Published in J Biol Chem on February 24, 2004
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Nox proteins in signal transduction. Free Radic Biol Med (2009) 3.47
Regulation of Nox and Duox enzymatic activity and expression. Free Radic Biol Med (2007) 3.44
Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system. Circ Res (2012) 3.02
Calcium-dependent protein kinases regulate the production of reactive oxygen species by potato NADPH oxidase. Plant Cell (2007) 2.36
Production of reactive oxygen species by plant NADPH oxidases. Plant Physiol (2006) 2.35
Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes (2005) 2.31
Molecular evolution of the reactive oxygen-generating NADPH oxidase (Nox/Duox) family of enzymes. BMC Evol Biol (2007) 2.29
Reactive oxygen species and angiogenesis: NADPH oxidase as target for cancer therapy. Cancer Lett (2008) 2.28
Regulation of rice NADPH oxidase by binding of Rac GTPase to its N-terminal extension. Plant Cell (2007) 2.11
Regulation of reactive oxygen species generation in cell signaling. Mol Cells (2011) 1.85
Hydrogen peroxide: a Jekyll and Hyde signalling molecule. Cell Death Dis (2011) 1.79
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases. Antioxid Redox Signal (2009) 1.71
Sources and targets of reactive oxygen species in synaptic plasticity and memory. Antioxid Redox Signal (2007) 1.69
CaMKII in the cardiovascular system: sensing redox states. Physiol Rev (2011) 1.67
Oxidases and peroxidases in cardiovascular and lung disease: new concepts in reactive oxygen species signaling. Free Radic Biol Med (2011) 1.56
NADPH oxidases in lung biology and pathology: host defense enzymes, and more. Free Radic Biol Med (2007) 1.50
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease. Cell Mol Life Sci (2012) 1.44
NADPH oxidase 4 is an oncoprotein localized to mitochondria. Cancer Biol Ther (2010) 1.38
Constitutive NADPH-dependent electron transferase activity of the Nox4 dehydrogenase domain. Biochemistry (2010) 1.38
Activation of dual oxidases Duox1 and Duox2: differential regulation mediated by camp-dependent protein kinase and protein kinase C-dependent phosphorylation. J Biol Chem (2009) 1.29
Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radic Biol Med (2008) 1.27
Evolution of NADPH Oxidase Inhibitors: Selectivity and Mechanisms for Target Engagement. Antioxid Redox Signal (2014) 1.23
Redox regulation of interleukin-4 signaling. Immunity (2008) 1.20
NADPH oxidases in vascular pathology. Antioxid Redox Signal (2013) 1.17
Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal (2009) 1.16
Redox signaling in cardiovascular health and disease. Free Radic Biol Med (2013) 1.16
Novel redox-dependent regulation of NOX5 by the tyrosine kinase c-Abl. Free Radic Biol Med (2007) 1.16
Regulation of superoxide production in neutrophils: role of calcium influx. J Leukoc Biol (2008) 1.15
Reactive oxygen species and nitric oxide mediate actin reorganization and programmed cell death in the self-incompatibility response of papaver. Plant Physiol (2011) 1.15
Reactive oxygen species, vascular Noxs, and hypertension: focus on translational and clinical research. Antioxid Redox Signal (2013) 1.14
NOX enzymes and Toll-like receptor signaling. Semin Immunopathol (2008) 1.13
Interplay between calcium and reactive oxygen/nitrogen species: an essential paradigm for vascular smooth muscle signaling. Antioxid Redox Signal (2010) 1.09
Nox regulation of smooth muscle contraction. Free Radic Biol Med (2007) 1.09
NADPH oxidases: an overview from structure to innate immunity-associated pathologies. Cell Mol Immunol (2014) 1.08
Lipid raft redox signaling: molecular mechanisms in health and disease. Antioxid Redox Signal (2011) 1.06
Calcium and ROS: A mutual interplay. Redox Biol (2015) 1.05
Phosphatidylinositol (4,5)-bisphosphate modulates Nox5 localization via an N-terminal polybasic region. Mol Biol Cell (2008) 1.05
NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium. Toxicol Sci (2011) 1.05
Structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications. J Biol Chem (2009) 1.03
Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility. Reprod Biol Endocrinol (2005) 1.02
Regulation of phagocyte NADPH oxidase by hydrogen peroxide through a Ca(2+)/c-Abl signaling pathway. Free Radic Biol Med (2010) 1.02
Inhibitory action of NoxA1 on dual oxidase activity in airway cells. J Biol Chem (2008) 1.01
Emerging evidence for the importance of phosphorylation in the regulation of NADPH oxidases. Antioxid Redox Signal (2009) 1.01
Nox enzymes in immune cells. Semin Immunopathol (2008) 1.01
NOX5 in human spermatozoa: expression, function, and regulation. J Biol Chem (2012) 0.98
Detection of superoxide anion and hydrogen peroxide production by cellular NADPH oxidases. Biochim Biophys Acta (2013) 0.97
Nox5 forms a functional oligomer mediated by self-association of its dehydrogenase domain. Biochemistry (2011) 0.96
Redox warfare between airway epithelial cells and Pseudomonas: dual oxidase versus pyocyanin. Immunol Res (2009) 0.96
NADPH oxidase expression and production of superoxide by human corneal stromal cells. Mol Vis (2009) 0.95
Physiological roles of NOX/NADPH oxidase, the superoxide-generating enzyme. J Clin Biochem Nutr (2011) 0.94
Expression and functional significance of NADPH oxidase 5 (Nox5) and its splice variants in human blood vessels. Am J Physiol Heart Circ Physiol (2012) 0.92
Nox enzymes in allergic airway inflammation. Biochim Biophys Acta (2011) 0.91
Nephropathy and elevated BP in mice with podocyte-specific NADPH oxidase 5 expression. J Am Soc Nephrol (2013) 0.91
Characterization of NADPH oxidase 5 expression in human tumors and tumor cell lines with a novel mouse monoclonal antibody. Free Radic Biol Med (2013) 0.90
Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs. PLoS One (2013) 0.89
Regulation of breast tumorigenesis through acid sensors. Oncogene (2015) 0.87
Transforming growth factor-β1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo. J Cell Mol Med (2014) 0.85
Diabetes and Kidney Disease: Role of Oxidative Stress. Antioxid Redox Signal (2016) 0.83
ROS signaling by NADPH oxidase 5 modulates the proliferation and survival of prostate carcinoma cells. Mol Carcinog (2015) 0.83
Reactive Oxygen Species (ROS): Beneficial Companions of Plants' Developmental Processes. Front Plant Sci (2016) 0.81
Selective recapitulation of conserved and nonconserved regions of putative NOXA1 protein activation domain confers isoform-specific inhibition of Nox1 oxidase and attenuation of endothelial cell migration. J Biol Chem (2013) 0.81
Conformational States and kinetics of the calcium binding domain of NADPH oxidase 5. Open Biochem J (2010) 0.81
NADPH oxidase-generated reactive oxygen species are required for stromal cell-derived factor-1α-stimulated angiogenesis. Arterioscler Thromb Vasc Biol (2014) 0.80
Role of intracellular calcium and NADPH oxidase NOX5-S in acid-induced DNA damage in Barrett's cells and Barrett's esophageal adenocarcinoma cells. Am J Physiol Gastrointest Liver Physiol (2014) 0.79
Characterization of the 1st and 2nd EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism. Chem Cent J (2012) 0.78
NADPH oxidase: recent evidence for its role in erectile dysfunction. Asian J Androl (2008) 0.78
Enzymatic regulation and functional relevance of NOX5. Curr Pharm Des (2015) 0.78
Human cell toxicogenomic analysis linking reactive oxygen species to the toxicity of monohaloacetic acid drinking water disinfection byproducts. Environ Sci Technol (2013) 0.78
Expression of NADPH oxidase (NOX) 5 in rabbit corneal stromal cells. PLoS One (2012) 0.78
NADPH Oxidase-Dependent Superoxide Production in Plant Reproductive Tissues. Front Plant Sci (2016) 0.76
NOX5-L can stimulate proliferation and apoptosis depending on its levels and cellular context, determining cancer cell susceptibility to cisplatin. Oncotarget (2015) 0.76
NADPH oxidases-do they play a role in TRPC regulation under hypoxia? Pflugers Arch (2015) 0.75
Nox Inhibitors & Therapies: Rational Design of Peptidic and Small Molecule Inhibitors. Curr Pharm Des (2015) 0.75
Microvascular NADPH oxidase in health and disease. Free Radic Biol Med (2017) 0.75
Gelsolin-Cu/ZnSOD interaction alters intracellular reactive oxygen species levels to promote cancer cell invasion. Oncotarget (2016) 0.75
Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis. Cell Death Dis (2016) 0.75
Evolutionary origin and function of NOX4-art, an arthropod specific NADPH oxidase. BMC Evol Biol (2017) 0.75
Cloning, Characteristics, and Functional Analysis of Rabbit NADPH Oxidase 5. Front Physiol (2016) 0.75
Oxidation of Са2+-Binding Domain of NADPH Oxidase 5 (NOX5): Toward Understanding the Mechanism of Inactivation of NOX5 by ROS. PLoS One (2016) 0.75
NADPH oxidase 5 (NOX5) - induced reactive oxygen signaling modulates normoxic HIF-1α and p27(Kip1) expression in malignant melanoma and other human tumors. Mol Carcinog (2017) 0.75
Melamine induces Ca(2+)-sensing receptor activation and elicits apoptosis in proximal tubular cells. Am J Physiol Cell Physiol (2017) 0.75
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev (2007) 21.13
NOX4 activity is determined by mRNA levels and reveals a unique pattern of ROS generation. Biochem J (2007) 3.88
Ageing and infection. Lancet Infect Dis (2002) 3.79
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev (2005) 2.78
Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem (2002) 2.41
NOX enzymes in the central nervous system: from signaling to disease. Antioxid Redox Signal (2009) 2.38
NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem (2004) 2.36
Pneumonia in the very old. Lancet Infect Dis (2004) 2.19
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol (2012) 2.17
Decreased blood pressure in NOX1-deficient mice. FEBS Lett (2005) 2.10
Mechanisms of vascular smooth muscle NADPH oxidase 1 (Nox1) contribution to injury-induced neointimal formation. Arterioscler Thromb Vasc Biol (2009) 2.01
NOX enzymes as novel targets for drug development. Semin Immunopathol (2008) 1.90
Small-molecule NOX inhibitors: ROS-generating NADPH oxidases as therapeutic targets. Antioxid Redox Signal (2009) 1.80
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol (2010) 1.80
A key role for NOX4 in epithelial cell death during development of lung fibrosis. Antioxid Redox Signal (2011) 1.79
The NADPH oxidase NOX4 drives cardiac differentiation: Role in regulating cardiac transcription factors and MAP kinase activation. Mol Biol Cell (2006) 1.76
A Sox1 to Pax6 switch drives neuroectoderm to radial glia progression during differentiation of mouse embryonic stem cells. Stem Cells (2009) 1.71
NOX family NADPH oxidases: not just in mammals. Biochimie (2007) 1.68
Nox1 mediates basic fibroblast growth factor-induced migration of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2007) 1.65
Does dementia predict adverse hospitalization outcomes? A prospective study in aged inpatients. Int J Geriatr Psychiatry (2009) 1.62
Rapid generation of stable transgenic embryonic stem cell lines using modular lentivectors. Stem Cells (2005) 1.48
Hyperinflammation in chronic granulomatous disease and anti-inflammatory role of the phagocyte NADPH oxidase. Semin Immunopathol (2008) 1.37
Neurotoxic activation of microglia is promoted by a nox1-dependent NADPH oxidase. J Neurosci (2008) 1.34
Demented versus non-demented very old inpatients: the same comorbidities but poorer functional and nutritional status. Age Ageing (2007) 1.32
NADPH oxidase-1 plays a crucial role in hyperoxia-induced acute lung injury in mice. Am J Respir Crit Care Med (2009) 1.30
NOX1 deficiency protects from aortic dissection in response to angiotensin II. Hypertension (2007) 1.29
Aging and infectious diseases in the developing world. Clin Infect Dis (2004) 1.29
Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol (2005) 1.27
Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Curr Biol (2006) 1.27
NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon. Mol Cell Biol (2010) 1.25
Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice. Nat Commun (2012) 1.25
NOX family NADPH oxidases in liver and in pancreatic islets: a role in the metabolic syndrome and diabetes? Biochem Soc Trans (2008) 1.20
Phagocyte NADPH oxidase, chronic granulomatous disease and mycobacterial infections. Cell Microbiol (2014) 1.18
NOX5 is expressed at the plasma membrane and generates superoxide in response to protein kinase C activation. Biochimie (2007) 1.17
Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry (2009) 1.17
NADPH oxidase 5 (NOX5) interacts with and is regulated by calmodulin. FEBS Lett (2007) 1.15
A pure population of ectodermal cells derived from human embryonic stem cells. Stem Cells (2007) 1.13
Distinct roles of BARD1 isoforms in mitosis: full-length BARD1 mediates Aurora B degradation, cancer-associated BARD1beta scaffolds Aurora B and BRCA2. Cancer Res (2009) 1.12
Prospective comparison of 6 comorbidity indices as predictors of 1-year post-hospital discharge institutionalization, readmission, and mortality in elderly individuals. J Am Med Dir Assoc (2011) 1.11
NOX5: from basic biology to signaling and disease. Free Radic Biol Med (2011) 1.08
Expression and function of alpha-smooth muscle actin during embryonic-stem-cell-derived cardiomyocyte differentiation. J Cell Sci (2006) 1.08
Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing. ALTEX (2010) 1.06
New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06
BARD1 induces apoptosis by catalysing phosphorylation of p53 by DNA-damage response kinase. Oncogene (2005) 1.03
A role for NOX NADPH oxidases in Alzheimer's disease and other types of dementia? IUBMB Life (2003) 1.02
The HIV-1 Nef protein and phagocyte NADPH oxidase activation. J Biol Chem (2002) 1.02
Haplotype-based banking of human pluripotent stem cells for transplantation: potential and limitations. Stem Cells Dev (2012) 1.02
C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain. Biochemistry (2003) 1.01
A key role for the microglial NADPH oxidase in APP-dependent killing of neurons. Neurobiol Aging (2005) 1.01
Nox activator 1: a potential target for modulation of vascular reactive oxygen species in atherosclerotic arteries. Circulation (2010) 1.00
Neuroendocrine profile in a rat model of psychosocial stress: relation to oxidative stress. Antioxid Redox Signal (2013) 0.98
Nuclear-cytoplasmic translocation of BARD1 is linked to its apoptotic activity. Oncogene (2004) 0.98
Calcium and magnesium binding to human centrin 3 and interaction with target peptides. Biochemistry (2005) 0.98
Aberrant expression of BARD1 in breast and ovarian cancers with poor prognosis. Int J Cancer (2006) 0.98
Calreticulin reveals a critical Ca(2+) checkpoint in cardiac myofibrillogenesis. J Cell Biol (2002) 0.97
NOX family NADPH oxidases: do they have built-in proton channels? J Gen Physiol (2002) 0.97
Telomere length and ApoE polymorphism in mild cognitive impairment, degenerative and vascular dementia. J Neurol Sci (2010) 0.97
NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion. Diabetes (2012) 0.97
The chemokine receptor CCR5 in the central nervous system. Prog Neurobiol (2010) 0.96
Geriatrics index of comorbidity was the most accurate predictor of death in geriatric hospital among six comorbidity scores. J Clin Epidemiol (2010) 0.96
Detection of reactive oxygen species derived from the family of NOX NADPH oxidases. Free Radic Biol Med (2012) 0.96
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood (2011) 0.96
Three common polymorphisms in the CYBA gene form a haplotype associated with decreased ROS generation. Hum Mutat (2009) 0.95
Targeting NOX enzymes in the central nervous system: therapeutic opportunities. Cell Mol Life Sci (2012) 0.95
The NADPH oxidase NOX2 controls glutamate release: a novel mechanism involved in psychosis-like ketamine responses. J Neurosci (2010) 0.95
Calnexin deficiency leads to dysmyelination. J Biol Chem (2010) 0.94
Comprehensive metagenomic analysis of glioblastoma reveals absence of known virus despite antiviral-like type I interferon gene response. Int J Cancer (2014) 0.94
Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxid Redox Signal (2012) 0.94
Regulation of NOX1 expression by GATA, HNF-1alpha, and Cdx transcription factors. Free Radic Biol Med (2007) 0.94
The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. ALTEX (2008) 0.93
Hyperinflammation of chronic granulomatous disease is abolished by NOX2 reconstitution in macrophages and dendritic cells. J Pathol (2012) 0.93
S100A16, a novel calcium-binding protein of the EF-hand superfamily. J Biol Chem (2006) 0.93
Identification of the binding site for the regulatory calcium-binding domain in the catalytic domain of NOX5. Biochemistry (2010) 0.93
Evolutionary forces shape the human RFPL1,2,3 genes toward a role in neocortex development. Am J Hum Genet (2008) 0.93
Neural progenitors derived from human embryonic stem cells are targeted by allogeneic T and natural killer cells. J Cell Mol Med (2009) 0.93
NOX-4 is expressed in thickened pulmonary arteries in idiopathic pulmonary fibrosis. Nat Med (2011) 0.92
NADPH oxidase (NOX) isoforms are inhibited by celastrol with a dual mode of action. Br J Pharmacol (2011) 0.92
NADPH oxidase 1 deficiency alters caveolin phosphorylation and angiotensin II-receptor localization in vascular smooth muscle. Antioxid Redox Signal (2009) 0.91
Booster vaccination and 1-year follow-up of 4-8-year-old children with a reduced-antigen-content dTpa-IPV vaccine. Eur J Pediatr (2007) 0.91
The Justy mutation identifies Gon4-like as a gene that is essential for B lymphopoiesis. J Exp Med (2010) 0.91
Telomere length is not predictive of dementia or MCI conversion in the oldest old. Neurobiol Aging (2008) 0.90
Test systems of developmental toxicity: state-of-the art and future perspectives. Arch Toxicol (2013) 0.90
Dissemination of intraperitoneal ovarian cancer: Discussion of mechanisms and demonstration of lymphatic spreading in ovarian cancer model. Crit Rev Oncol Hematol (2009) 0.90
Phenazopyridine induces and synchronizes neuronal differentiation of embryonic stem cells. J Cell Mol Med (2009) 0.89
Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach. Exp Gerontol (2005) 0.89
Evolution of the ferric reductase domain (FRD) superfamily: modularity, functional diversification, and signature motifs. PLoS One (2013) 0.89
The NADPH oxidase NOX2 plays a role in periodontal pathologies. Semin Immunopathol (2008) 0.87
Cellular diversity within embryonic stem cells: pluripotent clonal sublines show distinct differentiation potential. J Cell Mol Med (2012) 0.86
Pax6-induced alteration of cell fate: shape changes, expression of neuronal alpha tubulin, postmitotic phenotype, and cell migration. J Neurobiol (2006) 0.86
Zinc is required for the catalytic activity of the human deubiquitinating isopeptidase T. Biochemistry (2002) 0.86
Isoform- and dose-sensitive feedback interactions between paired box 6 gene and delta-catenin in cell differentiation and death. Exp Cell Res (2010) 0.85
Ca2+ binding to EF hands 1 and 3 is essential for the interaction of apoptosis-linked gene-2 with Alix/AIP1 in ocular melanoma. Biochemistry (2004) 0.85
Fyn binds to and phosphorylates T cell immunoglobulin and mucin domain-1 (Tim-1). Mol Immunol (2011) 0.84
Prospective comparison of six co-morbidity indices as predictors of 5 years post hospital discharge survival in the elderly. Rejuvenation Res (2010) 0.84
S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells. J Cell Sci (2002) 0.84