Published in J Am Chem Soc on January 01, 2008
The potential and challenges of nanopore sequencing. Nat Biotechnol (2008) 14.24
Continuous base identification for single-molecule nanopore DNA sequencing. Nat Nanotechnol (2009) 8.09
Nanopores: A journey towards DNA sequencing. Phys Life Rev (2012) 5.89
Nanopore sensors for nucleic acid analysis. Nat Nanotechnol (2011) 4.19
Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore. Proc Natl Acad Sci U S A (2009) 3.74
Single-molecule DNA detection with an engineered MspA protein nanopore. Proc Natl Acad Sci U S A (2008) 2.91
Electronic control of DNA polymerase binding and unbinding to single DNA molecules. ACS Nano (2009) 2.41
Processive replication of single DNA molecules in a nanopore catalyzed by phi29 DNA polymerase. J Am Chem Soc (2010) 2.36
Replication of individual DNA molecules under electronic control using a protein nanopore. Nat Nanotechnol (2010) 2.33
Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge. Proc Natl Acad Sci U S A (2008) 2.11
Nucleotide discrimination with DNA immobilized in the MspA nanopore. PLoS One (2011) 1.96
Identification of epigenetic DNA modifications with a protein nanopore. Chem Commun (Camb) (2010) 1.93
Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore. J Am Chem Soc (2012) 1.80
Error rates for nanopore discrimination among cytosine, methylcytosine, and hydroxymethylcytosine along individual DNA strands. Proc Natl Acad Sci U S A (2013) 1.75
Specific nucleotide binding and rebinding to individual DNA polymerase complexes captured on a nanopore. J Am Chem Soc (2009) 1.69
Applications of biological pores in nanomedicine, sensing, and nanoelectronics. Curr Opin Biotechnol (2010) 1.66
Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore. Nano Lett (2010) 1.51
Controlled translocation of individual DNA molecules through protein nanopores with engineered molecular brakes. Nano Lett (2011) 1.42
Multiple base-recognition sites in a biological nanopore: two heads are better than one. Angew Chem Int Ed Engl (2010) 1.41
Controlling molecular transport through nanopores. J R Soc Interface (2011) 1.30
DNA profiling using solid-state nanopores: detection of DNA-binding molecules. Nano Lett (2009) 1.29
Analysis of single nucleic acid molecules with protein nanopores. Methods Enzymol (2010) 1.29
Microscopic mechanics of hairpin DNA translocation through synthetic nanopores. Biophys J (2009) 1.24
Monitoring the escape of DNA from a nanopore using an alternating current signal. J Am Chem Soc (2010) 1.23
Nanopore sequencing: from imagination to reality. Clin Chem (2014) 1.23
Three decades of nanopore sequencing. Nat Biotechnol (2016) 1.21
Recent advances in nanopore sequencing. Electrophoresis (2012) 1.16
Distinct complexes of DNA polymerase I (Klenow fragment) for base and sugar discrimination during nucleotide substrate selection. J Biol Chem (2011) 1.13
Solid-State and Biological Nanopore for Real-Time Sensing of Single Chemical and Sequencing of DNA. Nano Today (2013) 1.13
Single-molecule site-specific detection of protein phosphorylation with a nanopore. Nat Biotechnol (2014) 1.10
Single molecule sensing by nanopores and nanopore devices. Analyst (2009) 1.09
Intelligent medical diagnostics via molecular logic. J Am Chem Soc (2009) 1.09
Urea facilitates the translocation of single-stranded DNA and RNA through the alpha-hemolysin nanopore. Biophys J (2010) 1.08
Individual RNA base recognition in immobilized oligonucleotides using a protein nanopore. Nano Lett (2012) 1.06
Nanopore-based fourth-generation DNA sequencing technology. Genomics Proteomics Bioinformatics (2015) 1.05
Nanopore-based identification of individual nucleotides for direct RNA sequencing. Nano Lett (2013) 1.04
Real-time monitoring of DNA polymerase function and stepwise single-nucleotide DNA strand translocation through a protein nanopore. Angew Chem Int Ed Engl (2010) 1.03
The properties and applications of single-molecule DNA sequencing. Genome Biol (2011) 1.00
DNA translocation and unzipping through a nanopore: some geometrical effects. Biophys J (2010) 1.00
Molecular dynamics study of MspA arginine mutants predicts slow DNA translocations and ion current blockades indicative of DNA sequence. ACS Nano (2012) 0.99
Base-excision repair activity of uracil-DNA glycosylase monitored using the latch zone of α-hemolysin. J Am Chem Soc (2013) 0.98
Direct observation of translocation in individual DNA polymerase complexes. J Biol Chem (2012) 0.98
DNA stretching and optimization of nucleobase recognition in enzymatic nanopore sequencing. Nanotechnology (2015) 0.98
Translocation of single-stranded DNA through the α-hemolysin protein nanopore in acidic solutions. Electrophoresis (2011) 0.95
The evolution of nanopore sequencing. Front Genet (2015) 0.91
High-throughput optical sensing of nucleic acids in a nanopore array. Nat Nanotechnol (2015) 0.89
Single-nanopore investigations with ion conductance microscopy. ACS Nano (2011) 0.89
Incorporation of a viral DNA-packaging motor channel in lipid bilayers for real-time, single-molecule sensing of chemicals and double-stranded DNA. Nat Protoc (2013) 0.88
Challenges in DNA motion control and sequence readout using nanopore devices. Nanotechnology (2015) 0.87
A semi-synthetic ion channel platform for detection of phosphatase and protease activity. ACS Nano (2009) 0.87
Functionalization of imprinted nanopores in nanometer-thin organic materials. Angew Chem Int Ed Engl (2008) 0.87
Flow of DNA in micro/nanofluidics: From fundamentals to applications. Biomicrofluidics (2016) 0.86
Detection of two isomeric binding configurations in a protein-aptamer complex with a biological nanopore. ACS Nano (2014) 0.86
Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel. Isr J Chem (2013) 0.85
Enzyme-modulated DNA translocation through a nanopore. J Am Chem Soc (2009) 0.84
Water Mediates Recognition of DNA Sequence via Ionic Current Blockade in a Biological Nanopore. ACS Nano (2016) 0.84
Translocation of a heterogeneous polymer. J Chem Phys (2012) 0.82
Resistive pulse sensing of magnetic beads and supraparticle structures using tunable pores. Biomicrofluidics (2012) 0.81
Watching single proteins using engineered nanopores. Protein Pept Lett (2014) 0.80
Long dwell-time passage of DNA through nanometer-scale pores: kinetics and sequence dependence of motion. Biophys J (2011) 0.79
The NTD Nanoscope: potential applications and implementations. BMC Bioinformatics (2011) 0.79
Single-molecule nanopore enzymology. Philos Trans R Soc Lond B Biol Sci (2017) 0.79
A Protein Rotaxane Controls the Translocation of Proteins Across a ClyA Nanopore. Nano Lett (2015) 0.78
Stimuli-responsive properties of peptide-based copolymers studied via directional growth of self-assembled patterns on solid substrate. Biomacromolecules (2009) 0.77
Engineering a nanopore with co-chaperonin function. Sci Adv (2015) 0.77
Channel-forming bacterial toxins in biosensing and macromolecule delivery. Toxins (Basel) (2014) 0.77
Progress toward the application of molecular force spectroscopy to DNA sequencing. Electrophoresis (2012) 0.76
Graphene Nanopores for Protein Sequencing. Adv Funct Mater (2016) 0.76
DNA Translocation through Nanopores at Physiological Ionic Strengths Requires Precise Nanoscale Engineering. ACS Nano (2016) 0.76
MspA nanopore as a single-molecule tool: From sequencing to SPRNT. Methods (2016) 0.76
Nanopore-based analysis of biochemical species. Mikrochim Acta (2015) 0.75
Genome sequencing in microfabricated high-density picolitre reactors. Nature (2005) 150.21
Accurate multiplex polony sequencing of an evolved bacterial genome. Science (2005) 20.91
Characterization of individual polynucleotide molecules using a membrane channel. Proc Natl Acad Sci U S A (1996) 18.77
Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science (1996) 16.69
Advanced sequencing technologies: methods and goals. Nat Rev Genet (2004) 9.31
Ten years of tension: single-molecule DNA mechanics. Nature (2003) 7.20
Direct observation of base-pair stepping by RNA polymerase. Nature (2005) 6.29
Rapid discrimination among individual DNA hairpin molecules at single-nucleotide resolution using an ion channel. Nat Biotechnol (2001) 6.07
Sequence information can be obtained from single DNA molecules. Proc Natl Acad Sci U S A (2003) 5.24
Sequence-specific detection of individual DNA strands using engineered nanopores. Nat Biotechnol (2001) 5.14
Initial transcription by RNA polymerase proceeds through a DNA-scrunching mechanism. Science (2006) 4.36
Single-molecule studies of the effect of template tension on T7 DNA polymerase activity. Nature (2000) 3.98
Abortive initiation and productive initiation by RNA polymerase involve DNA scrunching. Science (2006) 3.76
Backtracking by single RNA polymerase molecules observed at near-base-pair resolution. Nature (2003) 3.50
Replication by a single DNA polymerase of a stretched single-stranded DNA. Proc Natl Acad Sci U S A (2000) 3.29
Nanopore unzipping of individual DNA hairpin molecules. Biophys J (2004) 3.25
Detecting protein analytes that modulate transmembrane movement of a polymer chain within a single protein pore. Nat Biotechnol (2000) 3.11
Single-molecule analysis of DNA-protein complexes using nanopores. Nat Methods (2007) 2.99
Recognizing a single base in an individual DNA strand: a step toward DNA sequencing in nanopores. Angew Chem Int Ed Engl (2005) 2.83
Toward single molecule DNA sequencing: direct identification of ribonucleoside and deoxyribonucleoside 5'-monophosphates by using an engineered protein nanopore equipped with a molecular adapter. J Am Chem Soc (2006) 2.68
Differential detection of dual traps improves the spatial resolution of optical tweezers. Proc Natl Acad Sci U S A (2006) 2.48
A nanosensor for transmembrane capture and identification of single nucleic Acid molecules. Biophys J (2004) 2.27
Single-molecule and ensemble fluorescence assays for a functionally important conformational change in T7 DNA polymerase. Proc Natl Acad Sci U S A (2007) 2.06
Sequencing single molecules of DNA. Curr Opin Chem Biol (2006) 1.87
Promoter unwinding and promoter clearance by RNA polymerase: detection by single-molecule DNA nanomanipulation. Proc Natl Acad Sci U S A (2004) 1.81
A new class of homogeneous nucleic acid probes based on specific displacement hybridization. Nucleic Acids Res (2002) 1.76
Single-molecule, motion-based DNA sequencing using RNA polymerase. Science (2006) 1.69
Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl (2004) 1.48
Nanopore sequencing technology: research trends and applications. Trends Biotechnol (2006) 1.24
Single-molecule biology: what is it and how does it work? Mol Cell (2006) 1.22
A genetically encoded pore for the stochastic detection of a protein kinase. Chembiochem (2006) 1.04
Recognizing a single base in an individual DNA strand: a step toward DNA sequencing in nanopores. Angew Chem Int Ed Engl (2005) 2.83
A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2008) 1.48
Single DNA rotaxanes of a transmembrane pore protein. Angew Chem Int Ed Engl (2004) 1.48
Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus. Chem Biol (2011) 1.41
Heterocyclic peptide backbone modifications in an alpha-helical coiled coil. J Am Chem Soc (2004) 1.33
Systemic antibacterial activity of novel synthetic cyclic peptides. Antimicrob Agents Chemother (2005) 1.25
Modular multi-level circuits from immobilized DNA-based logic gates. J Am Chem Soc (2007) 1.23
Carbonyl sulfide-mediated prebiotic formation of peptides. Science (2004) 1.22
Self-assembling sequence-adaptive peptide nucleic acids. Science (2009) 1.21
Coiled coils at the edge of configurational heterogeneity. Structural analyses of parallel and antiparallel homotetrameric coiled coils reveal configurational sensitivity to a single solvent-exposed amino acid substitution. Biochemistry (2006) 1.21
Discovery of a biologically active thiostrepton fragment. J Am Chem Soc (2005) 1.20
A heterocyclic peptide nanotube. J Am Chem Soc (2003) 1.14
Design of a directed molecular network. Proc Natl Acad Sci U S A (2004) 1.13
Boolean logic functions of a synthetic peptide network. J Am Chem Soc (2004) 1.10
DNA-based photonic logic gates: AND, NAND, and INHIBIT. J Am Chem Soc (2003) 1.08
DNA detection and signal amplification via an engineered allosteric enzyme. J Am Chem Soc (2003) 1.08
Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides. Angew Chem Int Ed Engl (2009) 1.08
Real-time monitoring of DNA polymerase function and stepwise single-nucleotide DNA strand translocation through a protein nanopore. Angew Chem Int Ed Engl (2010) 1.03
Automated mass spectrometric sequence determination of cyclic peptide library members. J Comb Chem (2003) 1.02
Design of self-assembling peptide nanotubes with delocalized electronic states. Small (2006) 1.02
Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides. J Med Chem (2009) 1.02
Antiviral cyclic D,L-alpha-peptides: targeting a general biochemical pathway in virus infections. Bioorg Med Chem (2005) 1.02
Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis. J Med Chem (2013) 0.98
Sequence-addressable DNA logic. Small (2008) 0.98
Structure-based engineering of internal cavities in coiled-coil peptides. Biochemistry (2005) 0.97
Mimicry of high-density lipoprotein: functional peptide-lipid nanoparticles based on multivalent peptide constructs. J Am Chem Soc (2013) 0.94
Benign metastasizing leiomyoma: a rare metastatic lesion in the right ventricle. Ann Thorac Surg (2010) 0.94
Ion channel models based on self-assembling cyclic peptide nanotubes. Acc Chem Res (2013) 0.94
Efficient route to C2 symmetric heterocyclic backbone modified cyclic peptides. Org Lett (2005) 0.93
Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood (2006) 0.93
Modulating ion channel properties of transmembrane peptide nanotubes through heteromeric supramolecular assemblies. J Am Chem Soc (2002) 0.92
Importin alpha is an essential nuclear import carrier adaptor required for proper sexual and asexual development and secondary metabolism in Aspergillus nidulans. Fungal Genet Biol (2009) 0.91
Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions. Chembiochem (2008) 0.90
Conformationally homogeneous heterocyclic pseudotetrapeptides as three-dimensional scaffolds for rational drug design: receptor-selective somatostatin analogues. Angew Chem Int Ed Engl (2009) 0.90
Outcome and improvement predictors of mitral regurgitation after transcatheter aortic valve implantation. J Heart Valve Dis (2011) 0.89
Universal translators for nucleic acid diagnosis. J Am Chem Soc (2009) 0.88
Assessment of right ventricular function by real-time three-dimensional echocardiography improves accuracy and decreases interobserver variability compared with conventional two-dimensional views. Eur J Echocardiogr (2009) 0.87
Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis. PLoS One (2012) 0.86
Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures. J Am Chem Soc (2009) 0.86
The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells. Free Radic Biol Med (2012) 0.84
Design of molecular logic devices based on a programmable DNA-regulated semisynthetic enzyme. Angew Chem Int Ed Engl (2007) 0.84
Modulating charge transfer through cyclic D,L-alpha-peptide self-assembly. Chemistry (2005) 0.83
Amino acid dependent formation of phosphate anhydrides in water mediated by carbonyl sulfide. J Am Chem Soc (2006) 0.83
Mitral valve prolapse in Marfan syndrome: an old topic revisited. Echocardiography (2008) 0.83
Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR. ACS Med Chem Lett (2011) 0.82
Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem J (2004) 0.81
Antibacterial cyclic D,L-alpha-glycopeptides. Chem Commun (Camb) (2009) 0.80
The increasing incidence of Streptococcus bovis endocarditis and bacteraemia: a case series from 1997 to 2010. Int J Cardiol (2012) 0.79
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering. J Am Chem Soc (2007) 0.78
Biomimetic catalysis of intermodular aminoacyl transfer. J Am Chem Soc (2007) 0.78
A β-boronopeptide bundle of known structure as a vehicle for polyol recognition. Org Lett (2013) 0.77
Reproducibility and concordance in quantitative ultrasound measurements between densitometers: a comparative study. J Clin Densitom (2003) 0.76
Biomimetic catalysis of diketopiperazine and dipeptide syntheses. Angew Chem Int Ed Engl (2008) 0.75
Membrane-targeted self-assembling cyclic peptide nanotubes. Curr Top Med Chem (2014) 0.75
Human microbiome inspired antibiotics with improved β-lactam synergy against MDR Staphylococcus aureus. ACS Infect Dis (2017) 0.75
Synthesis of photoactive p-azidotetrafluorophenylalanine containing peptide by solid-phase Fmoc methodology. Org Lett (2002) 0.75
Breast implant mimicking pericardial effusion in a cancer patient undergoing gated heart pool radionuclide study. Med J Aust (2007) 0.75
Templated Self-Assembly of Dynamic Peptide Nucleic Acids. Biochemistry (2017) 0.75
Dynamic polythioesters via ring-opening polymerization of 1,4-thiazine-2,5-diones. Org Biomol Chem (2009) 0.75