Complete subunit architecture of the proteasome regulatory particle.

RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Struct Biol (2012) 10.13

Quantifying the local resolution of cryo-EM density maps. Nat Methods (2013) 4.36

Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome system. Cell Stem Cell (2012) 2.35

Chaperone machines for protein folding, unfolding and disaggregation. Nat Rev Mol Cell Biol (2013) 2.24

Near-atomic resolution structural model of the yeast 26S proteasome. Proc Natl Acad Sci U S A (2012) 2.04

Molecular architecture and assembly of the eukaryotic proteasome. Annu Rev Biochem (2013) 2.04

Enhanced protein degradation by branched ubiquitin chains. Cell (2014) 2.02

Structural visualization of key steps in human transcription initiation. Nature (2013) 1.91

Conformational switching of the 26S proteasome enables substrate degradation. Nat Struct Mol Biol (2013) 1.90

Molecular architecture of the 40S⋅eIF1⋅eIF3 translation initiation complex. Cell (2014) 1.76

Single-Particle Cryo-EM at Crystallographic Resolution. Cell (2015) 1.74

The ubiquitin-proteasome system of Saccharomyces cerevisiae. Genetics (2012) 1.73

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA. Nat Struct Mol Biol (2013) 1.66

Structure of the Rpn11-Rpn8 dimer reveals mechanisms of substrate deubiquitination during proteasomal degradation. Nat Struct Mol Biol (2014) 1.63

Regulated protein turnover: snapshots of the proteasome in action. Nat Rev Mol Cell Biol (2014) 1.57

Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11. Proc Natl Acad Sci U S A (2014) 1.57

Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine. Cell (2013) 1.56

Sequence composition of disordered regions fine-tunes protein half-life. Nat Struct Mol Biol (2015) 1.55

Regulation of proteasome activity in health and disease. Biochim Biophys Acta (2013) 1.52

Biochemistry. Integrative structural biology. Science (2013) 1.52

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell (2014) 1.52

Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation. Proc Natl Acad Sci U S A (2013) 1.50

An inducible chaperone adapts proteasome assembly to stress. Mol Cell (2014) 1.49

Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (2015) 1.47

Building and remodelling Cullin-RING E3 ubiquitin ligases. EMBO Rep (2013) 1.47

Structural biology of the proteasome. Annu Rev Biophys (2013) 1.42

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase. Nat Struct Mol Biol (2013) 1.40

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife (2014) 1.40

Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome. Proc Natl Acad Sci U S A (2014) 1.37

Rational design of a split-Cas9 enzyme complex. Proc Natl Acad Sci U S A (2015) 1.30

A mass spectrometry-based hybrid method for structural modeling of protein complexes. Nat Methods (2014) 1.28

Structural basis for a reciprocal regulation between SCF and CSN. Cell Rep (2012) 1.28

Development of proteasome inhibitors as research tools and cancer drugs. J Cell Biol (2012) 1.27

Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex. Mol Cell Proteomics (2014) 1.23

Identification of the Cdc48•20S proteasome as an ancient AAA+ proteolytic machine. Science (2012) 1.22

Invited review article: Methods for imaging weak-phase objects in electron microscopy. Rev Sci Instrum (2013) 1.22

Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs. J Biol Chem (2013) 1.20

Crystal structure of the human COP9 signalosome. Nature (2014) 1.20

A new in vivo cross-linking mass spectrometry platform to define protein-protein interactions in living cells. Mol Cell Proteomics (2014) 1.18

Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity. Mol Cell (2015) 1.17

Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes. Proc Natl Acad Sci U S A (2014) 1.17

Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates. EMBO J (2014) 1.15

Advancing cell biology through proteomics in space and time (PROSPECTS). Mol Cell Proteomics (2012) 1.15

Structure of mammalian eIF3 in the context of the 43S preinitiation complex. Nature (2015) 1.14

The RNA exosome and proteasome: common principles of degradation control. Nat Rev Mol Cell Biol (2013) 1.12

Perilous journey: a tour of the ubiquitin-proteasome system. Trends Cell Biol (2014) 1.11

Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling. Mol Cell Proteomics (2012) 1.10

Ubiquitin modifications. Cell Res (2016) 1.10

Architecture of human translation initiation factor 3. Structure (2013) 1.09

Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci (2015) 1.09

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching. Elife (2015) 1.07

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nat Med (2015) 1.07

A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly. Cell (2015) 1.06

Dual functions of the Hsm3 protein in chaperoning and scaffolding regulatory particle subunits during the proteasome assembly. Proc Natl Acad Sci U S A (2012) 1.05

Joining forces: integrating proteomics and cross-linking with the mass spectrometry of intact complexes. Mol Cell Proteomics (2011) 1.05

Proteasome regulation by ADP-ribosylation. Cell (2013) 1.05

One number does not fit all: mapping local variations in resolution in cryo-EM reconstructions. J Struct Biol (2013) 1.03

Altered composition of liver proteasome assemblies contributes to enhanced proteasome activity in the exceptionally long-lived naked mole-rat. PLoS One (2012) 1.02

Deubiquitinases and the new therapeutic opportunities offered to cancer. Endocr Relat Cancer (2015) 1.02

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res (2013) 1.02

Functional asymmetries of proteasome translocase pore. J Biol Chem (2012) 1.01

Intrinsically disordered segments affect protein half-life in the cell and during evolution. Cell Rep (2014) 1.01

Go hybrid: EM, crystallography, and beyond. Curr Opin Struct Biol (2012) 1.01

ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome. J Biol Chem (2012) 1.00

Paradigms of protein degradation by the proteasome. Curr Opin Struct Biol (2014) 1.00

Deciphering preferential interactions within supramolecular protein complexes: the proteasome case. Mol Syst Biol (2015) 1.00

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21. Proc Natl Acad Sci U S A (2015) 0.99

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome. Nat Struct Mol Biol (2015) 0.98

Design principles of a universal protein degradation machine. J Mol Biol (2012) 0.98

Structural characterization of the interaction of Ubp6 with the 26S proteasome. Proc Natl Acad Sci U S A (2015) 0.97

40S subunit dissociation and proteasome-dependent RNA degradation in nonfunctional 25S rRNA decay. EMBO J (2012) 0.97

Structure of the human 26S proteasome at a resolution of 3.9 Å. Proc Natl Acad Sci U S A (2016) 0.96

Bipartite determinants mediate an evolutionarily conserved interaction between Cdc48 and the 20S peptidase. Proc Natl Acad Sci U S A (2013) 0.96

An atomic structure of the human 26S proteasome. Nat Struct Mol Biol (2016) 0.96

The Colossus of ubiquitylation: decrypting a cellular code. Mol Cell (2013) 0.96

Reconfiguration of the proteasome during chaperone-mediated assembly. Nature (2013) 0.96

The proteasome under the microscope: the regulatory particle in focus. Curr Opin Struct Biol (2013) 0.95

Structural biology of the PCI-protein fold. Bioarchitecture (2012) 0.94

Marching to the beat of the ring: polypeptide translocation by AAA+ proteases. Trends Biochem Sci (2013) 0.93

Site-specific proteasome phosphorylation controls cell proliferation and tumorigenesis. Nat Cell Biol (2015) 0.92

Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell (2014) 0.91

Ubiquitin-Like Proteasome System Represents a Eukaryotic-Like Pathway for Targeted Proteolysis in Archaea. MBio (2016) 0.91

Functions of the 19S complex in proteasomal degradation. Trends Biochem Sci (2013) 0.90

Subunit asymmetry and roles of conformational switching in the hexameric AAA+ ring of ClpX. Nat Struct Mol Biol (2015) 0.90

ATP binding to neighbouring subunits and intersubunit allosteric coupling underlie proteasomal ATPase function. Nat Commun (2015) 0.90

Molecular snapshots of the Pex1/6 AAA+ complex in action. Nat Commun (2015) 0.90

Disassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6. J Biol Chem (2014) 0.89

Unfolding the mechanism of the AAA+ unfoldase VAT by a combined cryo-EM, solution NMR study. Proc Natl Acad Sci U S A (2016) 0.89

The intrinsically disordered Sem1 protein functions as a molecular tether during proteasome lid biogenesis. Mol Cell (2014) 0.89

Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity. Biochemistry (2013) 0.89

Structural and functional characterization of Rpn12 identifies residues required for Rpn10 proteasome incorporation. Biochem J (2012) 0.88

Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. J Biol Chem (2012) 0.87

Structural insights into proteasome activation by the 19S regulatory particle. Biochemistry (2013) 0.87

Studying protein complexes by the yeast two-hybrid system. Methods (2012) 0.87

The minimal deneddylase core of the COP9 signalosome excludes the Csn6 MPN- domain. PLoS One (2012) 0.87

The role of allostery in the ubiquitin-proteasome system. Crit Rev Biochem Mol Biol (2012) 0.87

Structural basis for dynamic regulation of the human 26S proteasome. Proc Natl Acad Sci U S A (2016) 0.87

Structure of an endogenous yeast 26S proteasome reveals two major conformational states. Proc Natl Acad Sci U S A (2016) 0.86

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. Elife (2016) 0.86

Disordered proteinaceous machines. Chem Rev (2014) 0.86

SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol (1996) 22.89

EMAN2: an extensible image processing suite for electron microscopy. J Struct Biol (2006) 14.70

Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol (2003) 14.19

A new generation of the IMAGIC image processing system. J Struct Biol (1996) 12.57

Recognition of the polyubiquitin proteolytic signal. EMBO J (2000) 10.12

Automated molecular microscopy: the new Leginon system. J Struct Biol (2005) 10.00

Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83

Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49

A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell (2009) 6.16

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell (1998) 5.78

Visualizing density maps with UCSF Chimera. J Struct Biol (2006) 5.75

Appion: an integrated, database-driven pipeline to facilitate EM image processing. J Struct Biol (2009) 5.71

A gated channel into the proteasome core particle. Nat Struct Biol (2000) 5.42

Bsoft: image processing and molecular modeling for electron microscopy. J Struct Biol (2006) 5.36

Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell (2000) 5.19

Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97

XMIPP: a new generation of an open-source image processing package for electron microscopy. J Struct Biol (2004) 4.95

Mechanism of DNA translocation in a replicative hexameric helicase. Nature (2006) 4.91

Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76

SPARX, a new environment for Cryo-EM image processing. J Struct Biol (2006) 4.66

The regulatory particle of the Saccharomyces cerevisiae proteasome. Mol Cell Biol (1998) 4.63

Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54

An unstructured initiation site is required for efficient proteasome-mediated degradation. Nat Struct Mol Biol (2004) 4.11

Rebuilt AAA + motors reveal operating principles for ATP-fuelled machines. Nature (2005) 4.05

Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system. Cell (2004) 3.84

DoG Picker and TiltPicker: software tools to facilitate particle selection in single particle electron microscopy. J Struct Biol (2009) 3.71

Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell (2008) 3.49

Running in reverse: the structural basis for translocation polarity in hexameric helicases. Cell (2009) 3.38

Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol (2002) 3.34

Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell (2006) 3.21

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11

Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87

Structural insights into the regulatory particle of the proteasome from Methanocaldococcus jannaschii. Mol Cell (2009) 2.75

A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J (2006) 2.69

ACE: automated CTF estimation. Ultramicroscopy (2005) 2.62

Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell (2011) 2.40

Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Mol Cell (2010) 2.35

Asymmetric interactions of ATP with the AAA+ ClpX6 unfoldase: allosteric control of a protein machine. Cell (2005) 2.33

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol (2010) 2.31

ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell (2011) 2.31

Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J Mol Biol (2006) 2.22

Polyubiquitination by HECT E3s and the determinants of chain type specificity. Mol Cell Biol (2009) 2.17

Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2). J Biol Chem (1992) 2.08

Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Proc Natl Acad Sci U S A (2010) 2.05

Differential roles of the COOH termini of AAA subunits of PA700 (19 S regulator) in asymmetric assembly and activation of the 26 S proteasome. J Biol Chem (2008) 1.93

Insights into the molecular architecture of the 26S proteasome. Proc Natl Acad Sci U S A (2009) 1.81

Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae. J Biol Chem (2004) 1.69

Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast. Methods Mol Biol (2005) 1.48

Defining the geometry of the two-component proteasome degron. Nat Chem Biol (2011) 1.45

Structure of the human 26S proteasome: subunit radial displacements open the gate into the proteolytic core. J Biol Chem (2008) 1.43

An asymmetric interface between the regulatory and core particles of the proteasome. Nat Struct Mol Biol (2011) 1.36

Structure of Rpn10 and its interactions with polyubiquitin chains and the proteasome subunit Rpn12. J Biol Chem (2010) 1.31

An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome. Biochem Biophys Res Commun (2009) 1.28

Electron microscopic evidence in support of alpha-solenoid models of proteasomal subunits Rpn1 and Rpn2. J Mol Biol (2009) 1.25

Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. BMC Biol (2011) 1.12

Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (2014) 5.13

The Dam1 kinetochore ring complex moves processively on depolymerizing microtubule ends. Nature (2006) 4.06

Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science (2005) 3.91

Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex. Mol Cell (2005) 3.86

Nucleotide-dependent bending flexibility of tubulin regulates microtubule assembly. Nature (2005) 3.54

Structure, function, and activator-induced conformations of the CRSP coactivator. Science (2002) 3.52

Microtubule structure at 8 A resolution. Structure (2002) 3.41

The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nat Struct Mol Biol (2011) 2.93

The Ndc80 kinetochore complex forms oligomeric arrays along microtubules. Nature (2010) 2.90

Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87

Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner. Nature (2007) 2.64

Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore. Curr Biol (2011) 2.62

Saccharomyces cerevisiae septins: supramolecular organization of heterooligomers and the mechanism of filament assembly. Proc Natl Acad Sci U S A (2008) 2.46

ClpX(P) generates mechanical force to unfold and translocate its protein substrates. Cell (2011) 2.31

In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release. Proc Natl Acad Sci U S A (2011) 2.27

An architectural map of the anaphase-promoting complex. Genes Dev (2006) 2.27

Structural insights into RNA processing by the human RISC-loading complex. Nat Struct Mol Biol (2009) 2.19

Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion. Elife (2012) 2.04

Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev (2002) 2.02

Structural visualization of key steps in human transcription initiation. Nature (2013) 1.91

Conformational switching of the 26S proteasome enables substrate degradation. Nat Struct Mol Biol (2013) 1.90

Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome. Mol Cell (2005) 1.89

Visualizing flexibility at molecular resolution: analysis of heterogeneity in single-particle electron microscopy reconstructions. Annu Rev Biophys Biomol Struct (2007) 1.81

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nat Struct Mol Biol (2006) 1.80

Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol (2007) 1.78

Architecture and flexibility of the yeast Ndc80 kinetochore complex. J Mol Biol (2008) 1.75

The structural basis for regulated assembly and function of the transcriptional activator NtrC. Genes Dev (2006) 1.74

Architecture of the yeast Rrp44 exosome complex suggests routes of RNA recruitment for 3' end processing. Proc Natl Acad Sci U S A (2007) 1.71

ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, sigma54. Structure (2007) 1.69

The orthogonal tilt reconstruction method: an approach to generating single-class volumes with no missing cone for ab initio reconstruction of asymmetric particles. J Struct Biol (2005) 1.69

A revised nomenclature for the human and rodent alpha-tubulin gene family. Genomics (2007) 1.68

Microtubule dynamics. J Cell Sci (2002) 1.65

Molecular architecture of human polycomb repressive complex 2. Elife (2012) 1.64

Phosphatidylinositol-4,5-bisphosphate promotes budding yeast septin filament assembly and organization. J Mol Biol (2010) 1.53

CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proc Natl Acad Sci U S A (2014) 1.53

Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method. Proc Natl Acad Sci U S A (2007) 1.49

Human TFIID binds to core promoter DNA in a reorganized structural state. Cell (2013) 1.47

Cryo-electron microscopy studies of human TFIID: conformational breathing in the integration of gene regulatory cues. Structure (2006) 1.46

Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med (2016) 1.46

Prolyl isomerization as a molecular timer in phage infection. Nat Struct Mol Biol (2005) 1.41

Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation. J Cell Biol (2011) 1.40

Reconstitution of the 26S proteasome reveals functional asymmetries in its AAA+ unfoldase. Nat Struct Mol Biol (2013) 1.40

Molecular architecture and conformational flexibility of human RNA polymerase II. Structure (2006) 1.36

Septin filament formation is essential in budding yeast. Dev Cell (2011) 1.33

Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A (2011) 1.30

Structural changes in TAF4b-TFIID correlate with promoter selectivity. Mol Cell (2008) 1.27

Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl (2012) 1.25

Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biol (2011) 1.22

Structures of three distinct activator-TFIID complexes. Genes Dev (2009) 1.20

Three-dimensional ultrastructure of the septin filament network in Saccharomyces cerevisiae. Mol Biol Cell (2011) 1.20

XKCM1 acts on a single protofilament and requires the C terminus of tubulin. J Mol Biol (2002) 1.19

Automated multi-model reconstruction from single-particle electron microscopy data. J Struct Biol (2010) 1.18

Multimodal microtubule binding by the Ndc80 kinetochore complex. Nat Struct Mol Biol (2012) 1.15

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex. J Mol Biol (2010) 1.15

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure. Mol Biol Cell (2013) 1.14

The development of cryo-EM into a mainstream structural biology technique. Nat Methods (2016) 1.12

Single-molecule denaturation and degradation of proteins by the AAA+ ClpXP protease. Proc Natl Acad Sci U S A (2009) 1.11

Architecture of human translation initiation factor 3. Structure (2013) 1.09

Formation of an intricate helical bundle dictates the assembly of the 26S proteasome lid. Structure (2013) 1.09

Substrate-specific structural rearrangements of human Dicer. Nat Struct Mol Biol (2013) 1.08

Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A (2006) 1.07

Molecular requirements for the formation of a kinetochore-microtubule interface by Dam1 and Ndc80 complexes. J Cell Biol (2012) 1.06

Maximum likelihood refinement of electron microscopy data with normalization errors. J Struct Biol (2009) 1.04

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome. Nucleic Acids Res (2011) 1.04

Multiple domains of human CLASP contribute to microtubule dynamics and organization in vitro and in Xenopus egg extracts. Cytoskeleton (Hoboken) (2012) 1.02

Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analogue, HTI-286, have mutations in alpha- or beta-tubulin and increased microtubule stability. Biochemistry (2004) 1.02

Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res (2013) 1.02

Semisynthesis of a homogeneous glycoprotein enzyme: ribonuclease C: part 2. Angew Chem Int Ed Engl (2009) 1.02

Go hybrid: EM, crystallography, and beyond. Curr Opin Struct Biol (2012) 1.01

Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis. Mol Cell (2009) 1.00

The Dam1 ring binds to the E-hook of tubulin and diffuses along the microtubule. Mol Biol Cell (2010) 0.99

Structural studies of the human PBAF chromatin-remodeling complex. Structure (2005) 0.99

An iterative Fourier-Bessel algorithm for reconstruction of helical structures with severe Bessel overlap. J Struct Biol (2005) 0.98

Design principles of a universal protein degradation machine. J Mol Biol (2012) 0.98

Characterization of cell types during rat liver development. Hepatology (2003) 0.97

Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability. Proc Natl Acad Sci U S A (2012) 0.96

The proteasome under the microscope: the regulatory particle in focus. Curr Opin Struct Biol (2013) 0.95

Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription. Prog Biophys Mol Biol (2010) 0.95

Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping. J Struct Biol (2008) 0.95

Ab initio reconstruction of helical samples with heterogeneity, disorder and coexisting symmetries. J Struct Biol (2009) 0.94

Red blood with blue-blood ancestry: intriguing structure of a snail hemoglobin. Proc Natl Acad Sci U S A (2006) 0.94

Structural insights into transcriptional repression by noncoding RNAs that bind to human Pol II. J Mol Biol (2012) 0.93

Subunit organization in the Dam1 kinetochore complex and its ring around microtubules. Mol Biol Cell (2011) 0.92

Simulations of tubulin sheet polymers as possible structural intermediates in microtubule assembly. PLoS One (2009) 0.90

Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IV. DNA Repair (Amst) (2011) 0.90

Cross-correlation of common lines: a novel approach for single-particle reconstruction of a structure containing a flexible domain. J Struct Biol (2007) 0.89

Stabilization of the cold shock protein CspB from Bacillus subtilis by evolutionary optimization of Coulombic interactions. J Mol Biol (2005) 0.89

Assembly of GMPCPP-bound tubulin into helical ribbons and tubes and effect of colchicine. Cell Cycle (2005) 0.89

Octomeric pyruvate-ferredoxin oxidoreductase from Desulfovibrio vulgaris. J Struct Biol (2007) 0.88

Comparative studies of microtubule mechanics with two competing models suggest functional roles of alternative tubulin lateral interactions. Biophys J (2012) 0.86

Evolutionary protein stabilization in comparison with computational design. J Mol Biol (2005) 0.85

Water contributes actively to the rapid crossing of a protein unfolding barrier. J Mol Biol (2002) 0.85

Semisynthesis of a homogeneous glycoprotein enzyme: ribonuclease C: part 1. Angew Chem Int Ed Engl (2009) 0.84

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. Elife (2013) 0.83

Septin filament organization in Saccharomyces cerevisiae. Commun Integr Biol (2012) 0.83

Visualizing kinetochore architecture. Curr Opin Struct Biol (2011) 0.83

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5. Nat Struct Mol Biol (2013) 0.82

Ranking TEM cameras by their response to electron shot noise. Ultramicroscopy (2013) 0.81