Published in J Immunol on December 15, 2005
Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity (2008) 5.82
Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cells. Proc Natl Acad Sci U S A (2006) 3.70
Flagellin as an adjuvant: cellular mechanisms and potential. J Immunol (2010) 2.68
Therapeutic targeting of Toll-like receptors for infectious and inflammatory diseases and cancer. Pharmacol Rev (2009) 2.30
The adaptor molecule MyD88 activates PI-3 kinase signaling in CD4+ T cells and enables CpG oligodeoxynucleotide-mediated costimulation. Immunity (2006) 2.04
TLR-dependent T cell activation in autoimmunity. Nat Rev Immunol (2011) 1.88
Toll-like receptor ligands induce human T cell activation and death, a model for HIV pathogenesis. PLoS One (2008) 1.83
The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol (2008) 1.75
TLR7 induces anergy in human CD4(+) T cells. Nat Immunol (2014) 1.56
TLR2-independent induction and regulation of chronic intestinal inflammation. Eur J Immunol (2010) 1.55
Regulatory T cell suppressive potency dictates the balance between bacterial proliferation and clearance during persistent Salmonella infection. PLoS Pathog (2010) 1.53
GITR Blockade Facilitates Treg Mediated Allograft Survival. Transplantation (2009) 1.48
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update (2009) 1.43
T cell expression of MyD88 is required for resistance to Toxoplasma gondii. Proc Natl Acad Sci U S A (2008) 1.43
Feeding our immune system: impact on metabolism. Clin Dev Immunol (2008) 1.42
Regulatory T-cell homeostasis: steady-state maintenance and modulation during inflammation. Immunol Rev (2014) 1.38
Ligation of TLR9 induced on human IL-10-secreting Tregs by 1alpha,25-dihydroxyvitamin D3 abrogates regulatory function. J Clin Invest (2009) 1.35
The effects of TLR activation on T-cell development and differentiation. Clin Dev Immunol (2012) 1.33
Toll-like receptor signalling on Tregs: to suppress or not to suppress? Immunology (2008) 1.33
Engagement of TLR2 does not reverse the suppressor function of mouse regulatory T cells, but promotes their survival. J Immunol (2009) 1.32
CpG DNA inhibits CD4+CD25+ Treg suppression through direct MyD88-dependent costimulation of effector CD4+ T cells. Immunol Lett (2007) 1.29
Toll-like receptors in the skin. Semin Immunopathol (2007) 1.27
Peripheral CD4 loss of regulatory T cells is associated with persistent viraemia in chronic HIV infection. Clin Exp Immunol (2007) 1.24
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology (2008) 1.23
Foxp3(+) regulatory T cells, immune stimulation and host defence against infection. Immunology (2012) 1.20
TLR agonists: our best frenemy in cancer immunotherapy. J Leukoc Biol (2013) 1.18
Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut (2007) 1.18
Toll-like receptors and immune regulation: their direct and indirect modulation on regulatory CD4+ CD25+ T cells. Immunology (2007) 1.16
Regulatory T cells overturned: the effectors fight back. Immunology (2009) 1.13
Microbial infection-induced expansion of effector T cells overcomes the suppressive effects of regulatory T cells via an IL-2 deprivation mechanism. J Immunol (2011) 1.11
How flagellin and toll-like receptor 5 contribute to enteric infection. Infect Immun (2006) 1.11
Translating tumor antigens into cancer vaccines. Clin Vaccine Immunol (2010) 1.09
The importance of Foxp3 antibody and fixation/permeabilization buffer combinations in identifying CD4+CD25+Foxp3+ regulatory T cells. Cytometry A (2009) 1.09
The expression and functions of toll-like receptors in atherosclerosis. Mediators Inflamm (2010) 1.07
Regulatory T cells in experimental autoimmune disease. Springer Semin Immunopathol (2006) 1.06
The immunomodulatory properties of the CD5 lymphocyte receptor in health and disease. Curr Opin Immunol (2011) 1.05
Treg functional stability and its responsiveness to the microenvironment. Immunol Rev (2014) 1.01
The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival. J Immunol (2010) 1.00
Therapeutic cancer vaccines: past, present, and future. Adv Cancer Res (2013) 0.99
The multiple facets of toll-like receptors in transplantation biology. Transplantation (2008) 0.99
Regulatory T cells and toll-like receptors: regulating the regulators. Ann Rheum Dis (2007) 0.99
Regulatory T cells and innate immune regulation in tumor immunity. Springer Semin Immunopathol (2006) 0.99
The emergence of immunomodulation: combinatorial immunochemotherapy opportunities for the next decade. Gynecol Oncol (2009) 0.99
Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci (2011) 0.96
Modulation of immune responses through direct activation of Toll-like receptors to T cells. Clin Exp Immunol (2010) 0.96
The contribution of direct TLR signaling to T cell responses. Immunol Res (2009) 0.94
Regulatory T cells and Toll-like receptors: what is the missing link? Int Immunopharmacol (2009) 0.94
Flagellin, a TLR5 agonist, reduces graft-versus-host disease in allogeneic hematopoietic stem cell transplantation recipients while enhancing antiviral immunity. J Immunol (2011) 0.93
TLR-2 activation induces regulatory T cells and long-term suppression of asthma manifestations in mice. PLoS One (2013) 0.93
Activation requirements and responses to TLR ligands in human CD4+ T cells: comparison of two T cell isolation techniques. J Immunol Methods (2009) 0.92
Microbe-dendritic cell dialog controls regulatory T-cell fate. Immunol Rev (2010) 0.92
Towards curative cancer immunotherapy: overcoming posttherapy tumor escape. Clin Dev Immunol (2012) 0.92
Toll-Like Receptor Activation in Immunity vs. Tolerance in Autoimmune Diabetes. Front Immunol (2014) 0.90
T regulatory cells: an overview and intervention techniques to modulate allergy outcome. Clin Mol Allergy (2009) 0.89
Foxp3+ regulatory T cells impede the priming of protective CD8+ T cells. J Immunol (2011) 0.89
Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells. Vet Immunol Immunopathol (2007) 0.89
NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells. PLoS One (2012) 0.88
Regulatory T cells in microbial infection. Springer Semin Immunopathol (2006) 0.88
The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice. Vaccine (2008) 0.87
Lactobacillus paracasei subsp. paracasei B21060 suppresses human T-cell proliferation. Infect Immun (2007) 0.87
Targeting of TLRs inhibits CD4+ regulatory T cell function and activates lymphocytes in human peripheral blood mononuclear cells. J Immunol (2014) 0.86
Gene-environment interactions between CD14 C-260T and endotoxin exposure on Foxp3+ and Foxp3- CD4+ lymphocyte numbers and total serum IgE levels in early childhood. Ann Allergy Asthma Immunol (2008) 0.85
Origin and functions of pro-inflammatory cytokine producing Foxp3+ regulatory T cells. Cytokine (2015) 0.85
MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus. J Immunol (2014) 0.84
Nonimmune Cells Contribute to Crosstalk between Immune Cells and Inflammatory Mediators in the Innate Response to Trypanosoma cruzi Infection. J Parasitol Res (2011) 0.84
Immunopathogenesis of IBD: insufficient suppressor function in the gut? Gut (2006) 0.84
Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression. Front Immunol (2016) 0.83
Commensal microbiota drive proliferation of conventional and Foxp3(+) regulatory CD4(+) T cells in mesenteric lymph nodes and Peyer's patches. Eur J Microbiol Immunol (Bp) (2013) 0.82
Burkholderia pseudomallei infection of T cells leads to T-cell costimulation partially provided by flagellin. Infect Immun (2008) 0.82
Insights into the Relationship between Toll Like Receptors and Gamma Delta T Cell Responses. Front Immunol (2014) 0.82
Regulatory T cells and the immune pathogenesis of prenatal infection. Reproduction (2013) 0.81
Toll-Like Receptors in the Pathogenesis of Autoimmune Diseases. Adv Pharm Bull (2015) 0.81
Selective targeting of Toll-like receptors and OX40 inhibit regulatory T-cell function in follicular lymphoma. Int J Cancer (2014) 0.80
Expression of IL-37 contributes to the immunosuppressive property of human CD4(+)CD25(+) regulatory T cells. Sci Rep (2015) 0.80
Recent advances in the role of toll-like receptors and TLR agonists in immunotherapy for human glioma. Protein Cell (2014) 0.80
Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production. Mol Immunol (2013) 0.80
rFliC prolongs allograft survival in association with the activation of recipient Tregs in a TLR5-dependent manner. Cell Mol Immunol (2013) 0.79
Intranasal immunization with a flagellin-adjuvanted peptide anticancer vaccine prevents tumor development by enhancing specific cytotoxic T lymphocyte response in a mouse model. Clin Exp Vaccine Res (2013) 0.79
Effects of Toll-like receptor signals in T-cell neoplasms. Future Oncol (2011) 0.79
Inclusion of Flagellin during Vaccination against Influenza Enhances Recall Responses in Nonhuman Primate Neonates. J Virol (2015) 0.78
MiRNome and transcriptome aided pathway analysis in human regulatory T cells. Genes Immun (2014) 0.78
TLR5 signaling enhances the proliferation of human allogeneic CD40-activated B cell induced CD4hiCD25+ regulatory T cells. PLoS One (2013) 0.78
Reevaluating the hype: four bacterial metabolites under scrutiny. Eur J Microbiol Immunol (Bp) (2015) 0.77
MALT1 is an intrinsic regulator of regulatory T cells. Cell Death Differ (2015) 0.77
Heat shock protein 60 reactive T cells in juvenile idiopathic arthritis: what is new? Arthritis Res Ther (2009) 0.77
Danger Signals and Graft-versus-host Disease: Current Understanding and Future Perspectives. Front Immunol (2016) 0.77
Expansion of melanoma-specific lymphocytes in alternate gamma chain cytokines: gene expression variances between T cells and T-cell subsets exposed to IL-2 versus IL-7/15. Cancer Gene Ther (2014) 0.76
Bacillus-derived poly-γ-glutamic acid reciprocally regulates the differentiation of T helper 17 and regulatory T cells and attenuates experimental autoimmune encephalomyelitis. Clin Exp Immunol (2012) 0.76
Close Encounters of Lymphoid Cells and Bacteria. Front Immunol (2016) 0.75
Regulatory T cell expressed MyD88 is critical for prolongation of allograft survival. Transpl Int (2016) 0.75
Leukocyte TLR5 deficiency inhibits atherosclerosis by reduced macrophage recruitment and defective T-cell responsiveness. Sci Rep (2017) 0.75
Non-invasive imaging of allogeneic transplanted skin graft by 131I-anti-TLR5 mAb. J Cell Mol Med (2014) 0.75
Toll like Receptor 2 engagement on CD4(+) T cells promotes TH9 differentiation and function. Eur J Immunol (2017) 0.75
Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity. Front Immunol (2017) 0.75
Transcriptional modulation of pattern recognition receptors in chronic colitis in mice is accompanied with Th1 and Th17 response. Biochem Biophys Rep (2017) 0.75
Bacterial flagellin-a potent immunomodulatory agent. Exp Mol Med (2017) 0.75
Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev (2006) 6.08
Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol (2007) 5.45
The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest (2005) 3.83
Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol (2013) 2.96
Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 2.58
Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood (2006) 2.12
CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol (2010) 2.03
The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells. Eur J Immunol (2009) 1.89
CD4+ T-regulatory cells: toward therapy for human diseases. Immunol Rev (2008) 1.85
Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur J Immunol (2002) 1.76
Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3. Mol Ther (2007) 1.64
STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. Int Immunol (2008) 1.58
Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur J Immunol (2008) 1.45
Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium. Infect Immun (2008) 1.41
Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol (2010) 1.40
Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5. J Biol Chem (2002) 1.37
Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells. J Immunol (2010) 1.32
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS One (2012) 1.26
Moving to tolerance: clinical application of T regulatory cells. Semin Immunol (2011) 1.25
The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology (2008) 1.23
Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers. Immunology (2012) 1.20
TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Front Immunol (2012) 1.17
Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci. J Immunol (2011) 1.17
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest (2011) 1.10
Suppression assays with human T regulatory cells: a technical guide. Eur J Immunol (2011) 1.10
Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. Blood (2010) 1.07
Graft-versus-host disease: suppression by statins. Nat Med (2008) 1.05
Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol (2011) 1.04
Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils. Eur J Immunol (2011) 1.02
SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol (2009) 1.02
Immune regulation in obesity-associated adipose inflammation. J Immunol (2013) 1.01
Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. Am J Trop Med Hyg (2003) 1.01
Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells. J Immunol (2006) 1.00
Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest (2016) 0.99
Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells. J Immunol Methods (2007) 0.99
Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. J Immunol (2007) 0.98
Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity. J Immunol (2013) 0.98
Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells. J Immunol (2010) 0.97
A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells. Blood (2012) 0.96
Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses. Am J Physiol Gastrointest Liver Physiol (2012) 0.95
Autoactivation of the AggR regulator of enteroaggregative Escherichia coli in vitro and in vivo. FEMS Immunol Med Microbiol (2010) 0.94
Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation. Immunology (2004) 0.93
TLR5 is not required for flagellin-mediated exacerbation of DSS colitis. Inflamm Bowel Dis (2010) 0.93
The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Front Immunol (2012) 0.91
Infectious diarrhea: new pathogens and new challenges in developed and developing areas. Clin Infect Dis (2006) 0.91
The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. J Immunol (2010) 0.90
Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells. J Allergy Clin Immunol (2010) 0.89
A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin. Biochem Biophys Res Commun (2006) 0.89
ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells. Blood (2009) 0.89
Exploiting lipid-free tubing passive samplers and embryonic zebrafish to link site specific contaminant mixtures to biological responses. Chemosphere (2010) 0.88
Environmental influences on T regulatory cells in inflammatory bowel disease. Semin Immunol (2011) 0.87
Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. J Clin Invest (2014) 0.86
Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. Am J Physiol Gastrointest Liver Physiol (2010) 0.86
Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods Mol Biol (2007) 0.86
CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol (2011) 0.86
The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells. Inflamm Bowel Dis (2010) 0.85
Control of tissue-localized immune responses by human regulatory T cells. Eur J Immunol (2014) 0.85
Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations. Blood (2009) 0.85
Retracted Polycyclic aromatic hydrocarbon (PAH) and oxygenated PAH (OPAH) air-water exchange during the deepwater horizon oil spill. Environ Sci Technol (2014) 0.84
An approach for calculating a confidence interval from a single aquatic sample for monitoring hydrophobic organic contaminants. Environ Toxicol Chem (2012) 0.83
Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineered bilayer skin substitute. Wound Repair Regen (2010) 0.83
Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans". J Immunol (2013) 0.82
Toll-like receptor 5 deficiency protects from wasting disease in a T cell transfer colitis model in T cell receptor-β-deficient mice. Inflamm Bowel Dis (2011) 0.82
A non-synonymous coding variant (L616F) in the TLR5 gene is potentially associated with Crohn's disease and influences responses to bacterial flagellin. PLoS One (2013) 0.81
Natural killer T cells constitutively expressing the interleukin-2 receptor α chain early in life are primed to respond to lower antigenic stimulation. Immunology (2010) 0.81
Cellular magnetic resonance imaging of monocyte-derived dendritic cell migration from healthy donors and cancer patients as assessed in a scid mouse model. Cytotherapy (2011) 0.81
Molecular regulation of cellular immunity by FOXP3. Adv Exp Med Biol (2009) 0.80
SHIP-deficient dendritic cells, unlike wild type dendritic cells, suppress T cell proliferation via a nitric oxide-independent mechanism. PLoS One (2011) 0.79
Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space. Micron (2010) 0.79
T regulatory cell therapy in transplantation: stability, localization and functional specialization. Curr Opin Organ Transplant (2012) 0.79
The role of FOXP3 in regulating immune responses. Int Rev Immunol (2013) 0.79
CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance. Cell Transplant (2015) 0.78
In vitro generation of human T regulatory cells: generation, culture, and analysis of FOXP3-transduced T cells. Methods Mol Biol (2013) 0.76
Retraction of "Polycyclic Aromatic Hydrocarbon (PAH) and Oxygenated PAH (OPAH) Air-Water Exchange during the Deepwater Horizon Oil Spill". Environ Sci Technol (2016) 0.76
Pro-tolerogenic effects of photodynamic therapy with TH9402 on dendritic cells. J Clin Apher (2008) 0.76
T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression. J Clin Invest (2016) 0.76
Passive sampling coupled to ultraviolet irradiation: a useful analytical approach for studying oxygenated polycyclic aromatic hydrocarbon formation in bioavailable mixtures. Environ Toxicol Chem (2013) 0.75
The p110α and p110β isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells. Mediators Inflamm (2010) 0.75
ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation. Eur J Immunol (2012) 0.75
The Obese Species: a special issue on obesity and metabolic disorders. Foreword. Dis Model Mech (2012) 0.75
3rd Keystone Symposium on T regulatory cells. Immunotherapy (2009) 0.75
Adenoviral-transduced dendritic cells are susceptible to suppression by T regulatory cells and promote interleukin 17 production. Cancer Immunol Immunother (2010) 0.75
Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation. Transplantation (2017) 0.75