Published in J Immunol on June 08, 2012
Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. Immunity (2013) 2.03
TWIST and ovarian cancer stem cells: implications for chemoresistance and metastasis. Oncotarget (2014) 0.99
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection. J Virol (2013) 0.92
Effector Vγ9Vδ2 T cells dominate the human fetal γδ T-cell repertoire. Proc Natl Acad Sci U S A (2015) 0.89
Individual T helper cells have a quantitative cytokine memory. Immunity (2014) 0.88
The transcription factor Etv5 controls TH17 cell development and allergic airway inflammation. J Allergy Clin Immunol (2014) 0.87
Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest. PLoS Genet (2013) 0.87
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation. J Immunol (2013) 0.85
The emerging role of Twist proteins in hematopoietic cells and hematological malignancies. Blood Cancer J (2014) 0.84
The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain. J Biol Chem (2013) 0.83
The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis. J Allergy Clin Immunol (2013) 0.82
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation. Ann Rheum Dis (2016) 0.81
A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue. Front Endocrinol (Lausanne) (2012) 0.80
Promoter-Specific Hypomethylation Is Associated with Overexpression of PLS3, GATA6, and TWIST1 in the Sezary Syndrome. J Invest Dermatol (2015) 0.77
Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators. J Immunol (2015) 0.75
Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target. BMC Cancer (2017) 0.75
Myor/ABF-1 mRNA [corrected] Expression Marks Follicular Helper T Cells but Is Dispensable for Tfh Cell Differentiation and Function In Vivo. PLoS One (2013) 0.75
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J Biol Chem (2007) 10.41
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Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature (1996) 6.23
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol (2008) 5.92
Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity (1998) 5.75
A twist code determines the onset of osteoblast differentiation. Dev Cell (2004) 5.40
Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Nat Immunol (2006) 4.81
daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex. Cell (1988) 3.94
Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol (2007) 3.72
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell (2003) 3.40
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12. Immunity (2009) 3.24
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The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity (2010) 2.38
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood (2006) 2.34
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity (2009) 2.24
Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in development. Genes Dev (1988) 2.13
Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol (2007) 2.13
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem (2008) 1.98
PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity (2005) 1.93
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. Nat Immunol (2010) 1.77
Twist mediates suppression of inflammation by type I IFNs and Axl. J Exp Med (2006) 1.76
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development. Development (2001) 1.71
A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol (2009) 1.62
An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation. Int Immunol (2011) 1.48
Autoregulation of Th1-mediated inflammation by twist1. J Exp Med (2008) 1.43
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities. J Biol Chem (2007) 1.34
Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling. J Cell Sci (2007) 1.32
SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor beta2 subunit. Biochem Biophys Res Commun (2003) 1.27
Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity (2007) 1.09
Phosphoregulation of Twist1 provides a mechanism of cell fate control. Curr Med Chem (2008) 1.09
Generation of a Twist1 conditional null allele in the mouse. Genesis (2007) 1.08
Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA. Nucleic Acids Res (2011) 0.98
Twist1 activity thresholds define multiple functions in limb development. Dev Biol (2010) 0.97
Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol (2008) 0.94
Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. Immunology (2004) 0.80
Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart. Circ Res (2008) 2.44
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood (2006) 2.34
A brief history of IL-9. J Immunol (2011) 2.27
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Mol Cell (2003) 2.16
IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol (2008) 2.06
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. Immunity (2013) 2.03
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity (2005) 1.93
Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med (2012) 1.89
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nat Genet (2005) 1.89
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol (2008) 1.79
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood (2012) 1.72
The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene. J Mol Cell Cardiol (2002) 1.64
A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol (2009) 1.62
STAT6-dependent regulation of Th9 development. J Immunol (2011) 1.60
Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med (2005) 1.59
Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development. Circ Res (2011) 1.57
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol (2009) 1.51
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol (2010) 1.49
Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity (2013) 1.43
Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J Immunol (2003) 1.42
Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. AIDS Res Hum Retroviruses (2006) 1.40
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39
Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer. Dev Biol (2007) 1.35
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities. J Biol Chem (2007) 1.34
Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol (2002) 1.34
Infected atopic dermatitis lesions contain pharmacologic amounts of lipoteichoic acid. J Allergy Clin Immunol (2009) 1.31
Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. J Virol (2011) 1.26
Cardiovascular development and the colonizing cardiac neural crest lineage. ScientificWorldJournal (2007) 1.26
An absence of Twist1 results in aberrant cardiac neural crest morphogenesis. Dev Biol (2008) 1.22
PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol (2009) 1.20
BATF transgenic mice reveal a role for activator protein-1 in NKT cell development. J Immunol (2003) 1.19
Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology (2009) 1.16
Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest (2013) 1.15
Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med (2007) 1.15
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol (2012) 1.13
Regulating Il9 transcription in T helper cells. Trends Immunol (2011) 1.12
IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J Immunol (2008) 1.12
STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus. J Biol Chem (2003) 1.12
The symphony of the ninth: the development and function of Th9 cells. Curr Opin Immunol (2012) 1.12
Scratching the surface: towards understanding the pathogenesis of atopic dermatitis. Crit Rev Immunol (2008) 1.10
The role of constitutively active Stat6 in leukemia and lymphoma. Crit Rev Oncol Hematol (2005) 1.10
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. J Virol (2012) 1.10
Predisposition to the development of IL-9-secreting T cells in atopic infants. J Allergy Clin Immunol (2011) 1.10
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. J Immunol (2012) 1.10
Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. J Immunol (2009) 1.10
Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent. J Immunol (2004) 1.09
Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia. J Exp Med (2013) 1.08
Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity (2002) 1.08
Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood (2009) 1.07
NGSQC: cross-platform quality analysis pipeline for deep sequencing data. BMC Genomics (2010) 1.07
Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life. J Allergy Clin Immunol (2010) 1.06
Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells. Blood (2011) 1.06
Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol (2010) 1.06
The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway. Mol Immunol (2013) 1.06
Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev Dyn (2008) 1.05
The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis (2012) 1.05
Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol (2006) 1.04
HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a. Dev Biol (2003) 1.04
Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects. Birth Defects Res A Clin Mol Teratol (2011) 1.03
HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses. Genome Res (2013) 1.03
Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol (2008) 1.01
Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol (2011) 1.00
Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons. J Interferon Cytokine Res (2008) 0.99
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J Immunol (2008) 0.98
STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines. J Immunol (2003) 0.97
Tobacco and HIV. Clin Occup Environ Med (2006) 0.97
Impaired interferon-gamma production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Blood (2005) 0.97
Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development. Dev Biol (2010) 0.96
STAT4 requires the N-terminal domain for efficient phosphorylation. J Biol Chem (2003) 0.96
Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol (2008) 0.94
IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol (2007) 0.94
Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation. Nat Chem Biol (2013) 0.94
Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn (2010) 0.94
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol (2011) 0.93
STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation. Diabetes (2013) 0.93
Cytokine-dependent induction of CD4+ T cells with cytotoxic potential during influenza virus infection. J Virol (2013) 0.92
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood (2013) 0.92
Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol (2005) 0.92
A bHLH code for cardiac morphogenesis. Pediatr Cardiol (2009) 0.91
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease. J Immunol (2008) 0.91
The homeostasis but not the differentiation of T cells is regulated by p27(Kip1). J Immunol (2002) 0.91
Agonist-driven development of CD4+CD25+Foxp3+ regulatory T cells requires a second signal mediated by Stat6. J Immunol (2007) 0.91
DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation. Proc Natl Acad Sci U S A (2011) 0.90
Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol (2002) 0.89
Human endogenous retrovirus K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1. J Virol (2012) 0.88
HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy. Biochem Biophys Res Commun (2002) 0.87
Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest. PLoS Genet (2013) 0.87
Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells. Cancer Res (2005) 0.87