Published in Mol Cell on October 28, 2005
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Chromatin-mediated epigenetic regulation in the malaria parasite Plasmodium falciparum. Eukaryot Cell (2010) 1.26
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The histone modifications governing TFF1 transcription mediated by estrogen receptor. J Biol Chem (2011) 1.10
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Rho family Guanine nucleotide exchange factor Brx couples extracellular signals to the glucocorticoid signaling system. J Biol Chem (2006) 0.99
Functional and physical interactions between yeast 14-3-3 proteins, acetyltransferases, and deacetylases in response to DNA replication perturbations. Mol Cell Biol (2007) 0.99
Telomeres, histone code, and DNA damage response. Cytogenet Genome Res (2009) 0.98
Sensing core histone phosphorylation - a matter of perfect timing. Biochim Biophys Acta (2014) 0.94
Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation. Adv Immunol (2013) 0.94
The glucocorticoid receptor and the coregulator Brm selectively modulate each other's occupancy and activity in a gene-specific manner. Mol Cell Biol (2011) 0.92
UVB-induced COX-2 expression requires histone H3 phosphorylation at Ser10 and Ser28. Oncogene (2012) 0.90
Direct interaction between scaffolding proteins RACK1 and 14-3-3ζ regulates brain-derived neurotrophic factor (BDNF) transcription. J Biol Chem (2011) 0.88
Histone H3 tails containing dimethylated lysine and adjacent phosphorylated serine modifications adopt a specific conformation during mitosis and meiosis. Mol Cell Biol (2008) 0.86
Phosphorylation of histone H2B serine 32 is linked to cell transformation. J Biol Chem (2011) 0.85
Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer. PLoS One (2012) 0.85
Structural characterization of a unique interface between carbohydrate response element-binding protein (ChREBP) and 14-3-3β protein. J Biol Chem (2012) 0.84
14-3-3 (Bmh) proteins regulate combinatorial transcription following RNA polymerase II recruitment by binding at Adr1-dependent promoters in Saccharomyces cerevisiae. Mol Cell Biol (2012) 0.83
Structural role of RKS motifs in chromatin interactions: a molecular dynamics study of HP1 bound to a variably modified histone tail. Biophys J (2012) 0.83
Comprehensive histone phosphorylation analysis and identification of Pf14-3-3 protein as a histone H3 phosphorylation reader in malaria parasites. PLoS One (2013) 0.83
The WD40-repeat protein Pwp1p associates in vivo with 25S ribosomal chromatin in a histone H4 tail-dependent manner. Nucleic Acids Res (2006) 0.83
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Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene. Biochim Biophys Acta (2015) 0.80
Epigenetics and chromatin remodeling in adult cardiomyopathy. J Pathol (2013) 0.80
Greater Than the Sum of Parts: Complexity of the Dynamic Epigenome. Mol Cell (2016) 0.80
Specific phosphorylation of histone demethylase KDM3A determines target gene expression in response to heat shock. PLoS Biol (2014) 0.80
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Molecular Modeling of Differentially Phosphorylated Serine 10 and Acetylated lysine 9/14 of Histone H3 Regulates their Interactions with 14-3-3ζ, MSK1, and MKP1. Bioinform Biol Insights (2013) 0.80
Mitogen- and stress-activated protein kinases 1 and 2 are required for maximal trefoil factor 1 induction. PLoS One (2013) 0.79
Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling. PLoS One (2015) 0.79
Mutation of histone H3 serine 86 disrupts GATA factor Ams2 expression and precise chromosome segregation in fission yeast. Sci Rep (2015) 0.78
Identification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis. Nucleic Acids Res (2015) 0.78
Cytomegalovirus latency and reactivation: recent insights into an age old problem. Rev Med Virol (2015) 0.78
Elucidating combinatorial histone modifications and crosstalks by coupling histone-modifying enzyme with biotin ligase activity. Nucleic Acids Res (2012) 0.78
Epigenetic activation of Sox2 gene in the developing vertebrate neural plate. Mol Biol Cell (2016) 0.77
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The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression. Biomol Ther (Seoul) (2014) 0.77
Effects of the activated mitogen-activated protein kinase pathway via the c-ros receptor tyrosine kinase on the T47D breast cancer cell line following alcohol exposure. Oncol Rep (2012) 0.77
Structural genomics of histone tail recognition. Bioinformatics (2010) 0.77
Inhibition of IKKα by BAY61-3606 Reveals IKKα-Dependent Histone H3 Phosphorylation in Human Cytomegalovirus Infected Cells. PLoS One (2016) 0.76
Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Res (2015) 0.76
Interfacing protein lysine acetylation and protein phosphorylation: ancient modifications meet on ancient proteins. Plant Signal Behav (2012) 0.75
Mitogen-induced distinct epi-alleles are phosphorylated at either H3S10 or H3S28 depending on H3K27 acetylation. Mol Biol Cell (2017) 0.75
Protein post-translational modifications: In silico prediction tools and molecular modeling. Comput Struct Biotechnol J (2017) 0.75
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res (2003) 15.74
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell (2003) 7.04
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science (2003) 6.97
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science (2003) 6.88
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
Protein kinase inhibitors: insights into drug design from structure. Science (2004) 4.86
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (2005) 4.75
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature (2008) 4.33
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell (2007) 4.01
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J (2007) 3.81
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell (2006) 3.59
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell (2005) 3.48
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38
Kinetic analysis of epidermal growth factor receptor somatic mutant proteins shows increased sensitivity to the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib. Cancer Res (2006) 3.34
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J (2003) 3.29
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol (2004) 3.26
Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol (2006) 3.18
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol (2002) 2.97
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
Natural-like function in artificial WW domains. Nature (2005) 2.76
Structure and function of Polo-like kinases. Oncogene (2005) 2.72
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (2013) 2.71
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res (2008) 2.62
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Estimating the impact of school closure on social mixing behaviour and the transmission of close contact infections in eight European countries. BMC Infect Dis (2009) 2.54
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J (2007) 2.48
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle (2011) 2.46
MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol (2002) 2.46
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature (2013) 2.46
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol (2006) 2.42
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions. Clin Exp Metastasis (2008) 2.30
Mechanistic biomarkers provide early and sensitive detection of acetaminophen-induced acute liver injury at first presentation to hospital. Hepatology (2013) 2.24
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell (2003) 2.23
The structural basis for control of eukaryotic protein kinases. Annu Rev Biochem (2012) 2.21
A structural basis for 14-3-3sigma functional specificity. J Biol Chem (2005) 2.20
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J (2005) 2.15
Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain. Structure (2003) 2.15
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med (2006) 2.03
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem (2004) 1.98
MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Lett (2003) 1.92
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol (2005) 1.88
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol (2007) 1.86
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84
Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth. Environ Health Perspect (2004) 1.84
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res (2006) 1.80
Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin. Nat Struct Mol Biol (2011) 1.79
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell (2010) 1.78
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78
Architecture of the Dam1 kinetochore ring complex and implications for microtubule-driven assembly and force-coupling mechanisms. Nat Struct Mol Biol (2007) 1.78
TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle (2006) 1.76
Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem (2005) 1.74
Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science (2006) 1.73
Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain. EMBO J (2005) 1.70
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem (2002) 1.67
14-3-3 Proteins--a focus on cancer and human disease. J Mol Cell Cardiol (2004) 1.67
A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Cell Rep (2013) 1.67
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) (2009) 1.66
The structural basis of localization and signaling by the focal adhesion targeting domain. Structure (2002) 1.65
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol (2011) 1.65
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Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Int J Cancer (2013) 1.60
A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev (2006) 1.60
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell (2003) 1.59
Generation of protein lattices by fusing proteins with matching rotational symmetry. Nat Nanotechnol (2011) 1.57
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol (2003) 1.53
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14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A (2012) 1.51
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol (2011) 1.49
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Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle (2009) 1.44
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MAP kinases as structural adaptors and enzymatic activators in transcription complexes. J Cell Sci (2004) 1.38