Published in EMBO J on November 10, 2005
Immune signaling by RIG-I-like receptors. Immunity (2011) 5.02
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Mol Cell Proteomics (2008) 2.56
Sensing of viral infection and activation of innate immunity by toll-like receptor 3. Clin Microbiol Rev (2008) 2.39
Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine (2008) 1.54
Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling. J Leukoc Biol (2009) 1.43
Optineurin negatively regulates the induction of IFNbeta in response to RNA virus infection. PLoS Pathog (2010) 1.39
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci U S A (2007) 1.35
Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem (2009) 1.34
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem (2012) 1.33
TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. J Biol Chem (2010) 1.29
Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. Proc Natl Acad Sci U S A (2009) 1.27
Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem (2010) 1.25
TLR3 immunity to infection in mice and humans. Curr Opin Immunol (2013) 1.22
The pivotal role of TBK1 in inflammatory responses mediated by macrophages. Mediators Inflamm (2012) 1.19
A functional C-terminal TRAF3-binding site in MAVS participates in positive and negative regulation of the IFN antiviral response. Cell Res (2011) 1.18
Function and regulation of retinoic acid-inducible gene-I. Crit Rev Immunol (2010) 1.15
STRIPAK complexes: structure, biological function, and involvement in human diseases. Int J Biochem Cell Biol (2013) 1.13
ORF45 of Kaposi's sarcoma-associated herpesvirus inhibits phosphorylation of interferon regulatory factor 7 by IKKε and TBK1 as an alternative substrate. J Virol (2012) 1.10
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Proc Natl Acad Sci U S A (2009) 1.08
miR-146a-5p circuitry uncouples cell proliferation and migration, but not differentiation, in human mesenchymal stem cells. Nucleic Acids Res (2013) 1.02
Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses. J Immunol (2010) 1.00
Negative regulation of interferon-β gene expression during acute and persistent virus infections. PLoS One (2011) 0.96
Hepatitis B virus X protein suppresses virus-triggered IRF3 activation and IFN-beta induction by disrupting the VISA-associated complex. Cell Mol Immunol (2010) 0.94
GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth. Cell Res (2008) 0.93
Signaling network of dendritic cells in response to pathogens: a community-input supported knowledgebase. BMC Syst Biol (2010) 0.92
TBK1-associated protein in endolysosomes (TAPE) is an innate immune regulator modulating the TLR3 and TLR4 signaling pathways. J Biol Chem (2010) 0.89
RING finger protein 11 targets TBK1/IKKi kinases to inhibit antiviral signaling. PLoS One (2013) 0.89
The microtubule-binding protein Cep170 promotes the targeting of the kinesin-13 depolymerase Kif2b to the mitotic spindle. Mol Biol Cell (2012) 0.88
TRIM11 negatively regulates IFNβ production and antiviral activity by targeting TBK1. PLoS One (2013) 0.85
MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling. Mol Immunol (2010) 0.85
Nemo-like kinase is critical for p53 stabilization and function in response to DNA damage. Cell Death Differ (2014) 0.83
Death-associated protein kinase 1 is an IRF3/7-interacting protein that is involved in the cellular antiviral immune response. Cell Mol Immunol (2014) 0.83
HCV infection and B-cell lymphomagenesis. Adv Hematol (2011) 0.81
Pattern-recognition receptor signaling regulator mRNA expression in humans and mice, and in transient inflammation or progressive fibrosis. Int J Mol Sci (2013) 0.81
ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner. J Biol Chem (2011) 0.81
Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice. Viruses (2012) 0.80
Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun (2016) 0.79
The complement C1qA enhances retinoic acid-inducible gene-I-mediated immune signalling. Immunology (2012) 0.79
The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases. Br J Pharmacol (2015) 0.78
NLRX1: friend or foe? EMBO Rep (2008) 0.78
Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway. Sci Rep (2016) 0.77
Specific IgA Enhances the Transcytosis and Excretion of Hepatitis A Virus. Sci Rep (2016) 0.77
STRIPAK complexes in cell signaling and cancer. Oncogene (2016) 0.77
Interferon regulatory factor 3-CL, an isoform of IRF3, antagonizes activity of IRF3. Cell Mol Immunol (2010) 0.77
Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1). J Biol Chem (2013) 0.77
DYRK2 Negatively Regulates Type I Interferon Induction by Promoting TBK1 Degradation via Ser527 Phosphorylation. PLoS Pathog (2015) 0.76
Genetic dissection of Iddm26 in the spontaneously diabetic BBDP rat. Genes Immun (2014) 0.75
Overexpression of suppressor of IKBKE 1 is associated with vincristine resistance in colon cancer cells. Biomed Rep (2016) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature (2001) 25.15
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway. Science (2003) 17.57
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature (2003) 10.97
Cell type-specific involvement of RIG-I in antiviral response. Immunity (2005) 9.37
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A (2004) 7.51
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol (2003) 7.06
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01
RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol (2004) 5.74
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity (1996) 5.45
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci U S A (2003) 4.33
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med (2004) 4.14
Structure and function of the interferon-beta enhanceosome. Cold Spring Harb Symp Quant Biol (1998) 3.81
NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J (1999) 3.78
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev (2001) 3.34
Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A (2003) 3.29
IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases. Int Immunol (1999) 2.84
Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med (2004) 2.80
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta. Proc Natl Acad Sci U S A (2004) 2.74
IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex. Mol Cell (2000) 2.52
Type I IFN modulates innate and specific antiviral immunity. J Immunol (2000) 2.26
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem (2004) 2.16
Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol (2004) 2.06
Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation. J Virol (2002) 2.04
Viruses know it all: new insights into IFN networks. Trends Immunol (2005) 1.62
Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. J Biol Chem (1999) 1.52
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem (2003) 1.52
RIGging an antiviral defense--it's in the CARDs. Nat Immunol (2004) 1.15
ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. J Biol Chem (2004) 0.99
VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell (2005) 14.20
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. Immunity (2008) 7.60
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci U S A (2009) 4.46
Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF. Immunity (2004) 4.00
Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma. N Engl J Med (2015) 3.18
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03
Exosomes from human CD34(+) stem cells mediate their proangiogenic paracrine activity. Circ Res (2011) 2.31
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. Immunity (2009) 2.21
Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells. Blood (2007) 2.18
Mechanisms of the TRIF-induced interferon-stimulated response element and NF-kappaB activation and apoptosis pathways. J Biol Chem (2004) 2.16
Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation (2009) 2.09
PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nat Immunol (2009) 2.07
A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett (2004) 1.98
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. Cardiovasc Res (2009) 1.88
Sonic hedgehog-modified human CD34+ cells preserve cardiac function after acute myocardial infarction. Circ Res (2012) 1.70
Ligand-receptor binding revealed by the TNF family member TALL-1. Nature (2003) 1.70
TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J Biol Chem (2004) 1.65
Olfactory control of blood progenitor maintenance. Cell (2013) 1.64
Elevated cytosolic Na+ increases mitochondrial formation of reactive oxygen species in failing cardiac myocytes. Circulation (2010) 1.61
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. Proc Natl Acad Sci U S A (2009) 1.60
TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. J Biol Chem (2003) 1.52
TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production. J Immunol (2002) 1.50
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Rep (2013) 1.49
Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory. J Neurosci (2009) 1.46
Variant brain-derived neurotrophic factor Val66Met polymorphism alters vulnerability to stress and response to antidepressants. J Neurosci (2012) 1.45
Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity (2010) 1.39
Tripartite motif 8 (TRIM8) modulates TNFα- and IL-1β-triggered NF-κB activation by targeting TAK1 for K63-linked polyubiquitination. Proc Natl Acad Sci U S A (2011) 1.36
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3. Cell Res (2008) 1.35
Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. Cardiovasc Res (2008) 1.35
Negative regulation of MDA5- but not RIG-I-mediated innate antiviral signaling by the dihydroxyacetone kinase. Proc Natl Acad Sci U S A (2007) 1.35
Regulation of virus-triggered signaling by OTUB1- and OTUB2-mediated deubiquitination of TRAF3 and TRAF6. J Biol Chem (2009) 1.34
TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination. J Biol Chem (2012) 1.33
Molecular evidence for natural hybridization in the mangrove fern genus Acrostichum. BMC Plant Biol (2013) 1.29
The application of nanofibrous scaffolds in neural tissue engineering. Adv Drug Deliv Rev (2009) 1.28
SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation. J Mol Cell Biol (2011) 1.28
Lamin B receptor plays a role in stimulating nuclear envelope production and targeting membrane vesicles to chromatin during nuclear envelope assembly through direct interaction with importin beta. J Cell Sci (2007) 1.26
Virus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral response. J Biol Chem (2010) 1.25
Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia. Blood (2008) 1.22
The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation. J Immunol (2010) 1.21
Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A (2011) 1.20
AMID, an apoptosis-inducing factor-homologous mitochondrion-associated protein, induces caspase-independent apoptosis. J Biol Chem (2002) 1.20
Smad2 positively regulates the generation of Th17 cells. J Biol Chem (2010) 1.17
Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. Cell Res (2012) 1.16
The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members. J Immunol (2006) 1.16
CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity. Circ Res (2010) 1.15
A 90-day subchronic feeding study of genetically modified maize expressing Cry1Ac-M protein in Sprague-Dawley rats. Food Chem Toxicol (2012) 1.15
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation. J Biol Chem (2007) 1.15
LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection. Proc Natl Acad Sci U S A (2012) 1.14
Identification of uteroglobin-related protein 1 and macrophage scavenger receptor with collagenous structure as a lung-specific ligand-receptor pair. J Immunol (2003) 1.13
SINK is a p65-interacting negative regulator of NF-kappaB-dependent transcription. J Biol Chem (2003) 1.11
The BREASTrial: stage I. Outcomes from the time of tissue expander and acellular dermal matrix placement to definitive reconstruction. Plast Reconstr Surg (2015) 1.10
Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. J Magn Reson Imaging (2010) 1.09
RIP5 is a RIP-homologous inducer of cell death. Biochem Biophys Res Commun (2004) 1.09
The Toxoplasma gondii parasitophorous vacuole membrane: transactions across the border. J Eukaryot Microbiol (2007) 1.09
Mitochondrial Ca2+ influx and efflux rates in guinea pig cardiac mitochondria: low and high affinity effects of cyclosporine A. Biochim Biophys Acta (2011) 1.08
WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation. Proc Natl Acad Sci U S A (2009) 1.08
Identification of downstream genes up-regulated by the tumor necrosis factor family member TALL-1. J Leukoc Biol (2002) 1.07
Combined TRPC3 and TRPC6 blockade by selective small-molecule or genetic deletion inhibits pathological cardiac hypertrophy. Proc Natl Acad Sci U S A (2014) 1.06
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J Hepatol (2013) 1.06
Regulation of IRF2 transcriptional activity by its sumoylation. Biochem Biophys Res Commun (2008) 1.05
Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling. FASEB J (2010) 1.05
Overexpression of PRMT5 promotes tumor cell growth and is associated with poor disease prognosis in epithelial ovarian cancer. J Histochem Cytochem (2013) 1.04
Adult repellency and larvicidal activity of five plant essential oils against mosquitoes. J Am Mosq Control Assoc (2006) 1.03
Microarray analysis of the gene expression profile in the midgut of silkworm infected with cytoplasmic polyhedrosis virus. Mol Biol Rep (2010) 1.02
NIK is a component of the EGF/heregulin receptor signaling complexes. Oncogene (2003) 1.01
TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways. J Cell Sci (2005) 1.01
Dynamics of matrix-free Ca2+ in cardiac mitochondria: two components of Ca2+ uptake and role of phosphate buffering. J Gen Physiol (2012) 1.01
TRIM38 inhibits TNFα- and IL-1β-triggered NF-κB activation by mediating lysosome-dependent degradation of TAB2/3. Proc Natl Acad Sci U S A (2014) 1.01
E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation. Proc Natl Acad Sci U S A (2013) 1.00
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. FEBS Lett (2006) 1.00
Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients. J Exp Clin Cancer Res (2011) 1.00
Phrasal Paraphrase Based Question Reformulation for Archived Question Retrieval. PLoS One (2013) 1.00
ZNF216 Is an A20-like and IkappaB kinase gamma-interacting inhibitor of NFkappaB activation. J Biol Chem (2004) 0.99