Published in J Biol Chem on April 13, 2010
Mammalian Krüppel-like factors in health and diseases. Physiol Rev (2010) 4.09
The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator. Genes Dev (2013) 1.79
Tumor suppressor functions of FBW7 in cancer development and progression. FEBS Lett (2012) 1.64
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PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis. Cancer Cell (2014) 1.06
Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein. J Biol Chem (2011) 1.05
FBW7 regulates endothelial functions by targeting KLF2 for ubiquitination and degradation. Cell Res (2013) 1.03
Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep (2011) 1.00
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Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells. Biochem J (2011) 0.94
Targeting the ubiquitin pathway for cancer treatment. Biochim Biophys Acta (2014) 0.93
The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein. J Biol Chem (2011) 0.91
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FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol (2011) 0.89
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A colon cancer-derived mutant of Krüppel-like factor 5 (KLF5) is resistant to degradation by glycogen synthase kinase 3β (GSK3β) and the E3 ubiquitin ligase F-box and WD repeat domain-containing 7α (FBW7α). J Biol Chem (2014) 0.84
Evaluating the prognostic significance of FBXW7 expression level in human breast cancer by a meta-analysis of transcriptional profiles. J Cancer Sci Ther (2012) 0.84
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FBW7-mediated ubiquitination and degradation of KLF5. World J Biol Chem (2014) 0.80
Regulation of c-Myc protein stability by proteasome activator REGγ. Cell Death Differ (2014) 0.80
Multiple novel alternative splicing forms of FBXW7α have a translational modulatory function and show specific alteration in human cancer. PLoS One (2012) 0.79
F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation. J Biol Chem (2013) 0.79
SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stability. Oncotarget (2014) 0.78
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Krüppel-like factors in mammalian stem cells and development. Development (2017) 0.75
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Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis. Elife (2017) 0.75
The FBW7-KLF2 axis regulates endothelial functions. Cell Res (2013) 0.75
The stability of Fbw7α in M-phase requires its phosphorylation by PKC. PLoS One (2017) 0.75
Smurf1 regulates lung cancer cell growth and migration through interaction with and ubiquitination of PIPKIγ. Oncogene (2017) 0.75
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A core Klf circuitry regulates self-renewal of embryonic stem cells. Nat Cell Biol (2008) 6.90
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science (2001) 6.29
Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol (2001) 5.81
Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Cell (2003) 5.72
Inactivation of hCDC4 can cause chromosomal instability. Nature (2004) 5.71
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation. Proc Natl Acad Sci U S A (2004) 5.37
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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J (2004) 4.95
FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med (2007) 4.59
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases. Mol Cell (2007) 3.97
FBXW7/hCDC4 is a general tumor suppressor in human cancer. Cancer Res (2007) 3.79
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science (2008) 3.78
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab (2005) 3.43
GSK3: a multifaceted kinase in Wnt signaling. Trends Biochem Sci (2009) 2.87
The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science (2004) 2.83
Identification of SCF ubiquitin ligase substrates by global protein stability profiling. Science (2008) 2.53
A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol (2004) 2.45
The diverse functions of Krüppel-like factors 4 and 5 in epithelial biology and pathobiology. Bioessays (2007) 2.40
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med (2008) 2.16
Intestinal-enriched Krüppel-like factor (Krüppel-like factor 5) is a positive regulator of cellular proliferation. J Biol Chem (2001) 2.01
Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene. Mol Cell Biol (2001) 1.98
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell (2008) 1.91
Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases. Cell Mol Life Sci (2009) 1.82
SCFCdc4 acts antagonistically to the PGC-1alpha transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis. Genes Dev (2008) 1.78
Fbw7/hCDC4 dimerization regulates its substrate interactions. Cell Div (2007) 1.64
Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells. Oncogene (2005) 1.64
Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells. J Biol Chem (2005) 1.56
Intestinal tumor progression is associated with altered function of KLF5. J Biol Chem (2004) 1.53
KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer. Prostate (2003) 1.47
KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line. Int J Cancer (2006) 1.44
Destabilization of Krüppel-like factor 4 protein in response to serum stimulation involves the ubiquitin-proteasome pathway. Cancer Res (2005) 1.43
Kruppel-like factor 5 shows proliferation-specific roles in vascular remodeling, direct stimulation of cell growth, and inhibition of apoptosis. J Biol Chem (2009) 1.43
Beta-arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2. J Biol Chem (2002) 1.41
beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Mol Cell Biol (2009) 1.37
Isoform- and cell cycle-dependent substrate degradation by the Fbw7 ubiquitin ligase. J Cell Biol (2008) 1.35
KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia. J Biol Chem (2006) 1.30
Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine. Cancer Res (2009) 1.29
Lysophosphatidic acid facilitates proliferation of colon cancer cells via induction of Krüppel-like factor 5. J Biol Chem (2007) 1.29
The amplified WWP1 gene is a potential molecular target in breast cancer. Int J Cancer (2007) 1.26
Expression of KLF5 is a prognostic factor for disease-free survival and overall survival in patients with breast cancer. Clin Cancer Res (2006) 1.24
Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer. Oncogene (2006) 1.19
SUMOylation regulates nuclear localization of Krüppel-like factor 5. J Biol Chem (2008) 1.18
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells. Histol Histopathol (2009) 1.15
Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. Oncogene (2009) 1.14
Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. Nucleic Acids Res (2003) 1.12
Krüppel-like factor 5 mediates transmissible murine colonic hyperplasia caused by Citrobacter rodentium infection. Gastroenterology (2008) 1.11
Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb. Oncogene (2009) 1.07
Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5. J Biol Chem (2004) 1.02
hCDC4 and genetic instability in cancer. Cell Cycle (2004) 1.00
Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening. Mol Cancer Ther (2009) 0.93
Overexpression of WWP1 is associated with the estrogen receptor and insulin-like growth factor receptor 1 in breast carcinoma. Int J Cancer (2009) 0.90
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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell (2011) 11.44
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature (2002) 10.96
The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study. Lancet (2008) 9.03
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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
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A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res (2008) 4.33
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