Published in J Lipid Res on December 10, 2005
Niemann-Pick C2 (NPC2) and intracellular cholesterol trafficking. Biochim Biophys Acta (2009) 1.54
Cholesterol-dependent balance between evoked and spontaneous synaptic vesicle recycling. J Physiol (2006) 1.35
Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases. Dis Model Mech (2012) 1.31
Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles. Mol Biol Cell (2009) 1.22
Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex. Proc Natl Acad Sci U S A (2008) 1.13
The Tetrahymena thermophila phagosome proteome. Eukaryot Cell (2006) 1.11
The oligomeric state sets GABA(B) receptor signalling efficacy. EMBO J (2011) 1.05
Early glial activation, synaptic changes and axonal pathology in the thalamocortical system of Niemann-Pick type C1 mice. Neurobiol Dis (2011) 1.00
Niemann-Pick C disease and mobilization of lysosomal cholesterol by cyclodextrin. J Lipid Res (2014) 0.96
Cholesterol in brain disease: sometimes determinant and frequently implicated. EMBO Rep (2014) 0.88
Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration. Mol Cell Proteomics (2010) 0.80
Brain Cholesterol Metabolism and Its Defects: Linkage to Neurodegenerative Diseases and Synaptic Dysfunction. Acta Naturae (2016) 0.77
Developmental delay in motor skill acquisition in Niemann-Pick C1 mice reveals abnormal cerebellar morphogenesis. Acta Neuropathol Commun (2016) 0.75
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell (2011) 2.75
Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes (2007) 2.24
Phosphatidylcholine and choline homeostasis. J Lipid Res (2008) 2.17
Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase. Cell Metab (2011) 2.14
The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis. Cell Metab (2006) 2.03
Phospholipid biosynthesis in mammalian cells. Biochem Cell Biol (2004) 1.98
Retrograde support of neuronal survival without retrograde transport of nerve growth factor. Science (2002) 1.97
The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Sci Transl Med (2011) 1.95
A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures. Cell Res (2009) 1.63
Is it time to reevaluate methyl balance in humans? Am J Clin Nutr (2006) 1.61
Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins. J Biol Chem (2004) 1.53
Phosphatidylcholine biosynthesis and lipoprotein metabolism. Biochim Biophys Acta (2011) 1.53
Disruption of the phosphatidylserine decarboxylase gene in mice causes embryonic lethality and mitochondrial defects. J Biol Chem (2005) 1.48
Glial lipoproteins stimulate axon growth of central nervous system neurons in compartmented cultures. J Biol Chem (2004) 1.45
Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity. J Biol Chem (2010) 1.44
An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem (2002) 1.43
Impaired ABCA1-dependent lipid efflux and hypoalphalipoproteinemia in human Niemann-Pick type C disease. J Biol Chem (2003) 1.40
Cholesterol accumulates in cell bodies, but is decreased in distal axons, of Niemann-Pick C1-deficient neurons. J Neurochem (2002) 1.36
Apolipoprotein E-containing lipoproteins protect neurons from apoptosis via a signaling pathway involving low-density lipoprotein receptor-related protein-1. J Neurosci (2007) 1.33
Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr (2007) 1.33
A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J Biol Chem (2003) 1.27
Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells. Biochim Biophys Acta (2009) 1.27
Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci (2005) 1.26
Microsomal triacylglycerol transfer protein is required for lumenal accretion of triacylglycerol not associated with ApoB, as well as for ApoB lipidation. J Biol Chem (2002) 1.25
Normalization of cholesterol homeostasis by 2-hydroxypropyl-β-cyclodextrin in neurons and glia from Niemann-Pick C1 (NPC1)-deficient mice. J Biol Chem (2012) 1.22
Phosphatidylcholine homeostasis and liver failure. J Biol Chem (2005) 1.20
Regulation of Wallerian degeneration and nerve growth factor withdrawal-induced pruning of axons of sympathetic neurons by the proteasome and the MEK/Erk pathway. Mol Cell Neurosci (2005) 1.20
Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion. FASEB J (2003) 1.20
Phosphatidylethanolamine deficiency in Mammalian mitochondria impairs oxidative phosphorylation and alters mitochondrial morphology. J Biol Chem (2012) 1.19
Early embryonic lethality caused by disruption of the gene for choline kinase alpha, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem (2007) 1.17
Defective cholesterol trafficking in Niemann-Pick C-deficient cells. FEBS Lett (2010) 1.16
Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem (2002) 1.14
A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis. J Biol Chem (2005) 1.12
Missense mutations in APOB within the betaalpha1 domain of human APOB-100 result in impaired secretion of ApoB and ApoB-containing lipoproteins in familial hypobetalipoproteinemia. J Biol Chem (2007) 1.12
Increased activity and altered subcellular distribution of lysosomal enzymes determine neuronal vulnerability in Niemann-Pick type C1-deficient mice. Am J Pathol (2009) 1.12
Choline deficiency-induced liver damage is reversible in Pemt(-/-) mice. J Nutr (2002) 1.10
Absence of stearoyl-CoA desaturase-1 ameliorates features of the metabolic syndrome in LDLR-deficient mice. J Lipid Res (2007) 1.09
Inhibition of hepatic phosphatidylcholine synthesis by 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside is independent of AMP-activated protein kinase activation. J Biol Chem (2006) 1.08
Ero1alpha requires oxidizing and normoxic conditions to localize to the mitochondria-associated membrane (MAM). Cell Stress Chaperones (2010) 1.07
Adverse hepatic and cardiac responses to rosiglitazone in a new mouse model of type 2 diabetes: relation to dysregulated phosphatidylcholine metabolism. Vascul Pharmacol (2006) 1.04
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem (2005) 1.04
Sequential synthesis and methylation of phosphatidylethanolamine promote lipid droplet biosynthesis and stability in tissue culture and in vivo. J Biol Chem (2011) 1.03
Physiological consequences of disruption of mammalian phospholipid biosynthetic genes. J Lipid Res (2008) 1.02
Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons. J Biol Chem (2002) 1.02
Hepatic CTP:phosphocholine cytidylyltransferase-alpha is a critical predictor of plasma high density lipoprotein and very low density lipoprotein. J Biol Chem (2007) 1.01
Regulation of the enzymes of hepatic microsomal triacylglycerol lipolysis and re-esterification by the glucocorticoid dexamethasone. Biochem J (2004) 1.01
Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice. Biochim Biophys Acta (2006) 1.01
A choline-deficient diet in mice inhibits neither the CDP-choline pathway for phosphatidylcholine synthesis in hepatocytes nor apolipoprotein B secretion. J Biol Chem (2004) 1.00
Apolipoprotein B and triacylglycerol secretion in human triacylglycerol hydrolase transgenic mice. J Lipid Res (2007) 1.00
Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. Diabetes (2010) 1.00
Transcriptional regulation of phosphatidylcholine biosynthesis. Prog Lipid Res (2008) 0.99
Defining the importance of phosphatidylserine synthase 2 in mice. J Biol Chem (2002) 0.99
Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis. Hepatology (2010) 0.99
Phosphorylation of Sp1 by cyclin-dependent kinase 2 modulates the role of Sp1 in CTP:phosphocholine cytidylyltransferase alpha regulation during the S phase of the cell cycle. J Biol Chem (2004) 0.99
Generation and function of astroglial lipoproteins from Niemann-Pick type C1-deficient mice. Biochem J (2005) 0.99
Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. J Biol Chem (2009) 0.98
Molecular dissection of the S-adenosylmethionine-binding site of phosphatidylethanolamine N-methyltransferase. J Biol Chem (2003) 0.97
Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia. J Biol Chem (2005) 0.96
Regulation of triacylglycerol hydrolase expression by dietary fatty acids and peroxisomal proliferator-activated receptors. Biochim Biophys Acta (2003) 0.95
Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice. J Biol Chem (2008) 0.95
Understanding the muscular dystrophy caused by deletion of choline kinase beta in mice. Biochim Biophys Acta (2009) 0.94
Spatial requirements for TrkA kinase activity in the support of neuronal survival and axon growth in rat sympathetic neurons. Neuropharmacology (2003) 0.94
Insights into the requirement of phosphatidylcholine synthesis for liver function in mice. J Lipid Res (2003) 0.94
Lipid homeostasis and lipoprotein secretion in Niemann-Pick C1-deficient hepatocytes. J Biol Chem (2006) 0.93
Expression of phosphatidylethanolamine N-methyltransferase in human hepatocellular carcinomas. Oncology (2003) 0.93
Phosphatidylcholine biosynthesis via CTP:phosphocholine cytidylyltransferase 2 facilitates neurite outgrowth and branching. J Biol Chem (2007) 0.93
Correction of apolipoprotein A-I-mediated lipid efflux and high density lipoprotein particle formation in human Niemann-Pick type C disease fibroblasts. J Biol Chem (2006) 0.92
Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim Biophys Acta (2010) 0.91
Triacylglycerol hydrolase is localized to the endoplasmic reticulum by an unusual retrieval sequence where it participates in VLDL assembly without utilizing VLDL lipids as substrates. Mol Biol Cell (2004) 0.90
Hepatic uptake and metabolism of phosphatidylcholine associated with high density lipoproteins. Biochim Biophys Acta (2009) 0.90
Choline Deficiency Attenuates Body Weight Gain and Improves Glucose Tolerance in ob/ob Mice. J Obes (2012) 0.90
Choline kinase and its function. Biochem Cell Biol (2010) 0.90
Choline redistribution during adaptation to choline deprivation. J Biol Chem (2007) 0.89
Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. Hepatology (2012) 0.89
Activation of CTP:phosphocholine cytidylyltransferase alpha expression during the S phase of the cell cycle is mediated by the transcription factor Sp1. J Biol Chem (2003) 0.89
Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes. Diabetes (2005) 0.88
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2009) 0.88
Metabolic insights into phospholipid function using gene-targeted mice. J Biol Chem (2005) 0.88
Impaired phosphatidylcholine biosynthesis reduces atherosclerosis and prevents lipotoxic cardiac dysfunction in ApoE-/- Mice. Circ Res (2011) 0.87