Published in J Cell Sci on August 25, 2004
Physical plasticity of the nucleus in stem cell differentiation. Proc Natl Acad Sci U S A (2007) 4.30
Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force. J Cell Biol (2013) 3.77
The physics of cancer: the role of physical interactions and mechanical forces in metastasis. Nat Rev Cancer (2011) 3.42
Nuclear shape, mechanics, and mechanotransduction. Circ Res (2008) 3.12
Influence of cell geometry on division-plane positioning. Cell (2011) 2.53
Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.53
Nuclear mechanics during cell migration. Curr Opin Cell Biol (2010) 2.32
The role of myosin II in glioma invasion of the brain. Mol Biol Cell (2008) 2.20
Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys J (2005) 2.19
Bringing KASH under the SUN: the many faces of nucleo-cytoskeletal connections. J Cell Biol (2009) 2.16
The Cell Nucleus Serves as a Mechanotransducer of Tissue Damage-Induced Inflammation. Cell (2016) 2.12
The nucleoskeleton as a genome-associated dynamic 'network of networks'. Nat Rev Mol Cell Biol (2011) 2.01
Nuclear positioning. Cell (2013) 2.01
Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat Commun (2012) 1.96
Local translation of extranuclear lamin B promotes axon maintenance. Cell (2012) 1.79
Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol (2004) 1.72
Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: effects of farnesyltransferase inhibitors. Aging Cell (2008) 1.61
Hierarchical structure controls nanomechanical properties of vimentin intermediate filaments. PLoS One (2009) 1.49
Mechanical properties of the cell nucleus and the effect of emerin deficiency. Biophys J (2006) 1.40
Microrheology and ROCK signaling of human endothelial cells embedded in a 3D matrix. Biophys J (2006) 1.39
The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration. Sci Rep (2012) 1.36
Nuclear actin extends, with no contraction in sight. Mol Biol Cell (2005) 1.36
Broken nuclei--lamins, nuclear mechanics, and disease. Trends Cell Biol (2013) 1.25
Lamins at the crossroads of mechanosignaling. Genes Dev (2015) 1.23
Dynamics of chromatin decondensation reveals the structural integrity of a mechanically prestressed nucleus. Biophys J (2008) 1.20
Prometaphase spindle maintenance by an antagonistic motor-dependent force balance made robust by a disassembling lamin-B envelope. J Cell Biol (2010) 1.19
A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells. Nat Cell Biol (2013) 1.19
Lamin B counteracts the kinesin Eg5 to restrain spindle pole separation during spindle assembly. J Biol Chem (2010) 1.17
Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. Nucleus (2010) 1.15
The tethering of chromatin to the nuclear envelope supports nuclear mechanics. Nat Commun (2015) 1.10
Mechano-topographic modulation of stem cell nuclear shape on nanofibrous scaffolds. Acta Biomater (2010) 1.07
Alpha-helical protein networks are self-protective and flaw-tolerant. PLoS One (2009) 1.05
Early spindle assembly in Drosophila embryos: role of a force balance involving cytoskeletal dynamics and nuclear mechanics. Mol Biol Cell (2005) 1.03
Nucleoskeleton mechanics at a glance. J Cell Sci (2011) 1.01
Mechanical model of blebbing in nuclear lamin meshworks. Proc Natl Acad Sci U S A (2013) 1.00
Fiber stretch and reorientation modulates mesenchymal stem cell morphology and fibrous gene expression on oriented nanofibrous microenvironments. Ann Biomed Eng (2011) 1.00
Direct force probe reveals the mechanics of nuclear homeostasis in the mammalian cell. Proc Natl Acad Sci U S A (2015) 1.00
Attenuated hypertrophic response to pressure overload in a lamin A/C haploinsufficiency mouse. J Mol Cell Cardiol (2009) 0.99
Characterization of NE81, the first lamin-like nucleoskeleton protein in a unicellular organism. Mol Biol Cell (2011) 0.99
Investigating cell mechanics with atomic force microscopy. J R Soc Interface (2015) 0.98
Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics. Microcirculation (2010) 0.98
Tissue specificity in the nuclear envelope supports its functional complexity. Nucleus (2013) 0.96
Deformation of stem cell nuclei by nanotopographical cues. Soft Matter (2010) 0.95
Biophysical coarse-grained modeling provides insights into transport through the nuclear pore complex. Biophys J (2011) 0.94
Macro- to microscale strain transfer in fibrous tissues is heterogeneous and tissue-specific. Biophys J (2013) 0.93
Influence of lamin A on the mechanical properties of amphibian oocyte nuclei measured by atomic force microscopy. Biophys J (2009) 0.92
Squish and squeeze-the nucleus as a physical barrier during migration in confined environments. Curr Opin Cell Biol (2016) 0.92
Mitotic membrane helps to focus and stabilize the mitotic spindle. Biophys J (2010) 0.91
Force-induced changes in subnuclear movement and rheology. Biophys J (2012) 0.89
Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments. Integr Biol (Camb) (2015) 0.88
Beyond lamins other structural components of the nucleoskeleton. Methods Cell Biol (2010) 0.88
Cytoskeletal tension induces the polarized architecture of the nucleus. Biomaterials (2015) 0.88
Moving Cell Boundaries Drive Nuclear Shaping during Cell Spreading. Biophys J (2015) 0.88
Nuclear mechanics in cancer. Adv Exp Med Biol (2014) 0.88
Lamin B1 overexpression increases nuclear rigidity in autosomal dominant leukodystrophy fibroblasts. FASEB J (2014) 0.87
Structure and stability of the lamin A tail domain and HGPS mutant. J Struct Biol (2011) 0.87
The role of chromatin structure in cell migration. Trends Cell Biol (2010) 0.87
Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. Biochem Biophys Res Commun (2011) 0.86
Nanomechanics of vascular endothelium. Cell Tissue Res (2014) 0.86
Experimental techniques for study of chromatin mechanics in intact nuclei and living cells. Chromosome Res (2008) 0.85
Mechanics of the nucleus. Compr Physiol (2011) 0.85
The cellular mastermind(?)-mechanotransduction and the nucleus. Prog Mol Biol Transl Sci (2014) 0.84
Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus. Mol Biol Cell (2017) 0.84
Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate. Biomaterials (2014) 0.83
Structure and dynamics of human vimentin intermediate filament dimer and tetramer in explicit and implicit solvent models. J Mol Model (2010) 0.83
LMNA variants cause cytoplasmic distribution of nuclear pore proteins in Drosophila and human muscle. Hum Mol Genet (2011) 0.83
Volume regulation and shape bifurcation in the cell nucleus. J Cell Sci (2015) 0.83
A lamin in lower eukaryotes? Nucleus (2012) 0.82
Nuclear and cellular alignment of primary corneal epithelial cells on topography. J Biomed Mater Res A (2012) 0.82
The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open (2013) 0.81
A novel role of PRR14 in the regulation of skeletal myogenesis. Cell Death Dis (2015) 0.81
Modeling nuclear blebs in a nucleoskeleton of independent filament networks. Cell Mol Bioeng (2011) 0.81
Viscoelastic behavior of human lamin A proteins in the context of dilated cardiomyopathy. PLoS One (2013) 0.81
Extracellular Forces Cause the Nucleus to Deform in a Highly Controlled Anisotropic Manner. Sci Rep (2016) 0.80
On the role of DNA biomechanics in the regulation of gene expression. J R Soc Interface (2011) 0.80
Chromatin decompaction by the nucleosomal binding protein HMGN5 impairs nuclear sturdiness. Nat Commun (2015) 0.80
Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Exp Biol Med (Maywood) (2015) 0.80
Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells. J Biol Chem (2015) 0.79
Assays to measure nuclear mechanics in interphase cells. Curr Protoc Cell Biol (2012) 0.79
How protein materials balance strength, robustness, and adaptability. HFSP J (2010) 0.78
The Cardiomyopathy Lamin A/C D192G Mutation Disrupts Whole-Cell Biomechanics in Cardiomyocytes as Measured by Atomic Force Microscopy Loading-Unloading Curve Analysis. Sci Rep (2015) 0.78
Under Pressure: Mechanical Stress Management in the Nucleus. Cells (2016) 0.77
A Case for the Nuclear Membrane as a Mechanotransducer. Cell Mol Bioeng (2016) 0.77
AFM single-cell force spectroscopy links altered nuclear and cytoskeletal mechanics to defective cell adhesion in cardiac myocytes with a nuclear lamin mutation. Nucleus (2015) 0.77
Vertical uniformity of cells and nuclei in epithelial monolayers. Sci Rep (2016) 0.77
The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion. Oncotarget (2016) 0.76
Dynamic, mechanical integration between nucleus and cell- where physics meets biology. Nucleus (2015) 0.76
The role of myosin II in glioma invasion: A mathematical model. PLoS One (2017) 0.75
Three-dimensional cage-like microscaffolds for cell invasion studies. Sci Rep (2015) 0.75
Roles of Cross-Membrane Transport and Signaling in the Maintenance of Cellular Homeostasis. Cell Mol Bioeng (2016) 0.75
Roles of endothelial A-type lamins in migration of T cells on and under endothelial layers. Sci Rep (2016) 0.75
Shape Transformation of the Nuclear Envelope during Closed Mitosis. Biophys J (2016) 0.75
In vitro characterization of the RS motif in N-terminal head domain of goldfish germinal vesicle lamin B3 necessary for phosphorylation of the p34cdc2 target serine by SRPK1. FEBS Open Bio (2013) 0.75
Going Nuclear: Evidence Implicating the Cell Nucleus in Mechanotransduction. J Biomech Eng (2016) 0.75
Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex. Curr Mol Biol Rep (2016) 0.75
Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies. Cells (2016) 0.75
Nuclear membrane stretch and its role in mechanotransduction. Nucleus (2017) 0.75
A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophys J (2016) 0.75
Model of T-cell nuclear deformation by the cortical actin layer. Biophys J (2013) 0.75
On the origin of shape fluctuations of the cell nucleus. Proc Natl Acad Sci U S A (2017) 0.75
Matrix elasticity directs stem cell lineage specification. Cell (2006) 43.00
Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38
Shape effects of filaments versus spherical particles in flow and drug delivery. Nat Nanotechnol (2007) 6.85
Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (2013) 6.43
The nuclear lamina comes of age. Nat Rev Mol Cell Biol (2005) 6.00
Physical plasticity of the nucleus in stem cell differentiation. Proc Natl Acad Sci U S A (2007) 4.30
Forced unfolding of proteins within cells. Science (2007) 3.95
Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. J Cell Sci (2008) 3.86
Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol (2006) 3.78
Distinct structural and mechanical properties of the nuclear lamina in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci U S A (2006) 2.53
Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (2013) 2.42
Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. J Cell Biol (2008) 2.39
Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov (2011) 2.32
Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water. Science (2009) 2.30
Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro. FEBS Lett (2002) 2.24
Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophys J (2005) 2.19
SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton. Nat Rev Mol Cell Biol (2006) 2.12
Polymer vesicles in vivo: correlations with PEG molecular weight. J Control Release (2003) 2.07
Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics. Nat Mater (2004) 2.07
Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol (2014) 2.01
The nucleoskeleton as a genome-associated dynamic 'network of networks'. Nat Rev Mol Cell Biol (2011) 2.01
Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. J Cell Sci (2006) 1.99
Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell (2002) 1.98
Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophys J (2006) 1.96
Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Adv Drug Deliv Rev (2007) 1.94
Barrier-to-autointegration factor: major roles in chromatin decondensation and nuclear assembly. J Cell Biol (2002) 1.88
Proteins that bind A-type lamins: integrating isolated clues. J Cell Sci (2004) 1.79
Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing. Biophys J (2003) 1.77
Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods Cell Biol (2007) 1.74
Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73
MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 1.73
Emerin caps the pointed end of actin filaments: evidence for an actin cortical network at the nuclear inner membrane. PLoS Biol (2004) 1.72
Transcriptional repressor germ cell-less (GCL) and barrier to autointegration factor (BAF) compete for binding to emerin in vitro. J Biol Chem (2002) 1.72
Cooperativity in forced unfolding of tandem spectrin repeats. Biophys J (2003) 1.70
Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J Control Release (2006) 1.69
Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. J Cell Biol (2012) 1.65
Species- and cell type-specific interactions between CD47 and human SIRPalpha. Blood (2005) 1.63
Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Mol Pharm (2006) 1.61
Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophys J (2005) 1.56
Barrier-to-autointegration factor is required to segregate and enclose chromosomes within the nuclear envelope and assemble the nuclear lamina. Proc Natl Acad Sci U S A (2005) 1.56
Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles. J Control Release (2004) 1.55
How deeply cells feel: methods for thin gels. J Phys Condens Matter (2010) 1.51
BAF: roles in chromatin, nuclear structure and retrovirus integration. Trends Cell Biol (2004) 1.49
Unfolding a linker between helical repeats. J Mol Biol (2005) 1.48
Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains. Biophys J (2003) 1.46
Matefin, a Caenorhabditis elegans germ line-specific SUN-domain nuclear membrane protein, is essential for early embryonic and germ cell development. Proc Natl Acad Sci U S A (2004) 1.46
Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage. Mol Pharm (2009) 1.45
Targeted worm micelles. Biomacromolecules (2004) 1.45
Dynamic interaction between BAF and emerin revealed by FRAP, FLIP, and FRET analyses in living HeLa cells. J Struct Biol (2004) 1.44
Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci Signal (2008) 1.42
Matrix strains induced by cells: Computing how far cells can feel. Cell Mol Bioeng (2009) 1.41
Emerin binding to Btf, a death-promoting transcriptional repressor, is disrupted by a missense mutation that causes Emery-Dreifuss muscular dystrophy. Eur J Biochem (2004) 1.41
Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nat Mater (2009) 1.40
Direct binding of nuclear membrane protein MAN1 to emerin in vitro and two modes of binding to barrier-to-autointegration factor. J Biol Chem (2005) 1.40
The nuclear envelope, lamins and nuclear assembly. Curr Opin Cell Biol (2002) 1.40
Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharm Res (2007) 1.38
Conformational changes and signaling in cell and matrix physics. Curr Biol (2009) 1.33
Barrier-to-autointegration factor phosphorylation on Ser-4 regulates emerin binding to lamin A in vitro and emerin localization in vivo. Mol Biol Cell (2005) 1.32
Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells Mol Dis (2010) 1.31
Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules (2004) 1.30
Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles. J Am Chem Soc (2005) 1.30
Patterning, prestress, and peeling dynamics of myocytes. Biophys J (2004) 1.29
The expression, lamin-dependent localization and RNAi depletion phenotype for emerin in C. elegans. J Cell Sci (2002) 1.29
Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proc Natl Acad Sci U S A (2011) 1.28
Actin- and protein-4.1-containing filaments link nuclear pore complexes to subnuclear organelles in Xenopus oocyte nuclei. J Cell Sci (2004) 1.25
Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes. Hum Mol Genet (2006) 1.23
Multiple and surprising new functions for emerin, a nuclear membrane protein. Curr Opin Cell Biol (2004) 1.22
Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood (2006) 1.22
Barrier-to-autointegration factor proteome reveals chromatin-regulatory partners. PLoS One (2009) 1.21
Topographical pattern dynamics in passive adhesion of cell membranes. Biophys J (2004) 1.21
Polymersome carriers: from self-assembly to siRNA and protein therapeutics. Eur J Pharm Biopharm (2008) 1.21
Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry (2009) 1.21
Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos. J Struct Biol (2002) 1.20
Binding of barrier to autointegration factor (BAF) to histone H3 and selected linker histones including H1.1. J Biol Chem (2005) 1.20
Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. J Biol Chem (2006) 1.20
Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. Integr Biol (Camb) (2012) 1.20
Adhesion-contractile balance in myocyte differentiation. J Cell Sci (2004) 1.20
Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology (2005) 1.17
The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials (2011) 1.17
Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Curr Biol (2013) 1.17
Direct actin binding to A- and B-type lamin tails and actin filament bundling by the lamin A tail. Nucleus (2010) 1.15
Molecular extensibility of mini-dystrophins and a dystrophin rod construct. J Mol Biol (2005) 1.13
Emerin interacts in vitro with the splicing-associated factor, YT521-B. Eur J Biochem (2003) 1.12
Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding. J Biol Chem (2004) 1.11
Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken) (2010) 1.08
Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Curr Opin Cell Biol (2008) 1.08
Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proc Natl Acad Sci U S A (2013) 1.06
Barrier to autointegration factor blocks premature cell fusion and maintains adult muscle integrity in C. elegans. J Cell Biol (2007) 1.06
Barrier-to-autointegration factor BAF binds p55 Gag and matrix and is a host component of human immunodeficiency virus type 1 virions. J Virol (2003) 1.06
Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix. Biophys J (2011) 1.06
Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods Cell Biol (2007) 1.05
Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophys J (2009) 1.05
Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation (2013) 1.04
Stem cells, microenvironment mechanics, and growth factor activation. Curr Opin Cell Biol (2009) 1.04
Protein unfolding accounts for the unusual mechanical behavior of fibrin networks. Acta Biomater (2011) 1.04
Polymersome delivery of siRNA and antisense oligonucleotides. J Control Release (2008) 1.04
Nuclear pore protein gp210 is essential for viability in HeLa cells and Caenorhabditis elegans. Mol Biol Cell (2003) 1.03
Endothelial targeting of antibody-decorated polymeric filomicelles. ACS Nano (2011) 1.03
Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophys J (2011) 1.03