Interference with AI-2-mediated bacterial cell-cell communication.

PubWeight™: 2.17‹?› | Rank: Top 2%

🔗 View Article (PMC 1388276)

Published in Nature on September 29, 2005

Authors

Karina B Xavier1, Bonnie L Bassler

Author Affiliations

1: Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, New Jersey 08544-1014, USA.

Articles citing this

Bacterial competition: surviving and thriving in the microbial jungle. Nat Rev Microbiol (2010) 5.63

Bacterial small-molecule signaling pathways. Science (2006) 5.14

Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med (2012) 3.65

Indole is an inter-species biofilm signal mediated by SdiA. BMC Microbiol (2007) 2.62

Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell (2006) 2.48

Quantifying the integration of quorum-sensing signals with single-cell resolution. PLoS Biol (2009) 2.40

Multiple small RNAs act additively to integrate sensory information and control quorum sensing in Vibrio harveyi. Genes Dev (2007) 2.33

The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers. Genes Dev (2006) 2.17

luxS in bacteria isolated from 25- to 40-million-year-old amber. FEMS Microbiol Lett (2013) 2.07

Revisiting the host as a growth medium. Nat Rev Microbiol (2008) 1.49

Complete genome sequence of the fire blight pathogen Erwinia pyrifoliae DSM 12163T and comparative genomic insights into plant pathogenicity. BMC Genomics (2010) 1.49

Social interaction in synthetic and natural microbial communities. Mol Syst Biol (2011) 1.48

Sugar synthesis in a protocellular model leads to a cell signalling response in bacteria. Nat Chem (2009) 1.46

Can bacteria evolve resistance to quorum sensing disruption? PLoS Pathog (2010) 1.43

Indole and 7-hydroxyindole diminish Pseudomonas aeruginosa virulence. Microb Biotechnol (2008) 1.38

Autoinducer-2-regulated genes in Streptococcus mutans UA159 and global metabolic effect of the luxS mutation. J Bacteriol (2007) 1.37

Enterohemorrhagic Escherichia coli biofilms are inhibited by 7-hydroxyindole and stimulated by isatin. Appl Environ Microbiol (2007) 1.36

Lack of genomic evidence of AI-2 receptors suggests a non-quorum sensing role for luxS in most bacteria. BMC Microbiol (2008) 1.35

Insights on Escherichia coli biofilm formation and inhibition from whole-transcriptome profiling. Environ Microbiol (2009) 1.26

Quorum sensing signal-response systems in Gram-negative bacteria. Nat Rev Microbiol (2016) 1.22

The regulatory network of natural competence and transformation of Vibrio cholerae. PLoS Genet (2012) 1.20

A LuxS-dependent cell-to-cell language regulates social behavior and development in Bacillus subtilis. J Bacteriol (2006) 1.17

Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria. Mol Microbiol (2008) 1.15

Medicinal chemistry as a conduit for the modulation of quorum sensing. J Med Chem (2010) 1.06

Identification and characterization of new LuxR/LuxI-type quorum sensing systems from metagenomic libraries. Environ Microbiol (2009) 1.06

Identification of functional LsrB-like autoinducer-2 receptors. J Bacteriol (2009) 1.06

Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein. J Biol Chem (2011) 1.03

Control of methionine synthesis and uptake by MetR and homocysteine in Streptococcus mutans. J Bacteriol (2007) 1.02

Autoinducer-2-based chemical communication in bacteria: complexities of interspecies signaling. Contrib Microbiol (2009) 1.01

Quorum sensing control of phosphorus acquisition in Trichodesmium consortia. ISME J (2011) 0.98

Non-coding sRNAs regulate virulence in the bacterial pathogen Vibrio cholerae. RNA Biol (2012) 0.97

Nematode-trapping fungi eavesdrop on nematode pheromones. Curr Biol (2012) 0.96

Antibiotic alternatives: the substitution of antibiotics in animal husbandry? Front Microbiol (2014) 0.95

Bench-to-bedside review: Quorum sensing and the role of cell-to-cell communication during invasive bacterial infection. Crit Care (2008) 0.95

4-Quinolones: smart phones of the microbial world. Chem Rev (2010) 0.94

Autoinducer-2 is produced in saliva-fed flow conditions relevant to natural oral biofilms. J Appl Microbiol (2008) 0.92

Quorum sensing in extreme environments. Life (Basel) (2013) 0.90

Quorum sensing in group A Streptococcus. Front Cell Infect Microbiol (2014) 0.89

Cytotoxicity in macrophages infected with rough Brucella mutants is type IV secretion system dependent. Infect Immun (2007) 0.89

Natural genome diversity of AI-2 quorum sensing in Escherichia coli: conserved signal production but labile signal reception. Genome Biol Evol (2013) 0.88

Development of quorum-based anti-virulence therapeutics targeting Gram-negative bacterial pathogens. Int J Mol Sci (2013) 0.86

The possible influence of LuxS in the in vivo virulence of rabbit enteropathogenic Escherichia coli. Vet Microbiol (2007) 0.85

Detection of AI-2 receptors in genomes of Enterobacteriaceae suggests a role of type-2 quorum sensing in closed ecosystems. Sensors (Basel) (2012) 0.84

The crystal structure of the Escherichia coli autoinducer-2 processing protein LsrF. PLoS One (2009) 0.83

α-Hydroxyketone synthesis and sensing by Legionella and Vibrio. Sensors (Basel) (2012) 0.83

Heterologous expression of sahH reveals that biofilm formation is autoinducer-2-independent in Streptococcus sanguinis but is associated with an intact activated methionine cycle. J Biol Chem (2012) 0.82

LsrF, a coenzyme A-dependent thiolase, catalyzes the terminal step in processing the quorum sensing signal autoinducer-2. Proc Natl Acad Sci U S A (2014) 0.81

Crystal structures of the LsrR proteins complexed with phospho-AI-2 and two signal-interrupting analogues reveal distinct mechanisms for ligand recognition. J Am Chem Soc (2013) 0.80

Escherichia coli pfs transcription: regulation and proposed roles in autoinducer-2 synthesis and purine excretion. J Bacteriol (2006) 0.80

Autoinducer-2 of Streptococcus mitis as a Target Molecule to Inhibit Pathogenic Multi-Species Biofilm Formation In Vitro and in an Endotracheal Intubation Rat Model. Front Microbiol (2016) 0.80

Screening of Actinobacillus pleuropneumoniae LuxS inhibitors. Curr Microbiol (2013) 0.79

LuxS and quorum-sensing in Campylobacter. Front Cell Infect Microbiol (2012) 0.79

Chemical conversations in the gut microbiota. Gut Microbes (2016) 0.79

Cloning, purification, crystallization and preliminary crystallographic analysis of LsrR from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.78

Zoosporic plant pathogens produce bacterial autoinducer-2 that affects Vibrio harveyi quorum sensing. FEMS Microbiol Lett (2009) 0.78

Multifactorial Competition and Resistance in a Two-Species Bacterial System. PLoS Genet (2015) 0.78

Microbial interactions: bacteria talk to (some of) their neighbors. Curr Biol (2009) 0.78

Evolution of resistance to quorum quenching in digital organisms. Artif Life (2012) 0.78

A chemical biology approach to interrogate quorum-sensing regulated behaviors at the molecular and cellular level. Chem Biol (2013) 0.77

Regulatory elements involved in the expression of competence genes in naturally transformable Vibrio cholerae. BMC Microbiol (2014) 0.77

Microbial Partnerships of Pathogenic Oomycetes. PLoS Pathog (2017) 0.77

Exploiting Quorum Sensing Interfering Strategies in Gram-Negative Bacteria for the Enhancement of Environmental Applications. Front Microbiol (2016) 0.77

Coaggregation and biofilm growth of Granulicatella spp. with Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans. BMC Microbiol (2015) 0.76

Life in a Diverse Oral Community - Strategies for Oxidative Stress Survival. J Oral Biosci (2014) 0.75

Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli. Nat Commun (2016) 0.75

Profile of Bonnie L. Bassler. Proc Natl Acad Sci U S A (2008) 0.75

Intrinsic and Extrinsic Aspects on Campylobacter jejuni Biofilms. Front Microbiol (2017) 0.75

Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria. Nat Rev Microbiol (2017) 0.75

How can the cystic fibrosis respiratory microbiome influence our clinical decision-making? Curr Opin Pulm Med (2017) 0.75

Regulation of bacteria population behaviors by AI-2 "consumer cells" and "supplier cells". BMC Microbiol (2017) 0.75

Quorum sensing signalling and biofilm formation of brewery-derived bacteria, and inhibition of signalling by natural compounds. Curr Microbiol (2014) 0.75

Articles cited by this

Pathogenicity islands and the evolution of microbes. Annu Rev Microbiol (2000) 9.51

The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell (2004) 8.89

Structural identification of a bacterial quorum-sensing signal containing boron. Nature (2002) 8.11

Intercellular signalling in Vibrio harveyi: sequence and function of genes regulating expression of luminescence. Mol Microbiol (1993) 7.03

Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production. Proc Natl Acad Sci U S A (1999) 6.89

Multiple signalling systems controlling expression of luminescence in Vibrio harveyi: sequence and function of genes encoding a second sensory pathway. Mol Microbiol (1994) 6.58

The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule. Mol Microbiol (2001) 6.27

Cross-species induction of luminescence in the quorum-sensing bacterium Vibrio harveyi. J Bacteriol (1997) 5.93

Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell (2002) 5.12

Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes. Science (1992) 4.44

Toxin-coregulated pilus, but not mannose-sensitive hemagglutinin, is required for colonization by Vibrio cholerae O1 El Tor biotype and O139 strains. Infect Immun (1996) 4.06

LuxS quorum sensing: more than just a numbers game. Curr Opin Microbiol (2003) 3.76

Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell (2004) 3.36

The LuxS-dependent autoinducer AI-2 controls the expression of an ABC transporter that functions in AI-2 uptake in Salmonella typhimurium. Mol Microbiol (2001) 3.15

cis-acting ompF mutations that result in OmpR-dependent constitutive expression. J Bacteriol (1991) 2.99

Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol (2005) 2.64

Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J Bacteriol (2004) 2.55

Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Mol Microbiol (2003) 2.47

Transcriptional regulation of Vibrio cholerae hemagglutinin/protease by the cyclic AMP receptor protein and RpoS. J Bacteriol (2004) 1.41

Articles by these authors

Quorum sensing: cell-to-cell communication in bacteria. Annu Rev Cell Dev Biol (2005) 13.88

The small RNA chaperone Hfq and multiple small RNAs control quorum sensing in Vibrio harveyi and Vibrio cholerae. Cell (2004) 8.89

Structural identification of a bacterial quorum-sensing signal containing boron. Nature (2002) 8.11

Bacterial quorum-sensing network architectures. Annu Rev Genet (2009) 6.14

Quorum-sensing regulators control virulence gene expression in Vibrio cholerae. Proc Natl Acad Sci U S A (2002) 6.10

Quorum sensing controls biofilm formation in Vibrio cholerae. Mol Microbiol (2003) 5.46

Bacterial small-molecule signaling pathways. Science (2006) 5.14

Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae. Cell (2002) 5.12

LuxS quorum sensing: more than just a numbers game. Curr Opin Microbiol (2003) 3.76

Bacterial quorum sensing: its role in virulence and possibilities for its control. Cold Spring Harb Perspect Med (2012) 3.65

The major Vibrio cholerae autoinducer and its role in virulence factor production. Nature (2007) 3.57

Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2. Mol Cell (2004) 3.36

Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi. J Bacteriol (2004) 3.30

Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli. J Bacteriol (2005) 2.64

CsrA and three redundant small RNAs regulate quorum sensing in Vibrio cholerae. Mol Microbiol (2005) 2.56

Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus. J Bacteriol (2004) 2.55

Interspecies communication in bacteria. J Clin Invest (2003) 2.55

Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing. Cell (2006) 2.48

Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium. Mol Microbiol (2003) 2.47

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation. Proc Natl Acad Sci U S A (2013) 2.46

Quorum sensing controls biofilm formation in Vibrio cholerae through modulation of cyclic di-GMP levels and repression of vpsT. J Bacteriol (2008) 2.45

Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth. Mol Microbiol (2006) 2.43

Quantifying the integration of quorum-sensing signals with single-cell resolution. PLoS Biol (2009) 2.40

Multiple small RNAs act additively to integrate sensory information and control quorum sensing in Vibrio harveyi. Genes Dev (2007) 2.33

Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria. ACS Chem Biol (2007) 2.20

An open letter to Elias Zerhouni. Science (2005) 2.19

Bacterial social engagements. Trends Cell Biol (2004) 2.17

The Vibrio harveyi quorum-sensing system uses shared regulatory components to discriminate between multiple autoinducers. Genes Dev (2006) 2.17

Regulatory small RNAs circumvent the conventional quorum sensing pathway in pandemic Vibrio cholerae. Proc Natl Acad Sci U S A (2007) 2.13

The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters. Mol Microbiol (2008) 2.11

Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi. Cell (2008) 2.10

Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression. EMBO J (2003) 1.99

Chemical communication among bacteria. Proc Natl Acad Sci U S A (2003) 1.98

Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2. Mol Cell (2005) 1.94

AphA and LuxR/HapR reciprocally control quorum sensing in vibrios. Genes Dev (2011) 1.79

A negative feedback loop involving small RNAs accelerates Vibrio cholerae's transition out of quorum-sensing mode. Genes Dev (2008) 1.74

Biofilm streamers cause catastrophic disruption of flow with consequences for environmental and medical systems. Proc Natl Acad Sci U S A (2013) 1.71

A fitness trade-off between local competition and dispersal in Vibrio cholerae biofilms. Proc Natl Acad Sci U S A (2011) 1.59

A quorum-sensing antagonist targets both membrane-bound and cytoplasmic receptors and controls bacterial pathogenicity. Mol Cell (2009) 1.55

Negative feedback loops involving small regulatory RNAs precisely control the Vibrio harveyi quorum-sensing response. Mol Cell (2010) 1.52

A strategy for antagonizing quorum sensing. Mol Cell (2011) 1.47

A small-RNA-mediated negative feedback loop controls quorum-sensing dynamics in Vibrio harveyi. Mol Microbiol (2008) 1.47

An expeditious synthesis of DPD and boron binding studies. Org Lett (2005) 1.45

Mob psychology. J Bacteriol (2002) 1.40

Information processing and signal integration in bacterial quorum sensing. Mol Syst Biol (2009) 1.39

Gene dosage compensation calibrates four regulatory RNAs to control Vibrio cholerae quorum sensing. EMBO J (2009) 1.37

Distinct sensory pathways in Vibrio cholerae El Tor and classical biotypes modulate cyclic dimeric GMP levels to control biofilm formation. J Bacteriol (2008) 1.33

Quorum-sensing non-coding small RNAs use unique pairing regions to differentially control mRNA targets. Mol Microbiol (2012) 1.32

Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems. Mol Microbiol (2011) 1.31

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA. Nat Chem Biol (2009) 1.26

The quorum-sensing molecule autoinducer 2 regulates motility and flagellar morphogenesis in Helicobacter pylori. J Bacteriol (2007) 1.26

Cutting through the complexity of cell collectives. Proc Biol Sci (2013) 1.20

Active regulation of receptor ratios controls integration of quorum-sensing signals in Vibrio harveyi. Mol Syst Biol (2011) 1.19

Mechanism of Vibrio cholerae autoinducer-1 biosynthesis. ACS Chem Biol (2011) 1.19

Individual and combined roles of the master regulators AphA and LuxR in control of the Vibrio harveyi quorum-sensing regulon. J Bacteriol (2012) 1.15

Quorum sensing in Chromobacterium violaceum: DNA recognition and gene regulation by the CviR receptor. J Bacteriol (2011) 1.13

Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules. Proc Natl Acad Sci U S A (2010) 1.12

The small nucleoid protein Fis is involved in Vibrio cholerae quorum sensing. Mol Microbiol (2006) 1.12

AI-1 influences the kinase activity but not the phosphatase activity of LuxN of Vibrio harveyi. J Biol Chem (2006) 1.11

Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios. PLoS Pathog (2012) 1.11

Measurement of the copy number of the master quorum-sensing regulator of a bacterial cell. Biophys J (2010) 1.11

Observing bacteria through the lens of social evolution. J Biol (2008) 1.08

Analysis of activator and repressor functions reveals the requirements for transcriptional control by LuxR, the master regulator of quorum sensing in Vibrio harveyi. MBio (2013) 1.08

Functional determinants of the quorum-sensing non-coding RNAs and their roles in target regulation. EMBO J (2013) 1.03

Chemical synthesis of S-ribosyl-L-homocysteine and activity assay as a LuxS substrate. Bioorg Med Chem Lett (2003) 0.98

Ligand and antagonist driven regulation of the Vibrio cholerae quorum-sensing receptor CqsS. Mol Microbiol (2012) 0.94

Boron binding with the quorum sensing signal AI-2 and analogues. Org Lett (2004) 0.92

Quorum regulatory small RNAs repress type VI secretion in Vibrio cholerae. Mol Microbiol (2014) 0.92

Solution structure and dynamics of LuxU from Vibrio harveyi, a phosphotransferase protein involved in bacterial quorum sensing. J Mol Biol (2005) 0.92

Control of the type 3 secretion system in Vibrio harveyi by quorum sensing through repression of ExsA. Appl Environ Microbiol (2010) 0.91

Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit. Bioorg Med Chem (2011) 0.89

Quorum sensing influences Vibrio harveyi growth rates in a manner not fully accounted for by the marker effect of bioluminescence. PLoS One (2008) 0.85

Role of the CAI-1 fatty acid tail in the Vibrio cholerae quorum sensing response. J Med Chem (2012) 0.83

Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa. J Med Chem (2015) 0.83

Determinants governing ligand specificity of the Vibrio harveyi LuxN quorum-sensing receptor. Mol Microbiol (2014) 0.81

CqsA-CqsS quorum-sensing signal-receptor specificity in Photobacterium angustum. Mol Microbiol (2014) 0.79

Protein-level fluctuation correlation at the microcolony level and its application to the Vibrio harveyi quorum-sensing circuit. Biophys J (2011) 0.78

Erratum: A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation. Nat Chem Biol (2017) 0.75

Erratum: A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation. Nat Chem Biol (2017) 0.75

Erratum: A Vibrio cholerae autoinducer-receptor pair that controls biofilm formation. Nat Chem Biol (2017) 0.75