Published in Gut on October 21, 2010
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci (2012) 4.95
Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A (2011) 4.91
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Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling. Schizophr Res (2014) 1.10
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Irritable bowel syndrome: a microbiome-gut-brain axis disorder? World J Gastroenterol (2014) 1.06
Intestinal microbiota, probiotics and mental health: from Metchnikoff to modern advances: Part II - contemporary contextual research. Gut Pathog (2013) 1.05
Intestinal microbiota in pathophysiology and management of irritable bowel syndrome. World J Gastroenterol (2014) 1.00
Mediterranean diet and health: food effects on gut microbiota and disease control. Int J Mol Sci (2014) 0.98
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The microbiota-gut-brain axis in functional gastrointestinal disorders. Gut Microbes (2014) 0.96
Neuropeptides and the microbiota-gut-brain axis. Adv Exp Med Biol (2014) 0.95
Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration. J Physiol (2016) 0.91
Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP. PLoS One (2014) 0.90
Neurologic effects of exogenous saccharides: a review of controlled human, animal, and in vitro studies. Nutr Neurosci (2012) 0.90
Gut microbial communities modulating brain development and function. Gut Microbes (2012) 0.90
The Central Nervous System and the Gut Microbiome. Cell (2016) 0.90
Brain-gut axis in the pathogenesis of Helicobacter pylori infection. World J Gastroenterol (2014) 0.90
The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity. Brain Behav Immun (2011) 0.89
The Infant Microbiome: Implications for Infant Health and Neurocognitive Development. Nurs Res (2015) 0.87
Genomics of schizophrenia: time to consider the gut microbiome? Mol Psychiatry (2014) 0.85
Host microbiota modulates development of social preference in mice. Microb Ecol Health Dis (2015) 0.85
Environmental enrichment and gut inflammation modify stress-induced c-Fos expression in the mouse corticolimbic system. PLoS One (2013) 0.83
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis? BMC Med (2016) 0.83
Growing up in a Bubble: Using Germ-Free Animals to Assess the Influence of the Gut Microbiota on Brain and Behavior. Int J Neuropsychopharmacol (2016) 0.82
Effect of Probiotics on Central Nervous System Functions in Animals and Humans: A Systematic Review. J Neurogastroenterol Motil (2016) 0.82
Metabolic tinkering by the gut microbiome: Implications for brain development and function. Gut Microbes (2014) 0.82
From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways. Mol Psychiatry (2016) 0.82
Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication. Brain Behav Immun (2016) 0.82
Probiotics normalize the gut-brain-microbiota axis in immunodeficient mice. Am J Physiol Gastrointest Liver Physiol (2014) 0.82
Formyl peptide receptor as a novel therapeutic target for anxiety-related disorders. PLoS One (2014) 0.81
Experimental gastritis leads to anxiety- and depression-like behaviors in female but not male rats. Behav Brain Funct (2013) 0.81
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke. Neurotherapeutics (2016) 0.81
Gut Microbiota: The Brain Peacekeeper. Front Microbiol (2016) 0.81
Cloacal Microbiome Structure in a Long-Distance Migratory Bird Assessed Using Deep 16sRNA Pyrosequencing. PLoS One (2015) 0.80
Lactobacillus casei-01 facilitates the ameliorative effects of proanthocyanidins extracted from lotus seedpod on learning and memory impairment in scopolamine-induced amnesia mice. PLoS One (2014) 0.80
Reframing the Teenage Wasteland: Adolescent Microbiota-Gut-Brain Axis. Can J Psychiatry (2016) 0.79
Probiotic modulation of the microbiota-gut-brain axis and behaviour in zebrafish. Sci Rep (2016) 0.79
Animal-microbe interactions and the evolution of nervous systems. Philos Trans R Soc Lond B Biol Sci (2016) 0.79
Gut Dysbiosis in Patients with Anorexia Nervosa. PLoS One (2015) 0.79
Matrix metalloproteinase 9 contributes to gut microbe homeostasis in a model of infectious colitis. BMC Microbiol (2012) 0.79
Influence of gut microbes on the brain-gut axis (Gut 2011;60:307-317). J Neurogastroenterol Motil (2011) 0.78
Lost in Translation: The Gut Microbiota in Psychiatric Illness. Can J Psychiatry (2015) 0.78
Influence of Tryptophan and Serotonin on Mood and Cognition with a Possible Role of the Gut-Brain Axis. Nutrients (2016) 0.78
Therapeutic Targets for Neurodevelopmental Disorders Emerging from Animal Models with Perinatal Immune Activation. Int J Mol Sci (2015) 0.77
Can attention to the intestinal microbiota improve understanding and treatment of anorexia nervosa? Expert Rev Gastroenterol Hepatol (2016) 0.77
Microbiota-gut-brain axis and the central nervous system. Oncotarget (2017) 0.76
The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders? Curr Obes Rep (2016) 0.76
The microbiome of the built environment and mental health. Microbiome (2015) 0.76
Neuroprotective Effects of Clostridium butyricum against Vascular Dementia in Mice via Metabolic Butyrate. Biomed Res Int (2015) 0.76
A psychology of the human brain-gut-microbiome axis. Soc Personal Psychol Compass (2017) 0.75
The link between inflammation, bugs, the intestine and the brain in alcohol dependence. Transl Psychiatry (2017) 0.75
The effects of a probiotic formulation (Lactobacillus rhamnosus and L. helveticus) on developmental trajectories of emotional learning in stressed infant rats. Transl Psychiatry (2016) 0.75
Role of probiotics as memory enhancer. Indian J Pharmacol (2013) 0.75
Salvia (Sage): A Review of its Potential Cognitive-Enhancing and Protective Effects. Drugs R D (2016) 0.75
Gut to Brain Dysbiosis: Mechanisms Linking Western Diet Consumption, the Microbiome, and Cognitive Impairment. Front Behav Neurosci (2017) 0.75
Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. Nat Commun (2017) 0.75
Gut Microbiota: A Modulator of Brain Plasticity and Cognitive Function in Ageing. Healthcare (Basel) (2015) 0.75
The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists. Cancer Res (2017) 0.75
Posttraumatic Stress Disorder: Does the Gut Microbiome Hold the Key? Can J Psychiatry (2016) 0.75
Microbiome-Gut-Brain Axis: A Pathway for Improving Brainstem Serotonin Homeostasis and Successful Autoresuscitation in SIDS-A Novel Hypothesis. Front Pediatr (2017) 0.75
The gut microbiome composition associates with bipolar disorder and illness severity. J Psychiatr Res (2016) 0.75
Effects of a Diet-Based Weight-Reducing Program with Probiotic Supplementation on Satiety Efficiency, Eating Behaviour Traits, and Psychosocial Behaviours in Obese Individuals. Nutrients (2017) 0.75
The mucosal immune system: master regulator of bidirectional gut-brain communications. Nat Rev Gastroenterol Hepatol (2017) 0.75
Salmonella Typhimurium and Multidirectional Communication in the Gut. Front Microbiol (2016) 0.75
Gut microbiota disturbance during helminth infection: can it affect cognition and behaviour of children? BMC Infect Dis (2017) 0.75
A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)? J Clin Med (2016) 0.75
Cross Talk: The Microbiota and Neurodevelopmental Disorders. Front Neurosci (2017) 0.75
The microbiota influences cell death and microglial colonization in the perinatal mouse brain. Brain Behav Immun (2017) 0.75
Gut Dysbiosis in Animals Due to Environmental Chemical Exposures. Front Cell Infect Microbiol (2017) 0.75
Close association between intestinal microbiota and irritable bowel syndrome. Eur J Clin Microbiol Infect Dis (2017) 0.75
Detection and Physicochemical Characterization of Membrane Vesicles (MVs) of Lactobacillus reuteri DSM 17938. Front Microbiol (2017) 0.75
The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment. Front Aging Neurosci (2017) 0.75
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Nod-like proteins in immunity, inflammation and disease. Nat Immunol (2006) 5.25
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem (2003) 3.83
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for the management of patients with bipolar disorder: update 2013. Bipolar Disord (2012) 3.01
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut (2011) 2.91
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 2.83
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med (2011) 2.48
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A (2007) 2.46
The role of the hippocampus in the pathophysiology of major depression. J Psychiatry Neurosci (2004) 2.43
Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol (2010) 2.22
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity (2007) 2.15
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. PLoS One (2013) 2.14
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature (2011) 2.04
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells. Cell Microbiol (2009) 1.87
Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol (2012) 1.86
Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell Host Microbe (2012) 1.81
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol (2003) 1.79
Nod2-dependent Th2 polarization of antigen-specific immunity. J Immunol (2008) 1.78
The IMPACT questionnaire: a valid measure of health-related quality of life in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr (2002) 1.75
Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains. Infect Immun (2004) 1.74
Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice. Cancer Res (2005) 1.74
NLRC5 limits the activation of inflammatory pathways. J Immunol (2010) 1.73
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner. Immunity (2013) 1.71
Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res (2003) 1.69
Probiotic treatment of rat pups normalises corticosterone release and ameliorates colonic dysfunction induced by maternal separation. Gut (2007) 1.69
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine. Gastroenterology (2002) 1.68
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci (2009) 1.62
An update on the use and investigation of probiotics in health and disease. Gut (2013) 1.62
Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Gastroenterology (2010) 1.61
Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J (2013) 1.61
Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies. Trends Microbiol (2002) 1.59
Chronic psychological stress in rats induces intestinal sensitization to luminal antigens. Am J Pathol (2006) 1.52
A major role for proteolytic activity and proteinase-activated receptor-2 in the pathogenesis of infectious colitis. Proc Natl Acad Sci U S A (2005) 1.45
Alterations in the gut microbiome of children with severe ulcerative colitis. Inflamm Bowel Dis (2011) 1.42
NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol (2005) 1.42
Scurvy diagnosed in a pediatric liver transplant patient awaiting combined kidney and liver retransplantation. Pediatr Transplant (2008) 1.42
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2007) 1.41
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep (2005) 1.41
Notice: the importance of adhering to The Journal's Guide for Authors. J Pediatr (2010) 1.39
The microbial and danger signals that activate Nod-like receptors. Cytokine (2008) 1.38
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Probiotics reduce bacterial colonization and gastric inflammation in H. pylori-infected mice. Dig Dis Sci (2004) 1.37
Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Infect Immun (2005) 1.36
Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice. Am J Pathol (2007) 1.35
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna) (2011) 1.35
Surface-layer protein extracts from Lactobacillus helveticus inhibit enterohaemorrhagic Escherichia coli O157:H7 adhesion to epithelial cells. Cell Microbiol (2006) 1.34
Setting research priorities to reduce mortality and morbidity of childhood diarrhoeal disease in the next 15 years. PLoS Med (2013) 1.34
Amelioration of the effects of Citrobacter rodentium infection in mice by pretreatment with probiotics. J Infect Dis (2005) 1.34
Helicobacter pylori activates Toll-like receptor 4 expression in gastrointestinal epithelial cells. Infect Immun (2003) 1.33
Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology (2009) 1.31
Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis. Infect Immun (2007) 1.31
Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol (2006) 1.29
Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J Biol Chem (2005) 1.29
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem (2005) 1.28
Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology (2005) 1.26
Innate immune sensing of microbes by Nod proteins. Ann N Y Acad Sci (2006) 1.24
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis. Proc Natl Acad Sci U S A (2008) 1.24
Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway. Eur J Immunol (2007) 1.24
Enhanced translocation of bacteria across metabolically stressed epithelia is reduced by butyrate. Inflamm Bowel Dis (2010) 1.22
Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice. Toxicol Pathol (2004) 1.21
Concurrent Helicobacter bilis infection in C57BL/6 mice attenuates proinflammatory H. pylori-induced gastric pathology. Infect Immun (2009) 1.20
Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Infect Immun (2010) 1.20
JlpA of Campylobacter jejuni interacts with surface-exposed heat shock protein 90alpha and triggers signalling pathways leading to the activation of NF-kappaB and p38 MAP kinase in epithelial cells. Cell Microbiol (2003) 1.19
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun (2006) 1.19
What is new with Nods? Curr Opin Immunol (2010) 1.18
Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol (2004) 1.18
Escherichia coli shiga-like toxins induce apoptosis and cleavage of poly(ADP-ribose) polymerase via in vitro activation of caspases. Infect Immun (2002) 1.17
Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses. Cancer Res (2002) 1.14
Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol (2011) 1.14
Muramylpeptide shedding modulates cell sensing of Shigella flexneri. Cell Microbiol (2007) 1.13
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology (2012) 1.12
Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat. Trends Immunol (2007) 1.12
Peptidoglycan: a critical activator of the mammalian immune system during infection and homeostasis. Immunol Rev (2011) 1.11
Innate signals from Nod2 block respiratory tolerance and program T(H)2-driven allergic inflammation. J Allergy Clin Immunol (2010) 1.10
Nod1 and Nod2 signaling does not alter the composition of intestinal bacterial communities at homeostasis. Gut Microbes (2013) 1.10
Helicobacter bilis-associated hepatitis in outbred mice. Comp Med (2004) 1.09
Helicobacter pylori activates myosin light-chain kinase to disrupt claudin-4 and claudin-5 and increase epithelial permeability. Infect Immun (2005) 1.08
Mammalian NLR proteins; discriminating foe from friend. Immunol Cell Biol (2007) 1.08
Lactobacillus rhamnosus GG attenuates interferon-{gamma} and tumour necrosis factor-alpha-induced barrier dysfunction and pro-inflammatory signalling. Microbiology (2010) 1.07
Environmental particulate matter induces murine intestinal inflammatory responses and alters the gut microbiome. PLoS One (2013) 1.07
Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses. Infect Immun (2006) 1.06
Role of Nod1 in mucosal dendritic cells during Salmonella pathogenicity island 1-independent Salmonella enterica serovar Typhimurium infection. Infect Immun (2009) 1.06
Detection of Campylobacter in stool and determination of significance by culture, enzyme immunoassay, and PCR in developing countries. J Clin Microbiol (2014) 1.06
The innate immune molecule, NOD1, regulates direct killing of Helicobacter pylori by antimicrobial peptides. Cell Microbiol (2009) 1.05
Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation. Proc Natl Acad Sci U S A (2011) 1.05
Identification of the critical residues involved in peptidoglycan detection by Nod1. J Biol Chem (2005) 1.05