Published in Nucleic Acids Res on September 28, 2005
Alternative splicing and evolution: diversification, exon definition and function. Nat Rev Genet (2010) 4.30
Heritability of alternative splicing in the human genome. Genome Res (2007) 2.76
Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol (2007) 2.35
Stochastic noise in splicing machinery. Nucleic Acids Res (2009) 2.06
Function of alternative splicing. Gene (2012) 2.00
Promoter-like epigenetic signatures in exons displaying cell type-specific splicing. Genome Biol (2015) 1.46
Alternative splicing regulation during C. elegans development: splicing factors as regulated targets. PLoS Genet (2008) 1.41
Genomic splice-site analysis reveals frequent alternative splicing close to the dominant splice site. RNA (2006) 1.22
Characteristics of transposable element exonization within human and mouse. PLoS One (2010) 1.09
Transcriptome analysis reveals strain-specific and conserved stemness genes in Schmidtea mediterranea. PLoS One (2012) 1.04
Accurate identification and analysis of human mRNA isoforms using deep long read sequencing. G3 (Bethesda) (2013) 1.03
Organization and post-transcriptional processing of focal adhesion kinase gene. BMC Genomics (2006) 1.03
LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq. Genome Res (2014) 1.02
Exon creation and establishment in human genes. Genome Biol (2008) 0.98
Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human. Nucleic Acids Res (2007) 0.93
Conserved and species-specific alternative splicing in mammalian genomes. BMC Evol Biol (2007) 0.92
Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene. BMC Mol Biol (2007) 0.91
Constant splice-isoform ratios in human lymphoblastoid cells support the concept of a splico-stat. Genetics (2011) 0.88
Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast. Genome Res (2015) 0.88
Cloning, expression, and characterization of an alternatively spliced variant of human heparanase. Biochem Biophys Res Commun (2007) 0.86
Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine species. BMC Dev Biol (2014) 0.80
Characterising alternate splicing and tissue specific expression in the chicken from ESTs. Cytogenet Genome Res (2007) 0.77
Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide. Endocrine (2016) 0.76
The Pfam protein families database. Nucleic Acids Res (2000) 42.28
NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res (2005) 37.39
SMART 4.0: towards genomic data integration. Nucleic Acids Res (2004) 19.37
A genomic view of alternative splicing. Nat Genet (2002) 12.62
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nat Rev Mol Cell Biol (2004) 11.39
Alternative splicing: increasing diversity in the proteomic world. Trends Genet (2001) 10.44
Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans. Proc Natl Acad Sci U S A (2002) 10.28
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem Sci (1998) 9.06
Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature (2002) 7.60
Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell (2000) 6.92
Nonsense-mediated mRNA decay in health and disease. Hum Mol Genet (1999) 6.90
Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss. Nat Genet (2003) 6.09
Nonsense-mediated decay approaches the clinic. Nat Genet (2004) 5.12
Transcriptome and genome conservation of alternative splicing events in humans and mice. Pac Symp Biocomput (2004) 4.25
Autoregulation of polypyrimidine tract binding protein by alternative splicing leading to nonsense-mediated decay. Mol Cell (2004) 4.13
How did alternative splicing evolve? Nat Rev Genet (2004) 3.88
How prevalent is functional alternative splicing in the human genome? Trends Genet (2004) 3.81
Alternative RNA splicing in the nervous system. Prog Neurobiol (2001) 3.38
The evolving roles of alternative splicing. Curr Opin Struct Biol (2004) 2.99
Increase of functional diversity by alternative splicing. Trends Genet (2003) 2.59
Unproductively spliced ribosomal protein mRNAs are natural targets of mRNA surveillance in C. elegans. Genes Dev (2000) 2.52
Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences. Nucleic Acids Res (2003) 2.50
An unappreciated role for RNA surveillance. Genome Biol (2004) 2.28
A non-EST-based method for exon-skipping prediction. Genome Res (2004) 2.15
Sequence conservation, relative isoform frequencies, and nonsense-mediated decay in evolutionarily conserved alternative splicing. Proc Natl Acad Sci U S A (2005) 1.93
Evidence for a subpopulation of conserved alternative splicing events under selection pressure for protein reading frame preservation. Nucleic Acids Res (2004) 1.93
Comparative analysis detects dependencies among the 5' splice-site positions. RNA (2004) 1.91
The Alternative Splicing Gallery (ASG): bridging the gap between genome and transcriptome. Nucleic Acids Res (2004) 1.91
Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. EMBO J (1997) 1.79
A computational and experimental approach toward a priori identification of alternatively spliced exons. RNA (2004) 1.79
Protein domains correlate strongly with exons in multiple eukaryotic genomes--evidence of exon shuffling? Trends Genet (2004) 1.53
Bioinformatics analysis of alternative splicing. Brief Bioinform (2005) 1.44
The nonsense-mediated decay pathway and mutually exclusive expression of alternatively spliced FGFR2IIIb and -IIIc mRNAs. J Biol Chem (2000) 1.42
Signatures of domain shuffling in the human genome. Genome Res (2002) 1.39
Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay. J Biol Chem (2004) 1.33
Boundary-independent polar nonsense-mediated decay. EMBO Rep (2002) 1.30
Evolutionary convergence of alternative splicing in ion channels. Trends Genet (2004) 1.20
The effects of alternative splicing on transmembrane proteins in the mouse genome. Pac Symp Biocomput (2004) 1.13
Regulation of the MID1 protein function is fine-tuned by a complex pattern of alternative splicing. Hum Genet (2004) 1.12
In silico screening for tumour-specific expressed sequences in human genome. FEBS Lett (2001) 1.05
Regulation of alternative pre-mRNA splicing. Brief Funct Genomic Proteomic (2002) 0.90
Characterization of the peach homologue of the ethylene receptor, PpETR1, reveals some unusual features regarding transcript processing. Planta (2002) 0.81
Chromatin organization marks exon-intron structure. Nat Struct Mol Biol (2009) 5.90
Alu-containing exons are alternatively spliced. Genome Res (2002) 5.45
The birth of an alternatively spliced exon: 3' splice-site selection in Alu exons. Science (2003) 5.04
Intronic sequences flanking alternatively spliced exons are conserved between human and mouse. Genome Res (2003) 5.01
Alternative splicing and evolution: diversification, exon definition and function. Nat Rev Genet (2010) 4.30
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. Mol Cell (2006) 4.11
How prevalent is functional alternative splicing in the human genome? Trends Genet (2004) 3.81
Different levels of alternative splicing among eukaryotes. Nucleic Acids Res (2006) 3.07
Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome. Genome Biol (2007) 2.35
Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB. Nat Struct Mol Biol (2010) 2.19
A non-EST-based method for exon-skipping prediction. Genome Res (2004) 2.15
Alternative splicing: current perspectives. Bioessays (2008) 1.95
Minimal conditions for exonization of intronic sequences: 5' splice site formation in alu exons. Mol Cell (2004) 1.93
Comparative analysis detects dependencies among the 5' splice-site positions. RNA (2004) 1.91
Detection and removal of biases in the analysis of next-generation sequencing reads. PLoS One (2011) 1.91
Large-scale comparative analysis of splicing signals and their corresponding splicing factors in eukaryotes. Genome Res (2007) 1.86
Insights into the connection between cancer and alternative splicing. Trends Genet (2007) 1.78
RNA-editing-mediated exon evolution. Genome Biol (2007) 1.77
Human-mouse comparative analysis reveals that branch-site plasticity contributes to splicing regulation. Hum Mol Genet (2005) 1.71
Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing. EMBO J (2010) 1.53
DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure. Genome Res (2013) 1.44
Differential GC content between exons and introns establishes distinct strategies of splice-site recognition. Cell Rep (2012) 1.41
Intronic Alus influence alternative splicing. PLoS Genet (2008) 1.35
SROOGLE: webserver for integrative, user-friendly visualization of splicing signals. Nucleic Acids Res (2009) 1.32
TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates. Nucleic Acids Res (2007) 1.30
The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates. Genome Biol (2010) 1.29
The "alternative" choice of constitutive exons throughout evolution. PLoS Genet (2007) 1.27
Regulation of alternative splicing through coupling with transcription and chromatin structure. Annu Rev Biochem (2015) 1.26
Alu exonization events reveal features required for precise recognition of exons by the splicing machinery. PLoS Comput Biol (2009) 1.20
AluGene: a database of Alu elements incorporated within protein-coding genes. Nucleic Acids Res (2004) 1.19
SR proteins: a foot on the exon before the transition from intron to exon definition. Trends Genet (2006) 1.15
The emergence of alternative 3' and 5' splice site exons from constitutive exons. PLoS Comput Biol (2007) 1.15
Multifactorial interplay controls the splicing profile of Alu-derived exons. Mol Cell Biol (2008) 1.12
Alternative splicing of Alu exons--two arms are better than one. Nucleic Acids Res (2008) 1.11
Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons. Genome Res (2011) 1.10
The U1 snRNP base pairs with the 5' splice site within a penta-snRNP complex. Mol Cell Biol (2003) 1.10
Characteristics of transposable element exonization within human and mouse. PLoS One (2010) 1.09
The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution. PLoS Genet (2009) 1.07
SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements. BMC Genet (2007) 1.05
Alternative splicing regulates biogenesis of miRNAs located across exon-intron junctions. Mol Cell (2013) 1.03
IKAP/hELP1 deficiency in the cerebrum of familial dysautonomia patients results in down regulation of genes involved in oligodendrocyte differentiation and in myelination. Hum Mol Genet (2007) 1.01
Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells. PLoS One (2010) 0.98
IKAP/Elp1 involvement in cytoskeleton regulation and implication for familial dysautonomia. Hum Mol Genet (2011) 0.96
Phosphatidylserine increases IKBKAP levels in a humanized knock-in IKBKAP mouse model. Hum Mol Genet (2013) 0.92
Alternative approach to a heavy weight problem. Genome Res (2007) 0.92
Biased exonization of transposed elements in duplicated genes: A lesson from the TIF-IA gene. BMC Mol Biol (2007) 0.91
Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing. J Cell Sci (2005) 0.91
Alternative splicing and disease. RNA Biol (2008) 0.89
Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements. Nucleic Acids Res (2009) 0.88
Reversible inhibition of the second step of splicing suggests a possible role of zinc in the second step of splicing. Nucleic Acids Res (2002) 0.87
Bioactivation of carbamate-based 20(S)-camptothecin prodrugs. Bioorg Med Chem (2004) 0.86
Pre-mRNA splicing is a determinant of nucleosome organization. PLoS One (2013) 0.82
Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing. RNA (2007) 0.82
When epigenetics meets alternative splicing: the roles of DNA methylation and GC architecture. Epigenomics (2013) 0.81
Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus. Mol Biol Cell (2004) 0.80
Overlapping splicing regulatory motifs--combinatorial effects on splicing. Nucleic Acids Res (2010) 0.79
Boric acid reversibly inhibits the second step of pre-mRNA splicing. FEBS Lett (2003) 0.78
Testing for natural selection in human exonic splicing regulators associated with evolutionary rate shifts. J Mol Evol (2013) 0.78
Transduplication resulted in the incorporation of two protein-coding sequences into the turmoil-1 transposable element of C. elegans. Biol Direct (2008) 0.78
TEs or not TEs? That is the evolutionary question. J Biol (2009) 0.77