Published in Nucleic Acids Res on September 07, 2007
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66
The Mediator complex and transcription regulation. Crit Rev Biochem Mol Biol (2013) 1.64
Complexity in transcription control at the activation domain-mediator interface. Sci Signal (2009) 1.29
Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12
MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol Cell Biol (2010) 1.06
Conditional ablation of mediator subunit MED1 (MED1/PPARBP) gene in mouse liver attenuates glucocorticoid receptor agonist dexamethasone-induced hepatic steatosis. Gene Expr (2009) 0.91
Regulation of triglyceride metabolism by glucocorticoid receptor. Cell Biosci (2012) 0.91
Deciphering the regulatory logic of an ancient, ultraconserved nuclear receptor enhancer module. Mol Endocrinol (2015) 0.85
HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter. J Biomed Biotechnol (2010) 0.79
Transcriptional regulation of FoxO3 gene by glucocorticoids in murine myotubes. Am J Physiol Endocrinol Metab (2016) 0.75
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev (2000) 11.65
Molecular mechanisms of action of steroid/thyroid receptor superfamily members. Annu Rev Biochem (1994) 10.75
Steroid receptor regulated transcription of specific genes and gene networks. Annu Rev Genet (1985) 10.62
Nuclear receptor coregulators: cellular and molecular biology. Endocr Rev (1999) 7.42
Structure and specificity of nuclear receptor-coactivator interactions. Genes Dev (1998) 5.28
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci U S A (1996) 3.61
Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell (1999) 3.47
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature (1999) 3.32
GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. Mol Cell Biol (1997) 3.26
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71
A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system. Genes Dev (1998) 2.63
Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell (2000) 2.39
Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J (1999) 2.24
Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem (1997) 2.10
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
Mechanisms of glucocorticoid signalling. Biochim Biophys Acta (2004) 1.78
MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol Endocrinol (2005) 1.76
Progesterone and glucocorticoid receptors recruit distinct coactivator complexes and promote distinct patterns of local chromatin modification. Mol Cell Biol (2003) 1.73
The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A (2002) 1.72
The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. Mol Cell (2000) 1.65
Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem (2004) 1.40
The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. Mol Cell Biol (2000) 1.38
Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol (2004) 1.31
Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors. Mol Cell Biol (2000) 1.23
Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol Cell Biol (2005) 1.13
Phosphorylation of transcriptional coactivator peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP). Stimulation of transcriptional regulation by mitogen-activated protein kinase. J Biol Chem (2002) 1.12
Role of mediator in transcriptional activation by the aryl hydrocarbon receptor. J Biol Chem (2004) 1.03
Selective recruitment of p160 coactivators on glucocorticoid-regulated promoters in Schwann cells. Mol Endocrinol (2004) 0.96
New insights into glucocorticoid and mineralocorticoid signaling: lessons from gene targeting. Adv Pharmacol (2000) 0.95
Differential activity of progesterone and glucocorticoid receptors on mouse mammary tumor virus templates differing in chromatin structure. J Biol Chem (1997) 0.88
DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. J Biol Chem (2004) 0.88
A ligand binding domain mutation in the mouse glucocorticoid receptor functionally links chromatin remodeling and transcription initiation. Mol Cell Biol (1999) 0.86
Nuclear structure-associated TIF2 recruits glucocorticoid receptor and its target DNA. Biochem Biophys Res Commun (2004) 0.86
Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. J Biol Chem (2004) 0.83
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46
Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40
Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53. Cell (2004) 5.30
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet (2010) 4.46
Dynamic regulation of pol II transcription by the mammalian Mediator complex. Trends Biochem Sci (2005) 4.37
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med (2008) 4.25
S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell (2003) 4.03
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell (2002) 3.99
RAD6-Mediated transcription-coupled H2B ubiquitylation directly stimulates H3K4 methylation in human cells. Cell (2009) 3.82
Regulation of the p300 HAT domain via a novel activation loop. Nat Struct Mol Biol (2004) 3.70
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature (2008) 3.55
Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature (2002) 3.42
Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci U S A (2005) 3.37
Retracted GlcNAcylation of a histone methyltransferase in retinoic-acid-induced granulopoiesis. Nature (2009) 3.10
Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo. Proc Natl Acad Sci U S A (2004) 3.06
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Mol Cell (2003) 2.97
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94
MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87
The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions. Mol Cell (2005) 2.79
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins. Mol Cell Biol (2003) 2.70
30 nm chromatin fibre decompaction requires both H4-K16 acetylation and linker histone eviction. J Mol Biol (2008) 2.62
Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell (2003) 2.31
Role for Dpy-30 in ES cell-fate specification by regulation of H3K4 methylation within bivalent domains. Cell (2011) 2.30
p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol (2002) 2.29
A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell (2004) 2.27
Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell (2010) 2.25
The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS. Cell (2010) 2.20
Suppression of the antiviral response by an influenza histone mimic. Nature (2012) 2.18
Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A (2006) 2.16
GlcNAcylation of histone H2B facilitates its monoubiquitination. Nature (2011) 2.14
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev (2013) 2.07
A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4. Proc Natl Acad Sci U S A (2009) 2.06
H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation. Cell (2013) 2.00
Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.97
E protein silencing by the leukemogenic AML1-ETO fusion protein. Science (2004) 1.89
Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. J Biol Chem (2002) 1.87
Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s. Mol Cell Biol (2002) 1.86
MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80
Mechanism of polymerase II transcription repression by the histone variant macroH2A. Mol Cell Biol (2006) 1.75
The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci U S A (2002) 1.72
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors. Mol Cell (2012) 1.71
CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes. Mol Cell (2008) 1.66
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexes. Proc Natl Acad Sci U S A (2011) 1.65
A Mediator-responsive form of metazoan RNA polymerase II. Proc Natl Acad Sci U S A (2006) 1.58
Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates. Cell (2006) 1.54
PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol Cell Biol (2008) 1.53
Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol (2003) 1.53
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol (2007) 1.50
The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (2011) 1.49
Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J Biol Chem (2006) 1.46
Selective requirements for histone H3 and H4 N termini in p300-dependent transcriptional activation from chromatin. Mol Cell (2002) 1.44
Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast. J Biol Chem (2009) 1.44
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A (2002) 1.43
Heterogeneous expression and functions of androgen receptor co-factors in primary prostate cancer. Am J Pathol (2002) 1.41
SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. J Biol Chem (2001) 1.40
Purification and identification of a novel complex which is involved in androgen receptor-dependent transcription. Mol Cell Biol (2003) 1.38
The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development. EMBO J (2002) 1.38
SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res (2002) 1.38
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53. Cell (2013) 1.38
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. Cancer Discov (2012) 1.33
MCEF, the newest member of the AF4 family of transcription factors involved in leukemia, is a positive transcription elongation factor-b-associated protein. J Biomed Sci (2002) 1.33
GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Mol Cell Biol (2006) 1.32
TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol (2002) 1.31
Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol (2004) 1.31
The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci U S A (2006) 1.30
Thyroid hormone-induced juxtaposition of regulatory elements/factors and chromatin remodeling of Crabp1 dependent on MED1/TRAP220. Mol Cell (2005) 1.30
Isolation and functional characterization of the TRAP/mediator complex. Methods Enzymol (2003) 1.28
Reconstitution and transcriptional analysis of chromatin in vitro. Methods Enzymol (2004) 1.25
A subunit of the mediator complex regulates vertebrate neuronal development. Proc Natl Acad Sci U S A (2006) 1.25
Characterization of the human beta-globin downstream promoter region. Nucleic Acids Res (2003) 1.24
Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer. Proc Natl Acad Sci U S A (2008) 1.23
SWI/SNF remodeling and p300-dependent transcription of histone variant H2ABbd nucleosomal arrays. EMBO J (2004) 1.23
RNF20 inhibits TFIIS-facilitated transcriptional elongation to suppress pro-oncogenic gene expression. Mol Cell (2011) 1.23
RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction. Cell Rep (2013) 1.22
TIP30 deficiency increases susceptibility to tumorigenesis. Cancer Res (2003) 1.20
The n-SET domain of Set1 regulates H2B ubiquitylation-dependent H3K4 methylation. Mol Cell (2013) 1.19
Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II. Mol Cell (2012) 1.18
Cell growth- and differentiation-dependent regulation of RNA polymerase III transcription. Cell Cycle (2010) 1.18
Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A (2011) 1.17
Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A (2013) 1.17
The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Mol Cell (2003) 1.15
Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci U S A (2010) 1.14
A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism. Proc Natl Acad Sci U S A (2010) 1.14
The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. Mol Cell Biol (2008) 1.13
Mediator-dependent nuclear receptor function. Semin Cell Dev Biol (2011) 1.12
Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. Mol Cell Biol (2008) 1.12
TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. J Biol Chem (2004) 1.11
Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator. Mol Cell Biol (2005) 1.10
Distinct transcriptional activation functions of STAT1alpha and STAT1beta on DNA and chromatin templates. J Biol Chem (2003) 1.10
Dynamic interactions and cooperative functions of PGC-1alpha and MED1 in TRalpha-mediated activation of the brown-fat-specific UCP-1 gene. Mol Cell (2009) 1.07
MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol Cell Biol (2010) 1.06
Nontranscriptional regulation of SYK by the coactivator OCA-B is required at multiple stages of B cell development. Cell (2006) 1.05
Direct association of p300 with unmodified H3 and H4 N termini modulates p300-dependent acetylation and transcription of nucleosomal templates. J Biol Chem (2002) 1.05
The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain. Proc Natl Acad Sci U S A (2006) 1.04
Direct interactions of OCA-B and TFII-I regulate immunoglobulin heavy-chain gene transcription by facilitating enhancer-promoter communication. Mol Cell (2011) 1.04