNA damage response, and apoptosis produced by high NaCl. Am J Physiol Renal Physiol (2008) 0.89
Regulation of proteoglycan synthesis rate in cartilage in vitro: influence of extracellular ionic composition. Biochim Biophys Acta (1989) 0.86
Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. Biochem Biophys Res Commun (2011) 0.86
Osmotic regulation of airway reactivity by epithelium. J Pharmacol Exp Ther (1999) 0.85
Effects of osmotic shocks on the ultrastructure of different tissues and cell types. Exp Cell Res (1985) 0.84
Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear. Ann Biomed Eng (2004) 0.81
Tracking chromatin states using controlled DNase I treatment and real-time PCR. Cell Mol Biol Lett (2007) 0.81
Chondrocyte nuclear response to osmotic loading. Conf Proc IEEE Eng Med Biol Soc (2006) 0.80
Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique. Med Biol Eng Comput (2001) 0.78
Sustained hyposmotic stress induces cell death: apoptosis by defeat. Am J Physiol Cell Physiol (2001) 0.76
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Global functional profiling of gene expression. Genomics (2003) 12.05
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38
Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol (2007) 6.85
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (2013) 6.43
Physical plasticity of the nucleus in stem cell differentiation. Proc Natl Acad Sci U S A (2007) 4.30
Forced unfolding of proteins within cells. Science (2007) 3.95
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci (2008) 3.86
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol (2006) 3.78
The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. J Cell Sci (2004) 2.47
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (2013) 2.42
Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol (2008) 2.39
Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov (2011) 2.32
Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water. Science (2009) 2.30
Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys J (2005) 2.19
Polymer vesicles in vivo: correlations with PEG molecular weight. J Control Release (2003) 2.07
Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics. Nat Mater (2004) 2.07
Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol (2014) 2.01
Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophys J (2006) 1.96
Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94
Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng (2004) 1.79
Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing. Biophys J (2003) 1.77
Long-distance root-to-shoot transport of phytochelatins and cadmium in Arabidopsis. Proc Natl Acad Sci U S A (2003) 1.74
Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods Cell Biol (2007) 1.74
Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73
Cooperativity in forced unfolding of tandem spectrin repeats. Biophys J (2003) 1.70
Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J Control Release (2006) 1.69
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. J Cell Biol (2012) 1.65
Species- and cell type-specific interactions between CD47 and human SIRPalpha. Blood (2005) 1.63
Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Mol Pharm (2006) 1.61
Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophys J (2005) 1.56
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles. J Control Release (2004) 1.55
How deeply cells feel: methods for thin gels. J Phys Condens Matter (2010) 1.51
Unfolding a linker between helical repeats. J Mol Biol (2005) 1.48
Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains. Biophys J (2003) 1.46
Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage. Mol Pharm (2009) 1.45
Targeted worm micelles. Biomacromolecules (2004) 1.45
Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci Signal (2008) 1.42
Matrix strains induced by cells: Computing how far cells can feel. Cell Mol Bioeng (2009) 1.41
Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nat Mater (2009) 1.40
The metabolism of human mesenchymal stem cells during proliferation and differentiation. J Cell Physiol (2011) 1.38
Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm Res (2007) 1.38
Conformational changes and signaling in cell and matrix physics. Curr Biol (2009) 1.33
Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells Mol Dis (2010) 1.31
Formation of polyglutamine inclusions in a wide range of non-CNS tissues in the HdhQ150 knock-in mouse model of Huntington's disease. PLoS One (2009) 1.31
Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles. J Am Chem Soc (2005) 1.30
Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules (2004) 1.30
Patterning, prestress, and peeling dynamics of myocytes. Biophys J (2004) 1.29
Crosslinking density influences the morphology of chondrocytes photoencapsulated in PEG hydrogels during the application of compressive strain. J Orthop Res (2004) 1.29
Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proc Natl Acad Sci U S A (2011) 1.28
Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death. Am J Physiol Cell Physiol (2003) 1.27
The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles. Ann Biomed Eng (2005) 1.27
Aqueous shunt exposure: a retrospective review of repair outcome. J Glaucoma (2013) 1.25
Primary cilia mediate mechanotransduction through control of ATP-induced Ca2+ signaling in compressed chondrocytes. FASEB J (2012) 1.23
Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood (2006) 1.22
Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biol Int (2010) 1.22
Polymersome carriers: from self-assembly to siRNA and protein therapeutics. Eur J Pharm Biopharm (2008) 1.21
Topographical pattern dynamics in passive adhesion of cell membranes. Biophys J (2004) 1.21
Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry (2009) 1.21
Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. J Biol Chem (2006) 1.20
Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. Integr Biol (Camb) (2012) 1.20
Adhesion-contractile balance in myocyte differentiation. J Cell Sci (2004) 1.20
Mechanical regulation of nuclear structure and function. Annu Rev Biomed Eng (2012) 1.19
Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology (2005) 1.17
The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials (2011) 1.17
Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Curr Biol (2013) 1.17
Molecular extensibility of mini-dystrophins and a dystrophin rod construct. J Mol Biol (2005) 1.13
Directing noble metal ion chemistry within a designed ferritin protein. Biochemistry (2008) 1.12
Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding. J Biol Chem (2004) 1.11
Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys (2003) 1.10
Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. J Invest Dermatol (2005) 1.09
Continuous and uninterrupted oxygen tension influences the colony formation and oxidative metabolism of human mesenchymal stem cells. Tissue Eng Part C Methods (2012) 1.08
Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Curr Opin Cell Biol (2008) 1.08
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken) (2010) 1.08
Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A (2013) 1.06
Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix. Biophys J (2011) 1.06
Rate of oxygen consumption by isolated articular chondrocytes is sensitive to medium glucose concentration. J Cell Physiol (2006) 1.06
Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods Cell Biol (2007) 1.05
Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophys J (2009) 1.05
Stem cells, microenvironment mechanics, and growth factor activation. Curr Opin Cell Biol (2009) 1.04
Dynamic compressive strain influences chondrogenic gene expression in human mesenchymal stem cells. Biorheology (2006) 1.04
Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway. J Orthop Res (2010) 1.04
Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation (2013) 1.04
Protein unfolding accounts for the unusual mechanical behavior of fibrin networks. Acta Biomater (2011) 1.04
Polymersome delivery of siRNA and antisense oligonucleotides. J Control Release (2008) 1.04
Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain. Methods Mol Med (2004) 1.03
Endothelial targeting of antibody-decorated polymeric filomicelles. ACS Nano (2011) 1.03
The influence of swelling and matrix degradation on the microstructural integrity of tendon. Acta Biomater (2006) 1.03
Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophys J (2011) 1.03
Visualizing worm micelle dynamics and phase transitions of a charged diblock copolymer in water. J Phys Chem B (2005) 1.02
Nuclear mechanics and methods. Methods Cell Biol (2007) 1.01
Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy. Oncotarget (2013) 1.00
Influence of lateral association on forced unfolding of antiparallel spectrin heterodimers. J Biol Chem (2004) 1.00