Published in Proc Natl Acad Sci U S A on September 21, 2005
Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med (2015) 1.64
Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A (2007) 1.40
Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32
Dipeptidyl peptidase IV inhibition with MK0431 improves islet graft survival in diabetic NOD mice partially via T-cell modulation. Diabetes (2008) 1.15
Protein kinase A activity and anchoring are required for ovarian cancer cell migration and invasion. PLoS One (2011) 1.08
Spatial distribution of protein kinase A activity during cell migration is mediated by A-kinase anchoring protein AKAP Lbc. J Biol Chem (2008) 1.08
Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol (2007) 1.08
cAMP inhibits cell migration by interfering with Rac-induced lamellipodium formation. J Biol Chem (2008) 1.08
Cross-talk between calcium and protein kinase A in the regulation of cell migration. Curr Opin Cell Biol (2011) 1.03
Spatial targeting of type II protein kinase A to filopodia mediates the regulation of growth cone guidance by cAMP. J Cell Biol (2007) 0.99
Anchored protein kinase A recruitment of active Rac GTPase. J Biol Chem (2011) 0.99
Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxis. J Biol Chem (2008) 0.98
Reciprocal regulation of PKA and Rac signaling. Proc Natl Acad Sci U S A (2013) 0.95
Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A (2010) 0.94
Sitagliptin (MK0431) inhibition of dipeptidyl peptidase IV decreases nonobese diabetic mouse CD4+ T-cell migration through incretin-dependent and -independent pathways. Diabetes (2010) 0.92
AMPK activity regulates trafficking of mitochondria to the leading edge during cell migration and matrix invasion. Mol Biol Cell (2016) 0.91
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor. PLoS One (2011) 0.91
cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC. Biochim Biophys Acta (2013) 0.90
Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells. Mol Biol Cell (2011) 0.89
Bacillus anthracis edema toxin suppresses human macrophage phagocytosis and cytoskeletal remodeling via the protein kinase A and exchange protein activated by cyclic AMP pathways. Infect Immun (2009) 0.88
Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides. J Biol Chem (2012) 0.88
Role of molecular determinants of store-operated Ca(2+) entry (Orai1, phospholipase A2 group 6, and STIM1) in focal adhesion formation and cell migration. J Biol Chem (2012) 0.84
Compartmentalization of cyclic nucleotide signaling: a question of when, where, and why? Pflugers Arch (2013) 0.83
AKAP-independent localization of type-II protein kinase A to dynamic actin microspikes. Cell Motil Cytoskeleton (2009) 0.82
Förster resonance energy transfer - an approach to visualize the spatiotemporal regulation of macromolecular complex formation and compartmentalized cell signaling. Biochim Biophys Acta (2014) 0.81
Regulation of motility of myogenic cells in filling limb muscle anlagen by Pitx2. PLoS One (2012) 0.80
WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions. J Biol Chem (2010) 0.80
Crosstalk between PKA and Epac regulates the phenotypic maturation and function of human dendritic cells. J Immunol (2010) 0.80
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. Mol Biol Cell (2009) 0.80
Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). J Biol Chem (2015) 0.79
Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons. J Neurochem (2007) 0.79
PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration. Cell Signal (2015) 0.79
Direct modulation of the protein kinase A catalytic subunit α by growth factor receptor tyrosine kinases. J Cell Biochem (2012) 0.78
Saltatory formation, sliding and dissolution of ER-PM junctions in migrating cancer cells. Biochem J (2013) 0.78
Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction. Dev Biol (2007) 0.78
The novel desmopressin analogue [V4Q5]dDAVP inhibits angiogenesis, tumour growth and metastases in vasopressin type 2 receptor-expressing breast cancer models. Int J Oncol (2015) 0.78
FRET biosensors reveal AKAP-mediated shaping of subcellular PKA activity and a novel mode of Ca(2+)/PKA crosstalk. Cell Signal (2016) 0.75
Methods to Study Mrp4-containing Macromolecular Complexes in the Regulation of Fibroblast Migration. J Vis Exp (2016) 0.75
Protein kinase A can block EphA2 receptor-mediated cell repulsion by increasing EphA2 S897 phosphorylation. Mol Biol Cell (2016) 0.75
Cell migration: a physically integrated molecular process. Cell (1996) 23.49
Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct (2000) 10.11
Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00
A cell's sense of direction. Science (1999) 6.00
Networks and crosstalk: integrin signalling spreads. Nat Cell Biol (2002) 4.66
Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol (2003) 4.22
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron (2004) 3.65
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol (2005) 3.44
Specificity in the cAMP/PKA signaling pathway. Differential expression,regulation, and subcellular localization of subunits of PKA. Front Biosci (2000) 2.70
Physiological substrates of cAMP-dependent protein kinase. Chem Rev (2001) 2.56
Regulation of anchorage-dependent signal transduction by protein kinase A and p21-activated kinase. Nat Cell Biol (2000) 2.37
Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST. Mol Cell Biol (1996) 2.30
Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem (2003) 2.28
AKAP mediated signal transduction. Annu Rev Pharmacol Toxicol (2002) 2.26
Regulation of actin-based cell migration by cAMP/PKA. Biochim Biophys Acta (2004) 2.15
Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold. EMBO J (2000) 2.13
Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol (2002) 1.99
Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol (2002) 1.87
Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Mol Biol Cell (2002) 1.81
How do Abl family kinases regulate cell shape and movement? Trends Cell Biol (2004) 1.71
Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol (2002) 1.64
Protein kinase A regulates Rac and is required for the growth factor-stimulated migration of carcinoma cells. J Biol Chem (2001) 1.60
AKAP signaling complexes at the cytoskeleton. J Cell Sci (2001) 1.60
Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol (2003) 1.58
Regulation of integrin alpha vbeta 3-mediated endothelial cell migration and angiogenesis by integrin alpha5beta1 and protein kinase A. J Biol Chem (2000) 1.52
Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Front Biosci (2002) 1.46
Role of Rac in controlling the actin cytoskeleton and chemotaxis in motile cells. Proc Natl Acad Sci U S A (2000) 1.46
Actin-based motility: stop and go with Ena/VASP proteins. Trends Biochem Sci (2001) 1.45
Phosphorylation of the integrin alpha 4 cytoplasmic domain regulates paxillin binding. J Biol Chem (2001) 1.25
PTP-PEST: a protein tyrosine phosphatase regulated by serine phosphorylation. EMBO J (1994) 1.25
PTP-PEST controls motility through regulation of Rac1. J Cell Sci (2002) 1.24
Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST. J Biol Chem (1999) 1.20
Endothelin 1 induces beta 1Pix translocation and Cdc42 activation via protein kinase A-dependent pathway. J Biol Chem (2004) 1.19
Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion. J Biol Chem (2002) 1.18
Prostaglandin E2 promotes integrin alpha Vbeta 3-dependent endothelial cell adhesion, rac-activation, and spreading through cAMP/PKA-dependent signaling. J Biol Chem (2002) 1.17
Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase. J Biol Chem (2002) 1.15
Inhibition of PKA blocks fibroblast migration in response to growth factors. Exp Cell Res (2001) 1.05
Positive regulation of cell-cell and cell-substrate adhesion by protein kinase A. J Cell Sci (2001) 0.96
Protein kinase C and cAMP-dependent protein kinase induce opposite effects on actin polymerizability. FEBS Lett (1987) 0.96
Cyclic AMP and protein kinase A stimulate Cdc42: role of A(2) adenosine receptors in human mast cells. Mol Pharmacol (2000) 0.96
Dephosphorylation of the focal adhesion protein VASP in vitro and in intact human platelets. FEBS Lett (1995) 0.92
Dual action of cAMP-dependent protein kinase on granulocyte movement. Biochem Biophys Res Commun (1997) 0.88
Antibody-induced activation of beta1 integrin receptors stimulates cAMP-dependent migration of breast cells on laminin-5. Mol Cell Biol Res Commun (2000) 0.83
Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats. J Nutr (2002) 1.42
Regulation of vasodilator-stimulated phosphoprotein phosphorylation and interaction with Abl by protein kinase A and cell adhesion. J Biol Chem (2002) 1.18
Crystal structure of Thermus aquaticus Gfh1, a Gre-factor paralog that inhibits rather than stimulates transcript cleavage. J Mol Biol (2005) 1.11
Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases. J Cell Sci (2002) 1.08
Protein kinase A regulates 3-phosphatidylinositide dynamics during platelet-derived growth factor-induced membrane ruffling and chemotaxis. J Biol Chem (2008) 0.98