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MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One (2009) 1.55

Macrophage pro-inflammatory response to Francisella novicida infection is regulated by SHIP. PLoS Pathog (2006) 1.38

Kinase AKT controls innate immune cell development and function. Immunology (2013) 0.92

Discovery and development of small molecule SHIP phosphatase modulators. Med Res Rev (2013) 0.91

Inositol phospholipid signaling and the biology of natural killer cells. J Innate Immun (2011) 0.89

Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner. J Immunol (2009) 0.84

A role for SHIP in stem cell biology and transplantation. Curr Stem Cell Res Ther (2008) 0.83

PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol (2011) 0.82

Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol (2015) 0.80

IMPDHII protein inhibits Toll-like receptor 2-mediated activation of NF-kappaB. J Biol Chem (2011) 0.78

Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 2. Efficacy studies in allergic and pulmonary inflammation models in vivo. Br J Pharmacol (2013) 0.78

The Role of M2000 as an Anti-inflammatory Agent in Toll-Like Receptor 2/microRNA-155 Pathway. Avicenna J Med Biotechnol (2017) 0.75

Altered expression of SHIP, a Toll-like receptor pathway inhibitor, is associated with the severity of liver fibrosis in chronic hepatitis C virus infection. J Infect Dis (2011) 0.75

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68

2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39

Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34

The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23

High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04

miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71

Transfusion-related acute lung injury: definition and review. Crit Care Med (2005) 3.98

Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol (2005) 3.38

Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol (2004) 2.89

HMGB1 develops enhanced proinflammatory activity by binding to cytokines. J Immunol (2008) 2.80

miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc Natl Acad Sci U S A (2009) 2.74

Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol (2003) 2.50

IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46

HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol (2005) 2.21

Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17

Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 2.15

Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med (2006) 2.05

Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood (2004) 1.95

The senescence-induced staygreen protein regulates chlorophyll degradation. Plant Cell (2007) 1.93

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Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82

Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial. Crit Care Med (2004) 1.80

Effectiveness of medical resident education in mechanical ventilation. Am J Respir Crit Care Med (2002) 1.79

Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77

Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med (2009) 1.77

LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis. Crit Care Med (2005) 1.77

HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am J Physiol Cell Physiol (2010) 1.75

Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med (2008) 1.73

Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol (2011) 1.70

HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock (2009) 1.64

Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med (2006) 1.63

Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury. Am J Respir Crit Care Med (2008) 1.62

Participation of the urokinase receptor in neutrophil efferocytosis. Blood (2009) 1.62

Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med (2008) 1.62

Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med (2008) 1.61

A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. Chest (2005) 1.57

Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. Crit Care Med (2003) 1.53

Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52

Reducing mortality in sepsis: new directions. Crit Care (2002) 1.52

The decline and fate of an iron-induced subarctic phytoplankton bloom. Nature (2004) 1.50

Genetic polymorphisms and sepsis. Shock (2005) 1.50

The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49

MicroRNAs in immune response and macrophage polarization. Arterioscler Thromb Vasc Biol (2013) 1.48

Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol (2004) 1.48

ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation. Crit Care Med (2007) 1.46

High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol (2008) 1.45

Participation of miR-200 in pulmonary fibrosis. Am J Pathol (2011) 1.43

Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury. Am J Respir Crit Care Med (2006) 1.42

Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity. FASEB J (2008) 1.39

Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med (2005) 1.33

Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg (2006) 1.30

miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol (2012) 1.29

The last 100 years of sepsis. Am J Respir Crit Care Med (2005) 1.27

PAI-1 inhibits neutrophil efferocytosis. Proc Natl Acad Sci U S A (2008) 1.27

Early alterations in neutrophil activation are associated with outcome in acute lung injury. Am J Respir Crit Care Med (2003) 1.27

p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury. J Immunol (2009) 1.27

Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J Immunol (2007) 1.26

Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking. Proc Natl Acad Sci U S A (2013) 1.26

MicroRNA let-7c regulates macrophage polarization. J Immunol (2013) 1.23

Intensive insulin therapy in critical illness. Am J Respir Crit Care Med (2005) 1.23

Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J Immunol (2004) 1.21

Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol (2008) 1.18

AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J (2011) 1.17

HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol (2013) 1.17

Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol (2009) 1.16

miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J (2013) 1.15

Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils. Am J Physiol Cell Physiol (2007) 1.14

Participation of superoxide in neutrophil activation and cytokine production. Biochim Biophys Acta (2006) 1.12

Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit. Pharmacotherapy (2002) 1.11

Functional and genomic changes induced by alveolar transmigration in human neutrophils. Am J Physiol Lung Cell Mol Physiol (2006) 1.09

Bone transport in the management of posttraumatic bone defects in the lower extremity. J Trauma (2004) 1.09

Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2003) 1.07

Alzheimer's disease and Notch signaling. Biochem Biophys Res Commun (2009) 1.07

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med (2010) 1.07

Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients. Antimicrob Agents Chemother (2005) 1.07

IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res (2002) 1.05

Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB. Cell Signal (2005) 1.05

Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Mol Pharmacol (2011) 1.04

HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury. Intensive Care Med (2007) 1.04

Lung cancer cell invasion and expression of intercellular adhesion molecule-1 (ICAM-1) are attenuated by secretory phospholipase A₂ inhibition. J Thorac Cardiovasc Surg (2012) 1.03

Participation of the receptor for advanced glycation end products in efferocytosis. J Immunol (2011) 1.03

Oxaliplatin with biweekly, low dose leucovorin and bolus and continuous infusion 5-fluorouracil (Modified FOLFOX 4) as first-line therapy for patients with metastatic colorectal cancer. Cancer Res Treat (2004) 1.02

S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem (2009) 1.02

miR-125a-5p regulates differential activation of macrophages and inflammation. J Biol Chem (2013) 1.02

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiol Aging (2008) 1.02

Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med (2012) 1.01

Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.01

Clinical manifestations and treatment outcomes of pulmonary aspergilloma. Korean J Intern Med (2004) 1.00

Retracted miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. FASEB J (2012) 0.99

Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. J Biol Chem (2009) 0.99

The C-terminal acidic tail is responsible for the inhibitory effects of HMGB1 on efferocytosis. J Leukoc Biol (2010) 0.97