Published in PLoS Genet on July 18, 2013
Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization. Genes Dev (2014) 1.76
Mechanisms of retinoic acid signalling and its roles in organ and limb development. Nat Rev Mol Cell Biol (2015) 1.29
Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes. Nat Commun (2015) 1.13
An Overview of Genome Organization and How We Got There: from FISH to Hi-C. Microbiol Mol Biol Rev (2015) 1.10
Retinoic acid controls body axis extension by directly repressing Fgf8 transcription. Development (2014) 0.91
Retinoid signaling in control of progenitor cell differentiation during mouse development. Semin Cell Dev Biol (2013) 0.89
Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity. PLoS Biol (2014) 0.89
An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci (2014) 0.84
Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo. Development (2014) 0.81
Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer. Genome Biol (2015) 0.81
HLXB9 gene expression, and nuclear location during in vitro neuronal differentiation in the SK-N-BE neuroblastoma cell line. PLoS One (2014) 0.79
Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. PLoS One (2015) 0.79
Transcriptional and epigenetic mechanisms of early cortical development: An examination of how Pax6 coordinates cortical development. J Comp Neurol (2015) 0.78
Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity. Development (2016) 0.78
From single molecules to life: microscopy at the nanoscale. Anal Bioanal Chem (2016) 0.76
Nuclear receptor corepressors Ncor1 and Ncor2 (Smrt) are required for retinoic acid-dependent repression of Fgf8 during somitogenesis. Dev Biol (2016) 0.76
ChAT-positive neurons participate in subventricular zone neurogenesis after middle cerebral artery occlusion in mice. Behav Brain Res (2016) 0.75
A new model of sperm nuclear architecture following assessment of the organization of centromeres and telomeres in three-dimensions. Sci Rep (2017) 0.75
The Multiple Roles of FGF Signaling in the Developing Spinal Cord. Front Cell Dev Biol (2017) 0.75
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol (2001) 7.20
Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophys J (2008) 6.86
Molecular maps of the reorganization of genome-nuclear lamina interactions during differentiation. Mol Cell (2010) 6.71
Subdiffraction multicolor imaging of the nuclear periphery with 3D structured illumination microscopy. Science (2008) 6.47
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet (1998) 5.95
Embryonic retinoic acid synthesis is essential for early mouse post-implantation development. Nat Genet (1999) 5.31
Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science (1997) 4.70
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol (2005) 4.52
Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development (1999) 3.84
Recruitment to the nuclear periphery can alter expression of genes in human cells. PLoS Genet (2008) 3.75
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol Cell Biol (2002) 3.17
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. Neuron (2003) 2.89
fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature (2004) 2.77
Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell (2010) 2.73
Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science (2011) 2.69
Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model. Science (1992) 2.69
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition. Proc Natl Acad Sci U S A (2003) 2.67
Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Curr Biol (2009) 2.22
Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation. Development (2007) 1.93
Redefining the progression of lineage segregations during mammalian embryogenesis by clonal analysis. Dev Cell (2009) 1.90
Nuclear re-organisation of the Hoxb complex during mouse embryonic development. Development (2005) 1.89
Deficiencies in lamin B1 and lamin B2 cause neurodevelopmental defects and distinct nuclear shape abnormalities in neurons. Mol Biol Cell (2011) 1.86
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation. Mol Cell (2010) 1.84
Stem cells, signals and vertebrate body axis extension. Development (2009) 1.83
Chromatin dynamics and gene positioning. Cell (2008) 1.81
Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science (2005) 1.66
Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6. Development (2003) 1.64
Retinoic-acid signalling in node ectoderm and posterior neural plate directs left-right patterning of somitic mesoderm. Nat Cell Biol (2006) 1.63
FGF signalling inhibits neural induction in human embryonic stem cells. EMBO J (2011) 1.61
Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron (2001) 1.59
Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology (2003) 1.55
Gene and cluster-specific expression of the Iroquois family members during mouse development. Mech Dev (2001) 1.53
eFGF regulates Xbra expression during Xenopus gastrulation. EMBO J (1994) 1.51
Establishing and interpreting graded Sonic Hedgehog signaling during vertebrate neural tube patterning: the role of negative feedback. Cold Spring Harb Perspect Biol (2009) 1.41
Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid. J Biol Chem (2010) 1.26
REST-mediated recruitment of polycomb repressor complexes in mammalian cells. PLoS Genet (2012) 1.26
FGF4 and FGF8 comprise the wavefront activity that controls somitogenesis. Proc Natl Acad Sci U S A (2011) 1.23
Requirement of mesodermal retinoic acid generated by Raldh2 for posterior neural transformation. Mech Dev (2005) 1.17
Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development (2010) 1.15
Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd. J Cell Sci (2008) 1.14
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. PLoS One (2012) 1.14
Transcription and the nuclear periphery: edge of darkness? Curr Opin Genet Dev (2009) 1.10
Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development (2009) 1.08
Promoter of FGF8 reveals a unique regulation by unliganded RARalpha. J Mol Biol (2002) 1.07
Positional cloning of a global regulator of anterior-posterior patterning in mice. Nature (1997) 1.07
Early posterior neural tissue is induced by FGF in the chick embryo. Development (1998) 1.06
In situ hybridization reveals co-expression of embryonic and adult alpha globin genes in the earliest murine erythrocyte progenitors. Development (1992) 1.02
Combinatorial signalling controls Neurogenin2 expression at the onset of spinal neurogenesis. Dev Biol (2008) 0.97
Neural induction intermediates exhibit distinct roles of Fgf signaling. Stem Cells (2010) 0.97
FGF signalling controls the timing of Pax6 activation in the neural tube. Development (2000) 0.93
Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling. Biochem Biophys Res Commun (2005) 0.76
Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell (2004) 5.84
Chromatin decondensation and nuclear reorganization of the HoxB locus upon induction of transcription. Genes Dev (2004) 5.11
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol (2011) 4.84
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination. Mol Cell (2010) 4.69
Chromatin motion is constrained by association with nuclear compartments in human cells. Curr Biol (2002) 3.99
Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem (2002) 3.92
Recruitment to the nuclear periphery can alter expression of genes in human cells. PLoS Genet (2008) 3.75
The role of chromatin structure in regulating the expression of clustered genes. Nat Rev Genet (2005) 3.40
The endosomal protein Appl1 mediates Akt substrate specificity and cell survival in vertebrate development. Cell (2008) 3.37
Retinoic acid in development: towards an integrated view. Nat Rev Genet (2008) 3.24
Single-cell dynamics of genome-nuclear lamina interactions. Cell (2013) 3.03
A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development (2007) 2.92
Transcription factories: gene expression in unions? Nat Rev Genet (2009) 2.92
Identification and characterization of rod-derived cone viability factor. Nat Genet (2004) 2.63
Genomics: ENCODE explained. Nature (2012) 2.62
Retinoic acid signalling during development. Development (2012) 2.47
Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development. Nat Genet (2002) 2.45
Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. J Cell Biol (2002) 2.40
Oral-facial-digital type I protein is required for primary cilia formation and left-right axis specification. Nat Genet (2005) 2.24
Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol (2005) 2.13
Does looping and clustering in the nucleus regulate gene expression? Curr Opin Cell Biol (2004) 2.10
Distinctive nuclear organisation of centromeres and regions involved in pluripotency in human embryonic stem cells. J Cell Sci (2005) 1.94
Nuclear reorganisation and chromatin decondensation are conserved, but distinct, mechanisms linked to Hox gene activation. Development (2007) 1.93
Spatial organization of active and inactive genes and noncoding DNA within chromosome territories. J Cell Biol (2002) 1.92
Nuclear re-organisation of the Hoxb complex during mouse embryonic development. Development (2005) 1.89
The radial positioning of chromatin is not inherited through mitosis but is established de novo in early G1. Curr Biol (2004) 1.85
Stem cells, signals and vertebrate body axis extension. Development (2009) 1.83
A robust system for RNA interference in the chicken using a modified microRNA operon. Dev Biol (2006) 1.83
CTIP1 and CTIP2 are differentially expressed during mouse embryogenesis. Gene Expr Patterns (2004) 1.83
Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet (2012) 1.82
Considering nuclear compartmentalization in the light of nuclear dynamics. Cell (2003) 1.72
Opposing FGF and retinoid pathways: a signalling switch that controls differentiation and patterning onset in the extending vertebrate body axis. Bioessays (2004) 1.68
Chromatin structure and evolution in the human genome. BMC Evol Biol (2007) 1.67
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse. Mech Dev (2002) 1.67
Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo. Science (2005) 1.66
miRNeye: a microRNA expression atlas of the mouse eye. BMC Genomics (2010) 1.59
Apical abscission alters cell polarity and dismantles the primary cilium during neurogenesis. Science (2014) 1.57
Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion. Gastroenterology (2003) 1.55
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse. Development (2002) 1.52
Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations. Mol Cell Biol (2006) 1.51
G9a histone methyltransferase contributes to imprinting in the mouse placenta. Mol Cell Biol (2007) 1.51
A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo. Dev Biol (2006) 1.50
Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Development (2002) 1.50
3D3/lyric: a novel transmembrane protein of the endoplasmic reticulum and nuclear envelope, which is also present in the nucleolus. Exp Cell Res (2004) 1.48
Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes. Genome Biol (2013) 1.47
Fluorescence in situ hybridization with high-complexity repeat-free oligonucleotide probes generated by massively parallel synthesis. Chromosome Res (2011) 1.46
Formation of facultative heterochromatin in the absence of HP1. EMBO J (2003) 1.45
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter. Biochem J (2008) 1.42
Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord. Development (2007) 1.42
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet (2012) 1.40
DNA methylation affects nuclear organization, histone modifications, and linker histone binding but not chromatin compaction. J Cell Biol (2007) 1.39
Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Mol Cell Biol (2002) 1.38
Retinoic acid regulates morphogenesis and patterning of posterior foregut derivatives. Dev Biol (2006) 1.37
The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system. Development (2003) 1.34
Mutations in TOPORS cause autosomal dominant retinitis pigmentosa with perivascular retinal pigment epithelium atrophy. Am J Hum Genet (2007) 1.33
Differential expression of the retinoic acid-metabolizing enzymes CYP26A1 and CYP26B1 during murine organogenesis. Mech Dev (2002) 1.31
Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice. Proc Natl Acad Sci U S A (2003) 1.30
In vivo role of the phosphate groove of PDK1 defined by knockin mutation. J Cell Sci (2005) 1.30
Chromatin organization in the mammalian nucleus. Int Rev Cytol (2005) 1.29
Cyp26C1 encodes a novel retinoic acid-metabolizing enzyme expressed in the hindbrain, inner ear, first branchial arch and tooth buds during murine development. Gene Expr Patterns (2003) 1.28
The effect of translocation-induced nuclear reorganization on gene expression. Genome Res (2010) 1.27
Lack of bystander activation shows that localization exterior to chromosome territories is not sufficient to up-regulate gene expression. Genome Res (2009) 1.26
Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis. Dev Biol (2006) 1.24
H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction. Genome Res (2013) 1.20
Activation of estrogen-responsive genes does not require their nuclear co-localization. PLoS Genet (2010) 1.18
Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons. Development (2005) 1.17
Stable morphology, but dynamic internal reorganisation, of interphase human chromosomes in living cells. PLoS One (2010) 1.17
The effects of histone deacetylase inhibitors on heterochromatin: implications for anticancer therapy? EMBO Rep (2005) 1.16
Wnt signals provide a timing mechanism for the FGF-retinoid differentiation switch during vertebrate body axis extension. Development (2007) 1.15
Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation. Development (2010) 1.15
Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain. EMBO J (2003) 1.15
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase. Dev Biol (2006) 1.15
Ectopic nuclear reorganisation driven by a Hoxb1 transgene transposed into Hoxd. J Cell Sci (2008) 1.14
A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesis. BMC Biol (2011) 1.14
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells. PLoS One (2012) 1.14
Retinoids control anterior and dorsal properties in the developing forebrain. Dev Biol (2006) 1.13
Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation. Development (2005) 1.13
Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis. Dev Biol (2006) 1.12
Loss of FGF-dependent mesoderm identity and rise of endogenous retinoid signalling determine cessation of body axis elongation. PLoS Biol (2012) 1.11
Nuclear organization of centromeric domains is not perturbed by inhibition of histone deacetylases. Chromosome Res (2004) 1.11
Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery. Genome Biol (2013) 1.11
Transcription and the nuclear periphery: edge of darkness? Curr Opin Genet Dev (2009) 1.10
Involvement of retinol dehydrogenase 10 in embryonic patterning and rescue of its loss of function by maternal retinaldehyde treatment. Proc Natl Acad Sci U S A (2011) 1.08
Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways. Development (2009) 1.08
Specification and maintenance of the spinal cord stem zone. Development (2005) 1.06
Chromosome organization in the nucleus - charting new territory across the Hi-Cs. Curr Opin Genet Dev (2012) 1.06
Chromosome territory reorganization in a human disease with altered DNA methylation. Proc Natl Acad Sci U S A (2007) 1.06
Expression of the murine retinol dehydrogenase 10 (Rdh10) gene correlates with many sites of retinoid signalling during embryogenesis and organ differentiation. Dev Dyn (2007) 1.05
Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling. Development (2002) 1.04
Kidney-specific inactivation of Ofd1 leads to renal cystic disease associated with upregulation of the mTOR pathway. Hum Mol Genet (2010) 1.02
Retinoic acid signalling is required for specification of pronephric cell fate. Dev Biol (2006) 1.02
Endogenous retinoic acid regulates cardiac progenitor differentiation. Proc Natl Acad Sci U S A (2010) 1.02
Mitotic spindle orientation can direct cell fate and bias Notch activity in chick neural tube. EMBO Rep (2012) 1.01
Retinaldehyde dehydrogenase 2 (RALDH2)-mediated retinoic acid synthesis regulates early mouse embryonic forebrain development by controlling FGF and sonic hedgehog signaling. Development (2006) 1.01
Hox genes define distinct progenitor sub-domains within the second heart field. Dev Biol (2011) 1.00
Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene. Gene (2004) 1.00
Anterior-posterior differences in HoxD chromatin topology in limb development. Development (2012) 1.00
FGF-dependent Notch signaling maintains the spinal cord stem zone. Genes Dev (2005) 0.99