Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 3408187)

Published in J Biol Chem on May 30, 2012

Authors

Chih-Hsien Wu1, Sheau-Chung Tang, Po-Hui Wang, Huei Lee, Jiunn-Liang Ko

Author Affiliations

1: Institute of Medicine, Chung Shan Medical University, Chung Shan Medical University Hospital, Taichung 40203, Taiwan.

Articles cited by this

The hallmarks of cancer. Cell (2000) 113.05

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99

Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol (2006) 23.04

Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol (2008) 7.37

Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res (2006) 5.90

EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest (2009) 4.41

The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem Sci (1999) 3.37

Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells. FASEB J (2004) 2.74

HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. J Exp Med (2005) 2.35

Nickel carcinogenesis. Mutat Res (2003) 2.16

TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle (2008) 1.97

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br J Cancer (2009) 1.85

Epigenetic changes induced by reactive oxygen species in hepatocellular carcinoma: methylation of the E-cadherin promoter. Gastroenterology (2008) 1.78

Snail family regulation and epithelial mesenchymal transitions in breast cancer progression. J Mammary Gland Biol Neoplasia (2010) 1.76

Hydrogen peroxide generation in peroxisome proliferator-induced oncogenesis. Mutat Res (2000) 1.39

Epigenetic versus genetic alterations in the inactivation of E-cadherin. Semin Cancer Biol (2002) 1.36

E-cadherin expression is silenced by 5' CpG island methylation in acute leukemia. Clin Cancer Res (2000) 1.26

Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells. Cell Death Differ (2010) 1.21

EMT and oxidative stress: a bidirectional interplay affecting tumor malignancy. Antioxid Redox Signal (2011) 1.21

Nickel carcinogenesis: epigenetics and hypoxia signaling. Mutat Res (2005) 1.19

Arsenite induces HIF-1alpha and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells. Mol Cell Biochem (2004) 1.15

Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis (2010) 1.14

Metal-induced carcinogenesis, oxidative stress and hypoxia signalling. Mutat Res (2008) 1.12

Soluble nickel interferes with cellular iron homeostasis. Mol Cell Biochem (2005) 1.11

Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features. Cancer (2007) 1.11

Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B. Toxicol In Vitro (2010) 1.06

The role of oxidative stress in mechanisms of metal-induced carcinogenesis. Crit Rev Oncol Hematol (2002) 1.04

Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition. Cancer Res (2009) 1.01

Epigenetic mechanisms of nickel carcinogenesis. J Environ Pathol Toxicol Oncol (2000) 1.00

Epigenetic and HIF-1 regulation of stanniocalcin-2 expression in human cancer cells. Exp Cell Res (2008) 0.97

Exploring the molecular mechanisms of nickel-induced genotoxicity and carcinogenicity: a literature review. Rev Environ Health (2011) 0.93

N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells. Mutat Res (2010) 0.90

Epigenetic inactivation of E-cadherin by promoter hypermethylation in oral carcinoma cells. Odontology (2007) 0.89

Aberrant gene methylation in the lymph nodes provides a possible marker for diagnosing micrometastasis in gastric cancer. Ann Surg Oncol (2009) 0.89

Nickel induces oxidative stress and genotoxicity in human lymphocytes. Toxicol Appl Pharmacol (2003) 0.85

Molecular mechanisms of nickel carcinogenesis: gene silencing by nickel delivery to the nucleus and gene activation/inactivation by nickel-induced cell signaling. J Environ Monit (2003) 0.84

Nickel-induced down-regulation of serpin by hypoxic signaling. Toxicol Appl Pharmacol (2004) 0.84

CpG methylation of promoter region inactivates E-cadherin gene in renal cell carcinoma. Mol Carcinog (2001) 0.84

Co-exposure to nickel and cobalt chloride enhances cytotoxicity and oxidative stress in human lung epithelial cells. Toxicol Appl Pharmacol (2011) 0.84

Nickel promotes the invasive potential of human lung cancer cells via TLR4/MyD88 signaling. Toxicology (2011) 0.82

N-acetyl cysteine and penicillamine induce apoptosis via the ER stress response-signaling pathway. Mol Carcinog (2010) 0.82

Free radicals and cell chemiluminescence. Biochemistry (Mosc) (2009) 0.81

The accumulation of nickel in human lungs. Environ Health Perspect (1989) 0.81

Articles by these authors

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00

Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res (2005) 4.25

PIK3CA mutations and copy number gains in human lung cancers. Cancer Res (2008) 3.42

Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int J Cancer (2003) 2.01

Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res (2010) 1.44

Association of p53 codon 72 genotypes and clinical outcome in human papillomavirus-infected lung cancer patients. Ann Thorac Surg (2013) 1.41

Loss of telomerase activity may be a potential favorable prognostic marker in lung carcinomas. Lung Cancer (2003) 1.34

Ets2 binding site single nucleotide polymorphism at the hTERT gene promoter--effect on telomerase expression and telomere length maintenance in non-small cell lung cancer. Eur J Cancer (2006) 1.34

Oxidative DNA damage in pterygium. Mol Vis (2005) 1.23

Human papillomavirus 16/18 E6 oncoprotein is expressed in lung cancer and related with p53 inactivation. Cancer Res (2007) 1.23

Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status. Ann Surg Oncol (2008) 1.13

Antibiotic therapy for necrotizing fasciitis caused by Vibrio vulnificus: retrospective analysis of an 8 year period. J Antimicrob Chemother (2011) 1.11

A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer. Clin Cancer Res (2011) 1.09

Accumulation of chromium and nickel metals in lung tumors from lung cancer patients in Taiwan. J Toxicol Environ Health A (2006) 1.07

Matrix metalloproteinase-13 expression is associated with bone marrow microinvolvement and prognosis in non-small cell lung cancer. Lung Cancer (2006) 1.07

The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer. Clin Cancer Res (2007) 1.06

Reduced p21(WAF1/CIP1) via alteration of p53-DDX3 pathway is associated with poor relapse-free survival in early-stage human papillomavirus-associated lung cancer. Clin Cancer Res (2011) 1.05

cIAP2 upregulated by E6 oncoprotein via epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT pathway confers resistance to cisplatin in human papillomavirus 16/18-infected lung cancer. Clin Cancer Res (2010) 1.03

The presence of human papillomavirus type 16/18 DNA in blood circulation may act as a risk marker of lung cancer in Taiwan. Cancer (2003) 1.03

IL-10 promotes tumor aggressiveness via upregulation of CIP2A transcription in lung adenocarcinoma. Clin Cancer Res (2013) 1.02

Comparison of Escherichia coli and Klebsiella pneumoniae liver abscesses. Am J Med Sci (2007) 1.02

Down-regulation of MMP-2 through the p38 MAPK-NF-kappaB-dependent pathway by aloe-emodin leads to inhibition of nasopharyngeal carcinoma cell invasion. Mol Carcinog (2010) 1.02

Dioscorea nipponica Makino inhibits migration and invasion of human oral cancer HSC-3 cells by transcriptional inhibition of matrix metalloproteinase-2 through modulation of CREB and AP-1 activity. Food Chem Toxicol (2011) 1.02

CD133+ glioblastoma stem-like cells induce vascular mimicry in vivo. Curr Neurovasc Res (2011) 1.00

Genetic determinants of pemetrexed responsiveness and nonresponsiveness in non-small cell lung cancer cells. J Thorac Oncol (2010) 0.98

An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection. Cancer Lett (2005) 0.98

Gender difference in the prognostic role of interleukin 6 in oral squamous cell carcinoma. PLoS One (2012) 0.97

Gender difference in estrogen receptor alpha promoter hypermethylation and its prognostic value in non-small cell lung cancer. Int J Cancer (2005) 0.97

Human papilloma virus 16 E6 oncoprotein associated with p53 inactivation in colorectal cancer. World J Gastroenterol (2012) 0.97

Effect of TIMP-1 and MMP in pterygium invasion. Invest Ophthalmol Vis Sci (2010) 0.97

Scoring of p16(INK4a) immunohistochemistry based on independent nuclear staining alone can sufficiently distinguish between endocervical and endometrial adenocarcinomas in a tissue microarray study. Mod Pathol (2009) 0.96

Loss of TIMP-3 promotes tumor invasion via elevated IL-6 production and predicts poor survival and relapse in HPV-infected non-small cell lung cancer. Am J Pathol (2012) 0.96

Exposure to mosquito coil smoke may be a risk factor for lung cancer in Taiwan. J Epidemiol (2008) 0.95

Pyogenic liver abscess in the elderly: clinical features, outcomes and prognostic factors. Age Ageing (2009) 0.95

Severity of disease as main predictor for mortality in patients with pyogenic liver abscess. Am J Surg (2009) 0.95

Interleukin-10 haplotype may predict survival and relapse in resected non-small cell lung cancer. PLoS One (2012) 0.95

ZAK inhibits human lung cancer cell growth via ERK and JNK activation in an AP-1-dependent manner. Cancer Sci (2010) 0.95

Urinary tract dysfunction after radical hysterectomy for cervical cancer. Gynecol Oncol (2002) 0.95

GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells. Autophagy (2011) 0.95

The mechanisms of action of Tianhua(™) on antitumor activity in lung cancer cells. Pharm Biol (2010) 0.94

High expression of interleukin 10 might predict poor prognosis in early stage oral squamous cell carcinoma patients. Clin Chim Acta (2012) 0.94

P53 gene mutation spectrum and the relationship between gene mutation and protein levels in pterygium. Mol Vis (2005) 0.94

Analysis of NQO1, GSTP1, and MnSOD genetic polymorphisms on lung cancer risk in Taiwan. Lung Cancer (2003) 0.93

Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization. J Exp Clin Cancer Res (2008) 0.93

Dual inhibitor of phosphoinositide 3-kinase/mammalian target of rapamycin NVP-BEZ235 effectively inhibits cisplatin-resistant urothelial cancer cell growth through autophagic flux. Toxicol Lett (2013) 0.92

Intravenous implanted neural stem cells migrate to injury site, reduce infarct volume, and improve behavior after cerebral ischemia. Curr Neurovasc Res (2010) 0.92

Bedside colonoscopy for critically ill patients with acute lower gastrointestinal bleeding. Intensive Care Med (2005) 0.92

NAT2 fast acetylator genotype is associated with an increased risk of lung cancer among never-smoking women in Taiwan. Cancer Lett (2005) 0.91

The correlation between aberrant connexin 43 mRNA expression induced by promoter methylation and nodal micrometastasis in non-small cell lung cancer. Clin Cancer Res (2003) 0.91

Comparing the scoring mechanisms of p16INK4a immunohistochemistry based on independent nucleic stains and independent cytoplasmic stains in distinguishing between endocervical and endometrial adenocarcinomas in a tissue microarray study. Arch Gynecol Obstet (2009) 0.91

Frequent p16INK4a promoter hypermethylation in human papillomavirus-infected female lung cancer in Taiwan. Int J Cancer (2005) 0.91

Different human papillomavirus 16/18 infection in Chinese non-small cell lung cancer patients living in Wuhan, China. Jpn J Clin Oncol (2006) 0.91

Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells. J Cell Biochem (2011) 0.90

N-acetyl cysteine mitigates curcumin-mediated telomerase inhibition through rescuing of Sp1 reduction in A549 cells. Mutat Res (2010) 0.90

Gender difference in human papillomarvirus infection for non-small cell lung cancer in Taiwan. Lung Cancer (2004) 0.90

Expression status of ribonucleotide reductase small subunits hRRM2/p53R2 as prognostic biomarkers in stage I and II non-small cell lung cancer. Anticancer Res (2011) 0.90

Origin of uterine teratoma differs from that of ovarian teratoma: a case of uterine mature cystic teratoma. Int J Gynecol Pathol (2011) 0.90

p53 Expression in pterygium by immunohistochemical analysis: a series report of 127 cases and review of the literature. Cornea (2005) 0.90

Differential impact of IL-10 expression on survival and relapse between HPV16-positive and -negative oral squamous cell carcinomas. PLoS One (2012) 0.90

Clinical outcomes and prognostic factors of cancer patients with pyogenic liver abscess. J Gastrointest Surg (2011) 0.90

Cyclooxygenase 2 expression in pterygium. Mol Vis (2007) 0.89

GMI, a Ganoderma immunomodulatory protein, down-regulates tumor necrosis factor α-induced expression of matrix metalloproteinase 9 via NF-κB pathway in human alveolar epithelial A549 cells. J Agric Food Chem (2010) 0.89

MnSOD promotes tumor invasion via upregulation of FoxM1-MMP2 axis and related with poor survival and relapse in lung adenocarcinomas. Mol Cancer Res (2012) 0.89

L-type calcium channel blockers reverse docetaxel and vincristine-induced multidrug resistance independent of ABCB1 expression in human lung cancer cell lines. Toxicol Lett (2009) 0.89

Distinguishing between primary endocervical and endometrial adenocarcinomas: is a 2-marker (Vim/CEA) panel enough? Virchows Arch (2010) 0.89

Association of cooking oil fumes exposure with lung cancer: involvement of inhibitor of apoptosis proteins in cell survival and proliferation in vitro. Mutat Res (2006) 0.89

Characterization of endogenous neural progenitor cells after experimental ischemic stroke. Curr Neurovasc Res (2010) 0.89

Human telomerase reverse transcriptase activated by E6 oncoprotein is required for human papillomavirus-16/18-infected lung tumorigenesis. Clin Cancer Res (2008) 0.88

Hepatitis delta virus epigenetically enhances clusterin expression via histone acetylation in human hepatocellular carcinoma cells. J Gen Virol (2009) 0.87

Assessment of salivary function change in nasopharyngeal carcinoma treated by parotid-sparing radiotherapy. Cancer J (2007) 0.87

Nm23-H1: a metastasis-associated gene. Taiwan J Obstet Gynecol (2006) 0.87

LKB1 loss at transcriptional level promotes tumor malignancy and poor patient outcomes in colorectal cancer. Ann Surg Oncol (2014) 0.87

Null type of glutathione S-transferase M1 polymorphism is associated with early onset pterygium. Mol Vis (2004) 0.87

HPV infection and p53 inactivation in pterygium. Mol Vis (2009) 0.87

Transcriptionally mediated inhibition of telomerase of fungal immunomodulatory protein from Ganoderma tsugae in A549 human lung adenocarcinoma cell line. Mol Carcinog (2006) 0.87

Up-regulation of interleukin-17 expression by human papillomavirus type 16 E6 in nonsmall cell lung cancer. Cancer (2010) 0.86

Clinical outcomes and prognostic factors for patients with Vibrio vulnificus infections requiring intensive care: a 10-yr retrospective study. Crit Care Med (2010) 0.86

The APE1 Asp/Asp genotype and the combination of APE1 Asp/Asp and hOGG1-Cys variants are associated with increased p53 mutation in non-small cell lung cancer. J Epidemiol (2012) 0.86

Undecylprodigiosin selectively induces apoptosis in human breast carcinoma cells independent of p53. Toxicol Appl Pharmacol (2007) 0.86

Genetic polymorphism of the tissue inhibitor of metalloproteinase-1 is associated with an increased risk of endometrial cancer. Clin Chim Acta (2009) 0.86

p53 dysfunction by xeroderma pigmentosum group C defects enhance lung adenocarcinoma metastasis via increased MMP1 expression. Cancer Res (2010) 0.86

CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization. Mol Vis (2010) 0.86

Up-regulation of osteopontin expression by aryl hydrocarbon receptor via both ligand-dependent and ligand-independent pathways in lung cancer. Gene (2011) 0.85

Preoperative prediction of extracapsular tumor extension at radical retropubic prostatectomy in Taiwanese patients with T1c prostate cancer. Jpn J Clin Oncol (2002) 0.85

Promoter methylation of O(6)-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53. DNA Repair (Amst) (2008) 0.85

Frequent FHIT gene loss of heterozygosity in human papillomavirus-infected non-smoking female lung cancer in Taiwan. Cancer Lett (2005) 0.85

Associations of MDM2 SNP309, transcriptional activity, mRNA expression, and survival in stage I non-small-cell lung cancer patients with wild-type p53 tumors. Ann Surg Oncol (2009) 0.85

Human papillomavirus up-regulates MMP-2 and MMP-9 expression and activity by inducing interleukin-8 in lung adenocarcinomas. PLoS One (2013) 0.85

Genetic polymorphism of the plasminogen activator inhibitor-1 is associated with an increased risk of endometrial cancer. J Surg Oncol (2011) 0.84

Long-term results of intensity-modulated radiotherapy concomitant with chemotherapy for hypopharyngeal carcinoma aimed at laryngeal preservation. BMC Cancer (2010) 0.84

Lipocalin 2, a new GADD153 target gene, as an apoptosis inducer of endoplasmic reticulum stress in lung cancer cells. Toxicol Appl Pharmacol (2012) 0.84

Loss of nuclear expression of Krüppel-like factor 4 is associated with poor prognosis in patients with oral cancer. Hum Pathol (2011) 0.84

Human papillomavirus type 16/18 up-regulates the expression of interleukin-6 and antiapoptotic Mcl-1 in non-small cell lung cancer. Clin Cancer Res (2008) 0.84

Activation of NF-κB by SOD2 promotes the aggressiveness of lung adenocarcinoma by modulating NKX2-1-mediated IKKβ expression. Carcinogenesis (2013) 0.84

Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells. Biochem Pharmacol (2004) 0.84