Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation.

PubWeight™: 3.81‹?› | Rank: Top 1%

🔗 View Article (PMC 2168397)

Published in EMBO J on December 20, 2007

Authors

John W Edmunds1, Louis C Mahadevan, Alison L Clayton

Author Affiliations

1: Nuclear Signalling Laboratory, Department of Biochemistry, Oxford University, Oxford, UK.

Articles citing this

(truncated to the top 100)

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature (2012) 10.99

Chromatin organization marks exon-intron structure. Nat Struct Mol Biol (2009) 5.90

Nucleosomes are well positioned in exons and carry characteristic histone modifications. Genome Res (2009) 3.95

Understanding the language of Lys36 methylation at histone H3. Nat Rev Mol Cell Biol (2012) 3.52

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. EMBO J (2010) 3.25

The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem (2010) 3.03

Neuronal cell depolarization induces intragenic chromatin modifications affecting NCAM alternative splicing. Proc Natl Acad Sci U S A (2009) 2.94

The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα. Cell (2013) 2.87

CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell (2010) 2.86

Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nat Cell Biol (2011) 2.85

Modeling gene expression using chromatin features in various cellular contexts. Genome Biol (2012) 2.76

The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev (2012) 2.55

The multi-tasking P-TEFb complex. Curr Opin Cell Biol (2008) 2.53

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell (2011) 2.27

ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature (2014) 2.24

Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol (2010) 2.20

KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature (2013) 2.17

Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol (2012) 2.12

The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev (2008) 2.10

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem (2009) 2.06

Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet (2014) 1.94

Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription. J Biol Chem (2009) 1.94

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. Nat Struct Mol Biol (2014) 1.89

Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36. Nat Struct Mol Biol (2011) 1.85

Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell (2010) 1.73

Pre-mRNA splicing is a determinant of histone H3K36 methylation. Proc Natl Acad Sci U S A (2011) 1.66

Molecular genetics of clear-cell renal cell carcinoma. J Clin Oncol (2014) 1.65

SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene (2015) 1.65

SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep (2014) 1.57

Dynamic changes in histone modifications precede de novo DNA methylation in oocytes. Genes Dev (2015) 1.56

Regulation of primary response genes. Mol Cell (2011) 1.56

Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol (2013) 1.54

Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing. EMBO J (2010) 1.53

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Genes Dev (2014) 1.53

Chromatin regulatory mechanisms in pluripotency. Annu Rev Cell Dev Biol (2010) 1.51

Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PLoS One (2011) 1.50

Dynamic protein methylation in chromatin biology. Cell Mol Life Sci (2009) 1.48

Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell (2016) 1.44

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation. Genes Dev (2012) 1.43

A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nat Methods (2017) 1.40

Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase. Mol Cell (2008) 1.38

Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes. PLoS One (2011) 1.34

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. Elife (2014) 1.33

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. Genome Res (2013) 1.31

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30

Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. J Biol Chem (2009) 1.28

Epigenetic inactivation of the Sotos overgrowth syndrome gene histone methyltransferase NSD1 in human neuroblastoma and glioma. Proc Natl Acad Sci U S A (2009) 1.27

Understanding the relationship between DNA methylation and histone lysine methylation. Biochim Biophys Acta (2014) 1.23

SET for life: biochemical activities and biological functions of SET domain-containing proteins. Trends Biochem Sci (2013) 1.22

The mRNA expression of SETD2 in human breast cancer: correlation with clinico-pathological parameters. BMC Cancer (2009) 1.20

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2. J Am Chem Soc (2012) 1.17

Defining the chromatin signature of inducible genes in T cells. Genome Biol (2009) 1.15

Balancing histone methylation activities in psychiatric disorders. Trends Mol Med (2011) 1.14

Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin. Genome Res (2011) 1.13

Targeting Huntington's disease through histone deacetylases. Clin Epigenetics (2011) 1.13

A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice. Nat Commun (2014) 1.12

Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. Nucleic Acids Res (2013) 1.12

Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc Natl Acad Sci U S A (2010) 1.11

The histone modifications governing TFF1 transcription mediated by estrogen receptor. J Biol Chem (2011) 1.10

Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels. Mol Syst Biol (2012) 1.10

Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function. Proc Natl Acad Sci U S A (2010) 1.09

The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol (2014) 1.07

Histone H3.3 mutations: a variant path to cancer. Cancer Cell (2013) 1.07

Metnase/SETMAR: a domesticated primate transposase that enhances DNA repair, replication, and decatenation. Genetica (2010) 1.06

The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA. Retrovirology (2015) 1.06

Epigenetic control of immunity. Cold Spring Harb Perspect Biol (2014) 1.05

BS69/ZMYND11 reads and connects histone H3.3 lysine 36 trimethylation-decorated chromatin to regulated pre-mRNA processing. Mol Cell (2014) 1.04

Cooperation and antagonism among cancer genes: the renal cancer paradigm. Cancer Res (2013) 1.04

A novel mammalian complex containing Sin3B mitigates histone acetylation and RNA polymerase II progression within transcribed loci. Mol Cell Biol (2010) 1.03

CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin. FEBS J (2009) 1.01

High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma. Oncogene (2015) 1.01

Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate. Genome Res (2014) 0.98

Driver mutations of cancer epigenomes. Protein Cell (2014) 0.98

miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma. Oncotarget (2015) 0.93

Epigenetic modifications are associated with inter-species gene expression variation in primates. Genome Biol (2014) 0.90

WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. EMBO J (2013) 0.89

Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein. J Biol Chem (2014) 0.89

Determinants of expression variability. Nucleic Acids Res (2014) 0.89

Neuroprotective effects of psychotropic drugs in Huntington's disease. Int J Mol Sci (2013) 0.88

Fibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors. J Biol Chem (2012) 0.87

Epigenetic control on cell fate choice in neural stem cells. Protein Cell (2012) 0.87

Cfp1 is required for gene expression-dependent H3K4 trimethylation and H3K9 acetylation in embryonic stem cells. Genome Biol (2014) 0.87

Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span. Genes Dev (2015) 0.87

An open and shut case for the role of NSD proteins as oncogenes. Transcription (2011) 0.86

Noncoding RNAs of the Ultrabithorax domain of the Drosophila bithorax complex. Genetics (2013) 0.86

Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1). Epigenetics Chromatin (2010) 0.86

Type II enteropathy-associated T-cell lymphoma features a unique genomic profile with highly recurrent SETD2 alterations. Nat Commun (2016) 0.85

Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem (2012) 0.85

Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes. PLoS One (2014) 0.85

The chromatin architectural proteins HMGD1 and H1 bind reciprocally and have opposite effects on chromatin structure and gene regulation. BMC Genomics (2014) 0.85

The Genetic Basis of Hepatosplenic T-cell Lymphoma. Cancer Discov (2017) 0.84

A Multidisciplinary Biospecimen Bank of Renal Cell Carcinomas Compatible with Discovery Platforms at Mayo Clinic, Scottsdale, Arizona. PLoS One (2015) 0.83

Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases. J Biol Chem (2013) 0.83

Dysregulation of protein methyltransferases in human cancer: An emerging target class for anticancer therapy. Cancer Sci (2016) 0.82

The histone demethylase Jhdm1a regulates hepatic gluconeogenesis. PLoS Genet (2012) 0.82

Regulation of primary response genes in B cells. J Biol Chem (2013) 0.82

Histone methyltransferases: novel targets for tumor and developmental defects. Am J Transl Res (2015) 0.82

DNA double strand break repair pathway choice: a chromatin based decision? Nucleus (2015) 0.81

Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. Nucleic Acids Res (2012) 0.81

Articles cited by this

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

Chromatin modifications and their function. Cell (2007) 55.98

The role of chromatin during transcription. Cell (2007) 26.48

A chromatin landmark and transcription initiation at most promoters in human cells. Cell (2007) 23.41

Genomic maps and comparative analysis of histone modifications in human and mouse. Cell (2005) 18.96

The mammalian epigenome. Cell (2007) 18.13

The complex language of chromatin regulation during transcription. Nature (2007) 16.97

Genome-wide map of nucleosome acetylation and methylation in yeast. Cell (2005) 15.08

Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity. Mol Cell (2003) 11.78

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell (2005) 10.68

Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. Genes Dev (2000) 10.64

Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73

Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17

Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nat Cell Biol (2003) 8.82

Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression. Annu Rev Biochem (2006) 8.66

MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes Dev (2004) 7.57

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Cell (2005) 7.21

Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol (2003) 6.79

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell (2002) 6.72

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Genes Dev (2001) 6.28

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. Mol Cell (2004) 6.08

Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation. Mol Cell (2000) 5.79

Global and Hox-specific roles for the MLL1 methyltransferase. Proc Natl Acad Sci U S A (2005) 5.53

Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42

Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol (2006) 5.01

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Genes Dev (2003) 4.93

Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem (2005) 4.78

Eaf3 chromodomain interaction with methylated H3-K36 links histone deacetylation to Pol II elongation. Mol Cell (2005) 4.77

A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Nature (2005) 4.70

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A (2004) 4.39

COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem (2002) 4.05

Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide. Mol Cell Biol (2005) 3.83

Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol (2005) 3.79

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation. J Biol Chem (2002) 3.70

Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell (2006) 3.59

Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation. EMBO J (2000) 3.35

Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell (2005) 2.97

MLL associates specifically with a subset of transcriptionally active target genes. Proc Natl Acad Sci U S A (2005) 2.87

Histone modifications defining active genes persist after transcriptional and mitotic inactivation. EMBO J (2004) 2.86

Transcriptional elongation by RNA polymerase II and histone methylation. J Biol Chem (2003) 2.76

NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J (2003) 2.72

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem (2005) 2.68

MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol (2002) 2.46

Increased Ser-10 phosphorylation of histone H3 in mitogen-stimulated and oncogene-transformed mouse fibroblasts. J Biol Chem (1999) 2.24

The histone 3 lysine 36 methyltransferase, SET2, is involved in transcriptional elongation. Nucleic Acids Res (2003) 2.20

Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. EMBO J (2007) 2.19

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell (2005) 2.10

Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex. Mol Cancer (2006) 2.09

Proline isomerization of histone H3 regulates lysine methylation and gene expression. Cell (2006) 1.93

MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Lett (2003) 1.92

Independent dynamic regulation of histone phosphorylation and acetylation during immediate-early gene induction. Mol Cell (2001) 1.78

Mitogen-stimulated phosphorylation of histone H3 is targeted to a small hyperacetylation-sensitive fraction. Proc Natl Acad Sci U S A (1994) 1.63

Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z. J Biol Chem (2005) 1.56

Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55

MAP kinase-mediated signalling to nucleosomes and immediate-early gene induction. Semin Cell Dev Biol (1999) 1.54

Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. PLoS Biol (2005) 1.53

Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell (2005) 1.50

Cdk9 is an essential kinase in Drosophila that is required for heat shock gene expression, histone methylation and elongation factor recruitment. Mol Genet Genomics (2006) 1.42

Sequence requirements for premature transcription arrest within the first intron of the mouse c-fos gene. Mol Cell Biol (1991) 1.36

The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2. Mol Cell Biol (2006) 1.35

Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain. J Biol Chem (2003) 1.31

Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription. J Virol (2004) 1.30

Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. Eukaryot Cell (2005) 1.29

Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction. J Cell Sci (1995) 1.25

Effects of the inhibition of p38/RK MAP kinase on induction of five fos and jun genes by diverse stimuli. Oncogene (1997) 1.13

Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol Cell (2004) 1.11

A novel calcium signaling pathway targets the c-fos intragenic transcriptional pausing site. J Biol Chem (1999) 0.89

Articles by these authors

Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell (2006) 3.59

Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol (2010) 3.38

MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J (2003) 3.29

MAPK-regulated transcription: a continuously variable gene switch? Nat Rev Mol Cell Biol (2002) 2.46

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell (2005) 2.10

MAP kinase-mediated phosphoacetylation of histone H3 and inducible gene regulation. FEBS Lett (2003) 1.92

Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun. PLoS Biol (2005) 1.53

MAP kinases as structural adaptors and enzymatic activators in transcription complexes. J Cell Sci (2004) 1.38

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP. Proc Natl Acad Sci U S A (2011) 1.30

MAP kinase-mediated phosphorylation of distinct pools of histone H3 at S10 or S28 via mitogen- and stress-activated kinase 1/2. J Cell Sci (2005) 1.29

Stability of histone modifications across mammalian genomes: implications for 'epigenetic' marking. J Cell Biochem (2009) 1.18

Cell signaling. Protein kinases seek close encounters with active genes. Science (2006) 1.18

Distinct stimulus-specific histone modifications at hsp70 chromatin targeted by the transcription factor heat shock factor-1. Mol Cell (2004) 1.11

Phosphorylation and acetylation of histone H3 at inducible genes: two controversies revisited. Novartis Found Symp (2004) 0.92

Signalling to chromatin through post-translational modifications of HMGN. Biochim Biophys Acta (2009) 0.88

Heat shock, histone H3 phosphorylation and the cell cycle. Cell Cycle (2005) 0.86

Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem (2012) 0.85

Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. Nucleic Acids Res (2012) 0.81