Published in J Neurosci on November 12, 2008
Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain (2009) 7.11
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86
NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury. Brain (2012) 1.82
Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci (2011) 1.64
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal (2014) 1.23
MFG-E8 mediates primary phagocytosis of viable neurons during neuroinflammation. J Neurosci (2012) 1.17
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase. J Biol Chem (2009) 1.15
IRAK-1 contributes to lipopolysaccharide-induced reactive oxygen species generation in macrophages by inducing NOX-1 transcription and Rac1 activation and suppressing the expression of antioxidative enzymes. J Biol Chem (2009) 1.10
Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein. J Neuroimmune Pharmacol (2012) 1.09
NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends Pharmacol Sci (2012) 1.08
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
Role of microglia in neuronal degeneration and regeneration. Semin Immunopathol (2009) 1.06
Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures. Free Radic Biol Med (2012) 1.02
Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters. Int J Mol Sci (2012) 1.02
Delayed inflammatory mRNA and protein expression after spinal cord injury. J Neuroinflammation (2011) 1.01
Isoprenoids, small GTPases and Alzheimer's disease. Biochim Biophys Acta (2010) 0.98
Oxidative stress in genetic mouse models of Parkinson's disease. Oxid Med Cell Longev (2012) 0.98
Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr (2011) 0.94
Motor neuron-immune interactions: the vicious circle of ALS. J Neural Transm (Vienna) (2010) 0.93
Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol (2014) 0.93
Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation (2014) 0.93
Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4. Am J Physiol Cell Physiol (2012) 0.93
Which NADPH oxidase isoform is relevant for ischemic stroke? The case for nox 2. Antioxid Redox Signal (2012) 0.91
Microglial physiopathology: how to explain the dual role of microglia after acute neural disorders? Brain Behav (2012) 0.90
The endotoxin-induced neuroinflammation model of Parkinson's disease. Parkinsons Dis (2011) 0.89
Membrane trafficking of NADPH oxidase p47(phox) in paraventricular hypothalamic neurons parallels local free radical production in angiotensin II slow-pressor hypertension. J Neurosci (2013) 0.88
Sildenafil attenuates inflammation and oxidative stress in pelvic ganglia neurons after bilateral cavernosal nerve damage. Int J Mol Sci (2014) 0.87
Novel neuroinflammatory targets in the chronically injured spinal cord. Neurotherapeutics (2011) 0.87
Inhibition of NOX2 reduces locomotor impairment, inflammation, and oxidative stress after spinal cord injury. J Neuroinflammation (2015) 0.86
Inhibition of NADPH oxidase by apocynin attenuates progression of atherosclerosis. Int J Mol Sci (2013) 0.84
Measurement of reactive oxygen species in the culture media using Acridan Lumigen PS-3 assay. J Biomol Tech (2011) 0.84
Redox regulation of NF-κB p50 and M1 polarization in microglia. Glia (2014) 0.83
Effects of chronic low dose rotenone treatment on human microglial cells. Mol Neurodegener (2009) 0.83
Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-κB. CNS Neurosci Ther (2014) 0.83
Farnesyltransferase haplodeficiency reduces neuropathology and rescues cognitive function in a mouse model of Alzheimer disease. J Biol Chem (2013) 0.82
Reactive oxygen species from human astrocytes induced functional impairment and oxidative damage. Neurochem Res (2013) 0.82
Characterization and inflammatory response of perivascular-resident macrophage-like melanocytes in the vestibular system. J Assoc Res Otolaryngol (2013) 0.82
Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation. Acta Neuropathol (2015) 0.82
A20 deficiency causes spontaneous neuroinflammation in mice. J Neuroinflammation (2014) 0.82
TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ. Proc Natl Acad Sci U S A (2015) 0.82
Methionine sulfoxide reductase A negatively controls microglia-mediated neuroinflammation via inhibiting ROS/MAPKs/NF-κB signaling pathways through a catalytic antioxidant function. Antioxid Redox Signal (2015) 0.81
Dual role of superoxide dismutase 2 induced in activated microglia: oxidative stress tolerance and convergence of inflammatory responses. J Biol Chem (2015) 0.80
NADPH Oxidase as a Therapeutic Target for Neuroprotection against Ischaemic Stroke: Future Perspectives. Brain Sci (2013) 0.79
ROS produced by NOX2 control in vitro development of cerebellar granule neurons development. ASN Neuro (2015) 0.79
Central Nervous System Injury and Nicotinamide Adenine Dinucleotide Phosphate Oxidase: Oxidative Stress and Therapeutic Targets. J Neurotrauma (2016) 0.78
Nox2 knockout delays infarct progression and increases vascular recovery through angiogenesis in mice following ischaemic stroke with reperfusion. PLoS One (2014) 0.78
Pathophysiology of the cochlear intrastrial fluid-blood barrier (review). Hear Res (2016) 0.78
Primary murine microglia are resistant to nitric oxide inhibition of indoleamine 2,3-dioxygenase. Brain Behav Immun (2010) 0.78
NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener (2017) 0.78
Pathophysiology and Treatments of Oxidative Injury in Ischemic Stroke: Focus on the Phagocytic NADPH Oxidase 2. Antioxid Redox Signal (2014) 0.77
The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress. Int J Physiol Pathophysiol Pharmacol (2012) 0.77
Complex molecular and functional outcomes of single versus sequential cytokine stimulation of rat microglia. J Neuroinflammation (2016) 0.77
Protein prenylation and synaptic plasticity: implications for Alzheimer's disease. Mol Neurobiol (2014) 0.77
Dieckol Attenuates Microglia-mediated Neuronal Cell Death via ERK, Akt and NADPH Oxidase-mediated Pathways. Korean J Physiol Pharmacol (2015) 0.77
Microglia toxicity in preterm brain injury. Reprod Toxicol (2014) 0.77
Histamine induces microglia activation and dopaminergic neuronal toxicity via H1 receptor activation. J Neuroinflammation (2016) 0.76
Binding of EBP50 to Nox organizing subunit p47phox is pivotal to cellular reactive species generation and altered vascular phenotype. Proc Natl Acad Sci U S A (2016) 0.75
Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase. Oxid Med Cell Longev (2017) 0.75
Naringin inhibits lipopolysaccharide-induced damage in human umbilical vein endothelial cells via attenuation of inflammation, apoptosis and MAPK pathways. Cytotechnology (2016) 0.75
Basic Fibroblast Growth Factor Inhibits Apoptosis and Promotes Proliferation of Adipose-Derived Mesenchymal Stromal Cells Isolated from Patients with Type 2 Diabetes by Reducing Cellular Oxidative Stress. Oxid Med Cell Longev (2017) 0.75
NADPH oxidase isoform expression is temporally regulated and may contribute to microglial/macrophage polarization after spinal cord injury. Mol Cell Neurosci (2016) 0.75
Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells. Sci Rep (2017) 0.75
Update on Inflammatory Biomarkers and Treatments in Ischemic Stroke. Int J Mol Sci (2016) 0.75
EXPRESS: Methylcobalamin ameliorates neuropathic pain induced by vincristine in rats: Effect on loss of peripheral nerve fibers and imbalance of cytokines in the spinal dorsal horn. Mol Pain (2016) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science (2007) 9.54
Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet (2013) 7.44
Direct isolation of satellite cells for skeletal muscle regeneration. Science (2005) 6.59
A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science (2005) 5.88
The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell (2009) 4.47
Pax3 and Pax7 have distinct and overlapping functions in adult muscle progenitor cells. J Cell Biol (2005) 3.96
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Ageing and infection. Lancet Infect Dis (2002) 3.79
A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol (2006) 3.74
Microglia promote the death of developing Purkinje cells. Neuron (2004) 3.42
CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation. J Exp Med (2009) 3.07
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes (2009) 2.92
Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin. Proc Natl Acad Sci U S A (2004) 2.88
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
Gene networks inference using dynamic Bayesian networks. Bioinformatics (2003) 2.74
A third vesicular glutamate transporter expressed by cholinergic and serotoninergic neurons. J Neurosci (2002) 2.71
In vitro proliferation of cells derived from adult human beta-cells revealed by cell-lineage tracing. Diabetes (2008) 2.64
Serotonin has a key role in pathogenesis of experimental colitis. Gastroenterology (2009) 2.55
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A (2009) 2.28
Intravenous scAAV9 delivery of a codon-optimized SMN1 sequence rescues SMA mice. Hum Mol Genet (2010) 2.26
Thymic stromal-derived lymphopoietin distinguishes fetal from adult B cell development. Nat Immunol (2003) 2.24
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. J Neurosci (2011) 2.21
Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci U S A (2003) 2.19
Pneumonia in the very old. Lancet Infect Dis (2004) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells. Nat Immunol (2011) 2.09
The hare and the tortoise: an embryonic haematopoietic race. Nat Rev Immunol (2002) 2.08
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Three pathways to mature macrophages in the early mouse yolk sac. Blood (2005) 1.76
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci U S A (2006) 1.75
Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc Natl Acad Sci U S A (2006) 1.74
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells (2009) 1.71
NOX family NADPH oxidases: not just in mammals. Biochimie (2007) 1.68
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry (2009) 1.62
Interleukin-7 is necessary to maintain the B cell potential in common lymphoid progenitors. J Exp Med (2005) 1.59
The repertoires of circulating human CD8(+) central and effector memory T cell subsets are largely distinct. Immunity (2003) 1.58
No major schizophrenia locus detected on chromosome 1q in a large multicenter sample. Science (2002) 1.57
ASPM-associated stem cell proliferation is involved in malignant progression of gliomas and constitutes an attractive therapeutic target. Cancer Cell Int (2010) 1.54
Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. PLoS One (2009) 1.53
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors. Stem Cells (2005) 1.48
Adult duct-lining cells can reprogram into β-like cells able to counter repeated cycles of toxin-induced diabetes. Dev Cell (2013) 1.46
An adult tissue-specific stem cell in its niche: a gene profiling analysis of in vivo quiescent and activated muscle satellite cells. Stem Cell Res (2009) 1.46
Inflammation recapitulates the ontogeny of lymphoid stromal cells. J Immunol (2009) 1.44
Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development. Development (2010) 1.43
System Xc- and apolipoprotein E expressed by microglia have opposite effects on the neurotoxicity of amyloid-beta peptide 1-40. J Neurosci (2006) 1.41
Relationship between radiosensitivity, initial DNA damage, apoptosis and gene expression: between reproducible works and technical artefacts. Breast (2013) 1.40
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing (2007) 1.32
Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells. PLoS One (2009) 1.32
Pax3:Foxc2 reciprocal repression in the somite modulates muscular versus vascular cell fate choice in multipotent progenitors. Dev Cell (2009) 1.31
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.30
NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension (2007) 1.29
Aging and infectious diseases in the developing world. Clin Infect Dis (2004) 1.29
The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells. PLoS Genet (2013) 1.28
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol (2005) 1.27
The mesenchyme controls the timing of pancreatic beta-cell differentiation. Diabetes (2006) 1.27
Characterization of the thymic IL-7 niche in vivo. Proc Natl Acad Sci U S A (2009) 1.27
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol (2010) 1.25
Expression of vesicular glutamate transporters in rat lumbar spinal cord, with a note on dorsal root ganglia. J Comp Neurol (2004) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
PA700, the regulatory complex of the 26S proteasome, interferes with alpha-synuclein assembly. FEBS J (2005) 1.23
Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro. PLoS One (2011) 1.23
Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J (2011) 1.23
TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex. Biol Psychiatry (2007) 1.22
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. Cell Microbiol (2014) 1.18
SOCS3-mediated blockade of JAK/STAT3 signaling pathway reveals its major contribution to spinal cord neuroinflammation and mechanical allodynia after peripheral nerve injury. J Neurosci (2010) 1.18
Development of a conditionally immortalized human pancreatic β cell line. J Clin Invest (2014) 1.17
Silencing of OB-RGRP in mouse hypothalamic arcuate nucleus increases leptin receptor signaling and prevents diet-induced obesity. Proc Natl Acad Sci U S A (2007) 1.17
NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie (2007) 1.17
Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells. Proc Natl Acad Sci U S A (2004) 1.17
Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry (2009) 1.17
Human retinoic acid receptor-related orphan receptor alpha1 overexpression protects neurones against oxidative stress-induced apoptosis. J Neurochem (2006) 1.15
The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration. J Biol Chem (2004) 1.15
Differentiation of B lymphocytes from hematopoietic stem cells. Methods Mol Biol (2004) 1.15
Non-integrating lentiviral vectors. Curr Gene Ther (2008) 1.13
A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells (2007) 1.13
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res (2009) 1.12
Inducible cAMP early repressor, an endogenous antagonist of cAMP responsive element-binding protein, evokes neuronal apoptosis in vitro. J Neurosci (2003) 1.12
Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment. Proc Natl Acad Sci U S A (2004) 1.11
Prospective comparison of 6 comorbidity indices as predictors of 1-year post-hospital discharge institutionalization, readmission, and mortality in elderly individuals. J Am Med Dir Assoc (2011) 1.11
Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate Schwann cells lead to functional recovery of the demyelinated mouse spinal cord. J Neurosci (2005) 1.09
Identification of the earliest prethymic bipotent T/NK progenitor in murine fetal liver. Blood (2002) 1.09