Published in J Exp Med on January 29, 2007
Launching the T-cell-lineage developmental programme. Nat Rev Immunol (2008) 3.86
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
E and ID proteins branch out. Nat Rev Immunol (2009) 2.68
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17
Delta-like 4 is indispensable in thymic environment specific for T cell development. J Exp Med (2008) 2.02
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A (2010) 1.84
Notch-induced T cell development requires phosphoinositide-dependent kinase 1. EMBO J (2007) 1.67
Regulation of innate and adaptive immunity by Notch. Nat Rev Immunol (2013) 1.58
Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell (2008) 1.58
Ikaros represses the transcriptional response to Notch signaling in T-cell development. Mol Cell Biol (2008) 1.33
Multilayered specification of the T-cell lineage fate. Immunol Rev (2010) 1.32
The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med (2008) 1.31
Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest (2013) 1.27
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem (2013) 1.19
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14
T-cell lineage determination. Immunol Rev (2010) 1.14
Transcriptional control of early T and B cell developmental choices. Annu Rev Immunol (2014) 1.03
Differential requirement for the SAP-Fyn interaction during NK T cell development and function. J Immunol (2008) 1.03
Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci U S A (2012) 0.99
Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major. PLoS Pathog (2012) 0.97
Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine Kras(G12D)-induced skin carcinogenesis in vivo. PLoS One (2010) 0.97
The Notch ligands Jagged2, Delta1, and Delta4 induce differentiation and expansion of functional human NK cells from CD34+ cord blood hematopoietic progenitor cells. Biol Blood Marrow Transplant (2009) 0.93
Human intrathymic development: a selective approach. Semin Immunopathol (2008) 0.88
Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development. Semin Immunopathol (2008) 0.88
Eliciting the T cell fate with Notch. Semin Immunol (2010) 0.86
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain. Dev Dyn (2009) 0.86
HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity. Clin Dev Immunol (2012) 0.86
Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development. Int Immunol (2010) 0.85
Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice. Stem Cells (2012) 0.84
Controlled major histocompatibility complex-T cell receptor signaling allows efficient generation of functional, antigen-specific CD8+ T cells from embryonic stem cells and thymic progenitors. Tissue Eng Part A (2010) 0.82
T Cell Genesis: In Vitro Veritas Est? Trends Immunol (2016) 0.82
AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway. Blood (2011) 0.82
Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. Nat Methods (2017) 0.81
Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes. Immunology (2013) 0.79
A Tale from TGF-β Superfamily for Thymus Ontogeny and Function. Front Immunol (2015) 0.79
Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells. PLoS One (2013) 0.78
Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis. PLoS One (2011) 0.78
Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice. J Immunol (2010) 0.78
In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination. Stem Cells (2015) 0.78
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun (2016) 0.78
STAT5-induced lunatic fringe during Th2 development alters delta-like 4-mediated Th2 cytokine production in respiratory syncytial virus-exacerbated airway allergic disease. J Immunol (2013) 0.77
Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet (2015) 0.76
A simple model system enabling human CD34(+) cells to undertake differentiation towards T cells. PLoS One (2013) 0.76
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors? Mol Cancer (2016) 0.75
Notch Stimulates Both Self-Renewal and Lineage Plasticity in a Subset of Murine CD9High Committed Megakaryocytic Progenitors. PLoS One (2016) 0.75
Assessment of human multi-potent hematopoietic stem/progenitor cell potential using a single in vitro screening system. PLoS One (2012) 0.75
Fate Decision Between Group 3 Innate Lymphoid and Conventional NK Cell Lineages by Notch Signaling in Human Circulating Hematopoietic Progenitors. J Immunol (2017) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res (1961) 18.57
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76
Deficient T cell fate specification in mice with an induced inactivation of Notch1. Immunity (1999) 8.33
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity (2002) 8.17
A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus. Mol Cell Biol (1985) 7.66
Notch1 expression in early lymphopoiesis influences B versus T lineage determination. Immunity (1999) 5.34
Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int Immunol (2002) 4.66
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat Immunol (2001) 3.89
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity (2003) 3.73
Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu Rev Immunol (2005) 3.58
Notch regulation of lymphocyte development and function. Nat Immunol (2004) 3.39
Control points in early T-cell development. Immunol Today (1993) 3.33
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity (2002) 2.83
Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes Dev (1998) 2.70
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol (2004) 2.63
Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. J Exp Med (2004) 2.58
Glycosylation regulates Notch signalling. Nat Rev Mol Cell Biol (2003) 2.48
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality. Development (1999) 2.05
Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med (2001) 2.02
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. J Exp Med (2001) 1.94
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
DNA polymerase kappa deficiency does not affect somatic hypermutation in mice. Eur J Immunol (2002) 1.79
Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors. Blood (2004) 1.68
Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles. Gene Expr Patterns (2005) 1.63
Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development. Int Immunol (1999) 1.60
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol (2006) 1.57
Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins. Methods Enzymol (2000) 1.50
Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood (2006) 1.34
Modulated expression of notch1 during thymocyte development. Blood (1996) 1.31
Molecular and cellular events in early thymocyte development. Adv Immunol (1998) 1.24
Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions. Immunol Rev (2006) 1.20
Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development. J Immunol (2006) 1.17
Stepwise specification of lymphocyte developmental lineages. Curr Opin Genet Dev (2000) 1.15
A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer. Blood (2001) 1.05
Ectopic expression of Delta4 impairs hematopoietic development and leads to lymphoproliferative disease. Blood (2002) 1.01
In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects. J Immunol (2005) 0.99
Active form of Notch imposes T cell fate in human progenitor cells. J Immunol (2002) 0.99
Extrathymic hemopoietic progenitors committed to T cell differentiation in the adult mouse. J Immunol (2005) 0.99
Unexpectedly late expression of intracellular CD3epsilon and TCR gammadelta proteins during adult thymus development. Int Immunol (1999) 0.97
Lack of Delta like 1 and 4 expressions in nude thymus anlages. Cell Immunol (2005) 0.92
Major T cell progenitor activity in bone marrow-derived spleen colonies. J Exp Med (2002) 0.86
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell (2008) 11.53
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Notch1 functions as a tumor suppressor in mouse skin. Nat Genet (2003) 6.76
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. Genes Dev (2004) 5.83
A thymic pathway of mouse natural killer cell development characterized by expression of GATA-3 and CD127. Nat Immunol (2006) 3.74
Transcription factor RORα is critical for nuocyte development. Nat Immunol (2012) 3.72
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med (2004) 3.16
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell (2008) 3.08
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO Rep (2008) 3.03
Notch signaling in the immune system. Immunity (2010) 3.00
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. Immunity (2002) 2.83
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. Blood (2004) 2.44
Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1. Hepatology (2013) 2.34
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. Immunity (2010) 2.29
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Notch signaling is required for exocrine regeneration after acute pancreatitis. Gastroenterology (2007) 2.26
Liver-specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice. Hepatology (2008) 2.21
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. J Exp Med (2008) 2.17
Multiple functions of Notch signaling in self-renewing organs and cancer. FEBS Lett (2006) 2.14
Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling. Nature (2012) 2.13
Simultaneous loss of beta- and gamma-catenin does not perturb hematopoiesis or lymphopoiesis. Blood (2007) 2.06
Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms. Immunity (2008) 2.05
The thymus exports long-lived fully committed T cell precursors that can colonize primary lymphoid organs. Nat Immunol (2005) 1.98
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin. PLoS One (2010) 1.92
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Dormant and self-renewing hematopoietic stem cells and their niches. Ann N Y Acad Sci (2007) 1.89
Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma. Proc Natl Acad Sci U S A (2010) 1.84
Hedgehog signaling is dispensable for adult hematopoietic stem cell function. Cell Stem Cell (2009) 1.84
Notch inhibits osteoblast differentiation and causes osteopenia. Endocrinology (2008) 1.78
Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78
Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res (2006) 1.75
Inducible inactivation of Notch1 causes nodular regenerative hyperplasia in mice. Hepatology (2005) 1.73
Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. J Neurosci (2010) 1.72
Notch1 is required for neuronal and glial differentiation in the cerebellum. Development (2002) 1.69
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J (2005) 1.68
Notch-induced T cell development requires phosphoinositide-dependent kinase 1. EMBO J (2007) 1.67
Notch signaling in solid tumors. Curr Top Dev Biol (2010) 1.66
Notch1 control of oligodendrocyte differentiation in the spinal cord. J Cell Biol (2002) 1.65
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood (2010) 1.60
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Multiple roles of Notch signaling in the regulation of epidermal development. Dev Cell (2008) 1.58
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nat Immunol (2006) 1.57
Loss of cutaneous TSLP-dependent immune responses skews the balance of inflammation from tumor protective to tumor promoting. Cancer Cell (2012) 1.56
Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation. Dev Biol (2005) 1.54
Corneal epithelial cell fate is maintained during repair by Notch1 signaling via the regulation of vitamin A metabolism. Dev Cell (2007) 1.49
Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors. J Neurosci (2004) 1.48
Stem cells living with a Notch. Development (2013) 1.48
Notch1 is essential for postnatal hair follicle development and homeostasis. Dev Biol (2005) 1.48
DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest (2015) 1.45
Control of Epstein-Barr virus reactivation by activated CD40 and viral latent membrane protein 1. Proc Natl Acad Sci U S A (2001) 1.40
Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev Dyn (2007) 1.40
Notch signaling in lymphopoiesis. Semin Immunol (2003) 1.37
Notch in T-ALL: new players in a complex disease. Trends Immunol (2011) 1.35
Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity (2010) 1.35
Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med (2008) 1.34
Mechanisms of T cell development and transformation. Annu Rev Cell Dev Biol (2011) 1.33
IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO J (2011) 1.33
The stream of precursors that colonizes the thymus proceeds selectively through the early T lineage precursor stage of T cell development. J Exp Med (2008) 1.31
Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J Immunol (2004) 1.31
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest (2011) 1.29
Enrichment of human CD4+ V(alpha)24/Vbeta11 invariant NKT cells in intrahepatic malignant tumors. J Immunol (2009) 1.25
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells. Immunity (2012) 1.24
Control of the adaptive response of the heart to stress via the Notch1 receptor pathway. J Exp Med (2008) 1.24
Stem cell biology meets systems biology. Development (2009) 1.22
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (2012) 1.21
Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system. Cell Microbiol (2005) 1.19
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med (2010) 1.18
Dynamic regulation of notch 1 and notch 2 surface expression during T cell development and activation revealed by novel monoclonal antibodies. J Immunol (2009) 1.17
Conditional ablation of Notch signaling in pancreatic development. Development (2008) 1.16
Characterization of T cell differentiation in the murine gut. J Exp Med (2002) 1.14