Avian influenza A (H5N1) infection in humans.

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Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21

Emergence and pandemic potential of swine-origin H1N1 influenza virus. Nature (2009) 11.34

Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38

Spatial, temporal, and species variation in prevalence of influenza A viruses in wild migratory birds. PLoS Pathog (2007) 6.04

Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev (2006) 5.92

Who should receive life support during a public health emergency? Using ethical principles to improve allocation decisions. Ann Intern Med (2009) 5.35

Epidemic influenza and vitamin D. Epidemiol Infect (2006) 5.32

Review of aerosol transmission of influenza A virus. Emerg Infect Dis (2006) 5.31

Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals. Am J Pathol (2007) 4.86

H5N1 and 1918 pandemic influenza virus infection results in early and excessive infiltration of macrophages and neutrophils in the lungs of mice. PLoS Pathog (2008) 4.79

Growth of H5N1 influenza A viruses in the upper respiratory tracts of mice. PLoS Pathog (2007) 4.49

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus. Proc Natl Acad Sci U S A (2009) 4.12

Inefficient transmission of H5N1 influenza viruses in a ferret contact model. J Virol (2007) 3.79

Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med (2007) 3.63

Empirical evidence for the effect of airline travel on inter-regional influenza spread in the United States. PLoS Med (2006) 3.60

Influenza virus receptor specificity and cell tropism in mouse and human airway epithelial cells. J Virol (2006) 3.60

Prediction and prevention of the next pandemic zoonosis. Lancet (2012) 3.44

Quasispecies theory and the behavior of RNA viruses. PLoS Pathog (2010) 3.19

Non-pharmaceutical public health interventions for pandemic influenza: an evaluation of the evidence base. BMC Public Health (2007) 2.90

Development of a triage protocol for critical care during an influenza pandemic. CMAJ (2006) 2.78

Pathology of human influenza revisited. Vaccine (2008) 2.71

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection. Antimicrob Agents Chemother (2006) 2.69

Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A (2007) 2.63

Identification of amino acids in HA and PB2 critical for the transmission of H5N1 avian influenza viruses in a mammalian host. PLoS Pathog (2009) 2.62

Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis. Am J Pathol (2011) 2.57

Critical role of IL-17RA in immunopathology of influenza infection. J Immunol (2009) 2.51

The influenza virus enigma. Cell (2009) 2.48

A systems analysis identifies a feedforward inflammatory circuit leading to lethal influenza infection. Cell (2013) 2.38

Human malarial disease: a consequence of inflammatory cytokine release. Malar J (2006) 2.36

Pathology, molecular biology, and pathogenesis of avian influenza A (H5N1) infection in humans. Am J Pathol (2008) 2.36

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci U S A (2008) 2.33

A modified sequential organ failure assessment score for critical care triage. Disaster Med Public Health Prep (2010) 2.28

Knowledge, attitudes, and practices of avian influenza, poultry workers, Italy. Emerg Infect Dis (2006) 2.27

Variation and infectivity neutralization in influenza. Immunology (2006) 2.23

Highly pathogenic avian influenza (H5N1): pathways of exposure at the animal-human interface, a systematic review. PLoS One (2011) 2.22

Healthy human subjects have CD4+ T cells directed against H5N1 influenza virus. J Immunol (2008) 2.21

Limited airborne transmission of H7N9 influenza A virus between ferrets. Nature (2013) 2.17

Ensemble-based virtual screening reveals potential novel antiviral compounds for avian influenza neuraminidase. J Med Chem (2008) 2.14

Preliminary findings of a randomized trial of non-pharmaceutical interventions to prevent influenza transmission in households. PLoS One (2008) 2.04

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection. Proc Natl Acad Sci U S A (2009) 2.04

Efficacy of oseltamivir therapy in ferrets inoculated with different clades of H5N1 influenza virus. Antimicrob Agents Chemother (2007) 2.03

Emerging influenza. J Clin Virol (2008) 2.02

Distinct contributions of vaccine-induced immunoglobulin G1 (IgG1) and IgG2a antibodies to protective immunity against influenza. Clin Vaccine Immunol (2006) 2.01

Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice. Antimicrob Agents Chemother (2006) 2.00

Treatment with protein synthesis inhibitors improves outcomes of secondary bacterial pneumonia after influenza. J Infect Dis (2009) 1.93

Animal models for the study of influenza pathogenesis and therapy. Antiviral Res (2009) 1.90

Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res (2008) 1.86

Natural variation can significantly alter the sensitivity of influenza A (H5N1) viruses to oseltamivir. Antimicrob Agents Chemother (2006) 1.85

H5N1 influenza A virus and infected human plasma. Emerg Infect Dis (2006) 1.84

Chronic alcohol consumption increases the severity of murine influenza virus infections. J Immunol (2008) 1.83

Seasonal and pandemic human influenza viruses attach better to human upper respiratory tract epithelium than avian influenza viruses. Am J Pathol (2010) 1.81

Differences in clinical outcomes after 2009 influenza A/H1N1 and seasonal influenza among hematopoietic cell transplant recipients. Blood (2011) 1.80

Risk for infection with highly pathogenic influenza A virus (H5N1) in chickens, Hong Kong, 2002. Emerg Infect Dis (2007) 1.79

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus. Nature (2008) 1.77

Environmental contamination during influenza A virus (H5N1) outbreaks, Cambodia, 2006. Emerg Infect Dis (2008) 1.77

Functional balance of the hemagglutinin and neuraminidase activities accompanies the emergence of the 2009 H1N1 influenza pandemic. J Virol (2012) 1.76

Intra- and interhost evolutionary dynamics of equine influenza virus. J Virol (2010) 1.75

Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial. BMJ (2013) 1.70

What is the best control strategy for multiple infectious disease outbreaks? Proc Biol Sci (2007) 1.68

The generation of influenza outbreaks by a network of host immune responses against a limited set of antigenic types. Proc Natl Acad Sci U S A (2007) 1.63

Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother (2008) 1.63

Monoclonal antibodies against the fusion peptide of hemagglutinin protect mice from lethal influenza A virus H5N1 infection. J Virol (2008) 1.62

A consensus-hemagglutinin-based DNA vaccine that protects mice against divergent H5N1 influenza viruses. Proc Natl Acad Sci U S A (2008) 1.59

The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus replication and pathogenesis in mice. J Virol (2013) 1.57

Reassortment between avian H5N1 and human H3N2 influenza viruses creates hybrid viruses with substantial virulence. Proc Natl Acad Sci U S A (2010) 1.56

Emerging respiratory viruses: challenges and vaccine strategies. Clin Microbiol Rev (2006) 1.52

Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic. J Virol (2009) 1.50

Cellular versus viral microRNAs in host-virus interaction. Nucleic Acids Res (2008) 1.50

Differential contribution of PB1-F2 to the virulence of highly pathogenic H5N1 influenza A virus in mammalian and avian species. PLoS Pathog (2011) 1.49

Pandemic influenza and hospital resources. Emerg Infect Dis (2007) 1.44

Lessons from the past: familial aggregation analysis of fatal pandemic influenza (Spanish flu) in Iceland in 1918. Proc Natl Acad Sci U S A (2008) 1.44

Antibody pressure by a human monoclonal antibody targeting the 2009 pandemic H1N1 virus hemagglutinin drives the emergence of a virus with increased virulence in mice. MBio (2012) 1.43

Modeling host genetic regulation of influenza pathogenesis in the collaborative cross. PLoS Pathog (2013) 1.43

Pathogenicity of highly pathogenic avian influenza virus in mammals. Vaccine (2008) 1.42

Bird flu and pandemic flu. BMJ (2005) 1.41

Pandemic flu: clinical management of patients with an influenza-like illness during an influenza pandemic. Provisional guidelines from the British Infection Society, British Thoracic Society, and Health Protection Agency in collaboration with the Department of Health. Thorax (2007) 1.41

Chinese guidelines for diagnosis and treatment of influenza (2011). J Thorac Dis (2011) 1.40

Comparison of nasopharyngeal and oropharyngeal swabs for the diagnosis of eight respiratory viruses by real-time reverse transcription-PCR assays. PLoS One (2011) 1.40

Influenza. Crit Care Med (2008) 1.39

Emerging pathogens: challenges and successes of molecular diagnostics. J Mol Diagn (2008) 1.38

Ferrets develop fatal influenza after inhaling small particle aerosols of highly pathogenic avian influenza virus A/Vietnam/1203/2004 (H5N1). Virol J (2010) 1.36

Analysis of hemagglutinin-mediated entry tropism of H5N1 avian influenza. Virol J (2009) 1.33

Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding. J Virol (2009) 1.32

H5N1 avian influenza virus induces apoptotic cell death in mammalian airway epithelial cells. J Virol (2008) 1.32

Two years after pandemic influenza A/2009/H1N1: what have we learned? Clin Microbiol Rev (2012) 1.31

Antiviral treatment for the control of pandemic influenza: some logistical constraints. J R Soc Interface (2008) 1.31

Multiple CD4+ T cell subsets produce immunomodulatory IL-10 during respiratory syncytial virus infection. J Immunol (2011) 1.30

Influenza virus infection among pediatric patients reporting diarrhea and influenza-like illness. BMC Infect Dis (2010) 1.30

Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol (2011) 1.30

Unique type I interferon responses determine the functional fate of migratory lung dendritic cells during influenza virus infection. PLoS Pathog (2011) 1.28

CXCL10-CXCR3 enhances the development of neutrophil-mediated fulminant lung injury of viral and nonviral origin. Am J Respir Crit Care Med (2012) 1.28

Influenza sequence and epitope database. Nucleic Acids Res (2008) 1.27

Heterologous HA DNA vaccine prime--inactivated influenza vaccine boost is more effective than using DNA or inactivated vaccine alone in eliciting antibody responses against H1 or H3 serotype influenza viruses. Vaccine (2008) 1.27

Detecting emerging transmissibility of avian influenza virus in human households. PLoS Comput Biol (2007) 1.27

Distinct glycan topology for avian and human sialopentasaccharide receptor analogues upon binding different hemagglutinins: a molecular dynamics perspective. J Mol Biol (2009) 1.27

Pandemic influenza: risk of multiple introductions and the need to prepare for them. PLoS Med (2006) 1.26

Sharing H5N1 viruses to stop a global influenza pandemic. PLoS Med (2007) 1.24

Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1). Virology (2008) 1.23

Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005. Emerg Infect Dis (2009) 1.23

Oseltamivir resistance during treatment of influenza A (H5N1) infection. N Engl J Med (2005) 15.53

Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 14.21

Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med (2004) 11.31

Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome. Lancet (2013) 10.66

Update on avian influenza A (H5N1) virus infection in humans. N Engl J Med (2008) 10.27

Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med (2004) 10.14

Dengue: a continuing global threat. Nat Rev Microbiol (2010) 9.96

Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med (2010) 9.90

Resistant influenza A viruses in children treated with oseltamivir: descriptive study. Lancet (2004) 8.62

Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci U S A (2005) 8.52

Non-pharmaceutical interventions for pandemic influenza, national and community measures. Emerg Infect Dis (2006) 6.85

Closure of schools during an influenza pandemic. Lancet Infect Dis (2009) 6.68

Seasonal influenza in adults and children--diagnosis, treatment, chemoprophylaxis, and institutional outbreak management: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis (2009) 6.52

Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma. N Engl J Med (2005) 6.47

Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev (2007) 6.38

Lack of transmission of H5N1 avian-human reassortant influenza viruses in a ferret model. Proc Natl Acad Sci U S A (2006) 6.35

Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J Virol (2012) 6.04

Hemofiltration and peritoneal dialysis in infection-associated acute renal failure in Vietnam. N Engl J Med (2002) 5.24

Dexamethasone in Vietnamese adolescents and adults with bacterial meningitis. N Engl J Med (2007) 5.12

Evolutionary history of Salmonella typhi. Science (2006) 5.00

Non-pharmaceutical interventions for pandemic influenza, international measures. Emerg Infect Dis (2006) 4.34

Viral infections in relation to age, atopy, and season of admission among children hospitalized for wheezing. J Allergy Clin Immunol (2004) 4.33

Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet (2009) 4.30

Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals. J Clin Invest (2008) 4.30

Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: implications for disease pathogenesis and clinical manifestation. J Infect Dis (2013) 4.28

Human disease from influenza A (H5N1), Thailand, 2004. Emerg Infect Dis (2005) 4.27

Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. Chest (2013) 4.16

A study of typhoid fever in five Asian countries: disease burden and implications for controls. Bull World Health Organ (2008) 4.11

Detection of influenza viruses resistant to neuraminidase inhibitors in global surveillance during the first 3 years of their use. Antimicrob Agents Chemother (2006) 4.02

Consent, confidentiality, and the threat to public health surveillance. BMJ (2002) 3.96

Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children. J Clin Microbiol (2007) 3.89

The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis. PLoS Pathog (2008) 3.79

Kinetics of influenza A virus infection in humans. J Virol (2006) 3.78

Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial. Lancet (2004) 3.72

Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. PLoS Med (2007) 3.63

Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis. N Engl J Med (2016) 3.59

Delayed clearance of viral load and marked cytokine activation in severe cases of pandemic H1N1 2009 influenza virus infection. Clin Infect Dis (2010) 3.49

Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials. Am J Epidemiol (2006) 3.48

Diagnostic accuracy of NS1 ELISA and lateral flow rapid tests for dengue sensitivity, specificity and relationship to viraemia and antibody responses. PLoS Negl Trop Dis (2009) 3.30

Coronavirus diversity, phylogeny and interspecies jumping. Exp Biol Med (Maywood) (2009) 3.27

Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic? J Infect (2012) 3.22

Streptococcus suis meningitis in adults in Vietnam. Clin Infect Dis (2008) 3.18

In vivo susceptibility of Plasmodium falciparum to artesunate in Binh Phuoc Province, Vietnam. Malar J (2012) 3.13

Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features. J Virol (2006) 3.07

Evaluation of diagnostic tests: dengue. Nat Rev Microbiol (2010) 2.91

Tuberculous meningitis: many questions, too few answers. Lancet Neurol (2005) 2.90

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Clinical and molecular epidemiology of human bocavirus in respiratory and fecal samples from children in Hong Kong. J Infect Dis (2007) 2.82

In vivo assessment of drug efficacy against Plasmodium falciparum malaria: duration of follow-up. Antimicrob Agents Chemother (2004) 2.77

Distribution of amantadine-resistant H5N1 avian influenza variants in Asia. J Infect Dis (2006) 2.76

Antimicrobial drug resistance of Salmonella enterica serovar typhi in asia and molecular mechanism of reduced susceptibility to the fluoroquinolones. Antimicrob Agents Chemother (2007) 2.73

Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): randomized, controlled trial of ibuprofen versus placebo for prevention of altitude illness. Wilderness Environ Med (2012) 2.70

Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection. Antimicrob Agents Chemother (2006) 2.69

Bats as a continuing source of emerging infections in humans. Rev Med Virol (2007) 2.61

Into the eye of the cytokine storm. Microbiol Mol Biol Rev (2012) 2.58

Human infection with highly pathogenic H5N1 influenza virus. Lancet (2008) 2.57

Transparent development of the WHO rapid advice guidelines. PLoS Med (2007) 2.57

Viral load in patients infected with pandemic H1N1 2009 influenza A virus. J Med Virol (2010) 2.55

Gatifloxacin versus chloramphenicol for uncomplicated enteric fever: an open-label, randomised, controlled trial. Lancet Infect Dis (2011) 2.54

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Progress towards a dengue vaccine. Lancet Infect Dis (2009) 2.45

How to maintain surveillance for novel influenza A H1N1 when there are too many cases to count. Lancet (2009) 2.44

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Identification of novel porcine and bovine parvoviruses closely related to human parvovirus 4. J Gen Virol (2008) 2.41

Ciprofloxacin decreased polyoma BK virus load in patients who underwent allogeneic hematopoietic stem cell transplantation. Clin Infect Dis (2005) 2.40

A community cluster of oseltamivir-resistant cases of 2009 H1N1 influenza. N Engl J Med (2009) 2.36

Hemorrhagic fever caused by a novel Bunyavirus in China: pathogenesis and correlates of fatal outcome. Clin Infect Dis (2011) 2.34

Viral population analysis and minority-variant detection using short read next-generation sequencing. Philos Trans R Soc Lond B Biol Sci (2013) 2.33

Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci U S A (2008) 2.33

Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis. PLoS Negl Trop Dis (2010) 2.33

Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study. Clin Infect Dis (2010) 2.32

Factors associated with uptake of vaccination against pandemic influenza: a systematic review. Vaccine (2011) 2.24

Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009. Clin Infect Dis (2010) 2.24

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Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay. Antiviral Res (2002) 2.22

Policy: An intergovernmental panel on antimicrobial resistance. Nature (2014) 2.22

Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values. J Clin Microbiol (2011) 2.18

Epidemiological factors associated with dengue shock syndrome and mortality in hospitalized dengue patients in Ho Chi Minh City, Vietnam. Am J Trop Med Hyg (2011) 2.17

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Emergence of the Asian 1 genotype of dengue virus serotype 2 in viet nam: in vivo fitness advantage and lineage replacement in South-East Asia. PLoS Negl Trop Dis (2010) 2.17

Hemorrhagic fever caused by a novel tick-borne Bunyavirus in Huaiyangshan, China. Zhonghua Liu Xing Bing Xue Za Zhi (2011) 2.15

High-throughput genotyping of Salmonella enterica serovar Typhi allowing geographical assignment of haplotypes and pathotypes within an urban District of Jakarta, Indonesia. J Clin Microbiol (2008) 2.14

Serologic survey of pandemic (H1N1) 2009 virus, Guangxi Province, China. Emerg Infect Dis (2009) 2.13

Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus. J Virol (2010) 2.11

Clinical characteristics of Dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital. Clin Infect Dis (2013) 2.08

Cross-reactive antibodies in convalescent SARS patients' sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests. J Infect (2013) 2.08

Granulicatella adiacens and Abiotrophia defectiva bacteraemia characterized by 16S rRNA gene sequencing. J Med Microbiol (2003) 2.07

Picornavirus infections in children diagnosed by RT-PCR during longitudinal surveillance with weekly sampling: Association with symptomatic illness and effect of season. J Med Virol (2006) 2.06