Published in EMBO Rep on December 01, 2005
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe (2009) 3.86
NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J Leukoc Biol (2007) 1.73
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection. PLoS Pathog (2009) 1.58
NLR functions beyond pathogen recognition. Nat Immunol (2011) 1.57
Bordetella pertussis pathogenesis: current and future challenges. Nat Rev Microbiol (2014) 1.40
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni. PLoS Pathog (2012) 1.34
Multiple peptidoglycan modification networks modulate Helicobacter pylori's cell shape, motility, and colonization potential. PLoS Pathog (2012) 1.26
Modifications to the peptidoglycan backbone help bacteria to establish infection. Infect Immun (2010) 1.22
The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol (2007) 1.21
Messenger functions of the bacterial cell wall-derived muropeptides. Biochemistry (2012) 1.17
Pertussis: Microbiology, Disease, Treatment, and Prevention. Clin Microbiol Rev (2016) 1.07
Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection. Infect Immun (2009) 1.06
Combined pulse electroporation--a novel strategy for highly efficient transfection of human and mouse cells. PLoS One (2010) 1.05
Peptidoglycan LD-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1. J Biol Chem (2014) 1.04
Hepcidin induction by pathogens and pathogen-derived molecules is strongly dependent on interleukin-6. Infect Immun (2013) 0.99
The lytic transglycosylases of Neisseria gonorrhoeae. Microb Drug Resist (2012) 0.93
Mice, men and the relatives: cross-species studies underpin innate immunity. Open Biol (2012) 0.91
NOD1 and NOD2 mediate sensing of periodontal pathogens. J Dent Res (2009) 0.91
Comparative Genomic and Sequence Analysis Provides Insight into the Molecular Functionality of NOD1 and NOD2. Front Immunol (2013) 0.88
NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation. Am J Physiol Gastrointest Liver Physiol (2013) 0.88
The Interplay between NLRs and Autophagy in Immunity and Inflammation. Front Immunol (2013) 0.86
Peptidoglycan fragment release from Neisseria meningitidis. Infect Immun (2013) 0.81
Activation of NOD receptors by Neisseria gonorrhoeae modulates the innate immune response. Innate Immun (2013) 0.80
Role of mouse peptidoglycan recognition protein PGLYRP2 in the innate immune response to Salmonella enterica serovar Typhimurium infection in vivo. Infect Immun (2012) 0.80
Bacterial peptidoglycan stimulates adipocyte lipolysis via NOD1. PLoS One (2014) 0.79
Characterization of natural human nucleotide-binding oligomerization domain protein 1 (Nod1) ligands from bacterial culture supernatant for elucidation of immune modulators in the environment. J Biol Chem (2010) 0.78
Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway. PLoS One (2014) 0.75
Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae. J Biol Chem (2016) 0.75
Nucleotide Binding Oligomerization Domain 1 Is an Essential Signal Transducer in Human Epithelial Cells Infected with Helicobacter pylori That Induces the Transepithelial Migration of Neutrophils. Gut Liver (2015) 0.75
The Dual NOD1/NOD2 Agonism of Muropeptides Containing a Meso-Diaminopimelic Acid Residue. PLoS One (2016) 0.75
Emerging Bordetella pertussis Strains Induce Enhanced Signaling of Human Pattern Recognition Receptors TLR2, NOD2 and Secretion of IL-10 by Dendritic Cells. PLoS One (2017) 0.75
SLC46 Family Transporters Facilitate Cytosolic Innate Immune Recognition of Monomeric Peptidoglycans. J Immunol (2017) 0.75
Attention seeker: Production, modification, and release of inflammatory peptidoglycan fragments in Neisseria. J Bacteriol (2017) 0.75
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem (2003) 9.37
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat Immunol (2003) 6.46
NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem (2005) 6.18
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem (2003) 3.83
Human Nod1 confers responsiveness to bacterial lipopolysaccharides. J Biol Chem (2000) 3.23
Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway. Immunity (2004) 2.77
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64
Detection, isolation, and analysis of a released Bordetella pertussis product toxic to cultured tracheal cells. Infect Immun (1982) 1.94
Ability of monomeric peptidoglycan fragments from Neisseria gonorrhoeae to damage human fallopian-tube mucosa. J Infect Dis (1984) 1.91
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90
Nod1 is an essential signal transducer in intestinal epithelial cells infected with bacteria that avoid recognition by toll-like receptors. Infect Immun (2004) 1.77
Peptidoglycan molecular requirements allowing detection by the Drosophila immune deficiency pathway. J Immunol (2004) 1.62
Biological activities and chemical composition of purified tracheal cytotoxin of Bordetella pertussis. Infect Immun (1989) 1.60
Major fragment of soluble peptidoglycan released from growing Bordetella pertussis is tracheal cytotoxin. Infect Immun (1987) 1.22
Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol (2004) 1.18
Peptidoglycans as promoters of slow-wave sleep. I. Structure of the sleep-promoting factor isolated from human urine. J Biol Chem (1984) 1.13
A structure-activity relationship for induction of meningeal inflammation by muramyl peptides. J Clin Invest (1993) 1.13
Synergistic epithelial responses to endotoxin and a naturally occurring muramyl peptide. Infect Immun (2000) 1.05
Battling enteroinvasive bacteria: Nod1 comes to the rescue. Trends Microbiol (2004) 0.83
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet (2008) 30.20
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat Immunol (2006) 10.55
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature (2006) 9.77
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell (2011) 9.75
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
The Listeria transcriptional landscape from saprophytism to virulence. Nature (2009) 5.88
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31
Nod-like proteins in immunity, inflammation and disease. Nat Immunol (2006) 5.25
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet (2008) 5.07
Bacterial invasion: the paradigms of enteroinvasive pathogens. Science (2004) 4.95
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals. Dev Cell (2010) 4.47
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem (2003) 3.83
Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver. Genes Dev (2010) 3.77
Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76
Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin. Genes Dev (2005) 3.59
The Drosophila amidase PGRP-LB modulates the immune response to bacterial infection. Immunity (2006) 3.51
An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses. Nat Immunol (2006) 3.41
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
The Drosophila immune system detects bacteria through specific peptidoglycan recognition. Nat Immunol (2003) 3.29
PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing. J Biol Chem (2002) 3.28
Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet (2010) 3.22
Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease. Gastroenterology (2011) 3.08
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17-secreting T cells. Blood (2010) 3.06
Bacterial infection causes stress-induced memory dysfunction in mice. Gut (2010) 3.06
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut (2011) 2.91
PYPAF1, a PYRIN-containing Apaf1-like protein that assembles with ASC and regulates activation of NF-kappa B. J Biol Chem (2002) 2.88
The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes. Proc Natl Acad Sci U S A (2005) 2.88
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 2.83
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett (2002) 2.66
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64
Life on the inside: the intracellular lifestyle of cytosolic bacteria. Nat Rev Microbiol (2009) 2.62
Listeria monocytogenes impairs SUMOylation for efficient infection. Nature (2010) 2.57
NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev (2003) 2.55
Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy. Cell Host Microbe (2009) 2.52
Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol (2005) 2.52
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet. Clin Gastroenterol Hepatol (2008) 2.50
Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med (2011) 2.48
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A (2007) 2.46
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46
Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell (2010) 2.38
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med (2011) 2.25
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem (2013) 2.24
Distinct roles of TLR2 and the adaptor ASC in IL-1beta/IL-18 secretion in response to Listeria monocytogenes. J Immunol (2006) 2.21
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Microvillous inclusion disease: how to improve the prognosis of a severe congenital enterocyte disorder. J Pediatr Gastroenterol Nutr (2011) 2.20
The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. Cancer Cell (2011) 2.18
Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity (2002) 2.17
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A (2003) 2.16
The biosynthesis of peptidoglycan lipid-linked intermediates. FEMS Microbiol Rev (2007) 2.16
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity (2007) 2.15
Crohn disease--associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J Clin Invest (2011) 2.10
Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy. PLoS Pathog (2011) 2.09
Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host Microbe (2007) 2.08
Infevers: an evolving mutation database for auto-inflammatory syndromes. Hum Mutat (2004) 2.07