Published in Biochim Biophys Acta on October 11, 2005
MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter. Cell Metab (2013) 2.15
Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci (Landmark Ed) (2009) 1.96
Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol (2007) 1.74
SR/ER-mitochondrial local communication: calcium and ROS. Biochim Biophys Acta (2009) 1.73
Mitochondrial ion channels. Annu Rev Physiol (2007) 1.70
Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67
High- and low-calcium-dependent mechanisms of mitochondrial calcium signalling. Cell Calcium (2008) 1.60
Mitochondria and Ca(2+) signaling: old guests, new functions. Pflugers Arch (2007) 1.47
Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol (2007) 1.45
Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta (2010) 1.32
Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle. J Biol Chem (2008) 1.28
Regulation of endothelial function by mitochondrial reactive oxygen species. Antioxid Redox Signal (2011) 1.25
Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondrial ca2+ uniporter (MCU) contribute to metabolism-secretion coupling in clonal pancreatic β-cells. J Biol Chem (2012) 1.24
HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. PLoS One (2008) 1.23
Mitochondrial free calcium regulation during sarcoplasmic reticulum calcium release in rat cardiac myocytes. J Mol Cell Cardiol (2009) 1.16
An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proc Natl Acad Sci U S A (2007) 1.11
Calcium signalling: fishing out molecules of mitochondrial calcium transport. Curr Biol (2010) 1.11
Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett (2010) 1.04
Studying mitochondrial Ca(2+) uptake - a revisit. Mol Cell Endocrinol (2011) 1.03
The role of mitochondria for the regulation of cardiac alternans. Front Physiol (2010) 1.02
Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem (2011) 1.01
Calcium signaling in cardiac mitochondria. J Mol Cell Cardiol (2013) 1.01
Calcium and mitochondrial reactive oxygen species generation: how to read the facts. J Alzheimers Dis (2010) 0.96
Mitochondrial calcium homeostasis as potential target for mitochondrial medicine. Mitochondrion (2011) 0.96
Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake. J Physiol (2014) 0.95
Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol (2011) 0.93
Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling. Antioxid Redox Signal (2014) 0.91
Manganese neurotoxicity and the role of reactive oxygen species. Free Radic Biol Med (2013) 0.90
Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease. J Gen Physiol (2012) 0.88
Distinctive characteristics and functions of multiple mitochondrial Ca2+ influx mechanisms. Sci China Life Sci (2011) 0.86
Mitochondrial ion channels as therapeutic targets. FEBS Lett (2010) 0.85
Distribution of ryanodine receptors in rat ventricular myocytes. J Muscle Res Cell Motil (2009) 0.84
Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity. Oncotarget (2015) 0.84
Mitochondrial Ca(2+) uptake pathways. J Bioenerg Biomembr (2016) 0.83
Overexpression of ryanodine receptor type 1 enhances mitochondrial fragmentation and Ca2+-induced ATP production in cardiac H9c2 myoblasts. Am J Physiol Heart Circ Physiol (2013) 0.82
Molecular and functional identification of a mitochondrial ryanodine receptor in neurons. Neurosci Lett (2014) 0.79
Initiation of electron transport chain activity in the embryonic heart coincides with the activation of mitochondrial complex 1 and the formation of supercomplexes. PLoS One (2014) 0.79
Modulation of the matrix redox signaling by mitochondrial Ca(2.). World J Biol Chem (2015) 0.78
Mitochondrial targets for arrhythmia suppression: is there a role for pharmacological intervention? J Interv Card Electrophysiol (2013) 0.78
Temperature acclimation has no effect on ryanodine receptor expression or subcellular localization in rainbow trout heart. J Comp Physiol B (2009) 0.78
A computational model of cytosolic and mitochondrial [ca] in paced rat ventricular myocytes. Korean J Physiol Pharmacol (2011) 0.77
A Novel Nicotinamide Adenine Dinucleotide Correction Method for Mitochondrial Ca(2+) Measurement with FURA-2-FF in Single Permeabilized Ventricular Myocytes of Rat. Korean J Physiol Pharmacol (2015) 0.75
The excitation-contraction coupling mechanism in skeletal muscle. Biophys Rev (2014) 0.75
The Mitochondrial Voltage-Dependent Anion Channel 1, Ca(2+) Transport, Apoptosis, and Their Regulation. Front Oncol (2017) 0.75
The Mitochondrial Ca(2+) Uniporter: Structure, Function, and Pharmacology. Handb Exp Pharmacol (2017) 0.75
Gene-expression profiles predict survival of patients with lung adenocarcinoma. Nat Med (2002) 21.28
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet (2009) 7.48
Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am J Physiol Cell Physiol (2004) 7.23
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity. Nat Genet (2013) 4.48
Superoxide flashes in single mitochondria. Cell (2008) 4.08
Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA. Science (2009) 3.62
Verification and unmasking of widely used human esophageal adenocarcinoma cell lines. J Natl Cancer Inst (2010) 2.79
Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. J Clin Invest (2007) 2.68
The iron chelator deferasirox protects mice from mucormycosis through iron starvation. J Clin Invest (2007) 2.48
ATGL has a key role in lipid droplet/adiposome degradation in mammalian cells. EMBO Rep (2006) 2.26
Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res (2012) 2.26
Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology (2011) 2.14
Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice. Gastroenterology (2012) 2.11
Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell (2009) 2.10
Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1. Hum Mol Genet (2005) 2.07
Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1. Am J Physiol Cell Physiol (2006) 2.02
Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res (2008) 1.98
Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. FASEB J (2005) 1.97
Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci (Landmark Ed) (2009) 1.96
Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med (2009) 1.88
Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice. FASEB J (2009) 1.88
Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A (2006) 1.85
Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. J Biol Chem (2008) 1.85
Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1. J Biol Chem (2006) 1.85
Expression analysis and genomic characterization of human melanoma differentiation associated gene-5, mda-5: a novel type I interferon-responsive apoptosis-inducing gene. Oncogene (2004) 1.83
Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy. J Gen Physiol (2006) 1.83
Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. J Biol Chem (2006) 1.82
Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures. Mol Biol Cell (2008) 1.80
The antifungal vaccine derived from the recombinant N terminus of Als3p protects mice against the bacterium Staphylococcus aureus. Infect Immun (2008) 1.77
Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle. J Gen Physiol (2010) 1.73
Draft genome of the kiwifruit Actinidia chinensis. Nat Commun (2013) 1.72
Nonclassic lipoid congenital adrenal hyperplasia masquerading as familial glucocorticoid deficiency. J Clin Endocrinol Metab (2009) 1.68
Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67
Two small GTPases act in concert with the bactofilin cytoskeleton to regulate dynamic bacterial cell polarity. Dev Cell (2013) 1.63
Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia. Clin Cancer Res (2003) 1.62
Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem (2005) 1.59
The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell (2011) 1.52
Mutations in the p53 tumor suppressor gene and early onset breast cancer. Cancer Biol Ther (2002) 1.52
Assessment of ischemia-modified albumin levels for emergency room diagnosis of acute coronary syndrome. Int J Cardiol (2010) 1.49
Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1. J Physiol (2008) 1.48
Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol (2009) 1.48
Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation (2006) 1.46
Protein disulfide isomerase inhibitors constitute a new class of antithrombotic agents. J Clin Invest (2012) 1.45
Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol (2007) 1.45
Phosphorylated FADD induces NF-kappaB, perturbs cell cycle, and is associated with poor outcome in lung adenocarcinomas. Proc Natl Acad Sci U S A (2005) 1.44
DNA origami as a carrier for circumvention of drug resistance. J Am Chem Soc (2012) 1.42
Long noncoding RNAs in development and disease of the central nervous system. Trends Genet (2013) 1.42
miR-135a Suppresses Calcification in Senescent VSMCs by Regulating KLF4/STAT3 Pathway. Curr Vasc Pharmacol (2016) 1.42
Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circ Res (2005) 1.41
Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins. Proc Natl Acad Sci U S A (2009) 1.41
Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Hum Mol Genet (2011) 1.37
Hierarchical modeling for rare event detection and cell subset alignment across flow cytometry samples. PLoS Comput Biol (2013) 1.35
Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. Am J Hum Genet (2010) 1.35
Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol (2007) 1.34
Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem (2010) 1.34
Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J (2011) 1.33
Sarcoplasmic reticulum: the dynamic calcium governor of muscle. Muscle Nerve (2006) 1.33
Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection. PLoS One (2012) 1.32
Is mPTP the gatekeeper for necrosis, apoptosis, or both? Biochim Biophys Acta (2010) 1.32
NADPH oxidase contributes to renal damage and dysfunction in Dahl salt-sensitive hypertension. Am J Physiol Regul Integr Comp Physiol (2008) 1.31
Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction coupling. J Gen Physiol (2007) 1.30
Cell death in development: shaping the embryo. Histochem Cell Biol (2006) 1.30
DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons. Neuron (2011) 1.30
Steroidogenic factor-1 (SF-1, NR5A1) and human disease. Mol Cell Endocrinol (2010) 1.29
Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. Neoplasia (2006) 1.28
Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling. Am J Physiol Cell Physiol (2004) 1.28
Mutational analysis of steroidogenic factor 1 (NR5a1) in 24 boys with bilateral anorchia: a French collaborative study. Hum Reprod (2007) 1.27
The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis. Mol Microbiol (2010) 1.27
Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins. Blood (2012) 1.26
The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. Mol Cell Biol (2005) 1.26
Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice. Kidney Int (2012) 1.25
Anaplastic large cell lymphoma involving the breast: a clinicopathologic study of 6 cases and review of the literature. Arch Pathol Lab Med (2009) 1.24
Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol (2008) 1.23
CYP24A1 is an independent prognostic marker of survival in patients with lung adenocarcinoma. Clin Cancer Res (2010) 1.23
The spectrum of phenotypes associated with mutations in steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) includes severe penoscrotal hypospadias in 46,XY males without adrenal insufficiency. Eur J Endocrinol (2009) 1.23
Characterization and temporal development of cores in a mouse model of malignant hyperthermia. Proc Natl Acad Sci U S A (2009) 1.22
GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor. J Biol Chem (2003) 1.22
A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice. Proc Natl Acad Sci U S A (2009) 1.22
Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. Ann Thorac Surg (2012) 1.21
Mitochondrial contact sites: their role in energy metabolism and apoptosis. Biochim Biophys Acta (2005) 1.21
Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol (2006) 1.20
A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension. J Clin Endocrinol Metab (2012) 1.20
Piglets cloned from induced pluripotent stem cells. Cell Res (2012) 1.19
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med (2012) 1.19
Oral ginseng formulae for stable chronic obstructive pulmonary disease: a systematic review. Respir Med (2010) 1.18
Five novel mutations in steroidogenic factor 1 (SF1, NR5A1) in 46,XY patients with severe underandrogenization but without adrenal insufficiency. Hum Mutat (2008) 1.18
Protein kinase a mediates activity-dependent Kv4.2 channel trafficking. J Neurosci (2008) 1.18
Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. Transgenic Res (2009) 1.17
FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. J Biol Chem (2003) 1.17
Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol (2007) 1.17
Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol (2007) 1.16
L1 elements, processed pseudogenes and retrogenes in mammalian genomes. IUBMB Life (2006) 1.16
Antibody titer threshold predicts anti-candidal vaccine efficacy even though the mechanism of protection is induction of cell-mediated immunity. J Infect Dis (2008) 1.15
Bladder cancer determination via two urinary metabolites: a biomarker pattern approach. Mol Cell Proteomics (2011) 1.14
The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell (2010) 1.13