Published in Nat Rev Genet on October 01, 2005
Analysis of the vertebrate insulator protein CTCF-binding sites in the human genome. Cell (2007) 16.66
lincRNAs act in the circuitry controlling pluripotency and differentiation. Nature (2011) 11.31
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Genome architectures revealed by tethered chromosome conformation capture and population-based modeling. Nat Biotechnol (2011) 4.56
Genomic and transcriptional co-localization of protein-coding and long non-coding RNA pairs in the developing brain. PLoS Genet (2009) 3.38
Association between active genes occurs at nuclear speckles and is modulated by chromatin environment. J Cell Biol (2008) 3.13
Transcription factories: gene expression in unions? Nat Rev Genet (2009) 2.92
Architectural roles of multiple chromatin insulators at the human apolipoprotein gene cluster. EMBO J (2009) 2.56
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. Nat Struct Mol Biol (2013) 2.09
Heritability and genomics of gene expression in peripheral blood. Nat Genet (2014) 2.00
Epigenetic analysis of KSHV latent and lytic genomes. PLoS Pathog (2010) 1.94
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Chromatin dynamics and gene positioning. Cell (2008) 1.81
DNA methylation regulates long-range gene silencing of an X-linked homeobox gene cluster in a lineage-specific manner. Genes Dev (2006) 1.76
Human gene organization driven by the coordination of replication and transcription. Genome Res (2007) 1.71
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. Nat Genet (2011) 1.60
LncRNAs expression signatures of renal clear cell carcinoma revealed by microarray. PLoS One (2012) 1.59
Evolution of genome architecture. Int J Biochem Cell Biol (2008) 1.48
Epigenetic mechanisms in the development of type 2 diabetes. Trends Endocrinol Metab (2009) 1.46
Comparison of the three-dimensional organization of sperm and fibroblast genomes using the Hi-C approach. Genome Biol (2015) 1.45
Global chromatin domain organization of the Drosophila genome. PLoS Genet (2008) 1.45
Radial chromatin positioning is shaped by local gene density, not by gene expression. Chromosoma (2007) 1.45
Regulon organization of Arabidopsis. BMC Plant Biol (2008) 1.42
Transcription and chromatin organization of a housekeeping gene cluster containing an integrated beta-globin locus control region. PLoS Genet (2008) 1.38
The B-type lamin is required for somatic repression of testis-specific gene clusters. Proc Natl Acad Sci U S A (2009) 1.37
Operons. Cell Mol Life Sci (2009) 1.33
Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study. BMC Cancer (2014) 1.29
Nucleosome geometry and internucleosomal interactions control the chromatin fiber conformation. Biophys J (2008) 1.28
Epigenetics and phenotypic variation in mammals. Mamm Genome (2006) 1.26
Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression. Genome Res (2009) 1.26
Replication timing and epigenetic reprogramming of gene expression: a two-way relationship? Nat Rev Genet (2009) 1.22
The human insulin gene is part of a large open chromatin domain specific for human islets. Proc Natl Acad Sci U S A (2009) 1.17
Developmental origins of adult disease. Pediatr Clin North Am (2009) 1.13
Coexpression of linked genes in Mammalian genomes is generally disadvantageous. Mol Biol Evol (2008) 1.12
Gene positioning. Cold Spring Harb Perspect Biol (2010) 1.12
Dynamic chromatin organization during foregut development mediated by the organ selector gene PHA-4/FoxA. PLoS Genet (2010) 1.12
Chromatin domains in higher eukaryotes: insights from genome-wide mapping studies. Chromosoma (2008) 1.12
Whole-genome expression plasticity across tropical and temperate Drosophila melanogaster populations from Eastern Australia. Mol Biol Evol (2010) 1.10
Genome organization and gene expression shape the transposable element distribution in the Drosophila melanogaster euchromatin. PLoS Genet (2007) 1.09
Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. PLoS Genet (2013) 1.08
Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes. PLoS One (2009) 1.08
Gene clusters for secondary metabolic pathways: an emerging theme in plant biology. Plant Physiol (2010) 1.07
Coordinated postnatal down-regulation of multiple growth-promoting genes: evidence for a genetic program limiting organ growth. FASEB J (2010) 1.07
Chromosome territory reorganization in a human disease with altered DNA methylation. Proc Natl Acad Sci U S A (2007) 1.06
Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines. PLoS One (2012) 1.03
Gold-nanoparticle-assisted laser perturbation of chromatin assembly reveals unusual aspects of nuclear architecture within living cells. Biophys J (2007) 1.03
A chromosome-centric human proteome project (C-HPP) to characterize the sets of proteins encoded in chromosome 17. J Proteome Res (2012) 1.03
Preservation of large-scale chromatin structure in FISH experiments. Chromosoma (2006) 1.02
Long-range regulation of cytokine gene expression. Curr Opin Immunol (2008) 1.01
Paucity and preferential suppression of transgenes in late replication domains of the D. melanogaster genome. BMC Genomics (2010) 1.00
The Quest to Understand the Basis and Mechanisms that Control Expression of Introduced Transgenes in Crop Plants. Plant Signal Behav (2006) 1.00
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition. Semin Cancer Biol (2015) 0.99
Chromatin structure and gene regulation in T cell development and function. Curr Opin Immunol (2006) 0.99
Cell type-specific chromatin decondensation of a metabolic gene cluster in oats. Plant Cell (2009) 0.99
Properties of untranslated regions of the S. cerevisiae genome. BMC Genomics (2009) 0.98
Gene expression profile of neuronal progenitor cells derived from hESCs: activation of chromosome 11p15.5 and comparison to human dopaminergic neurons. PLoS One (2008) 0.97
Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. Nucleic Acids Res (2009) 0.96
Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells. Proc Natl Acad Sci U S A (2010) 0.96
Dynamic access of the glucocorticoid receptor to response elements in chromatin. Int J Biochem Cell Biol (2008) 0.94
53BP1 alters the landscape of DNA rearrangements and suppresses AID-induced B cell lymphoma. Mol Cell (2013) 0.93
Deletion of immunoproteasome subunits imprints on the transcriptome and has a broad impact on peptides presented by major histocompatibility complex I molecules. Mol Cell Proteomics (2010) 0.92
Conserved chromosomal clustering of genes governed by chromatin regulators in Drosophila. Genome Biol (2008) 0.90
Unraveling the dynamic transcriptome. Plant Cell (2006) 0.90
Probing the dynamic organization of transcription compartments and gene loci within the nucleus of living cells. Biophys J (2008) 0.89
Divergence of mammalian higher order chromatin structure is associated with developmental loci. PLoS Comput Biol (2013) 0.89
Analysis of the dynamics of limb transcriptomes during mouse development. BMC Dev Biol (2011) 0.89
Epigenetic domains found in mouse embryonic stem cells via a hidden Markov model. BMC Bioinformatics (2010) 0.89
Neighboring Genes Show Correlated Evolution in Gene Expression. Mol Biol Evol (2015) 0.89
Chromosomal patterns of gene expression from microarray data: methodology, validation and clinical relevance in gliomas. BMC Bioinformatics (2006) 0.88
Super-resolution microscopy reveals decondensed chromatin structure at transcription sites. Sci Rep (2014) 0.88
Visualization of the spatial positioning of the SNRPN, UBE3A, and GABRB3 genes in the normal human nucleus by three-color 3D fluorescence in situ hybridization. Chromosome Res (2012) 0.86
Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells. Mol Cell Biol (2012) 0.86
Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. Mol Microbiol (2013) 0.86
Identifying and mapping cell-type-specific chromatin programming of gene expression. Proc Natl Acad Sci U S A (2014) 0.85
Programming the genome in embryonic and somatic stem cells. J Cell Mol Med (2007) 0.85
Co-expression of adjacent genes in yeast cannot be simply attributed to shared regulatory system. BMC Genomics (2007) 0.85
Chromosomal organization: mingling with the neighbors. PLoS Biol (2006) 0.84
Modeling and experimental methods to probe the link between global transcription and spatial organization of chromosomes. PLoS One (2012) 0.83
hCAF1/CNOT7 regulates interferon signalling by targeting STAT1. EMBO J (2013) 0.83
Chromatin physics: Replacing multiple, representation-centered descriptions at discrete scales by a continuous, function-dependent self-scaled model. Eur Phys J E Soft Matter (2006) 0.82
Neighbourhood continuity is not required for correct testis gene expression in Drosophila. PLoS Biol (2010) 0.82
Regional regulation of transcription in the chicken genome. BMC Genomics (2010) 0.82
Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer. Genome Biol (2015) 0.81
The adjacent positioning of co-regulated gene pairs is widely conserved across eukaryotes. BMC Genomics (2012) 0.81
Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold. Proc Natl Acad Sci U S A (2013) 0.81
Differential Expression of Long Noncoding RNAs in Human Cumulus Cells Related to Embryo Developmental Potential: A Microarray Analysis. Reprod Sci (2014) 0.81
Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. PLoS Genet (2014) 0.80
Quantitative superresolution microscopy reveals differences in nuclear DNA organization of multiple myeloma and monoclonal gammopathy of undetermined significance. J Cell Biochem (2015) 0.79
Functional characterization of four metallothionein genes in Daphnia pulex exposed to environmental stressors. Aquat Toxicol (2011) 0.79
Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis. BMC Bioinformatics (2011) 0.79
Genome-wide analysis of the effect of histone modifications on the coexpression of neighboring genes in Saccharomyces cerevisiae. BMC Genomics (2010) 0.79
The nucleus introduced. Cold Spring Harb Perspect Biol (2011) 0.78
Histone methyltransferase Setd8 represses Gata2 expression and regulates erythroid maturation. Mol Cell Biol (2015) 0.78
Specific positioning of the casein gene cluster in active nuclear domains in luminal mammary epithelial cells. Chromosome Res (2011) 0.78
Coordinate regulation of the gel-forming mucin genes at chromosome 11p15.5. J Biol Chem (2013) 0.78
Modulation of dendritic cell function by Trichomonas vaginalis-derived secretory products. BMB Rep (2015) 0.77
Foreword. Comparative cytogenetics in the genomics era: cytogenomics comes of age. Chromosome Res (2008) 0.77
Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell (2004) 5.84
Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. Genes Dev (2004) 5.11
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
Chromatin motion is constrained by association with nuclear compartments in human cells. Curr Biol (2002) 3.99
Severe global DNA hypomethylation blocks differentiation and induces histone hyperacetylation in embryonic stem cells. Mol Cell Biol (2004) 3.76
Recruitment to the nuclear periphery can alter expression of genes in human cells. PLoS Genet (2008) 3.75
Single-cell dynamics of genome-nuclear lamina interactions. Cell (2013) 3.03
Transcription factories: gene expression in unions? Nat Rev Genet (2009) 2.92
Genomics: ENCODE explained. Nature (2012) 2.62
Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. J Cell Biol (2002) 2.40
Does looping and clustering in the nucleus regulate gene expression? Curr Opin Cell Biol (2004) 2.10
Transcription forms and remodels supercoiling domains unfolding large-scale chromatin structures. Nat Struct Mol Biol (2013) 2.09
Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells. J Cell Sci (2005) 1.94
Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation. Development (2007) 1.93
Spatial organization of active and inactive genes and noncoding DNA within chromosome territories. J Cell Biol (2002) 1.92
The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci. Nat Cell Biol (2004) 1.90
Nuclear re-organisation of the Hoxb complex during mouse embryonic development. Development (2005) 1.89
The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1. Curr Biol (2004) 1.85
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet (2012) 1.82
Considering nuclear compartmentalization in the light of nuclear dynamics. Cell (2003) 1.72
Chromatin structure and evolution in the human genome. BMC Evol Biol (2007) 1.67
Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology (2003) 1.55
Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol (2006) 1.51
G9a histone methyltransferase contributes to imprinting in the mouse placenta. Mol Cell Biol (2007) 1.51
3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res (2004) 1.48
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
Fluorescence in situ hybridization with high-complexity repeat-free oligonucleotide probes generated by massively parallel synthesis. Chromosome Res (2011) 1.46
Formation of facultative heterochromatin in the absence of HP1. EMBO J (2003) 1.45
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet (2012) 1.40
DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction. J Cell Biol (2007) 1.39
Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol Cell Biol (2002) 1.38
Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. Am J Hum Genet (2007) 1.33
Chromatin organization in the mammalian nucleus. Int Rev Cytol (2005) 1.29
The effect of translocation-induced nuclear reorganization on gene expression. Genome Res (2010) 1.27
Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression. Genome Res (2009) 1.26
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction. Genome Res (2013) 1.20
Activation of estrogen-responsive genes does not require their nuclear co-localization. PLoS Genet (2010) 1.18
Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells. PLoS One (2010) 1.17
The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? EMBO Rep (2005) 1.16
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase. Dev Biol (2006) 1.15
Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd. J Cell Sci (2008) 1.14
Analysis of active and inactive X chromosome architecture reveals the independent organization of 30 nm and large-scale chromatin structures. Mol Cell (2010) 1.14
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. PLoS One (2012) 1.14
Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression. Nucleic Acids Res (2012) 1.12
Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. Chromosome Res (2004) 1.11
Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. Genome Biol (2013) 1.11
Transcription and the nuclear periphery: edge of darkness? Curr Opin Genet Dev (2009) 1.10
Chromosome territory reorganization in a human disease with altered DNA methylation. Proc Natl Acad Sci U S A (2007) 1.06
Chromosome organization in the nucleus - charting new territory across the Hi-Cs. Curr Opin Genet Dev (2012) 1.06
DNA methylation in mouse embryonic stem cells and development. Cell Tissue Res (2007) 1.01
Anterior-posterior differences in HoxD chromatin topology in limb development. Development (2012) 1.00
Bone marrow stem cells contribute to alcohol liver fibrosis in humans. Stem Cells Dev (2010) 0.98
Enhancers: from developmental genetics to the genetics of common human disease. Dev Cell (2011) 0.96
FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription. PLoS Genet (2013) 0.95
Does radial nuclear organisation influence DNA damage? Chromosome Res (2005) 0.92
Altered protein dynamics of disease-associated lamin A mutants. BMC Cell Biol (2004) 0.92
Divergence of mammalian higher order chromatin structure is associated with developmental loci. PLoS Comput Biol (2013) 0.89
Regional chromatin decompaction in Cornelia de Lange syndrome associated with NIPBL disruption can be uncoupled from cohesin and CTCF. Hum Mol Genet (2013) 0.89
KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies. J Cell Sci (2009) 0.85
Characterisation of osteoprotegerin autoantibodies in coeliac disease. Calcif Tissue Int (2015) 0.85
Chromatin at the nuclear periphery and the regulation of genome functions. Histochem Cell Biol (2015) 0.83
The relationship between higher-order chromatin structure and transcription. Biochem Soc Symp (2006) 0.81
Changes in chromatin structure during processing of wax-embedded tissue sections. Chromosome Res (2010) 0.81
Divergent RNA transcription: a role in promoter unwinding? Transcription (2013) 0.81
Altered states: how gene expression is changed during differentiation. Curr Opin Genet Dev (2010) 0.80
Global chromatin fibre compaction in response to DNA damage. Biochem Biophys Res Commun (2011) 0.79
Genomic profiling of type-1 adult diabetic and aged normoglycemic mouse liver. BMC Endocr Disord (2014) 0.78
A condensed view of chromatin during T cell development. EMBO J (2011) 0.77
Porin new light onto chromatin and nuclear organization. Genome Biol (2008) 0.77
Transcription. Flashing a light on the spatial organization of transcription. Science (2013) 0.75
Polymers for the cell-specific immobilisation of megakaryocytic cell lines. Macromol Biosci (2013) 0.75
Investigating DNA supercoiling in eukaryotic genomes. Brief Funct Genomics (2017) 0.75
Elective tracheotomy facilitates total artificial heart implantation in calves. ASAIO J (2009) 0.75