Published in J Biol Chem on February 24, 2005
AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell (2008) 16.72
The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development. Trends Cell Biol (2008) 3.30
14-3-3 proteins act as intracellular receptors for rice Hd3a florigen. Nature (2011) 2.20
Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A (2006) 1.95
A critical role for phosphatase haplodeficiency in the selective suppression of deletion 5q MDS by lenalidomide. Proc Natl Acad Sci U S A (2009) 1.83
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) (2009) 1.66
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol (2011) 1.65
14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell (2015) 1.63
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62
14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation. EMBO J (2006) 1.40
Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc Natl Acad Sci U S A (2005) 1.36
14-3-3 Proteins: diverse functions in cell proliferation and cancer progression. Semin Cell Dev Biol (2011) 1.31
14-3-3sigma Modulates pancreatic cancer cell survival and invasiveness. Clin Cancer Res (2008) 1.17
An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel. J Biol Chem (2008) 1.12
The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins. J Struct Funct Genomics (2007) 1.07
14-3-3sigma, the double-edged sword of human cancers. Am J Transl Res (2009) 1.07
Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis. BMC Cancer (2010) 1.05
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases. Antioxid Redox Signal (2009) 1.01
Pichia pastoris 14-3-3 regulates transcriptional activity of the methanol inducible transcription factor Mxr1 by direct interaction. Mol Microbiol (2012) 0.98
14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification? Front Plant Sci (2012) 0.97
In vivo functional specificity and homeostasis of Drosophila 14-3-3 proteins. Genetics (2007) 0.96
Microfluidic preparative free-flow isoelectric focusing: system optimization for protein complex separation. Anal Chem (2010) 0.95
14-3-3σ regulates β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β. PLoS One (2012) 0.94
14-3-3sigma controls corneal epithelial cell proliferation and differentiation through the Notch signaling pathway. Biochem Biophys Res Commun (2010) 0.93
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis. Mol Biol Cell (2012) 0.90
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming. Nat Commun (2015) 0.90
Loratadine dysregulates cell cycle progression and enhances the effect of radiation in human tumor cell lines. Radiat Oncol (2010) 0.89
Effects of partner proteins on BCA2 RING ligase activity. BMC Cancer (2012) 0.89
14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis. PLoS One (2011) 0.88
Stratifin (14-3-3 σ) limits plakophilin-3 exchange with the desmosomal plaque. PLoS One (2013) 0.86
Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation. PLoS Comput Biol (2010) 0.85
Structural basis for the 14-3-3 protein-dependent inhibition of the regulator of G protein signaling 3 (RGS3) function. J Biol Chem (2011) 0.85
14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif. DNA Repair (Amst) (2012) 0.85
Scaffold Function of Ca2+-Dependent Protein Kinase: Tobacco Ca2+-DEPENDENT PROTEIN KINASE1 Transfers 14-3-3 to the Substrate REPRESSION OF SHOOT GROWTH after Phosphorylation. Plant Physiol (2014) 0.85
Critical residue that promotes protein dimerization: a story of partially exposed Phe25 in 14-3-3σ. J Chem Inf Model (2011) 0.84
Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. J Biol Chem (2013) 0.84
Factorial combinations of protein interactions generate a multiplicity of florigen activation complexes in wheat and barley. Plant J (2015) 0.84
Exposed loop domains of complexed 14-3-3 proteins contribute to structural diversity and functional specificity. Plant Physiol (2006) 0.84
14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol (2012) 0.83
Mechanism of cancer cell death induced by depletion of an essential replication regulator. PLoS One (2012) 0.83
The application of modular protein domains in proteomics. FEBS Lett (2012) 0.82
14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes. Biochem Biophys Res Commun (2009) 0.82
14-3-3 sigma increases the transcriptional activity of the androgen receptor in the absence of androgens. Cancer Lett (2007) 0.82
Insight into conformational change for 14-3-3σ protein by molecular dynamics simulation. Int J Mol Sci (2014) 0.82
14-3-3σ regulates keratinocyte proliferation and differentiation by modulating Yap1 cellular localization. J Invest Dermatol (2015) 0.81
Revealing the binding modes and the unbinding of 14-3-3σ proteins and inhibitors by computational methods. Sci Rep (2015) 0.80
Genome-wide identification, classification, and expression analysis of 14-3-3 gene family in Populus. PLoS One (2015) 0.80
Determinants of 14-3-3σ protein dimerization and function in drug and radiation resistance. J Biol Chem (2013) 0.80
Specificity of ε and non-ε isoforms of arabidopsis 14-3-3 proteins towards the H+-ATPase and other targets. PLoS One (2014) 0.80
Characterization of 14-3-3 proteins from Cryptosporidium parvum. PLoS One (2011) 0.79
Structural Analysis of the 14-3-3ζ/Chibby Interaction Involved in Wnt/β-Catenin Signaling. PLoS One (2015) 0.79
Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573. PLoS One (2012) 0.79
Interaction of 14-3-3σ with KCMF1 suppresses the proliferation and colony formation of human colon cancer stem cells. World J Gastroenterol (2013) 0.79
PP2A: The Achilles Heal in MDS with 5q Deletion. Front Oncol (2014) 0.79
Genome-Wide Identification and Expression Analysis of the 14-3-3 Family Genes in Medicago truncatula. Front Plant Sci (2016) 0.79
Altered expression of microRNA-451 in eutopic endometrium of baboons (Papio anubis) with endometriosis. Hum Reprod (2015) 0.78
Dual binding of 14-3-3 protein regulates Arabidopsis nitrate reductase activity. J Biol Inorg Chem (2015) 0.77
14-3-3σ Gene Loss Leads to Activation of the Epithelial to Mesenchymal Transition Due to the Stabilization of c-Jun Protein. J Biol Chem (2016) 0.77
Loss of the 14-3-3σ is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway. Sci Rep (2016) 0.76
Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using Limited Proteolysis. J Proteome Res (2016) 0.76
Identification of Novel 14-3-3 Residues That Are Critical for Isoform-specific Interaction with GluN2C to Regulate N-Methyl-D-aspartate (NMDA) Receptor Trafficking. J Biol Chem (2015) 0.76
PAR-5 is a PARty hub in the germline: Multitask proteins in development and disease. Worm (2013) 0.76
A role of TGFß1 dependent 14-3-3σ phosphorylation at Ser69 and Ser74 in the regulation of gene transcription, stemness and radioresistance. PLoS One (2013) 0.75
Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia. Sci Rep (2016) 0.75
Identification of 14-3-3 Proteins Phosphopeptide-Binding Specificity Using an Affinity-Based Computational Approach. PLoS One (2016) 0.75
Retrospective Proteomic Screening of 100 Breast Cancer Tissues. Proteomes (2017) 0.75
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res (2003) 15.74
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell (2003) 7.04
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science (2003) 6.97
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science (2003) 6.88
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (2005) 4.75
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature (2008) 4.33
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell (2007) 4.01
Sculpting the proteome with AAA(+) proteases and disassembly machines. Cell (2004) 3.83
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell (2005) 3.48
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol (2004) 3.26
Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol (2006) 3.18
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol (2002) 2.97
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
Natural-like function in artificial WW domains. Nature (2005) 2.76
Structure and function of Polo-like kinases. Oncogene (2005) 2.72
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (2013) 2.71
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J (2007) 2.48
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle (2011) 2.46
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature (2013) 2.46
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol (2006) 2.42
Allosteric activation of DegS, a stress sensor PDZ protease. Cell (2007) 2.32
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell (2003) 2.23
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J (2005) 2.15
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell (2005) 2.10
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med (2006) 2.03
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem (2004) 1.98
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol (2005) 1.88
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol (2007) 1.86
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res (2006) 1.80
Specificity versus stability in computational protein design. Proc Natl Acad Sci U S A (2005) 1.80
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell (2010) 1.78
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78
TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle (2006) 1.76
Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem (2005) 1.74
Polo-like kinase Cdc5 controls the local activation of Rho1 to promote cytokinesis. Science (2006) 1.73
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem (2002) 1.67
14-3-3 Proteins--a focus on cancer and human disease. J Mol Cell Cardiol (2004) 1.67
A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Cell Rep (2013) 1.67
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) (2009) 1.66
Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell (2008) 1.65
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol (2011) 1.65
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics (2003) 1.61
A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev (2006) 1.60
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell (2003) 1.59
Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag. Mol Cell (2003) 1.57
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol (2003) 1.53
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A (2012) 1.51
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol (2011) 1.49
Computational approaches for analyzing information flow in biological networks. Sci Signal (2012) 1.49
Nucleotide-dependent substrate handoff from the SspB adaptor to the AAA+ ClpXP protease. Mol Cell (2004) 1.48
Exploiting synthetic lethal interactions for targeted cancer therapy. Cell Cycle (2009) 1.44
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
The rhoptry proteins ROP18 and ROP5 mediate Toxoplasma gondii evasion of the murine, but not the human, interferon-gamma response. PLoS Pathog (2012) 1.41
Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A (2009) 1.37
Determinants of BH3 binding specificity for Mcl-1 versus Bcl-xL. J Mol Biol (2010) 1.37
The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36
A synthetic coiled-coil interactome provides heterospecific modules for molecular engineering. J Am Chem Soc (2010) 1.32
Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal (2011) 1.31
Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2. Cancer Res (2008) 1.31
Crystal structure of the catalytic core of an RNA-polymerase ribozyme. Science (2009) 1.27
Caged phosphopeptides reveal a temporal role for 14-3-3 in G1 arrest and S-phase checkpoint function. Nat Biotechnol (2004) 1.26
Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes. Protein Sci (2010) 1.24
The Polo-box domain: a molecular integrator of mitotic kinase cascades and Polo-like kinase function. Cell Cycle (2004) 1.23
Fluorescent caged phosphoserine peptides as probes to investigate phosphorylation-dependent protein associations. J Am Chem Soc (2003) 1.22
Versatile modes of peptide recognition by the AAA+ adaptor protein SspB. Nat Struct Mol Biol (2005) 1.22
Functional dynamics of Polo-like kinase 1 at the centrosome. Mol Cell Biol (2009) 1.21
Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress. Mol Syst Biol (2012) 1.20
SIRT1 shows no substrate specificity in vitro. J Biol Chem (2005) 1.20
Identification of high affinity polo-like kinase 1 (Plk1) polo-box domain binding peptides using oxime-based diversification. ACS Chem Biol (2012) 1.16
Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res (2010) 1.16
Structural and functional analysis of phosphothreonine-dependent FHA domain interactions. Structure (2010) 1.13
PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies. Mol Cell Proteomics (2010) 1.13
Distinct ligand-dependent roles for p38 MAPK in priming and activation of the neutrophil NADPH oxidase. J Biol Chem (2004) 1.12
Quantitative phospho-proteomics to investigate the polo-like kinase 1-dependent phospho-proteome. Mol Cell Proteomics (2011) 1.11
Phosphatidylinositol 3-phosphate-dependent and -independent functions of p40phox in activation of the neutrophil NADPH oxidase. J Biol Chem (2007) 1.09
TAZ as a novel enhancer of MyoD-mediated myogenic differentiation. FASEB J (2010) 1.09
Is post-transcriptional stabilization, splicing and translation of selective mRNAs a key to the DNA damage response? Cell Cycle (2011) 1.08
14-3-3 family members act coordinately to regulate mitotic progression. Cell Cycle (2004) 1.06
OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism. Structure (2009) 1.06