Published in Nat Immunol on November 01, 2005
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood (2009) 4.80
Interleukin-17 is a negative regulator of established allergic asthma. J Exp Med (2006) 4.38
Endogenous IL-17 contributes to reduced tumor growth and metastasis. Blood (2009) 4.13
T(H)17 cells in tumour immunity and immunotherapy. Nat Rev Immunol (2010) 3.39
Induction of IL-17+ T cell trafficking and development by IFN-gamma: mechanism and pathological relevance in psoriasis. J Immunol (2008) 3.22
The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest (2008) 2.66
CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. Immunol Rev (2006) 2.49
T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med (2006) 2.38
Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Infect Immun (2007) 2.08
TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol (2008) 1.97
Immunomodulatory effects of cyclophosphamide and implementations for vaccine design. Semin Immunopathol (2011) 1.80
IL-17 promotes progression of cutaneous leishmaniasis in susceptible mice. J Immunol (2009) 1.63
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53
IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J Immunol (2010) 1.35
Prostaglandin mediates IL-23/IL-17-induced neutrophil migration in inflammation by inhibiting IL-12 and IFNgamma production. Proc Natl Acad Sci U S A (2009) 1.31
Subnormal cytokine profile in the tear fluid of keratoconus patients. PLoS One (2011) 1.23
Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut (2007) 1.18
Decreasing TNF-alpha results in less fibrosis and earlier resolution of granulomatous experimental autoimmune thyroiditis. J Leukoc Biol (2006) 1.12
The absence of Toll-like receptor 4 signaling in C3H/HeJ mice predisposes them to overwhelming rickettsial infection and decreased protective Th1 responses. Infect Immun (2008) 1.10
S-nitrosoglutathione a physiologic nitric oxide carrier attenuates experimental autoimmune encephalomyelitis. J Neuroimmune Pharmacol (2010) 1.09
Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect Immun (2009) 1.08
Altered chemokine profile associated with exacerbated autoimmune pathology under conditions of genetic interferon-gamma deficiency. Invest Ophthalmol Vis Sci (2007) 1.06
Characterization of the Histoplasma capsulatum-induced granuloma. J Immunol (2006) 0.98
The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature. Clin Exp Immunol (2008) 0.96
Th17 cells and HIV infection. Curr Opin HIV AIDS (2010) 0.96
Analysis of the dynamics of infiltrating CD4(+) T cell subsets in the heart during experimental Trypanosoma cruzi infection. PLoS One (2013) 0.92
Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I). Clin Vaccine Immunol (2010) 0.91
Enhancement of neutrophil function by interleukin-18 therapy protects burn-injured mice from methicillin-resistant Staphylococcus aureus. Infect Immun (2011) 0.90
The Aryl Hydrocarbon Receptor: A Key Bridging Molecule of External and Internal Chemical Signals. Environ Sci Technol (2015) 0.90
Intestinal cytokine mRNA expression in canine inflammatory bowel disease: a meta-analysis with critical appraisal. Comp Med (2009) 0.89
Th17: a new participant in gut dysfunction in mice infected with Trichinella spiralis. Mediators Inflamm (2009) 0.85
The Role of Th17 in Neuroimmune Disorders: Target for CAM Therapy. Part I. Evid Based Complement Alternat Med (2011) 0.85
What determines the success or failure of intracellular cutaneous parasites? Lessons learned from leishmaniasis. Med Microbiol Immunol (2009) 0.85
Higher levels of interleukin IL-17 and antigen-specific IL-17 responses in pulmonary sarcoidosis patients with Löfgren's syndrome. Clin Exp Immunol (2014) 0.83
Depletion of regulatory T lymphocytes reverses the imbalance between pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses. PLoS One (2012) 0.82
Differentiation of human T cells alters their repertoire of G protein alpha-subunits. J Biol Chem (2010) 0.81
Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation? J Gastroenterol (2007) 0.81
Ustekinumab in the therapy of chronic plaque psoriasis. Biologics (2009) 0.79
No evidence for activation of T(H)1 or T(H)17 pathways in unstimulated peripheral blood mononuclear cells from children with β-cell autoimmunity or T1D. J Inflamm Res (2008) 0.78
T-helper cells in the etiopathogenesis of periodontal disease: A mini review. J Indian Soc Periodontol (2011) 0.78
Atopy and autoimmune thyroid diseases: melatonin can be useful? Ital J Pediatr (2016) 0.77
Th1 responses are more susceptible to infliximab-mediated immunosuppression than Th17 responses. Dig Dis Sci (2011) 0.77
Phenotypical and functional analysis of intraepithelial lymphocytes from small intestine of mice in oral tolerance. Clin Dev Immunol (2012) 0.76
Uncarinic Acid C Isolated from Uncaria rhynchophylla Induces Differentiation of Th1-Promoting Dendritic Cells Through TLR4 Signaling. Biomark Insights (2011) 0.76
Eosinophils infiltrate thyroids, but have no apparent role in induction or resolution of experimental autoimmune thyroiditis in interferon-gamma(-/-) mice. Immunology (2009) 0.76
Persistent hyperglycemia modulates gut immune function and microbiota in rats. J Intensive Care (2015) 0.75
Interleukin-17 plays a critical role in the acute rejection of intestinal transplantation. World J Gastroenterol (2013) 0.75
High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID). BMC Bioinformatics (2005) 14.02
Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol (2011) 12.21
Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med (2007) 4.47
Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol (2008) 4.31
Arginase-1-expressing macrophages suppress Th2 cytokine-driven inflammation and fibrosis. PLoS Pathog (2009) 4.12
Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med (2010) 3.44
The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest (2006) 3.33
Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol (2011) 3.16
Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol (2011) 2.92
Immunopathology of schistosomiasis. Immunol Cell Biol (2006) 2.74
Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med (2003) 2.71
A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol (2003) 2.69
An essential role for TH2-type responses in limiting acute tissue damage during experimental helminth infection. Nat Med (2012) 2.60
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J Immunol (2004) 2.50
Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain. Nat Immunol (2007) 2.50
Global gene expression profiles during acute pathogen-induced pulmonary inflammation reveal divergent roles for Th1 and Th2 responses in tissue repair. J Immunol (2003) 2.48
IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. J Immunol (2004) 2.47
Regulation of pathogenesis and immunity in helminth infections. J Exp Med (2009) 2.39
Evolution of Th2 immunity: a rapid repair response to tissue destructive pathogens. PLoS Pathog (2011) 2.25
Host responses in tissue repair and fibrosis. Annu Rev Pathol (2012) 2.10
Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology (2008) 2.09
Retnla (relmalpha/fizz1) suppresses helminth-induced Th2-type immunity. PLoS Pathog (2009) 2.07
Type 2 immunity and wound healing: evolutionary refinement of adaptive immunity by helminths. Nat Rev Immunol (2013) 1.96
Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med (2011) 1.88
Immunoglobulin class switch recombination is impaired in Atm-deficient mice. J Exp Med (2004) 1.87
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci U S A (2003) 1.80
Resistance of C57BL/6 mice to amoebiasis is mediated by nonhemopoietic cells but requires hemopoietic IL-10 production. J Immunol (2006) 1.77
Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity. Infect Immun (2006) 1.76
NK cell-derived IFN-gamma differentially regulates innate resistance and neutrophil response in T cell-deficient hosts infected with Mycobacterium tuberculosis. J Immunol (2006) 1.76
The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol (2009) 1.76
Granulomas in schistosome and mycobacterial infections: a model of local immune responses. Trends Immunol (2003) 1.75
Chitinase dependent control of protozoan cyst burden in the brain. PLoS Pathog (2012) 1.68
Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation (2013) 1.68
Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology. Adv Parasitol (2002) 1.61
Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol (2008) 1.58
IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. J Immunol (2002) 1.58
Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med (2014) 1.54
Redundant and pathogenic roles for IL-22 in mycobacterial, protozoan, and helminth infections. J Immunol (2010) 1.53
IL-13Ralpha2 and IL-10 coordinately suppress airway inflammation, airway-hyperreactivity, and fibrosis in mice. J Clin Invest (2007) 1.47
Fibrosis is regulated by Th2 and Th17 responses and by dynamic interactions between fibroblasts and macrophages. Am J Physiol Gastrointest Liver Physiol (2011) 1.44
Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood (2006) 1.42
Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol (2010) 1.40
Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and disease. Immunol Rev (2004) 1.37
Structure of the catalytic domain of human polo-like kinase 1. Biochemistry (2007) 1.37
Matrix metalloproteinase 12-deficiency augments extracellular matrix degrading metalloproteinases and attenuates IL-13-dependent fibrosis. J Immunol (2010) 1.35
Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. Am J Pathol (2010) 1.33
Macrophage activation governs schistosomiasis-induced inflammation and fibrosis. Eur J Immunol (2011) 1.31
Endogenous pro- and anti-inflammatory cytokines differentially regulate an in vivo humoral response to Streptococcus pneumoniae. Infect Immun (2002) 1.30
Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J Immunol (2006) 1.26
Regulation of macrophage arginase expression and tumor growth by the Ron receptor tyrosine kinase. J Immunol (2011) 1.26
Alternatively activated dendritic cells regulate CD4+ T-cell polarization in vitro and in vivo. Proc Natl Acad Sci U S A (2012) 1.24
T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses. Proc Natl Acad Sci U S A (2007) 1.23
Colitis and intestinal inflammation in IL10-/- mice results from IL-13Rα2-mediated attenuation of IL-13 activity. Gastroenterology (2010) 1.22
Cationic amino acid transporter-2 regulates immunity by modulating arginase activity. PLoS Pathog (2008) 1.19
IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. J Immunol (2008) 1.16
Exploiting worm and allergy models to understand Th2 cytokine biology. Curr Opin Allergy Clin Immunol (2005) 1.14
Inhibition of T helper 2-type responses, IgE production and eosinophilia by synthetic lipopeptides. Eur J Immunol (2003) 1.14
IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J Immunol (2009) 1.13
miR-182 and miR-10a are key regulators of Treg specialisation and stability during Schistosome and Leishmania-associated inflammation. PLoS Pathog (2013) 1.11
Regulation of helminth-induced Th2 responses by thymic stromal lymphopoietin. J Immunol (2009) 1.11
Strain-dependent genomic factors affect allergen-induced airway hyperresponsiveness in mice. Am J Respir Cell Mol Biol (2011) 1.11
Immunopathogenic mechanisms in schistosomiasis: what can be learnt from human studies? Trends Parasitol (2005) 1.09
Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity. PLoS One (2013) 1.09
Cytokine mediated tissue fibrosis. Biochim Biophys Acta (2012) 1.06
Fibrosis under arrest. Nat Med (2010) 1.05
Accelerated and progressive and lethal liver fibrosis in mice that lack interleukin (IL)-10, IL-12p40, and IL-13Rα2. Gastroenterology (2011) 1.05
IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni. PLoS Pathog (2011) 1.03
Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One (2013) 1.02
Gene microarray analysis reveals interleukin-5-dependent transcriptional targets in mouse bone marrow. Blood (2003) 0.97
Basophils trump dendritic cells as APCs for T(H)2 responses. Nat Immunol (2009) 0.96
Blood fluke exploitation of non-cognate CD4+ T cell help to facilitate parasite development. PLoS Pathog (2010) 0.95
An efferocytosis-induced, IL-4-dependent macrophage-iNKT cell circuit suppresses sterile inflammation and is defective in murine CGD. Blood (2013) 0.92
RGS16 attenuates pulmonary Th2/Th17 inflammatory responses. J Immunol (2012) 0.89
Conventional NK cells can produce IL-22 and promote host defense in Klebsiella pneumoniae pneumonia. J Immunol (2014) 0.89
IL-33-induced alterations in murine intestinal function and cytokine responses are MyD88, STAT6, and IL-13 dependent. Am J Physiol Gastrointest Liver Physiol (2012) 0.87
Plasminogen activator inhibitor-2 (PAI-2) in eosinophilic leukocytes. J Leukoc Biol (2004) 0.84
Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo. Eur J Haematol (2006) 0.83
Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity. Int J Parasitol (2008) 0.82
A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity. PLoS Pathog (2013) 0.82
Chronic graft-versus-host disease: how can we release Prometheus? Biol Blood Marrow Transplant (2008) 0.81
Myeloid-cell differentiation redefined in cancer. Nat Immunol (2013) 0.78
Shedding LIGHT on severe asthma. Nat Med (2011) 0.77
Mapping mouse IL-13 binding regions using structure modeling, molecular docking, and high-density peptide microarray analysis. Proteins (2011) 0.77
Enhanced interleukin-12 and CD40 ligand activities but reduced Staphylococcus aureus Cowan 1-induced responses suggest a generalized and progressively impaired type 1 cytokine pattern for human schistosomiasis. Infect Immun (2002) 0.76
Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): a tale of two waters. Bioorg Med Chem Lett (2012) 0.75