Published in J Immunol on December 15, 2005
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov (2009) 10.32
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Aiding and abetting roles of NOX oxidases in cellular transformation. Nat Rev Cancer (2012) 1.57
Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncol (2012) 1.56
PRAME expression in hairy cell leukemia. Leuk Res (2008) 1.41
A p67Phox-like regulator is recruited to control hyphal branching in a fungal-grass mutualistic symbiosis. Plant Cell (2006) 1.34
Nox5 and the regulation of cellular function. Antioxid Redox Signal (2009) 1.28
Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radic Biol Med (2008) 1.27
Expression of NADPH oxidase homologues and accessory genes in human cancer cell lines, tumours and adjacent normal tissues. Free Radic Res (2009) 1.16
Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J Biol Chem (2008) 1.08
Role of oxidative stress in stem, cancer, and cancer stem cells. Cancers (Basel) (2010) 1.06
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell (2008) 1.05
Nox enzymes in immune cells. Semin Immunopathol (2008) 1.01
NADPH oxidases: a perspective on reactive oxygen species production in tumor biology. Antioxid Redox Signal (2013) 0.99
NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem (2012) 0.98
Central role of protein kinase Cepsilon in constitutive activation of ERK1/2 and Rac1 in the malignant cells of hairy cell leukemia. Am J Pathol (2007) 0.97
Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain. Biochemistry (2011) 0.96
NADPH oxidase as a therapeutic target for oxalate induced injury in kidneys. Oxid Med Cell Longev (2013) 0.95
Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr (2011) 0.94
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody. Free Radic Biol Med (2013) 0.90
NADPH oxidase biology and the regulation of tyrosine kinase receptor signaling and cancer drug cytotoxicity. Int J Mol Sci (2013) 0.89
Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance. Redox Biol (2013) 0.87
PARADOXICAL ROLES OF DUAL OXIDASES IN CANCER BIOLOGY. Free Radic Biol Med (2017) 0.83
NADPH oxidase-generated reactive oxygen species are required for stromal cell-derived factor-1α-stimulated angiogenesis. Arterioscler Thromb Vasc Biol (2014) 0.80
Enzymatic regulation and functional relevance of NOX5. Curr Pharm Des (2015) 0.78
Expression and distribution of NADPH oxidase isoforms in human myometrium--role in angiotensin II-induced hypertrophy. Biol Reprod (2009) 0.78
Impact of Nox5 polymorphisms on basal and stimulus-dependent ROS generation. PLoS One (2014) 0.78
GTPase-Rac enhances depolarization-induced superoxide production by the macula densa during tubuloglomerular feedback. Am J Physiol Regul Integr Comp Physiol (2009) 0.77
The Importance of NADPH Oxidases and Redox Signaling in Angiogenesis. Antioxidants (Basel) (2017) 0.76
Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype. J Virol (2015) 0.76
Cloning, Characteristics, and Functional Analysis of Rabbit NADPH Oxidase 5. Front Physiol (2016) 0.75
The role of peroxiredoxins in cancer. Mol Clin Oncol (2017) 0.75
Is elevated gastric tissue NOX2 associated with lymphoma of mucosa-associated lymphoid tissue? Antioxid Redox Signal (2012) 0.75
NADPH oxidase 5 (NOX5) - induced reactive oxygen signaling modulates normoxic HIF-1α and p27(Kip1) expression in malignant melanoma and other human tumors. Mol Carcinog (2017) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat Genet (2008) 4.37
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Ageing and infection. Lancet Infect Dis (2002) 3.79
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk. Nat Genet (2010) 2.45
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Pneumonia in the very old. Lancet Infect Dis (2004) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
Smaller cerebral aneurysms producing more extensive subarachnoid hemorrhage following rupture: a radiological investigation and discussion of theoretical determinants. J Neurosurg (2003) 2.17
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
Surgical restoration of left ventricular diastolic function: possible treatment for noncompaction cardiomyopathy. J Card Surg (2014) 2.00
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem (2004) 1.86
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome. Pain (2013) 1.77
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells (2009) 1.71
NOX family NADPH oxidases: not just in mammals. Biochimie (2007) 1.68
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry (2009) 1.62
Relationship between p53 dysfunction, CD38 expression, and IgV(H) mutation in chronic lymphocytic leukemia. Blood (2002) 1.61
Perventricular device closure of ventricular septal defects: six months results in 30 young children. Ann Thorac Surg (2008) 1.59
Recurrent glioblastoma treated with bevacizumab: contrast-enhanced T1-weighted subtraction maps improve tumor delineation and aid prediction of survival in a multicenter clinical trial. Radiology (2013) 1.55
Vascular endothelial growth factor stimulates protein kinase CbetaII expression in chronic lymphocytic leukemia cells. Blood (2010) 1.51
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors. Stem Cells (2005) 1.48
Biased gene fractionation and dominant gene expression among the subgenomes of Brassica rapa. PLoS One (2012) 1.47
CYP2B6*6 is an independent determinant of inferior response to fludarabine plus cyclophosphamide in chronic lymphocytic leukemia. Blood (2013) 1.46
Cancerous inhibitor of PP2A (CIP2A) at diagnosis of chronic myeloid leukemia is a critical determinant of disease progression. Blood (2011) 1.46
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci (2008) 1.34
Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing (2007) 1.32
Differential expression and regulation of protease-activated receptors in human peripheral monocytes and monocyte-derived antigen-presenting cells. Blood (2003) 1.32
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.30
The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. Blood (2002) 1.30
NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension (2007) 1.29
Aging and infectious diseases in the developing world. Clin Infect Dis (2004) 1.29
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol (2010) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
Chronic myeloid leukemia patients with the e13a2 BCR-ABL fusion transcript have inferior responses to imatinib compared to patients with the e14a2 transcript. Haematologica (2009) 1.23
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20
Prognostic significance of osteopontin expression in human prostate cancer. Int J Cancer (2006) 1.18
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. Cell Microbiol (2014) 1.18
NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie (2007) 1.17
ProGMap: an integrated annotation resource for protein orthology. Nucleic Acids Res (2009) 1.17
Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry (2009) 1.17
A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells (2007) 1.13
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res (2009) 1.12
Prospective comparison of 6 comorbidity indices as predictors of 1-year post-hospital discharge institutionalization, readmission, and mortality in elderly individuals. J Am Med Dir Assoc (2011) 1.11
Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images. Neuro Oncol (2013) 1.11
NOX5: from basic biology to signaling and disease. Free Radic Biol Med (2011) 1.08
Ribosomal protein l19 is a prognostic marker for human prostate cancer. Clin Cancer Res (2006) 1.08
Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation. J Cell Sci (2006) 1.08
Telomere dysfunction accurately predicts clinical outcome in chronic lymphocytic leukaemia, even in patients with early stage disease. Br J Haematol (2014) 1.07
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
Regulation of hairy-cell survival through constitutive activation of mitogen-activated protein kinase pathways. Oncogene (2003) 1.05
Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects. Haematologica (2009) 1.05
TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α. Lab Invest (2011) 1.04
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene (2005) 1.03
The Brassica rapa FLC homologue FLC2 is a key regulator of flowering time, identified through transcriptional co-expression networks. J Exp Bot (2013) 1.03
CLL, but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium. Blood (2005) 1.03
Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations. Stem Cells Dev (2012) 1.02
The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J Biol Chem (2002) 1.02
A role for NOX NADPH oxidases in Alzheimer's disease and other types of dementia? IUBMB Life (2003) 1.02
The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia. Br J Haematol (2004) 1.02
Testing the annual nature of speleothem banding. Sci Rep (2013) 1.02
Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition. Haematologica (2009) 1.01
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons. Neurobiol Aging (2005) 1.01
Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas. Neuroimage (2011) 1.01
B-cell receptor translocation to lipid rafts and associated signaling differ between prognostically important subgroups of chronic lymphocytic leukemia. Cancer Res (2005) 1.00
Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer. Hum Pathol (2007) 1.00
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation (2010) 1.00
B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetaII. Blood (2006) 0.98