Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection.

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Published in J Exp Med on February 05, 2007

Authors

Dragana Jankovic1, Marika C Kullberg, Carl G Feng, Romina S Goldszmid, Carmen M Collazo, Mark Wilson, Thomas A Wynn, Masahito Kamanaka, Richard A Flavell, Alan Sher

Author Affiliations

1: Immunobiology Section and 2Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. DJankovic@niaid.nih.gov

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Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo. J Immunol (2010) 3.25

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. J Exp Med (2006) 3.22

Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19

Obstacles and opportunities for understanding macrophage polarization. J Leukoc Biol (2011) 3.16

Blocking TGF-beta-Smad2/3 innate immune signaling mitigates Alzheimer-like pathology. Nat Med (2008) 3.15

Cutting edge: MyD88 is required for resistance to Toxoplasma gondii infection and regulates parasite-induced IL-12 production by dendritic cells. J Immunol (2002) 3.12

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2012) 3.12

The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol (2002) 3.08