Published in J Leukoc Biol on February 03, 2006
Msh2-dependent DNA repair mitigates a unique susceptibility of B cell progenitors to c-Myc-induced lymphomas. Proc Natl Acad Sci U S A (2009) 0.83
Effects of prostaglandin E2 on p53 mRNA transcription and p53 mutagenesis during T-cell-independent human B-cell clonal expansion. FASEB J (2013) 0.77
A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion. J Immunol (2012) 0.77
Metformin Suppresses Systemic Autoimmunity in Roquin(san/san) Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3. J Immunol (2017) 0.75
Stat3 and Stat4 direct development of IL-17-secreting Th cells. J Immunol (2007) 5.16
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat Immunol (2010) 3.97
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci U S A (2008) 3.04
The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci (2002) 2.37
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood (2006) 2.34
A brief history of IL-9. J Immunol (2011) 2.27
IL-23 promotes maintenance but not commitment to the Th17 lineage. J Immunol (2008) 2.06
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination. Immunity (2008) 2.04
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to Nutlin-3. Cancer Res (2006) 2.03
Interferon regulatory factor 4 sustains CD8(+) T cell expansion and effector differentiation. Immunity (2013) 2.03
The transcription factor STAT3 is required for T helper 2 cell development. Immunity (2011) 2.03
PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity (2005) 1.93
Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med (2012) 1.89
Transcriptional regulation by STAT6. Immunol Res (2011) 1.81
Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol (2008) 1.79
Autonomous murine T-cell progenitor production in the extra-embryonic yolk sac before HSC emergence. Blood (2012) 1.72
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy. J Biol Chem (2001) 1.66
Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified. J Biol Chem (2005) 1.62
STAT6-dependent regulation of Th9 development. J Immunol (2011) 1.60
Interleukin (IL)-4 inhibits IL-10 to promote IL-12 production by dendritic cells. J Exp Med (2005) 1.59
Rap1a null mice have altered myeloid cell functions suggesting distinct roles for the closely related Rap1a and 1b proteins. J Immunol (2007) 1.56
PTEN and p53 are required for hypoxia induced expression of maspin in glioblastoma cells. Cell Cycle (2009) 1.54
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines. J Immunol (2009) 1.51
TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. J Clin Invest (2009) 1.50
IL-4 regulates skin homeostasis and the predisposition toward allergic skin inflammation. J Immunol (2010) 1.49
Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. Immunity (2013) 1.43
Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells. J Immunol (2003) 1.42
Detection of HERV-K(HML-2) viral RNA in plasma of HIV type 1-infected individuals. AIDS Res Hum Retroviruses (2006) 1.40
Distinct requirements for the naturally occurring splice forms Stat4alpha and Stat4beta in IL-12 responses. EMBO J (2003) 1.39
Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation. J Biol Chem (2003) 1.37
Delayed activation of insulin-like growth factor-1 receptor/Src/MAPK/Egr-1 signaling regulates clusterin expression, a pro-survival factor. J Biol Chem (2005) 1.36
Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain. DNA Repair (Amst) (2009) 1.35
Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation. EMBO J (2007) 1.34
Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma. Am J Pathol (2002) 1.34
Infected atopic dermatitis lesions contain pharmacologic amounts of lipoteichoic acid. J Allergy Clin Immunol (2009) 1.31
PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res (2003) 1.27
Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. J Virol (2011) 1.26
Type 1 TNF receptor forms a complex with and uses Jak2 and c-Src to selectively engage signaling pathways that regulate transcription factor activity. J Immunol (2008) 1.24
PU.1 regulates TCR expression by modulating GATA-3 activity. J Immunol (2009) 1.20
BATF transgenic mice reveal a role for activator protein-1 in NKT cell development. J Immunol (2003) 1.19
Akt regulates basal and induced processing of NF-kappaB2 (p100) to p52. J Biol Chem (2006) 1.18
Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res (2007) 1.18
Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol Cancer Res (2010) 1.18
Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells. Immunology (2009) 1.16
Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors. Oncogene (2004) 1.16
Th9 cell development requires a BATF-regulated transcriptional network. J Clin Invest (2013) 1.15
Thymic selection pathway regulates the effector function of CD4 T cells. J Exp Med (2007) 1.15
Tissue transglutaminase regulates matrix metalloproteinase-2 in ovarian cancer by modulating cAMP-response element-binding protein activity. J Biol Chem (2009) 1.14
The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells. J Biol Chem (2006) 1.13
Bcl6 controls the Th2 inflammatory activity of regulatory T cells by repressing Gata3 function. J Immunol (2012) 1.13
Regulating Il9 transcription in T helper cells. Trends Immunol (2011) 1.12
IL-4 is a critical determinant in the generation of allergic inflammation initiated by a constitutively active Stat6. J Immunol (2008) 1.12
The symphony of the ninth: the development and function of Th9 cells. Curr Opin Immunol (2012) 1.12
STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus. J Biol Chem (2003) 1.12
Scratching the surface: towards understanding the pathogenesis of atopic dermatitis. Crit Rev Immunol (2008) 1.10
The role of constitutively active Stat6 in leukemia and lymphoma. Crit Rev Oncol Hematol (2005) 1.10
Expression of human endogenous retrovirus type K (HML-2) is activated by the Tat protein of HIV-1. J Virol (2012) 1.10
Predisposition to the development of IL-9-secreting T cells in atopic infants. J Allergy Clin Immunol (2011) 1.10
Gcn5 is required for PU.1-dependent IL-9 induction in Th9 cells. J Immunol (2012) 1.10
Temporal induction pattern of STAT4 target genes defines potential for Th1 lineage-specific programming. J Immunol (2009) 1.10
Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther (2012) 1.09
Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent. J Immunol (2004) 1.09
Hdm2 nuclear export, regulated by insulin-like growth factor-I/MAPK/p90Rsk signaling, mediates the transformation of human cells. J Biol Chem (2006) 1.08
Innate Stat3-mediated induction of the antimicrobial protein Reg3γ is required for host defense against MRSA pneumonia. J Exp Med (2013) 1.08
Th1 cells regulate hematopoietic progenitor cell homeostasis by production of oncostatin M. Immunity (2002) 1.08
NGSQC: cross-platform quality analysis pipeline for deep sequencing data. BMC Genomics (2010) 1.07
Impaired development of human Th1 cells in patients with deficient expression of STAT4. Blood (2009) 1.07
Evaluation of airway reactivity and immune characteristics as risk factors for wheezing early in life. J Allergy Clin Immunol (2010) 1.06
Tc17 cells are capable of mediating immunity to vaccinia virus by acquisition of a cytotoxic phenotype. J Immunol (2010) 1.06
The Bcl6 target gene microRNA-21 promotes Th2 differentiation by a T cell intrinsic pathway. Mol Immunol (2013) 1.06
Tumor necrosis factor activates CRE-binding protein through a p38 MAPK/MSK1 signaling pathway in endothelial cells. Am J Physiol Cell Physiol (2004) 1.05
The environmental stressor ultraviolet B radiation inhibits murine antitumor immunity through its ability to generate platelet-activating factor agonists. Carcinogenesis (2012) 1.05
Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J Immunol (2006) 1.04
HIV infection reveals widespread expansion of novel centromeric human endogenous retroviruses. Genome Res (2013) 1.03
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function. J Immunol (2012) 1.02
Stat6 signaling suppresses VLA-4 expression by CD8+ T cells and limits their ability to infiltrate tumor lesions in vivo. J Immunol (2008) 1.01
Thymic stromal lymphopoietin interferes with airway tolerance by suppressing the generation of antigen-specific regulatory T cells. J Immunol (2011) 1.00
CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET). J Biol Chem (2011) 1.00
Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons. J Interferon Cytokine Res (2008) 0.99
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis. J Immunol (2008) 0.98
STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines. J Immunol (2003) 0.97
Impaired interferon-gamma production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma. Blood (2005) 0.97
Tobacco and HIV. Clin Occup Environ Med (2006) 0.97
Galectin-3 regulates apoptosis and doxorubicin chemoresistance in papillary thyroid cancer cells. Biochem Biophys Res Commun (2009) 0.96
STAT4 requires the N-terminal domain for efficient phosphorylation. J Biol Chem (2003) 0.96
Expression and endocytosis of VEGF and its receptors in human colonic vascular endothelial cells. Am J Physiol Gastrointest Liver Physiol (2002) 0.95
Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery (2009) 0.95
IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding. J Leukoc Biol (2007) 0.94
Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation. J Immunol (2008) 0.94
Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation. Nat Chem Biol (2013) 0.94
Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity. Clin Cancer Res (2011) 0.94
Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res (2009) 0.93
Periostin regulates goblet cell metaplasia in a model of allergic airway inflammation. J Immunol (2011) 0.93
STAT4 deficiency reduces obesity-induced insulin resistance and adipose tissue inflammation. Diabetes (2013) 0.93
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood (2013) 0.92