Published in Crit Rev Oncol Hematol on October 05, 2005
STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer (2009) 15.45
PI3K and STAT3: a new alliance. Cancer Discov (2011) 1.31
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. Blood (2008) 1.12
STAT6 expression in glioblastoma promotes invasive growth. BMC Cancer (2011) 1.05
Glycolytic rate and lymphomagenesis depend on PARP14, an ADP ribosyltransferase of the B aggressive lymphoma (BAL) family. Proc Natl Acad Sci U S A (2011) 0.99
Constitutively active STAT6 predisposes toward a lymphoproliferative disorder. Blood (2007) 0.90
DNA methylation regulates constitutive expression of Stat6 regulatory genes SOCS-1 and SHP-1 in colon cancer cells. J Cancer Res Clin Oncol (2009) 0.85
PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem (2010) 0.84
Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation. Chromosome Res (2015) 0.82
Reprogramming of lysosomal gene expression by interleukin-4 and Stat6. BMC Genomics (2013) 0.82
miR-135b inhibits tumour metastasis in prostate cancer by targeting STAT6. Oncol Lett (2015) 0.78
Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival. J Virol (2015) 0.77
Clinicopathological significance of STAT4 in hepatocellular carcinoma and its effect on cell growth and apoptosis. Onco Targets Ther (2016) 0.77
A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip. PLoS One (2012) 0.77
Interaction of STAT6 with its co-activator SRC-1/NCoA-1 is regulated by dephosphorylation of the latter via PP2A. Nucleic Acids Res (2010) 0.76
Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk. Haematologica (2010) 0.75
Differential IL-4/Stat6 activities correlate with differential expression of regulatory genes SOCS-1, SHP-1, and PP2A in colon cancer cells. J Cancer Res Clin Oncol (2008) 0.75
Stat6 Promotes Intestinal Tumorigenesis in a Mouse Model of Adenomatous Polyposis by Expansion of MDSCs and Inhibition of Cytotoxic CD8 Response. Neoplasia (2017) 0.75
Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood (2006) 2.34
A brief history of IL-9. J Immunol (2011) 2.27
IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol (2008) 2.06
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. Immunity (2013) 2.03
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity (2005) 1.93
Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med (2012) 1.89
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol (2008) 1.79
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood (2012) 1.72
STAT6-dependent regulation of Th9 development. J Immunol (2011) 1.60
Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med (2005) 1.59
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol (2009) 1.51
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol (2010) 1.49
Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity (2013) 1.43
Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J Immunol (2003) 1.42
Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. AIDS Res Hum Retroviruses (2006) 1.40
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol (2002) 1.34
Infected atopic dermatitis lesions contain pharmacologic amounts of lipoteichoic acid. J Allergy Clin Immunol (2009) 1.31
Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. J Virol (2011) 1.26
PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol (2009) 1.20
BATF transgenic mice reveal a role for activator protein-1 in NKT cell development. J Immunol (2003) 1.19
Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology (2009) 1.16
Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest (2013) 1.15
Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med (2007) 1.15
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol (2012) 1.13
Regulating Il9 transcription in T helper cells. Trends Immunol (2011) 1.12
IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J Immunol (2008) 1.12
The symphony of the ninth: the development and function of Th9 cells. Curr Opin Immunol (2012) 1.12
STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus. J Biol Chem (2003) 1.12
Scratching the surface: towards understanding the pathogenesis of atopic dermatitis. Crit Rev Immunol (2008) 1.10
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. J Virol (2012) 1.10
Predisposition to the development of IL-9-secreting T cells in atopic infants. J Allergy Clin Immunol (2011) 1.10
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. J Immunol (2012) 1.10
Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. J Immunol (2009) 1.10
Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent. J Immunol (2004) 1.09
Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia. J Exp Med (2013) 1.08
Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity (2002) 1.08
NGSQC: cross-platform quality analysis pipeline for deep sequencing data. BMC Genomics (2010) 1.07
Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood (2009) 1.07
Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life. J Allergy Clin Immunol (2010) 1.06
Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol (2010) 1.06
The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway. Mol Immunol (2013) 1.06
The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis (2012) 1.05
Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol (2006) 1.04
HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses. Genome Res (2013) 1.03
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol (2012) 1.02
Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol (2008) 1.01
Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol (2011) 1.00
Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons. J Interferon Cytokine Res (2008) 0.99
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J Immunol (2008) 0.98
STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines. J Immunol (2003) 0.97
Tobacco and HIV. Clin Occup Environ Med (2006) 0.97
Impaired interferon-gamma production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Blood (2005) 0.97
STAT4 requires the N-terminal domain for efficient phosphorylation. J Biol Chem (2003) 0.96
IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol (2007) 0.94
Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol (2008) 0.94
Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation. Nat Chem Biol (2013) 0.94
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol (2011) 0.93
STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation. Diabetes (2013) 0.93
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection. J Virol (2013) 0.92
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood (2013) 0.92
Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol (2005) 0.92
Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J Immunol (2007) 0.91
The homeostasis but not the differentiation of T cells is regulated by p27(Kip1). J Immunol (2002) 0.91
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol (2008) 0.91
DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation. Proc Natl Acad Sci U S A (2011) 0.90
Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol (2002) 0.89
Human endogenous retrovirus K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1. J Virol (2012) 0.88
Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. Cancer Res (2005) 0.87
Signal transducer and activator of transcription (Stat)-6-dependent, but not Stat4-dependent, immunity is required for the development of autoimmunity in Graves' hyperthyroidism. Endocrinology (2004) 0.86
Respiratory syncytial virus causes increased bronchial epithelial permeability. Chest (2004) 0.86
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. J Immunol (2013) 0.85
Wheezing and itching: The requirement for STAT proteins in allergic inflammation. JAKSTAT (2012) 0.84
Increased skin barrier disruption by sodium lauryl sulfate in mice expressing a constitutively active STAT6 in T cells. Arch Dermatol Res (2011) 0.84
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain. J Biol Chem (2013) 0.83
Changing the STATus quo in T helper cells. Transcription (2011) 0.83
Topical application of a vitamin D analogue exacerbates atopic dermatitis and induces the atopic dermatitis-like phenotype in Stat6VT mice. Pediatr Dermatol (2013) 0.83
T cell regulation of hematopoiesis. Front Biosci (2008) 0.83
The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections. J Allergy Clin Immunol (2011) 0.81
Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation. J Immunol (2002) 0.81
Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Endocrinology (2005) 0.81
CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis. Eur J Immunol (2009) 0.81
Regulation of IL-17 expression by the developmental pathway of CD4 T cells in the thymus. Mol Immunol (2010) 0.81
Identification of staphylococcal protein A in infected atopic dermatitis lesions. J Invest Dermatol (2010) 0.80
Influence of increased CD4 cell counts on the genetic variability of hepatitis C virus in patients co-infected with human immunodeficiency virus I. J Biomol Tech (2006) 0.80
Elevated IL-6 expression in CD4 T cells via PKCtheta and NF-kappaB induces Th2 cytokine production. Mol Immunol (2009) 0.80
The transcriptional repressor Bcl6 controls the stability of regulatory T cells by intrinsic and extrinsic pathways. Immunology (2015) 0.80
T helper cell subsets in the development of atopic dermatitis. J Drugs Dermatol (2012) 0.80
p53 regulates Btk-dependent B cell proliferation but not differentiation. J Leukoc Biol (2006) 0.79
Altered STAT4 Isoform Expression in Patients with Inflammatory Bowel Disease. Inflamm Bowel Dis (2015) 0.79
Serum MicroRNA-21 as a Biomarker for Allergic Inflammatory Disease in Children. Microrna (2015) 0.79
Allergic airway disease in mice alters T and B cell responses during an acute respiratory poxvirus infection. PLoS One (2013) 0.79