Published in Hum Mol Genet on October 05, 2005
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy. J Cell Biol (2010) 7.62
The PINK1/Parkin pathway regulates mitochondrial morphology. Proc Natl Acad Sci U S A (2008) 7.41
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc Natl Acad Sci U S A (2006) 5.78
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc Natl Acad Sci U S A (2008) 5.43
Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin. Proc Natl Acad Sci U S A (2010) 5.17
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A (2008) 4.97
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A (2008) 4.50
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol (2007) 3.86
Genetic animal models of Parkinson's disease. Neuron (2010) 3.86
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc Natl Acad Sci U S A (2008) 3.65
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A (2007) 3.50
PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death. Mol Cell (2009) 3.17
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PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy. Sci Rep (2012) 2.60
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria. Nat Commun (2012) 2.55
Mitochondrial import and accumulation of alpha-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J Biol Chem (2008) 2.53
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell (2012) 2.52
Txnip balances metabolic and growth signaling via PTEN disulfide reduction. Proc Natl Acad Sci U S A (2008) 2.41
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PINK1 cleavage at position A103 by the mitochondrial protease PARL. Hum Mol Genet (2010) 2.30
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Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling. Hum Mol Genet (2009) 2.10
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Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A (2006) 2.08
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Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. EMBO Mol Med (2009) 1.89
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Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. J Neurochem (2009) 1.52
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The loss of PGAM5 suppresses the mitochondrial degeneration caused by inactivation of PINK1 in Drosophila. PLoS Genet (2010) 1.41
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Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth. J Biol Chem (2009) 1.36
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The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. BMC Genomics (2007) 1.10
Tickled PINK1: mitochondrial homeostasis and autophagy in recessive Parkinsonism. Biochim Biophys Acta (2009) 1.09
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Pink1 kinase and its membrane potential (Deltaψ)-dependent cleavage product both localize to outer mitochondrial membrane by unique targeting mode. J Biol Chem (2012) 1.06
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Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener (2009) 1.05
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Toxin-induced and genetic animal models of Parkinson's disease. Parkinsons Dis (2010) 1.04
Redox regulation of protein folding in the mitochondrial intermembrane space. Biochim Biophys Acta (2008) 1.04
Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS One (2011) 1.03
Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation. Proc Natl Acad Sci U S A (2010) 1.03
A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochim Biophys Acta (2009) 1.02
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PINK1-mediated phosphorylation of Parkin boosts Parkin activity in Drosophila. PLoS Genet (2014) 0.99
Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. Mitochondrion (2009) 0.98
Cytosolic cleaved PINK1 represses Parkin translocation to mitochondria and mitophagy. EMBO Rep (2013) 0.98
PINK1 mutations and parkinsonism. Neurology (2008) 0.98
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Microtubule affinity-regulating kinase 2 (MARK2) turns on phosphatase and tensin homolog (PTEN)-induced kinase 1 (PINK1) at Thr-313, a mutation site in Parkinson disease: effects on mitochondrial transport. J Biol Chem (2012) 0.95
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Parkin mitochondria in the autophagosome. J Cell Biol (2008) 0.92
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Hyperexcitable substantia nigra dopamine neurons in PINK1- and HtrA2/Omi-deficient mice. J Neurophysiol (2010) 0.90
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BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS One (2014) 0.89
Function and characteristics of PINK1 in mitochondria. Oxid Med Cell Longev (2013) 0.89
Structural determinants of PINK1 topology and dual subcellular distribution. BMC Cell Biol (2010) 0.88
SARM1 and TRAF6 bind to and stabilize PINK1 on depolarized mitochondria. Mol Biol Cell (2013) 0.87
PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Hum Mol Genet (2013) 0.87
PINK1 as a molecular checkpoint in the maintenance of mitochondrial function and integrity. Mol Cells (2012) 0.87
To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease. Antioxid Redox Signal (2011) 0.87
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Eryptosis as a marker of Parkinson's disease. Aging (Albany NY) (2014) 0.86
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PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. J Biol Chem (2014) 0.84
The mitochondrial kinase PINK1, stress response and Parkinson's disease. J Bioenerg Biomembr (2009) 0.84
Cannabinoid receptor signalling in neurodegenerative diseases: a potential role for membrane fluidity disturbance. Br J Pharmacol (2011) 0.84
Tom70 is essential for PINK1 import into mitochondria. PLoS One (2013) 0.84
Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment. J Cell Sci (2015) 0.84
Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection. BMC Biol (2015) 0.83
A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson's Research. Dis Model Mech (2013) 0.83
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