Published in Neurobiol Aging on November 02, 2005
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury. J Neuroinflammation (2010) 1.40
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
NADPH oxidase as a therapeutic target in Alzheimer's disease. BMC Neurosci (2008) 1.27
The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease. J Neuroinflammation (2006) 1.25
Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP+)-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology (2007) 1.20
NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia. J Cereb Blood Flow Metab (2010) 1.17
Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors. Cell Mol Life Sci (2012) 1.14
Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev (2015) 1.13
NADPH oxidase 1-mediated oxidative stress leads to dopamine neuron death in Parkinson's disease. Antioxid Redox Signal (2012) 1.12
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Pharmacol Sci (2012) 1.08
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiol Aging (2010) 0.97
Oligomeric amyloid β induces IL-1β processing via production of ROS: implication in Alzheimer's disease. Cell Death Dis (2013) 0.96
Revisiting oxidative damage in ALS: microglia, Nox, and mutant SOD1. J Clin Invest (2008) 0.95
Natural compounds as modulators of NADPH oxidases. Oxid Med Cell Longev (2013) 0.94
NADPH oxidase and neurodegeneration. Curr Neuropharmacol (2012) 0.92
Oxidative stress, redox signalling and endothelial dysfunction in ageing-related neurodegenerative diseases: a role of NADPH oxidase 2. Br J Clin Pharmacol (2014) 0.83
NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78
Transcriptional signatures mediated by acetylation overlap with early-stage Alzheimer's disease. Exp Brain Res (2012) 0.76
NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease. Front Cell Neurosci (2017) 0.75
Tuberatolide B Suppresses Cancer Progression by Promoting ROS-Mediated Inhibition of STAT3 Signaling. Mar Drugs (2017) 0.75
Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in Alzheimer's disease and Parkinson's disease. Drug Des Devel Ther (2017) 0.75
Preparation and antioxidant/pro-oxidant activities of 3-monosubstituted 5-hydroxyoxindole derivatives. J Clin Biochem Nutr (2016) 0.75
RAGE-Specific Inhibitor FPS-ZM1 Attenuates AGEs-Induced Neuroinflammation and Oxidative Stress in Rat Primary Microglia. Neurochem Res (2017) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol (2003) 16.63
Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res (2009) 15.15
A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science (2004) 6.62
Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61
The genome of the model beetle and pest Tribolium castaneum. Nature (2008) 6.50
Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4. Nature (2006) 6.28
Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication. J Virol (2007) 4.64
A G protein-coupled receptor is a plasma membrane receptor for the plant hormone abscisic acid. Science (2007) 4.61
RNA-Seq analysis to capture the transcriptome landscape of a single cell. Nat Protoc (2010) 4.35
Limitations and potentials of current motif discovery algorithms. Nucleic Acids Res (2005) 4.28
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Ageing and infection. Lancet Infect Dis (2002) 3.79
Uncovering a macrophage transcriptional program by integrating evidence from motif scanning and expression dynamics. PLoS Comput Biol (2008) 3.02
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
MyD88-dependent immune activation mediated by human immunodeficiency virus type 1-encoded Toll-like receptor ligands. J Virol (2007) 2.77
Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol (2011) 2.75
Cerebrospinal fluid pressure in glaucoma: a prospective study. Ophthalmology (2009) 2.60
HIV-1 adaptation to NK-cell-mediated immune pressure. Nature (2011) 2.59
Tau pathology in Alzheimer disease and other tauopathies. Biochim Biophys Acta (2005) 2.46
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Immune-driven recombination and loss of control after HIV superinfection. J Exp Med (2008) 2.34
Pre-enucleation chemotherapy for eyes severely affected by retinoblastoma masks risk of tumor extension and increases death from metastasis. J Clin Oncol (2011) 2.33
SCLERAL AND CHOROIDAL THICKNESS IN SECONDARY HIGH AXIAL MYOPIA. Retina (2016) 2.28
Pneumonia in the very old. Lancet Infect Dis (2004) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
Viral sequence evolution in acute hepatitis C virus infection. J Virol (2007) 2.13
S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis. Sci Transl Med (2010) 2.13
Serum γ-glutamyltransferase and the risk of heart failure in men and women in Finland. Heart (2012) 2.10
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
The Human Intermediate Filament Database: comprehensive information on a gene family involved in many human diseases. Hum Mutat (2008) 1.97
Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. J Virol (2008) 1.94
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol Aging (2008) 1.89
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Dev Biol (2005) 1.85
HIV-1 DNA/MVA vaccination reduces the per exposure probability of infection during repeated mucosal SHIV challenges. Virology (2006) 1.83
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
Diaqua-1κO,2κO-(2,2'-bi-1H-imidazole-1κN,N)(oxalato-2κO,O)di-μ-oxido-κO:O-dioxido-1κO,2κO-dimolyb-denum(V) trihydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.74
Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma. Langenbecks Arch Surg (2011) 1.72
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells (2009) 1.71
NOX family NADPH oxidases: not just in mammals. Biochimie (2007) 1.68
Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell (2004) 1.67
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A (2008) 1.65
Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry (2009) 1.62
Fast protein tertiary structure retrieval based on global surface shape similarity. Proteins (2008) 1.60
Cerebrospinal fluid pressure in ocular hypertension. Acta Ophthalmol (2011) 1.59
Bis{tris-[3-(2-pyrid-yl)-1H-pyrazole]zinc(II)} dodeca-molybdosilicate hexa-hydrate. Acta Crystallogr Sect E Struct Rep Online (2010) 1.58
Risk factors for intrahepatic cholangiocarcinoma: a case-control study in China. World J Gastroenterol (2008) 1.58
Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol (2005) 1.54
Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system. Neurosci Lett (2009) 1.53
Impact of lymphatic vessel invasion on survival in curative resected gastric cancer. J Gastrointest Surg (2011) 1.52
Hepatitis C virus-induced up-regulation of microRNA-155 promotes hepatocarcinogenesis by activating Wnt signaling. Hepatology (2012) 1.50
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors. Stem Cells (2005) 1.48
A role for orexin in central vestibular motor control. Neuron (2011) 1.48
The yeast eukaryotic initiation factor 4G (eIF4G) HEAT domain interacts with eIF1 and eIF5 and is involved in stringent AUG selection. Mol Cell Biol (2003) 1.46
Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med (2016) 1.46
Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J Biol Chem (2010) 1.45
Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. Hepatology (2007) 1.44
Concurrent MEK2 mutation and BRAF amplification confer resistance to BRAF and MEK inhibitors in melanoma. Cell Rep (2013) 1.43
Meta-analysis of radiofrequency ablation versus hepatic resection for small hepatocellular carcinoma. BMC Gastroenterol (2010) 1.41
The HIV protease inhibitor nelfinavir downregulates Akt phosphorylation by inhibiting proteasomal activity and inducing the unfolded protein response. Neoplasia (2007) 1.40
The functional role of a conserved loop in EAL domain-based cyclic di-GMP-specific phosphodiesterase. J Bacteriol (2009) 1.39
A genome-wide inventory of neurohormone GPCRs in the red flour beetle Tribolium castaneum. Front Neuroendocrinol (2007) 1.38
Complete genome sequence of a novel porcine circovirus-like agent. J Virol (2012) 1.37
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Notch1 regulates the growth of human colon cancers. Cancer (2010) 1.37
Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. Eur J Neurosci (2007) 1.36
Prevalence of porcine circovirus-like agent P1 in Jiangsu, China. Virol J (2011) 1.35
Primary malignant amelanotic melanoma of the female genital tract: report of two cases and review of literature. Melanoma Res (2009) 1.35
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci (2008) 1.34
Reduction of false positives by internal features for polyp detection in CT-based virtual colonoscopy. Med Phys (2005) 1.34
Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci U S A (2006) 1.33
Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing (2007) 1.32
Clinical features of solitary necrotic nodule of the liver. Hepatobiliary Pancreat Dis Int (2008) 1.32
Functional analysis of four neuropeptides, EH, ETH, CCAP and bursicon, and their receptors in adult ecdysis behavior of the red flour beetle, Tribolium castaneum. Mech Dev (2008) 1.31
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.30
Construction of a high-density genetic map based on large-scale markers developed by specific length amplified fragment sequencing (SLAF-seq) and its application to QTL analysis for isoflavone content in Glycine max. BMC Genomics (2014) 1.30
NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension (2007) 1.29
Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production. J Immunol (2007) 1.29
Aging and infectious diseases in the developing world. Clin Infect Dis (2004) 1.29
An improved electronic colon cleansing method for detection of colonic polyps by virtual colonoscopy. IEEE Trans Biomed Eng (2006) 1.28
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol (2005) 1.27