Published in J Biol Chem on October 19, 2005
Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2009) 1.94
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay. J Biol Chem (2009) 1.91
Novel cannabinoid receptors. Br J Pharmacol (2007) 1.55
Oxidized LDL: diversity, patterns of recognition, and pathophysiology. Antioxid Redox Signal (2010) 1.47
Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2. J Lipid Res (2012) 1.28
G2A and LPC: regulatory functions in immunity. Prostaglandins Other Lipid Mediat (2009) 1.15
Signaling via macrophage G2A enhances efferocytosis of dying neutrophils by augmentation of Rac activity. J Biol Chem (2011) 1.13
Serum oxylipin profiles in IgA nephropathy patients reflect kidney functional alterations. Metabolomics (2012) 1.09
Aspergillus oxylipin signaling and quorum sensing pathways depend on g protein-coupled receptors. Toxins (Basel) (2012) 1.06
Free fatty acid receptors: emerging targets for treatment of diabetes and its complications. Ther Adv Endocrinol Metab (2010) 1.06
Phenotypic modulation of macrophages in response to plaque lipids. Curr Opin Lipidol (2011) 1.05
Lipoprotein lipase releases esterified oxylipins from very low-density lipoproteins. Prostaglandins Leukot Essent Fatty Acids (2008) 1.02
Novel lysophosphoplipid receptors: their structure and function. J Lipid Res (2014) 0.94
Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem (2009) 0.94
Molecular hydrogen regulates gene expression by modifying the free radical chain reaction-dependent generation of oxidized phospholipid mediators. Sci Rep (2016) 0.92
Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. Elife (2015) 0.92
G2A deficiency in mice promotes macrophage activation and atherosclerosis. Circ Res (2008) 0.89
20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor. Biochemistry (2011) 0.88
7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: roles of NADPH oxidase, mitochondria, and lipid rafts. Free Radic Biol Med (2006) 0.88
Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist. Proc Natl Acad Sci U S A (2015) 0.86
Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. Cell Death Differ (2016) 0.82
The G protein-coupled receptor G2A: involvement in hepatic lipid metabolism and gallstone formation in mice. Hepatology (2008) 0.82
Phosphatidylcholine hydroperoxide-induced THP-1 cell adhesion to intracellular adhesion molecule-1. J Lipid Res (2008) 0.81
Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα12/13-Rho-Rac1 pathway. J Mol Signal (2013) 0.81
Intercellular Lipid Mediators and GPCR Drug Discovery. Biomol Ther (Seoul) (2013) 0.77
Selective Production of 9R-Hydroxy-10E,12Z,15Z-Octadecatrienoic Acid from α-Linolenic Acid in Perilla Seed Oil Hydrolyzate by a Lipoxygenase from Nostoc Sp. SAG 25.82. PLoS One (2015) 0.76
The phospholipase iPLA2γ is a major mediator releasing oxidized aliphatic chains from cardiolipin integrating mitochondrial bioenergetics and signaling. J Biol Chem (2017) 0.75
Oxidized lipids and lysophosphatidylcholine induce the chemotaxis, up-regulate the expression of CCR9 and CXCR4 and abrogate the release of IL-6 in human monocytes. Toxins (Basel) (2014) 0.75
Production of cross-kingdom oxylipins by pathogenic fungi: An update on their role in development and pathogenicity. J Microbiol (2016) 0.75
Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A (2017) 0.75
Selective propofol injection into the M1 segment of the middle cerebral artery (MCA Wada test) reduces adverse effects and enhances the reliability of the Wada test for determining speech dominance. World Neurosurg (2011) 2.04
A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. Clin Pharmacol Ther (2003) 1.84
Cystathionine gamma-Lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury. J Biol Chem (2010) 1.61
Risk of aneurysmal rupture: the importance of neck orifice positioning-assessment using computational flow simulation. Neurosurgery (2008) 1.61
Clinical follow-up study of adult-onset Still's disease. J Dermatol (2012) 1.47
Linear lupus erythematosus profundus on the scalp following the lines of Blaschko. Eur J Dermatol (2003) 1.13
G2A as a receptor for oxidized free fatty acids. Prostaglandins Other Lipid Mediat (2008) 1.10
Edoxaban transport via P-glycoprotein is a key factor for the drug's disposition. Drug Metab Dispos (2014) 1.06
Lysophosphatidic acid, a growth factor-like lipid, in the saliva. J Lipid Res (2002) 1.05
G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid. J Invest Dermatol (2007) 1.01
Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2: differential pharmacological properties and tissue distribution. J Biol Chem (2002) 1.00
CDK5-dependent phosphorylation of the Rho family GTPase TC10(alpha) regulates insulin-stimulated GLUT4 translocation. J Biol Chem (2008) 0.99
A study of upper extremity training for patients with stroke using a virtual environment system. J Phys Ther Sci (2013) 0.98
A case of giant common carotid artery aneurysm associated with vascular Behçet disease: successfully treated with a covered stent. Surg Neurol (2008) 0.95
Thioesterase activity and subcellular localization of acylprotein thioesterase 1/lysophospholipase 1. Biochim Biophys Acta (2009) 0.94
A novel glycerophosphodiester phosphodiesterase, GDE5, controls skeletal muscle development via a non-enzymatic mechanism. J Biol Chem (2010) 0.93
Genetic background conversion ameliorates semi-lethality and permits behavioral analyses in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia. Hum Mol Genet (2008) 0.91
Magnetic resonance fluid dynamics for intracranial aneurysms--comparison with computed fluid dynamics. Acta Neurochir (Wien) (2012) 0.91
A novel pressure sensor with an optical system for coil embolization of intracranial aneurysms. Laboratory investigation. J Neurosurg (2009) 0.89
Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. J Allergy Clin Immunol (2003) 0.88
Human carboxymethylenebutenolidase as a bioactivating hydrolase of olmesartan medoxomil in liver and intestine. J Biol Chem (2010) 0.87
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria. Free Radic Biol Med (2012) 0.87
Sp1 is a co-activator with Ets-1, and Net is an important repressor of the transcription of CTP:phosphocholine cytidylyltransferase alpha. J Biol Chem (2005) 0.87
Bosentan for digital ulcers in patients with systemic sclerosis. J Dermatol (2011) 0.86
Prediction of human pharmacokinetics of therapeutic monoclonal antibodies from simple allometry of monkey data. Drug Metab Pharmacokinet (2011) 0.85
Detection of G protein-coupled receptor-mediated cellular response involved in cytoskeletal rearrangement using surface plasmon resonance. Biosens Bioelectron (2009) 0.84
Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. J Allergy Clin Immunol (2002) 0.84
Usefulness of three-dimensional digital subtraction angiography in endovascular treatment of a spinal dural arteriovenous fistula. J Neurosurg Spine (2008) 0.84
Human pharmacokinetic prediction of UDP-glucuronosyltransferase substrates with an animal scale-up approach. Drug Metab Dispos (2011) 0.83
Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice. Arch Toxicol (2009) 0.83
Fenestration of a supraclinoid internal carotid artery associated with dual aneurysms: case report. Neurosurgery (2011) 0.82
Nuclear-localization-signal-dependent and nuclear-export-signal-dependent mechanisms determine the localization of 5-lipoxygenase. Biochem J (2002) 0.82
Stress-induced nuclear export of 5-lipoxygenase. Biochem Biophys Res Commun (2005) 0.82
Arachidonate 5-lipoxygenase establishes adaptive humoral immunity by controlling primary B cells and their cognate T-cell help. Am J Pathol (2010) 0.82
Identification of Ets-1 as an important transcriptional activator of CTP:phosphocholine cytidylyltransferase alpha in COS-7 cells and co-activation with transcriptional enhancer factor-4. J Biol Chem (2003) 0.81
Interindividual variability of carboxymethylenebutenolidase homolog, a novel olmesartan medoxomil hydrolase, in the human liver and intestine. Drug Metab Dispos (2013) 0.80
Functional characterization of single nucleotide polymorphisms with amino acid substitution in CYP1A2, CYP2A6, and CYP2B6 found in the Japanese population. Drug Metab Pharmacokinet (2004) 0.80
Evaluation of the characteristics of various types of coils for the embolization of intracranial aneurysms with an optical pressure sensor system. Neuroradiology (2010) 0.80
A case study of new assessment and training of unilateral spatial neglect in stroke patients: effect of visual image transformation and visual stimulation by using a Head Mounted Display system (HMD). J Neuroeng Rehabil (2010) 0.80
The 'one and a half round microcatheterization technique' for stent-assisted coil embolization of intracranial aneurysm: technical case series. J Neurointerv Surg (2013) 0.80
Paraoxonase 1 as a major bioactivating hydrolase for olmesartan medoxomil in human blood circulation: molecular identification and contribution to plasma metabolism. Drug Metab Dispos (2011) 0.80
Glutaredoxin is involved in the formation of the pharmacologically active metabolite of clopidogrel from its GSH conjugate. Drug Metab Dispos (2012) 0.79
Glucocorticoids up-regulate leukotriene B4 receptor-1 expression during neutrophilic differentiation of HL-60 cells. Biochem Biophys Res Commun (2003) 0.79
The intestine as an important contributor to prasugrel active metabolite formation in vivo. Drug Metab Dispos (2010) 0.79
Different hydrolases involved in bioactivation of prodrug-type angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1. Drug Metab Dispos (2013) 0.79
An atypical protein kinase C, PKC zeta, regulates human eosinophil effector functions. Immunology (2005) 0.79
Stent/balloon combination assist technique for wide-necked basilar terminal aneurysms. Interv Neuroradiol (2013) 0.79
Moyamoya syndrome associated with γ knife surgery for cerebral arteriovenous malformation: case report. Neurol Med Chir (Tokyo) (2012) 0.79
Differential induction of cystathionine gamma-lyase in the livers and kidneys of mouse dams during gestation and lactation. Biol Pharm Bull (2006) 0.79
Endovascular coil embolization for saccular-shaped blood blister-like aneurysms of the internal carotid artery. Acta Neurochir (Wien) (2010) 0.78
Receptor-dependent metabolism of platelet-activating factor in murine macrophages. J Biol Chem (2002) 0.78
Glutathione S-transferase pi trapping method for generation and characterization of drug-protein adducts in human liver microsomes using liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal (2012) 0.78
Virtual histology analysis of carotid atherosclerotic plaque: plaque composition at the minimum lumen site and of the entire carotid plaque. J Neuroimaging (2012) 0.78
Results and current trends of multimodality treatment for infectious intracranial aneurysms. Neurol Med Chir (Tokyo) (2015) 0.78
Ticlopidine-induced hepatotoxicity in a GSH-depleted rat model. Arch Toxicol (2010) 0.78
Genomic and proteomic characterization of the large Myoviridae bacteriophage ϕTMA of the extreme thermophile Thermus thermophilus. Bacteriophage (2011) 0.78
Proteomic analysis identifies proteins that continue to grow hepatic stem-like cells without differentiation. Cytotechnology (2008) 0.78
Inhibition mechanism of carbapenem antibiotics on acylpeptide hydrolase, a key enzyme in the interaction with valproic acid. Xenobiotica (2011) 0.78
Purification and characterization of lysophospholipase D from rat brain. Biochim Biophys Acta (2006) 0.77
Identification and analysis of two splice variants of human G2A generated by alternative splicing. J Pharmacol Exp Ther (2009) 0.77
No association of atherosclerosis with digital ulcers in Japanese patients with systemic sclerosis: evaluation of carotid intima-media thickness and plaque characteristics. J Dermatol (2014) 0.77
Prediction of human plasma concentration-time profiles of monoclonal antibodies from monkey data by a species-invariant time method. Drug Metab Pharmacokinet (2011) 0.77
6β-Hydroxycortisol is an endogenous probe for evaluation of drug-drug interactions involving a multispecific renal organic anion transporter, OAT3/SLC22A8, in healthy subjects. Drug Metab Dispos (2014) 0.77
[Resistance to antiplatelet agents assessed by a point-of-care platelet function test and thromboembolic adverse events in neurointervention]. No Shinkei Geka (2012) 0.77
Effect of the fluoroquinolone antibacterial agent DX-619 on the apparent formation and renal clearances of 6β-hydroxycortisol, an endogenous probe for CYP3A4 inhibition, in healthy subjects. Pharm Res (2012) 0.77
Effect of the moisture content in aerosol on the spray performance of Stmerin D HFA preparations. Chem Pharm Bull (Tokyo) (2006) 0.76
Effect of the moisture content in aerosol on the spray performance of Stmerin ® D hydrofluoroalkane preparations (2). Chem Pharm Bull (Tokyo) (2012) 0.76
Unilateral generalized morphea in childhood. J Dermatol (2002) 0.76
Assessment of visual space recognition in patients with visual field defects using head mounted display (HMD) system: case study with severe visual field defect. Conf Proc IEEE Eng Med Biol Soc (2013) 0.76
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug Metab Dispos (2011) 0.76
Identification of bioactivating enzymes involved in the hydrolysis of laninamivir octanoate, a long-acting neuraminidase inhibitor, in human pulmonary tissue. Drug Metab Dispos (2014) 0.76
Integrated approach of in vivo and in vitro evaluation of the involvement of hepatic uptake organic anion transporters in the drug disposition in rats using rifampicin as an inhibitor. Drug Metab Dispos (2013) 0.76
Endovascular intervention for acute cervical carotid artery occlusion. Acta Neurochir (Wien) (2013) 0.75
Clinical analysis of leg ulcers and gangrene in rheumatoid arthritis. J Dermatol (2013) 0.75
Novel comb-shaped PEG modification enhances the osteoclastic inhibitory effect and bone delivery of osteoprotegerin after intravenous administration in ovariectomized rats. Pharm Res (2012) 0.75
Spinal cord infarction is an unusual complication of intracranial neuroendovascular intervention. Interv Neuroradiol (2013) 0.75
Reformulation of Stmerin(®) D CFC formulation using HFA propellants. Pharm Dev Technol (2012) 0.75
A system utilizing metal hydride actuators to achieve passive motion of toe joints for prevention of pressure ulcers: a pilot study. Rehabil Res Pract (2012) 0.75
5-Oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G(12/13). J Biochem (2006) 0.75
A unique type of dural arteriovenous fistula at confluence of sinuses treated with endovascular embolization: a case report. Neurointervention (2013) 0.75
[Progress in proton-sensitive GPCR research]. Seikagaku (2008) 0.75
Absorption, distribution, metabolism and excretion of loxoprofen after dermal application of loxoprofen gel to rats. Xenobiotica (2014) 0.75
Ceramide induces myogenic differentiation and apoptosis in Drosophila Schneider cells. J Radiat Res (2009) 0.75
[Oxidized free fatty acids as lipid mediators and functions of G2A as their receptor]. Seikagaku (2011) 0.75
Metabolism and disposition of [(14)C]tivantinib after oral administration to humans, dogs and rats. Xenobiotica (2014) 0.75
Identification of novel peptide agonists from a random peptide library for a 5-oxo-ETE receptor, a receptor for bioactive lipids. J Pept Sci (2008) 0.75
Absorption, elimination, and metabolism of CS-1036, a novel α-amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption. Drug Metab Dispos (2013) 0.75
Alpha-amylase inhibitor, CS-1036 binds to serum amylase in a concentration-dependent and saturable manner. Drug Metab Dispos (2013) 0.75
Development of a wearable electro-larynx for laryngectomees and its evaluation. Conf Proc IEEE Eng Med Biol Soc (2007) 0.75
[Assessment of mental condition and anxiety in patients receiving neuroendovascular treatment]. No Shinkei Geka (2008) 0.75
Tissue distribution and identification of radioactivity components at elimination phase after oral administration of [¹⁴C]CS-1036, an α-amylase inhibitor, to rats. Drug Metab Dispos (2013) 0.75
Pharmacokinetic mechanism involved in the prolonged high retention of laninamivir in mouse respiratory tissues after intranasal administration of its prodrug laninamivir octanoate. Drug Metab Dispos (2012) 0.75