High levels of Hsp90 cochaperone p23 promote tumor progression and poor prognosis in breast cancer by increasing lymph node metastases and drug resistance.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3007122)

Published in Cancer Res on September 16, 2010

Authors

Natalie E Simpson1, W Marcus Lambert, Renecia Watkins, Shah Giashuddin, S Joseph Huang, Ellinor Oxelmark, Rezina Arju, Tsivia Hochman, Judith D Goldberg, Robert J Schneider, Luiz Fernando Lima Reiz, Fernando Augusto Soares, Susan K Logan, Michael J Garabedian

Author Affiliations

1: Department of Pharmacology, and NYU Cancer Institute, NYU School of Medicine, New York, New York 10016, USA.

Articles citing this

The mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives. Blood (2012) 1.15

Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol Cell (2011) 1.09

Gedunin inactivates the co-chaperone p23 protein causing cancer cell death by apoptosis. J Biol Chem (2013) 1.07

The estrogen-regulated anterior gradient 2 (AGR2) protein in breast cancer: a potential drug target and biomarker. Breast Cancer Res (2013) 1.02

Molecular cochaperones: tumor growth and cancer treatment. Scientifica (Cairo) (2013) 0.92

Research resource: enhanced genome-wide occupancy of estrogen receptor α by the cochaperone p23 in breast cancer cells. Mol Endocrinol (2011) 0.86

Role of the HSP90-associated cochaperone p23 in enhancing activity of the androgen receptor and significance for prostate cancer. Mol Endocrinol (2012) 0.85

TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. Oncotarget (2014) 0.82

Ailanthone targets p23 to overcome MDV3100 resistance in castration-resistant prostate cancer. Nat Commun (2016) 0.82

Mechanisms of Resistance to Hsp90 Inhibitor Drugs: A Complex Mosaic Emerges. Pharmaceuticals (Basel) (2011) 0.81

A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies. Br J Cancer (2015) 0.80

The co-chaperone p23 promotes prostate cancer motility and metastasis. Mol Oncol (2014) 0.77

AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway. Mol Oncol (2015) 0.76

Integrated analysis of DNA methylation, immunohistochemistry and mRNA expression, data identifies a methylation expression index (MEI) robustly associated with survival of ER-positive breast cancer patients. Breast Cancer Res Treat (2015) 0.75

FEN1 promotes tumor progression and confers cisplatin resistance in non-small cell lung cancer. Mol Oncol (2017) 0.75

Elevated levels of ribosomal proteins eL36 and eL42 control expression of Hsp90 in rhabdomyosarcoma. Translation (Austin) (2016) 0.75

TM4SF1 promotes the self-renewal of esophageal cancer stem-like cells and is regulated by miR-141. Oncotarget (2016) 0.75

Apigenin inhibits growth and induces apoptosis in human cholangiocarcinoma cells. Oncol Lett (2017) 0.75

Articles cited by this

Genes that mediate breast cancer metastasis to lung. Nature (2005) 19.85

Genome-wide analysis of estrogen receptor binding sites. Nat Genet (2006) 18.63

Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47

Estrogen receptor-alpha directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell (2003) 10.42

XBP1 controls diverse cell type- and condition-specific transcriptional regulatory networks. Mol Cell (2007) 4.93

Disassembly of transcriptional regulatory complexes by molecular chaperones. Science (2002) 4.20

Global gene expression profiling of circulating tumor cells. Cancer Res (2005) 3.41

Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell (2006) 3.22

Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev (1999) 3.19

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin. Mol Cell (1999) 3.15

Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes. Mol Cell Biol (2004) 2.71

Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res (1997) 2.67

Chaperone function of Hsp90-associated proteins. Science (1996) 2.66

Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis. J Biol Chem (2000) 2.47

A novel chaperone complex for steroid receptors involving heat shock proteins, immunophilins, and p23. J Biol Chem (1994) 2.17

Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomas. Cancer Res (2005) 1.94

The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity. Methods (2007) 1.92

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor beta growth inhibition in p16INK4A(-) human mammary epithelial cells. Proc Natl Acad Sci U S A (2001) 1.83

Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes. Mol Cell Biol (1994) 1.83

The co-chaperone p23 arrests the Hsp90 ATPase cycle to trap client proteins. J Mol Biol (2005) 1.74

Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression. Breast Cancer Res (2004) 1.71

Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J Biol Chem (2001) 1.56

The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies. Genes Dev (2000) 1.54

MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci U S A (2009) 1.53

The Hsp90 chaperone complex is both a facilitator and a repressor of the dsRNA-dependent kinase PKR. EMBO J (2001) 1.50

Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins. Mol Cell Biol (1998) 1.48

Model for breast cancer survival: relative prognostic roles of axillary nodal status, TNM stage, estrogen receptor concentration, and tumor necrosis. Cancer Res (1988) 1.34

Roles of AKT signal in breast cancer. Front Biosci (2007) 1.33

FLT3 expressing leukemias are selectively sensitive to inhibitors of the molecular chaperone heat shock protein 90 through destabilization of signal transduction-associated kinases. Clin Cancer Res (2003) 1.29

The Hsp90 cochaperone p23 is essential for perinatal survival. Mol Cell Biol (2006) 1.28

SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci (2003) 1.27

Molecular genetics of autosomal-dominant demyelinating Charcot-Marie-Tooth disease. Neuromolecular Med (2006) 1.24

Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma. Int J Cancer (2001) 1.23

Role for Hsp90-associated cochaperone p23 in estrogen receptor signal transduction. Mol Cell Biol (1999) 1.22

p23/Sba1p protects against Hsp90 inhibitors independently of its intrinsic chaperone activity. Mol Cell Biol (2008) 1.20

Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer. Clin Cancer Res (2006) 1.16

cPGES/p23 is required for glucocorticoid receptor function and embryonic growth but not prostaglandin E2 synthesis. Mol Cell Biol (2007) 1.14

A role for Hsp90 in retinoid receptor signal transduction. Mol Biol Cell (1995) 1.13

Repression of ESR1 through actions of estrogen receptor alpha and Sin3A at the proximal promoter. Mol Cell Biol (2009) 1.09

Expression profiling of ABC transporters in a drug-resistant breast cancer cell line using AmpArray. Mol Pharmacol (2005) 1.05

The p23 molecular chaperone promotes functional telomerase complexes through DNA dissociation. Proc Natl Acad Sci U S A (2007) 1.04

The cochaperone p23 differentially regulates estrogen receptor target genes and promotes tumor cell adhesion and invasion. Mol Cell Biol (2006) 1.02

Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. J Biol Chem (2009) 1.01

Physiological and pharmacological functions of Mrp2, Mrp3 and Mrp4 as determined from recent studies on gene-disrupted mice. Cancer Metastasis Rev (2007) 1.01

Genetic dissection of p23, an Hsp90 cochaperone, reveals a distinct surface involved in estrogen receptor signaling. J Biol Chem (2003) 0.98

The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel. Mol Cancer Ther (2009) 0.95

ALG-2: a Ca2+ -binding modulator protein involved in cell proliferation and in cell death. Biochim Biophys Acta (2002) 0.93

Distinct elements of the peripheral myelin protein 22 (PMP22) promoter regulate expression in Schwann cells and sensory neurons. Mol Cell Neurosci (2003) 0.89

Properties of the co-chaperone protein p23 erroneously attributed to ALG-2 (apoptosis-linked gene 2). FEBS Lett (2003) 0.86

Expression of Com-1/P8 in human breast cancer and its relevance to clinical outcome and ER status. Int J Cancer (2005) 0.83

Articles by these authors

Translational control in cancer. Nat Rev Cancer (2010) 4.59

Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res (2009) 3.30

The enigmatic X gene of hepatitis B virus. J Virol (2004) 2.98

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proc Natl Acad Sci U S A (2003) 2.63

Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol (2008) 2.61

Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison. Int J Radiat Oncol Biol Phys (2007) 2.55

A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell (2007) 2.44

Prone vs supine positioning for breast cancer radiotherapy. JAMA (2012) 2.32

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy. J Cell Biol (2008) 2.26

Essential role for eIF4GI overexpression in the pathogenesis of inflammatory breast cancer. Nat Cell Biol (2009) 1.99

Survival in familial dysautonomia: Impact of early intervention. J Pediatr (2002) 1.98

Modulation of glucocorticoid receptor function via phosphorylation. Ann N Y Acad Sci (2004) 1.97

Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem (2002) 1.95

Transforming growth factor-beta and microRNA:mRNA regulatory networks in epithelial plasticity. Cells Tissues Organs (2007) 1.95

mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. Mol Cell (2012) 1.86

Cost and utilization outcomes of patients receiving hospital-based palliative care consultation. J Palliat Med (2006) 1.85

Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol (2008) 1.81

The generation and utilization of a cancer-oriented representation of the human transcriptome by using expressed sequence tags. Proc Natl Acad Sci U S A (2003) 1.79

Selective degradation of AU-rich mRNAs promoted by the p37 AUF1 protein isoform. Mol Cell Biol (2003) 1.79

Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70. Am J Pathol (2007) 1.77

MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol Endocrinol (2005) 1.76

Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Mol Cell Biol (2006) 1.76

Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes Dev (2006) 1.74

Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects. J Neurosurg Anesthesiol (2004) 1.73

Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress. Mol Endocrinol (2007) 1.68

Endothelin receptor type B gene promoter hypermethylation in salivary rinses is independently associated with risk of oral cavity cancer and premalignancy. Cancer Prev Res (Phila) (2010) 1.68

Tissue distribution of AU-rich mRNA-binding proteins involved in regulation of mRNA decay. J Biol Chem (2004) 1.63

Nutritional control of mRNA stability is mediated by a conserved AU-rich element that binds the cytoplasmic shuttling protein HuR. J Biol Chem (2002) 1.61

Ethical, legal, and social issues related to genomics and cancer research: the impending crisis. J Am Coll Radiol (2005) 1.60

Tumor necrosis factor alpha inhibition of hepatitis B virus replication involves disruption of capsid Integrity through activation of NF-kappaB. J Virol (2003) 1.55

Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect. Proc Natl Acad Sci U S A (2008) 1.54

Nuclear import and export functions in the different isoforms of the AUF1/heterogeneous nuclear ribonucleoprotein protein family. J Biol Chem (2003) 1.54

Fludrocortisone in patients with familial dysautonomia--assessing effect on clinical parameters and gene expression. Clin Auton Res (2005) 1.52

Regulation of protein synthesis by ionizing radiation. Mol Cell Biol (2009) 1.52

Mifepristone inhibits GRβ coupled prostate cancer cell proliferation. J Urol (2012) 1.51

Prone accelerated partial breast irradiation after breast-conserving surgery: preliminary clinical results and dose-volume histogram analysis. Int J Radiat Oncol Biol Phys (2004) 1.51

Hepatitis B virus DNA replication is coordinated by core protein serine phosphorylation and HBx expression. J Virol (2005) 1.47

Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs. Proc Natl Acad Sci U S A (2002) 1.46

Topical TLR7 agonist imiquimod can induce immune-mediated rejection of skin metastases in patients with breast cancer. Clin Cancer Res (2012) 1.46

Gene expression profile associated with response to doxorubicin-based therapy in breast cancer. Clin Cancer Res (2005) 1.46

Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Clin Cancer Res (2010) 1.43

Detection of micrometastases in pN0 non-small cell lung cancer: an alternative method combining tissue microarray and immunohistochemistry. J Bras Pneumol (2008) 1.41

Cell-specific regulation of androgen receptor phosphorylation in vivo. J Biol Chem (2005) 1.38

Modulation of glucocorticoid receptor phosphorylation and transcriptional activity by a C-terminal-associated protein phosphatase. Mol Endocrinol (2006) 1.37

LEF1 in androgen-independent prostate cancer: regulation of androgen receptor expression, prostate cancer growth, and invasion. Cancer Res (2009) 1.34

Astrocyte elevated gene-1 promotes hepatocarcinogenesis: novel insights from a mouse model. Hepatology (2012) 1.32

Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting. Genes Dev (2004) 1.30

Histologic features are important prognostic indicators in early stages lung adenocarcinomas. Mod Pathol (2006) 1.29

Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells. Biol Reprod (2008) 1.28

Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. J Virol (2003) 1.28

Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA. J Virol (2007) 1.27

GLUT1 and GLUT3 as potential prognostic markers for Oral Squamous Cell Carcinoma. Molecules (2010) 1.27

Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J Steroid Biochem Mol Biol (2008) 1.26

Statins promote the regression of atherosclerosis via activation of the CCR7-dependent emigration pathway in macrophages. PLoS One (2011) 1.25

Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase. J Biol Chem (2004) 1.24

Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2008) 1.23

ART-27, an androgen receptor coactivator regulated in prostate development and cancer. J Biol Chem (2004) 1.23

Computed tomography guided needle biopsy: experience from 1,300 procedures. Sao Paulo Med J (2006) 1.23

Phase I-II trial of prone accelerated intensity modulated radiation therapy to the breast to optimally spare normal tissue. J Clin Oncol (2007) 1.23

Assembly of AUF1 with eIF4G-poly(A) binding protein complex suggests a translation function in AU-rich mRNA decay. RNA (2006) 1.22

Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory T(H)2 cells via an IL-12- and OX40L-dependent pathway. Cancer Cell (2011) 1.22

Outcomes of the RESTOR-MV Trial (Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve). J Am Coll Cardiol (2010) 1.20

Reciprocal changes in gene expression profiles of cocultured breast epithelial cells and primary fibroblasts. Int J Cancer (2009) 1.19

Developing a multidisciplinary prospective melanoma biospecimen repository to advance translational research. Am J Transl Res (2009) 1.17

Metformin targets c-MYC oncogene to prevent prostate cancer. Carcinogenesis (2013) 1.17

Androgen receptor levels are upregulated by Akt in prostate cancer. Endocr Relat Cancer (2011) 1.16

Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol (2008) 1.14

Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol (2005) 1.13

BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A (2012) 1.13

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival. Breast Cancer Res Treat (2010) 1.12

Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol (2009) 1.12

CT scan screening for lung cancer: risk factors for nodules and malignancy in a high-risk urban cohort. PLoS One (2012) 1.12

Concomitant expression of epithelial-mesenchymal transition biomarkers in breast ductal carcinoma: association with progression. Oncol Rep (2010) 1.11

Identification and characterization of ART-27, a novel coactivator for the androgen receptor N terminus. Mol Biol Cell (2002) 1.11

Auf1/Hnrnpd-deficient mice develop pruritic inflammatory skin disease. J Invest Dermatol (2008) 1.10

Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas. Neuro Oncol (2012) 1.10

Prospective assessment of optimal individual position (prone versus supine) for breast radiotherapy: volumetric and dosimetric correlations in 100 patients. Int J Radiat Oncol Biol Phys (2012) 1.10

Mitotic raptor promotes mTORC1 activity, G(2)/M cell cycle progression, and internal ribosome entry site-mediated mRNA translation. Mol Cell Biol (2010) 1.09

Regression of atherosclerosis is characterized by broad changes in the plaque macrophage transcriptome. PLoS One (2012) 1.09

Intra- and interfractional patient motion for a variety of immobilization devices. Med Phys (2005) 1.09

Global functional map of the p23 molecular chaperone reveals an extensive cellular network. Mol Cell (2011) 1.09

Decrease in stromal androgen receptor associates with androgen-independent disease and promotes prostate cancer cell proliferation and invasion. J Cell Mol Med (2008) 1.09

Association of income and prescription drug coverage with generic medication use among older adults with hypertension. Am J Manag Care (2006) 1.08

Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress. Cancer Res (2009) 1.07

HPV vaccine acceptability by Latino parents: a comparison of U.S. and Salvadoran populations. J Pediatr Adolesc Gynecol (2009) 1.06