Published in Am J Respir Crit Care Med on October 20, 2005
Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care (2007) 3.80
Diagnosis of bacteremia in whole-blood samples by use of a commercial universal 16S rRNA gene-based PCR and sequence analysis. J Clin Microbiol (2009) 2.19
G9a and HP1 couple histone and DNA methylation to TNFalpha transcription silencing during endotoxin tolerance. J Biol Chem (2008) 1.96
Ghrelin attenuates sepsis-induced acute lung injury and mortality in rats. Am J Respir Crit Care Med (2007) 1.37
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
Gene silencing in severe systemic inflammation. Am J Respir Crit Care Med (2007) 1.27
Mesenchymal stromal cells improve survival during sepsis in the absence of heme oxygenase-1: the importance of neutrophils. Stem Cells (2013) 1.08
Long-term outcome and quality of life of patients treated in surgical intensive care: a comparison between sepsis and trauma. Crit Care (2006) 1.04
Comparison of pathogen DNA isolation methods from large volumes of whole blood to improve molecular diagnosis of bloodstream infections. PLoS One (2013) 1.04
Chitohexaose activates macrophages by alternate pathway through TLR4 and blocks endotoxemia. PLoS Pathog (2012) 1.00
Identification of human pathogens isolated from blood using microarray hybridisation and signal pattern recognition. BMC Microbiol (2007) 0.96
Sepsis: from bench to bedside. Clinics (Sao Paulo) (2008) 0.91
Proinflammatory mediators of toxic shock and their correlation to lethality. Mediators Inflamm (2010) 0.90
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. Mol Med (2013) 0.90
LPS pretreatment ameliorates multiple organ injuries and improves survival in a murine model of polymicrobial sepsis. Inflamm Res (2011) 0.87
Sepsis: from pattern to mechanism and back. Crit Rev Biomed Eng (2012) 0.87
Canine uterine bacterial infection induces upregulation of proteolysis-related genes and downregulation of homeobox and zinc finger factors. PLoS One (2009) 0.86
Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses. J Theor Biol (2014) 0.83
The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation. Crit Care (2015) 0.82
Evaluation of a PCR assay to detect enterococcusfaecalis in blood and determine glycopeptides resistance genes: van a and van B. Iran J Med Sci (2012) 0.82
Transcriptomic analysis of peritoneal cells in a mouse model of sepsis: confirmatory and novel results in early and late sepsis. BMC Genomics (2012) 0.77
Sepsis: a review for the neurohospitalist. Neurohospitalist (2012) 0.76
The effects of lazaroid U-74389G in a rat sepsis model. Inflamm Res (2010) 0.75
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
Transfusion-related acute lung injury: definition and review. Crit Care Med (2005) 3.98
Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol (2005) 3.38
Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol (2004) 2.89
HMGB1 develops enhanced proinflammatory activity by binding to cytokines. J Immunol (2008) 2.80
miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc Natl Acad Sci U S A (2009) 2.74
Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol (2003) 2.50
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46
HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol (2005) 2.21
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 2.15
Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med (2006) 2.05
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood (2004) 1.95
Sepsis. Am J Med (2007) 1.93
Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82
Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial. Crit Care Med (2004) 1.80
Effectiveness of medical resident education in mechanical ventilation. Am J Respir Crit Care Med (2002) 1.79
Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77
Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med (2009) 1.77
LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis. Crit Care Med (2005) 1.77
HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am J Physiol Cell Physiol (2010) 1.75
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med (2008) 1.73
Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol (2011) 1.70
HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock (2009) 1.64
Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med (2006) 1.63
Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury. Am J Respir Crit Care Med (2008) 1.62
Participation of the urokinase receptor in neutrophil efferocytosis. Blood (2009) 1.62
Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med (2008) 1.62
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med (2008) 1.61
A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. Chest (2005) 1.57
Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. Crit Care Med (2003) 1.53
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52
Reducing mortality in sepsis: new directions. Crit Care (2002) 1.52
The decline and fate of an iron-induced subarctic phytoplankton bloom. Nature (2004) 1.50
Genetic polymorphisms and sepsis. Shock (2005) 1.50
The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49
MicroRNAs in immune response and macrophage polarization. Arterioscler Thromb Vasc Biol (2013) 1.48
Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol (2004) 1.48
ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation. Crit Care Med (2007) 1.46
High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol (2008) 1.45
Participation of miR-200 in pulmonary fibrosis. Am J Pathol (2011) 1.43
Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury. Am J Respir Crit Care Med (2006) 1.42
Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity. FASEB J (2008) 1.39
Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med (2005) 1.33
Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg (2006) 1.30
miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol (2012) 1.29
PAI-1 inhibits neutrophil efferocytosis. Proc Natl Acad Sci U S A (2008) 1.27
Early alterations in neutrophil activation are associated with outcome in acute lung injury. Am J Respir Crit Care Med (2003) 1.27
p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury. J Immunol (2009) 1.27
Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J Immunol (2007) 1.26
MicroRNA let-7c regulates macrophage polarization. J Immunol (2013) 1.23
Intensive insulin therapy in critical illness. Am J Respir Crit Care Med (2005) 1.23
Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J Immunol (2004) 1.21
Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol (2008) 1.18
AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J (2011) 1.17
HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol (2013) 1.17
Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol (2009) 1.16
miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J (2013) 1.15
Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils. Am J Physiol Cell Physiol (2007) 1.14
Participation of superoxide in neutrophil activation and cytokine production. Biochim Biophys Acta (2006) 1.12
Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit. Pharmacotherapy (2002) 1.11
Functional and genomic changes induced by alveolar transmigration in human neutrophils. Am J Physiol Lung Cell Mol Physiol (2006) 1.09
Bone transport in the management of posttraumatic bone defects in the lower extremity. J Trauma (2004) 1.09
Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med (2010) 1.07
Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2003) 1.07
Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients. Antimicrob Agents Chemother (2005) 1.07
IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res (2002) 1.05
Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB. Cell Signal (2005) 1.05
HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury. Intensive Care Med (2007) 1.04
Participation of the receptor for advanced glycation end products in efferocytosis. J Immunol (2011) 1.03
S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem (2009) 1.02
miR-125a-5p regulates differential activation of macrophages and inflammation. J Biol Chem (2013) 1.02
Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med (2012) 1.01
Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.01
Retracted miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. FASEB J (2012) 0.99
Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. J Biol Chem (2009) 0.99
Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol (2005) 0.99
The kringle domain of urokinase-type plasminogen activator potentiates LPS-induced neutrophil activation through interaction with {alpha}V{beta}3 integrins. J Leukoc Biol (2005) 0.97
The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis. J Leukoc Biol (2010) 0.97
The human long noncoding RNA lnc-IL7R regulates the inflammatory response. Eur J Immunol (2014) 0.97
Pulmonary edema fluid antioxidants are depressed in acute lung injury. Crit Care Med (2003) 0.97
Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Am J Physiol Cell Physiol (2003) 0.96
Intracellular HMGB1 negatively regulates efferocytosis. J Immunol (2011) 0.94
Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway. Thromb Haemost (2006) 0.93
Induction of tissue factor by urokinase in lung epithelial cells and in the lungs. Am J Respir Crit Care Med (2010) 0.93
When is a negative phase II trial truly negative? Am J Respir Crit Care Med (2008) 0.92
Extracellular histones inhibit efferocytosis. Mol Med (2012) 0.92
Involvement of the urokinase kringle domain in lipopolysaccharide-induced acute lung injury. J Immunol (2006) 0.92
Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity. J Immunol (2007) 0.92
Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cell Signal (2003) 0.92
Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol (2014) 0.89
Immunomodulation and sepsis: impact of the pathogen. Shock (2004) 0.89
Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. J Biol Chem (2009) 0.88
Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils. Am J Respir Crit Care Med (2010) 0.88
Effects of catecholamines on kinase activation in lung neutrophils after hemorrhage or endotoxemia. J Leukoc Biol (2002) 0.88