Calcium, ATP, and ROS: a mitochondrial love-hate triangle.

PubWeight™: 7.23‹?› | Rank: Top 1%

🔗 View Article (PMID 15355853)

Published in Am J Physiol Cell Physiol on October 01, 2004

Authors

Paul S Brookes1, Yisang Yoon, James L Robotham, M W Anders, Shey-Shing Sheu

Author Affiliations

1: University of Rochester Medical Center, 601 Elmwood Ave., Box 711, Rochester, NY 14642, USA.

Articles citing this

(truncated to the top 100)

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano (2008) 5.68

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli. Mol Syst Biol (2007) 3.98

Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66

Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention. Chem Rev (2011) 2.48

Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal (2009) 2.28

Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res (2008) 2.23

Endoplasmic reticulum stress and type 2 diabetes. Annu Rev Biochem (2012) 2.10

Integration of cellular bioenergetics with mitochondrial quality control and autophagy. Biol Chem (2012) 2.08

The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol (2007) 2.07

Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab (2011) 2.06

Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. J Physiol (2006) 2.06

The NLRP3 Inflammasome and IL-1β Accelerate Immunologically Mediated Pathology in Experimental Viral Fulminant Hepatitis. PLoS Pathog (2015) 2.04

Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci (Landmark Ed) (2009) 1.96

Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function. Antioxid Redox Signal (2009) 1.89

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J (2009) 1.78

C. elegans epidermal wounding induces a mitochondrial ROS burst that promotes wound repair. Dev Cell (2014) 1.77

Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience (2007) 1.76

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Proc Natl Acad Sci U S A (2007) 1.76

Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol (2007) 1.74

Selective role for superoxide in InsP3 receptor-mediated mitochondrial dysfunction and endothelial apoptosis. J Cell Biol (2005) 1.73

Cardioprotection by metabolic shut-down and gradual wake-up. J Mol Cell Cardiol (2009) 1.68

Mitochondrial criticality: a new concept at the turning point of life or death. Biochim Biophys Acta (2005) 1.68

Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation. Mol Neurobiol (2012) 1.67

Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67

N-Acetylcysteine ameliorates skeletal muscle pathophysiology in mdx mice. J Physiol (2008) 1.60

Cardioprotection and mitochondrial S-nitrosation: effects of S-nitroso-2-mercaptopropionyl glycine (SNO-MPG) in cardiac ischemia-reperfusion injury. J Mol Cell Cardiol (2007) 1.59

Mechanisms regulating cytochrome c release in pancreatic mitochondria. Gut (2008) 1.58

Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55

The Ca 2+ leak paradox and rogue ryanodine receptors: SR Ca 2+ efflux theory and practice. Prog Biophys Mol Biol (2005) 1.54

The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell (2011) 1.52

Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities. PLoS Genet (2015) 1.52

Mitochondrial fusion and division: Regulation and role in cell viability. Semin Cell Dev Biol (2009) 1.51

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease. Prog Lipid Res (2012) 1.51

Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol (2009) 1.48

Different mechanisms of mitochondrial proton leak in ischaemia/reperfusion injury and preconditioning: implications for pathology and cardioprotection. Biochem J (2006) 1.47

Mitochondrial dynamics in diabetes. Antioxid Redox Signal (2010) 1.46

Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol (2007) 1.45

Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J Biol Chem (2009) 1.41

The calcium-dependent ribonuclease XendoU promotes ER network formation through local RNA degradation. J Cell Biol (2014) 1.41

Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal (2010) 1.40

The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability. Nature (2017) 1.39

High Glucose Attenuates Anesthetic Cardioprotection in Stem-Cell-Derived Cardiomyocytes: The Role of Reactive Oxygen Species and Mitochondrial Fission. Anesth Analg (2016) 1.38

A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction. Biophys J (2005) 1.38

Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle. J Physiol (2005) 1.37

Ru360, a specific mitochondrial calcium uptake inhibitor, improves cardiac post-ischaemic functional recovery in rats in vivo. Br J Pharmacol (2006) 1.36

Thiol chemistry in peroxidase catalysis and redox signaling. Antioxid Redox Signal (2008) 1.35

Mechanisms of stretch-induced muscle damage in normal and dystrophic muscle: role of ionic changes. J Physiol (2005) 1.34

Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol (2006) 1.33

The endogenous mitochondrial complex II inhibitor malonate regulates mitochondrial ATP-sensitive potassium channels: implications for ischemic preconditioning. Biochim Biophys Acta (2008) 1.33

Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J (2011) 1.33

Methods for assessing mitochondrial function in diabetes. Diabetes (2013) 1.31

Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circ Res (2012) 1.31

The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology. Physiol Rev (2015) 1.31

Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proc Natl Acad Sci U S A (2007) 1.30

Potential role of carotenoids as antioxidants in human health and disease. Nutrients (2014) 1.29

Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle. J Biol Chem (2008) 1.28

Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest. J Clin Invest (2010) 1.27

Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death. Parasit Vectors (2010) 1.22

Characterization and temporal development of cores in a mouse model of malignant hyperthermia. Proc Natl Acad Sci U S A (2009) 1.22

Analysis of cardiac mitochondrial Na+-Ca2+ exchanger kinetics with a biophysical model of mitochondrial Ca2+ handling suggests a 3:1 stoichiometry. J Physiol (2008) 1.22

Induction of the permeability transition and cytochrome c release by 15-deoxy-Delta12,14-prostaglandin J2 in mitochondria. Biochem J (2006) 1.22

Reactive oxygen species production by forward and reverse electron fluxes in the mitochondrial respiratory chain. PLoS Comput Biol (2011) 1.21

The role of protein O-linked beta-N-acetylglucosamine in mediating cardiac stress responses. Biochim Biophys Acta (2009) 1.21

Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium. Blood (2008) 1.21

Initiation and perpetuation of NLRP3 inflammasome activation and assembly. Immunol Rev (2015) 1.18

Pb neurotoxicity: neuropsychological effects of lead toxicity. Biomed Res Int (2014) 1.18

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements. Eur J Pharmacol (2012) 1.16

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca²⁺ and reactive oxygen species signaling. J Cell Sci (2013) 1.16

Reciprocal amplification of ROS and Ca(2+) signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch (2009) 1.16

Mitochondrial signaling contributes to disuse muscle atrophy. Am J Physiol Endocrinol Metab (2012) 1.16

Mitochondria and cardioprotection. Heart Fail Rev (2007) 1.14

The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions. J Neurosci (2011) 1.14

Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol (2011) 1.14

Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Rev Endocrinol Metab (2010) 1.11

Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes. Biochim Biophys Acta (2010) 1.10

Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol (2014) 1.10

Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. BMC Genomics (2007) 1.09

Role of mitochondrial reactive oxygen species in hypoxia-dependent increase in intracellular calcium in pulmonary artery myocytes. Free Radic Biol Med (2006) 1.08

Measuring mitochondrial function in intact cardiac myocytes. J Mol Cell Cardiol (2011) 1.07

Mitochondria in traumatic brain injury and mitochondrial-targeted multipotential therapeutic strategies. Br J Pharmacol (2012) 1.07

Dose response effects of 810 nm laser light on mouse primary cortical neurons. Lasers Surg Med (2011) 1.06

Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis. J Neurosci (2010) 1.06

Trypanosoma cruzi infection disturbs mitochondrial membrane potential and ROS production rate in cardiomyocytes. Free Radic Biol Med (2009) 1.06

Effect of calcium on the oxidative phosphorylation cascade in skeletal muscle mitochondria. Biochemistry (2013) 1.05

Na+/H+ exchangers: physiology and link to hypertension and organ ischemia. Curr Opin Nephrol Hypertens (2005) 1.05

Calcium and ROS: A mutual interplay. Redox Biol (2015) 1.05

Negative regulation of UCP2 by TGFβ signaling characterizes low and intermediate-grade primary breast cancer. Cell Death Dis (2010) 1.05

Measuring local gradients of intramitochondrial [Ca(2+)] in cardiac myocytes during sarcoplasmic reticulum Ca(2+) release. Circ Res (2012) 1.05

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett (2010) 1.04

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biol Chem (2013) 1.04

The kallikrein-kinin system in health and in diseases of the kidney. Kidney Int (2009) 1.04

Astrocytic calcium signaling: mechanism and implications for functional brain imaging. Methods Mol Biol (2009) 1.04

Epoxyeicosatrienoic acids attenuate reactive oxygen species level, mitochondrial dysfunction, caspase activation, and apoptosis in carcinoma cells treated with arsenic trioxide. J Pharmacol Exp Ther (2011) 1.04

NLRP3 inflammasome activation induced by engineered nanomaterials. Small (2012) 1.03

A biophysically based mathematical model for the kinetics of mitochondrial calcium uniporter. Biophys J (2009) 1.03

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell (2012) 1.03

Mitochondrial depolarization underlies delay in permeability transition by preconditioning with isoflurane: roles of ROS and Ca2+. Am J Physiol Cell Physiol (2010) 1.03

Articles by these authors

Superoxide flashes in single mitochondria. Cell (2008) 4.08

Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A (2006) 4.07

Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide. J Clin Invest (1979) 2.40

Dynamin-like protein 1 is involved in peroxisomal fission. J Biol Chem (2002) 2.18

Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res (2008) 1.98

Crosstalk signaling between mitochondrial Ca2+ and ROS. Front Biosci (Landmark Ed) (2009) 1.96

Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine. Drug Metab Dispos (1974) 1.94

Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J Cell Sci (2004) 1.92

A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cells. Mol Biol Cell (2005) 1.89

Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1. J Cell Sci (2005) 1.75

Targeting antioxidants to mitochondria: a new therapeutic direction. Biochim Biophys Acta (2005) 1.68

Characteristics and possible functions of mitochondrial Ca(2+) transport mechanisms. Biochim Biophys Acta (2009) 1.67

Perturbations in mitochondrial dynamics induced by human mutant PINK1 can be rescued by the mitochondrial division inhibitor mdivi-1. J Biol Chem (2010) 1.65

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells. J Biol Chem (2005) 1.59

The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell (2011) 1.52

Morphological dynamics of mitochondria--a special emphasis on cardiac muscle cells. J Mol Cell Cardiol (2009) 1.48

Inhibiting p90 ribosomal S6 kinase prevents (Na+)-H+ exchanger-mediated cardiac ischemia-reperfusion injury. Circulation (2006) 1.46

Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol (2007) 1.45

Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol Pharmacol (2002) 1.44

Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol (2007) 1.34

Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. FASEB J (2011) 1.33

High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission. Antioxid Redox Signal (2010) 1.32

Mitochondria and peroxisomes: are the 'big brother' and the 'little sister' closer than assumed? Bioessays (2007) 1.30

Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting. Circ Res (2013) 1.29

Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling. Biochim Biophys Acta (2005) 1.28

Control of mitochondrial morphology through differential interactions of mitochondrial fusion and fission proteins. PLoS One (2011) 1.27

Mitochondrial contact sites: their role in energy metabolism and apoptosis. Biochim Biophys Acta (2005) 1.21

Mitochondrial clustering induced by overexpression of the mitochondrial fusion protein Mfn2 causes mitochondrial dysfunction and cell death. Eur J Cell Biol (2007) 1.19

Mitochondria-specific function of the dynamin family protein DLP1 is mediated by its C-terminal domains. J Biol Chem (2004) 1.17

Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol (2007) 1.17

Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol (2007) 1.16

Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate. Chem Res Toxicol (2000) 1.14

Glutathione conjugate mediated toxicities. Toxicol Appl Pharmacol (1990) 1.14

Glutathione transferase zeta catalyses the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem J (1998) 1.13

Enhancement and inhibition of drug metabolism. Annu Rev Pharmacol (1971) 1.12

Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. Pharmacogenetics (2000) 1.10

Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes. Biochim Biophys Acta (2010) 1.10

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem Pharmacol (1986) 1.09

Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radic Biol Med (2011) 1.09

Lung-marginated monocytes modulate pulmonary microvascular injury during early endotoxemia. Am J Respir Crit Care Med (2005) 1.08

Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity. J Biol Chem (2013) 1.08

Metabolic disposition of cephalothin and deacetylcephalothin in children and adults: comparison of high-performance liquid chromatographic and microbial assay procedures. Clin Pharmacol Ther (1977) 1.07

Inhibition of Drp1-dependent mitochondrial division impairs myogenic differentiation. Am J Physiol Regul Integr Comp Physiol (2013) 1.06

Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethylmorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HC1 (SKF 525-A) and related compounds. Mol Pharmacol (1966) 1.06

Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking alpha-haloalkanoic acids. Chem Res Toxicol (1999) 1.05

Metabolism of dihalomethanes to carbon monoxide--III. Studies on the mechanism of the reaction. Biochem Pharmacol (1978) 1.05

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Lett (2010) 1.04

S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1. Anal Biochem (2007) 1.04

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity. DNA Repair (Amst) (2009) 1.04

Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis. Biochem J (1998) 1.03

Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins. Mol Pharmacol (1974) 1.03

Metabolism of dihalomethanes to formaldehyde and inorganic halide--II. Studies on the mechanism of the reaction. Biochem Pharmacol (1978) 1.02

Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate beta-lyase pathway. Adv Pharmacol (1994) 1.02

ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes. Am J Pathol (2003) 1.01

Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other alpha-haloacids. Chem Res Toxicol (1998) 1.01

Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. J Biol Chem (2011) 1.01

The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta (2007) 1.00

GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase. Pharmacogenetics (2001) 1.00

Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity. Drug Metab Dispos (1990) 0.99

Human glutathione transferase zeta. Methods Enzymol (2005) 0.99

Bioenergetics, mitochondria, and cardiac myocyte differentiation. Prog Pediatr Cardiol (2011) 0.98

Mitochondrial morphology in metabolic diseases. Antioxid Redox Signal (2012) 0.98

Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies. Drug Metab Dispos (1976) 0.98

Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochem Pharmacol (2002) 0.97

Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition. J Biol Chem (2002) 0.97

Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. J Mol Cell Cardiol (2008) 0.97

Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorooctanesulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450. Chem Res Toxicol (2004) 0.96

NDUFS4: creation of a mouse model mimicking a Complex I disorder. Mitochondrion (2009) 0.95

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways. Mol Pharmacol (2005) 0.94

Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies. Drug Metab Dispos (1974) 0.94

Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. J Neurochem (2002) 0.93

Calcium transport across the inner mitochondrial membrane: molecular mechanisms and pharmacology. Mol Cell Endocrinol (2011) 0.93

Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress. Diabetes (2012) 0.93

The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction. Exp Cell Res (2008) 0.93

Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxid Redox Signal (2014) 0.92

Renal processing of glutathione conjugates. Role in nephrotoxicity. Biochem Pharmacol (1984) 0.92

Mitochondrial ion channels/transporters as sensors and regulators of cellular redox signaling. Antioxid Redox Signal (2014) 0.91

Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1. Mol Cell Biochem (2005) 0.91

Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases. Am J Pathol (2004) 0.91

Metabolism of drugs by the kidney. Kidney Int (1980) 0.91

Polymorphisms in the human glutathione transferase zeta promoter. Pharmacogenet Genomics (2006) 0.90

Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone. Chem Res Toxicol (2002) 0.90

Glutathione transferase zeta: discovery, polymorphic variants, catalysis, inactivation, and properties of Gstz1-/- mice. Drug Metab Rev (2011) 0.90

Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta. Chem Res Toxicol (2002) 0.90

Perspectives on: SGP symposium on mitochondrial physiology and medicine: what comes first, misshape or dysfunction? The view from metabolic excess. J Gen Physiol (2012) 0.90

Activation of rat liver microsomal glutathione S-transferase by hydrogen peroxide: role for protein-dimer formation. Arch Biochem Biophys (1992) 0.89

Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochem J (2003) 0.89

Glutamine transaminase K and cysteine conjugate beta-lyase. Ann N Y Acad Sci (1990) 0.89

Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. J Biol Chem (1986) 0.89

Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine. Mol Pharmacol (1987) 0.89

Expression and characterization of human glutamate-cysteine ligase. Arch Biochem Biophys (1998) 0.88

Perspectives on: SGP symposium on mitochondrial physiology and medicine: molecular identities of mitochondrial Ca2+ influx mechanism: updated passwords for accessing mitochondrial Ca2+-linked health and disease. J Gen Physiol (2012) 0.88

Bioactivation of [13C]dichloromethane in mouse, rat, and human liver cytosol: 13C nuclear magnetic resonance spectroscopic studies. Chem Res Toxicol (1994) 0.88

Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. J Biol Chem (1986) 0.88

Losartan metabolite EXP3179 activates Akt and endothelial nitric oxide synthase via vascular endothelial growth factor receptor-2 in endothelial cells: angiotensin II type 1 receptor-independent effects of EXP3179. Circulation (2005) 0.88