Published in Science on June 08, 2006
Polo-like kinases: conservation and divergence in their functions and regulation. Nat Rev Mol Cell Biol (2009) 4.09
Unleashing formins to remodel the actin and microtubule cytoskeletons. Nat Rev Mol Cell Biol (2009) 3.45
Function and regulation in MAPK signaling pathways: lessons learned from the yeast Saccharomyces cerevisiae. Biochim Biophys Acta (2007) 3.07
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J (2007) 2.48
Regulation of cell wall biogenesis in Saccharomyces cerevisiae: the cell wall integrity signaling pathway. Genetics (2011) 2.47
Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci U S A (2007) 2.37
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78
Predicting protein post-translational modifications using meta-analysis of proteome scale data sets. Mol Cell Proteomics (2008) 1.76
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. PLoS One (2007) 1.53
Yeast formins Bni1 and Bnr1 utilize different modes of cortical interaction during the assembly of actin cables. Mol Biol Cell (2007) 1.46
Cell polarization and cytokinesis in budding yeast. Genetics (2012) 1.45
A coupled chemical-genetic and bioinformatic approach to Polo-like kinase pathway exploration. Chem Biol (2007) 1.42
Actin depolymerization drives actomyosin ring contraction during budding yeast cytokinesis. Dev Cell (2012) 1.41
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev (2009) 1.34
Morphogenesis and the cell cycle. Genetics (2012) 1.29
Mechanisms for concentrating Rho1 during cytokinesis. Genes Dev (2009) 1.28
Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. J Cell Biol (2009) 1.21
Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast. EMBO J (2007) 1.20
Recruitment of Polo kinase to the spindle midzone during cytokinesis requires the Feo/Klp3A complex. PLoS One (2007) 1.12
Mitotic exit and separation of mother and daughter cells. Genetics (2012) 1.10
Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis. Genes Dev (2011) 1.09
The Rho1 GTPase acts together with a vacuolar glutathione S-conjugate transporter to protect yeast cells from oxidative stress. Genetics (2011) 1.08
The yeast Tor signaling pathway is involved in G2/M transition via polo-kinase. PLoS One (2008) 1.06
Polo-like kinase 1 is involved in invasion through extracellular matrix. Cancer Res (2007) 1.05
Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes. J Biol Chem (2010) 1.04
Polo-like kinase 1 is overexpressed in colorectal cancer and participates in the migration and invasion of colorectal cancer cells. Med Sci Monit (2012) 1.01
Inhibition of Cdc42 during mitotic exit is required for cytokinesis. J Cell Biol (2013) 0.98
Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis. Mol Biol Cell (2012) 0.98
The anaphase-promoting complex promotes actomyosin-ring disassembly during cytokinesis in yeast. Mol Biol Cell (2008) 0.96
Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis. J Cell Biol (2013) 0.95
Immobile myosin-II plays a scaffolding role during cytokinesis in budding yeast. J Cell Biol (2013) 0.94
The synthetic genetic network around PKC1 identifies novel modulators and components of protein kinase C signaling in Saccharomyces cerevisiae. Eukaryot Cell (2008) 0.94
G1/S cyclin-dependent kinase regulates small GTPase Rho1p through phosphorylation of RhoGEF Tus1p in Saccharomyces cerevisiae. Mol Biol Cell (2008) 0.93
Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability. Proc Natl Acad Sci U S A (2011) 0.92
Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction. J Biol Chem (2010) 0.91
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2. Proc Natl Acad Sci U S A (2012) 0.91
Regulation of the formin Bnr1 by septins anda MARK/Par1-family septin-associated kinase. Mol Biol Cell (2012) 0.89
A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity. PLoS Biol (2013) 0.89
Rho signaling participates in membrane fluidity homeostasis. PLoS One (2012) 0.87
Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis. Mol Biol Cell (2013) 0.87
The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth. EMBO J (2012) 0.85
PTEN regulates PLK1 and controls chromosomal stability during cell division. Cell Cycle (2016) 0.85
Single cells (put a ring on it). Genes Dev (2009) 0.81
Inferring a transcriptional regulatory network of the cytokinesis-related genes by network component analysis. BMC Syst Biol (2009) 0.81
Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis. Mol Cell Proteomics (2013) 0.81
Rho1- and Pkc1-dependent phosphorylation of the F-BAR protein Syp1 contributes to septin ring assembly. Mol Biol Cell (2015) 0.81
The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis. Mol Biol Cell (2014) 0.80
Phosphorylation of Cdc5 regulates its accumulation. Cell Div (2011) 0.79
Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. BMC Genomics (2008) 0.79
Analysis of biophysical and functional consequences of tropomyosin-fluorescent protein fusions. FEBS Lett (2016) 0.79
The budding yeast Polo-like kinase Cdc5 is released from the nucleus during anaphase for timely mitotic exit. Cell Cycle (2014) 0.78
The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast. J Biol Chem (2014) 0.77
Actomyosin ring driven cytokinesis in budding yeast. Semin Cell Dev Biol (2016) 0.77
Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling. Eukaryot Cell (2008) 0.76
Zds1/Zds2-PP2ACdc55 complex specifies signaling output from Rho1 GTPase. J Cell Biol (2016) 0.76
The final cut: cell polarity meets cytokinesis at the bud neck in S. cerevisiae. Cell Mol Life Sci (2016) 0.76
Septin-Associated Protein Kinases in the Yeast Saccharomyces cerevisiae. Front Cell Dev Biol (2016) 0.75
Cell cycle-dependent phosphorylation of Sec4p controls membrane deposition during cytokinesis. J Cell Biol (2016) 0.75
The budding yeast amphiphysin complex is required for contractile actin ring (CAR) assembly and post-contraction GEF-independent accumulation of Rho1-GTP. PLoS One (2014) 0.75
Timing it right: precise ON/OFF switches for Rho1 and Cdc42 GTPases in cytokinesis. J Cell Biol (2013) 0.75
Phosphorylation and dephosphorylation regulate APC/C(Cdh1) substrate degradation. Cell Cycle (2015) 0.75
The budding yeast Polo-like kinase localizes to distinct populations at centrosomes during mitosis. Mol Biol Cell (2017) 0.75
PP1-Dependent Formin Bnr1 Dephosphorylation and Delocalization from a Cell Division Site. PLoS One (2016) 0.75
Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res (2003) 15.74
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
A mechanism linking extra centrosomes to chromosomal instability. Nature (2009) 9.45
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 8.71
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39
The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell (2003) 7.04
Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science (2003) 6.97
Systematic discovery of in vivo phosphorylation networks. Cell (2007) 6.94
BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science (2003) 6.88
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature (2005) 6.86
The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science (2011) 6.75
Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
DNA breaks and chromosome pulverization from errors in mitosis. Nature (2012) 5.19
Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev (2007) 4.96
A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science (2005) 4.75
From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol (2004) 4.72
An actin nucleation mechanism mediated by Bni1 and profilin. Nat Cell Biol (2002) 4.52
Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell (2010) 4.37
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature (2008) 4.33
Causes and consequences of aneuploidy in cancer. Nat Rev Genet (2012) 4.08
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell (2007) 4.01
Yeast formins regulate cell polarity by controlling the assembly of actin cables. Nat Cell Biol (2002) 3.81
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev (2008) 3.79
Linear motif atlas for phosphorylation-dependent signaling. Sci Signal (2008) 3.77
Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture. Cell (2004) 3.51
MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell (2005) 3.48
TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal. Nat Cell Biol (2008) 3.44
Plus end-specific depolymerase activity of Kip3, a kinesin-8 protein, explains its role in positioning the yeast mitotic spindle. Nat Cell Biol (2006) 3.39
Formin-2, polyploidy, hypofertility and positioning of the meiotic spindle in mouse oocytes. Nat Cell Biol (2002) 3.34
Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer. Nat Struct Mol Biol (2004) 3.26
Data-driven modelling of signal-transduction networks. Nat Rev Mol Cell Biol (2006) 3.18
Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol (2009) 3.15
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell (2011) 2.99
14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature (2007) 2.98
14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol (2002) 2.97
Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell (2004) 2.96
Genome-wide genetic analysis of polyploidy in yeast. Nature (2006) 2.85
A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Mol Biol Cell (2003) 2.77
Natural-like function in artificial WW domains. Nature (2005) 2.76
Structure and function of Polo-like kinases. Oncogene (2005) 2.72
mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin. Science (2013) 2.71
NetworKIN: a resource for exploring cellular phosphorylation networks. Nucleic Acids Res (2007) 2.69
Surfing on microtubule ends. Trends Cell Biol (2003) 2.61
Cell cycle control of kinesin-mediated transport of Bik1 (CLIP-170) regulates microtubule stability and dynein activation. Dev Cell (2004) 2.60
Determinants of S. cerevisiae dynein localization and activation: implications for the mechanism of spindle positioning. Curr Biol (2003) 2.56
The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev (2009) 2.56
Proteomic screen defines the Polo-box domain interactome and identifies Rock2 as a Plk1 substrate. EMBO J (2007) 2.48
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle (2011) 2.46
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. Nature (2013) 2.46
Centrosomes and cilia in human disease. Trends Genet (2011) 2.42
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol (2006) 2.42
The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins. J Cell Biol (2003) 2.39
Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat Chem Biol (2010) 2.26
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell (2003) 2.23
A structural basis for 14-3-3sigma functional specificity. J Biol Chem (2005) 2.20
The transcriptional co-activator TAZ interacts differentially with transcriptional enhancer factor-1 (TEF-1) family members. Biochem J (2005) 2.15
Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell (2005) 2.10
The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. J Exp Med (2006) 2.03
Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Mol Cell (2002) 1.99
TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J Biol Chem (2004) 1.98
Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem (2004) 1.97
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol (2010) 1.90
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol (2005) 1.88
TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol Cell Biol (2007) 1.86
Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1. Nat Struct Mol Biol (2009) 1.84
ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res (2006) 1.80
DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol Cell (2010) 1.78
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. PLoS Biol (2009) 1.78
TAZ: a beta-catenin-like molecule that regulates mesenchymal stem cell differentiation. Cell Cycle (2006) 1.76
Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae. Nat Cell Biol (2004) 1.75
Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. BMC Biochem (2005) 1.74
Limiting the proliferation of polyploid cells. Cell (2007) 1.72
Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. J Biol Chem (2002) 1.67
A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivo. Cell Rep (2013) 1.67
14-3-3 Proteins--a focus on cancer and human disease. J Mol Cell Cardiol (2004) 1.67
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response. DNA Repair (Amst) (2009) 1.66
Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell (2008) 1.65
14-3-3 proteins as signaling integration points for cell cycle control and apoptosis. Semin Cell Dev Biol (2011) 1.65
Spatial exclusivity combined with positive and negative selection of phosphorylation motifs is the basis for context-dependent mitotic signaling. Sci Signal (2011) 1.62
Phospho-Ser/Thr-binding domains: navigating the cell cycle and DNA damage response. Nat Rev Mol Cell Biol (2013) 1.62
A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics (2003) 1.61
Chromothripsis and beyond: rapid genome evolution from complex chromosomal rearrangements. Genes Dev (2013) 1.61
Genetic complexity and quantitative trait loci mapping of yeast morphological traits. PLoS Genet (2007) 1.61
A positive feedback loop couples Ras activation and CD44 alternative splicing. Genes Dev (2006) 1.60
A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase. Mol Cell (2003) 1.59
A little CIN may cost a lot: revisiting aneuploidy and cancer. Curr Opin Genet Dev (2009) 1.57
Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics (2002) 1.57
Proteomic identification of 14-3-3zeta as a mitogen-activated protein kinase-activated protein kinase 2 substrate: role in dimer formation and ligand binding. Mol Cell Biol (2003) 1.53
Centrosomes and cancer: how cancer cells divide with too many centrosomes. Cancer Metastasis Rev (2009) 1.52
14-3-3 fusion oncogenes in high-grade endometrial stromal sarcoma. Proc Natl Acad Sci U S A (2012) 1.51
Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8. Mol Cell (2011) 1.51
Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel. Nat Chem Biol (2011) 1.49