Published in Pflugers Arch on August 02, 2008
The role of adipose tissue and adipokines in obesity-related inflammatory diseases. Mediators Inflamm (2010) 1.59
Clinical review: adiponectin biology and its role in inflammation and critical illness. Crit Care (2011) 1.19
Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjects. Lipids Health Dis (2010) 0.97
Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents. Nutr J (2012) 0.88
Investigation of nuclear factor-κB inhibitors and interleukin-10 as regulators of inflammatory signalling in human adipocytes. Clin Exp Immunol (2010) 0.85
Obesity and IL-6 interact in modulating the response to endotoxemia in mice. Cytokine (2012) 0.81
Lipopolysaccharide induces a downregulation of adiponectin receptors in-vitro and in-vivo. PeerJ (2015) 0.80
Visceral and subcutaneous adipose tissue from lean women respond differently to lipopolysaccharide-induced alteration of inflammation and glyceroneogenesis. Nutr Diabetes (2012) 0.79
Circulating anti-inflammatory adipokines High Molecular Weight Adiponectin and Zinc-α2-glycoprotein (ZAG) are inhibited in early sepsis, but increase with clinical recovery: a pilot study. BMC Anesthesiol (2014) 0.79
The inflammatory response seen when human omental adipose tissue explants are incubated in primary culture is not dependent upon albumin and is primarily in the nonfat cells. J Inflamm (Lond) (2010) 0.79
Short-Term Dietary Restriction Rescues Mice From Lethal Abdominal Sepsis and Endotoxemia and Reduces the Inflammatory/Coagulant Potential of Adipose Tissue. Crit Care Med (2016) 0.77
Implication of REDD1 in the activation of inflammatory pathways. Sci Rep (2017) 0.75
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med (2001) 46.58
Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22
Intensive insulin therapy in critically ill patients. N Engl J Med (2001) 40.00
Inflammation and metabolic disorders. Nature (2006) 33.33
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 32.01
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 25.54
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun (1999) 14.25
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med (2001) 9.68
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation (2000) 6.96
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes (2007) 6.81
Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr (2004) 6.31
Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci U S A (2003) 6.06
Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab (1997) 5.84
Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation (2000) 5.36
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab (2007) 4.94
Cecal ligation and puncture. Shock (2005) 3.93
Increased plasma levels of interleukin-6 in sepsis. Blood (1989) 3.92
Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) (2007) 3.72
Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem (2003) 3.57
Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol Metab (2000) 3.42
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest (1996) 2.68
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun (2006) 2.56
Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc (2001) 2.54
Signalling role of adipose tissue: adipokines and inflammation in obesity. Biochem Soc Trans (2005) 2.53
Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia. J Exp Med (1997) 2.48
Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab (2007) 2.48
Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch (2007) 2.39
Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans. J Infect Dis (1998) 2.27
Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand (2005) 1.94
The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem (2000) 1.87
Hypoxia, HIF-1, and the pathophysiology of common human diseases. Adv Exp Med Biol (2000) 1.79
Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun (2003) 1.79
Oxygen, a source of life and stress. FEBS Lett (2007) 1.67
IL-1 beta mediates leptin induction during inflammation. Am J Physiol (1998) 1.57
Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. Am J Physiol Endocrinol Metab (2004) 1.51
Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochem Biophys Res Commun (2006) 1.48
Outcome of morbid obesity in the intensive care unit. J Intensive Care Med (2005) 1.36
The effect of body mass index on patient outcomes in a medical ICU. Chest (2005) 1.33
Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes Relat Metab Disord (2003) 1.22
Tumor necrosis factor-alpha induces apoptosis of human adipose cells. Diabetes (1997) 1.21
Targets for TNF-alpha-induced lipolysis in human adipocytes. Biochem Biophys Res Commun (2004) 1.16
The microcirculation as a functional system. Crit Care (2005) 1.16
Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats. Gut (1998) 1.14
The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol (2005) 1.11
The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytes. Biochem Biophys Res Commun (2005) 1.06
Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. Pflugers Arch (2006) 1.06
Hypoxia-inducible factor-1 (HIF-1). Crit Care Med (2005) 1.03
Effect of short-term intralipid infusion on the immune response during low-dose endotoxemia in humans. Am J Physiol Endocrinol Metab (2007) 0.98
Leptin and interleukin-6 in sepsis. Horm Metab Res (1998) 0.96
NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Am J Physiol Endocrinol Metab (2004) 0.92
Effects of hyperglycemia and insulin therapy on outcome in a hyperglycemic septic model of critical illness. J Trauma (2006) 0.88
Sepsis-induced regulation of lipoprotein lipase expression in rat adipose tissue and soleus muscle. J Lipid Res (1997) 0.81
The lipolytic responsiveness to endotoxin in subcutaneous adipose tissue is greater than mesenteric adipose tissue. Tohoku J Exp Med (2003) 0.80
Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patients with sepsis or circulatory failure. Clin Physiol Funct Imaging (2003) 0.79
Advances in sepsis research derived from animal models. Int J Med Microbiol (2007) 0.76
Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit Care (2013) 3.90
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins. Br J Nutr (2003) 2.62
Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch (2007) 2.39
The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients. Crit Care Med (2011) 2.21
IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes. Biochem Biophys Res Commun (2009) 1.86
Arterial pressure-based cardiac output monitoring: a multicenter validation of the third-generation software in septic patients. Intensive Care Med (2010) 1.77
Cellular hypoxia and adipose tissue dysfunction in obesity. Proc Nutr Soc (2009) 1.71
Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre study. J Clin Monit Comput (2013) 1.70
Circulating Histones Are Major Mediators of Cardiac Injury in Patients With Sepsis. Crit Care Med (2015) 1.63
Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia. Proc Natl Acad Sci U S A (2004) 1.55
Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha. Am J Physiol Endocrinol Metab (2004) 1.51
Comments on Reinhart et al.: consensus statement of the ESICM task force on colloid volume therapy in critically ill patients. Intensive Care Med (2012) 1.47
Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX). Crit Care Med (2015) 1.40
Sevoflurane exposure prevents diaphragmatic oxidative stress during mechanical ventilation but reduces force and affects protein metabolism even during spontaneous breathing in a rat model. Anesth Analg (2015) 1.38
Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology (2008) 1.34
Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women. Eur J Endocrinol (2007) 1.31
Vitamin D signalling in adipose tissue. Br J Nutr (2012) 1.28
Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes. FEBS Lett (2005) 1.24
The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr (2005) 1.24
Hydroxyethylstarch impairs renal function and induces interstitial proliferation, macrophage infiltration and tubular damage in an isolated renal perfusion model. Crit Care (2009) 1.23
Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium. Pflugers Arch (2009) 1.21
Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes. J Endocrinol (2008) 1.18
Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes. Pflugers Arch (2009) 1.17
The value of rotation thromboelastometry to monitor disturbed perioperative haemostasis and bleeding risk in patients with cardiopulmonary bypass. Blood Coagul Fibrinolysis (2008) 1.09
Activated protein C induces the release of microparticle-associated endothelial protein C receptor. Blood (2004) 1.09
The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytes. Biochem Biophys Res Commun (2005) 1.06
Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture. Pflugers Arch (2006) 1.06
Rhythmic diurnal gene expression in human adipose tissue from individuals who are lean, overweight, and type 2 diabetic. Diabetes (2011) 1.05
Clinical validation of a new thermodilution system for the assessment of cardiac output and volumetric parameters. Crit Care (2012) 1.05
Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes. Biochem Biophys Res Commun (2007) 1.03
Obesity, its associated disorders and the role of inflammatory adipokines in companion animals. Vet J (2010) 1.03
Plasma concentrations of alpha-MSH, AgRP and leptin in lean and obese men and their relationship to differing states of energy balance perturbation. Clin Endocrinol (Oxf) (2004) 1.02
Antimicrobial peptides and their potential application in inflammation and sepsis. Crit Care (2012) 1.02
Ontogenic loss of brown adipose tissue sensitivity to beta-adrenergic stimulation in the ovine. Endocrinology (2006) 1.02
Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Biochem Biophys Res Commun (2003) 0.99
Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma. Biochem Biophys Res Commun (2004) 0.98
A microarray analysis of the hypoxia-induced modulation of gene expression in human adipocytes. Arch Physiol Biochem (2012) 0.96
Dexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activation. J Transl Med (2013) 0.96
New insights into adipose tissue atrophy in cancer cachexia. Proc Nutr Soc (2009) 0.94
NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines. Am J Physiol Endocrinol Metab (2004) 0.92
PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes. Biochem Biophys Res Commun (2008) 0.91
Assessment and clinical course of hypocalcemia in critical illness. Crit Care (2013) 0.91
Inflammatory gene expression patterns revealed by DNA microarray analysis in TNF-alpha-treated SGBS human adipocytes. Yonsei Med J (2006) 0.90
Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes. Br J Nutr (2007) 0.90
The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study. Crit Care (2013) 0.89
The clinical and functional relevance of microparticles induced by activated protein C treatment in sepsis. Crit Care (2011) 0.89
Characterization of buccal microvascular response in patients with septic shock. Eur J Anaesthesiol (2010) 0.89
Minimally invasive haemodynamic monitoring. Eur J Anaesthesiol (2009) 0.88
Hemodynamic changes during acute elevation of intra-abdominal pressure in rabbits. Paediatr Anaesth (2006) 0.88
Effects of propofol on early and late cytokines in lipopolysaccharide-induced septic shock in rats. J Biomed Res (2010) 0.88
Postnatal expression of zinc-alpha2-glycoprotein in rat white and brown adipose tissue. Mol Cell Endocrinol (2007) 0.87
Effects of dexmedetomidine on early and late cytokines during polymicrobial sepsis in mice. Inflamm Res (2013) 0.87
The German quality indicators in intensive care medicine 2013--second edition. Ger Med Sci (2013) 0.86
Regulation of adipose tissue metabolism in cancer cachexia. Curr Opin Clin Nutr Metab Care (2008) 0.86
Impairment of renal function using hyperoncotic colloids in a two hit model of shock: a prospective randomized study. Crit Care (2012) 0.86
Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite. Nutrition (2012) 0.86
Modulation of adipokine production, glucose uptake and lactate release in human adipocytes by small changes in oxygen tension. Pflugers Arch (2011) 0.86
Analysis of regional compliance in a porcine model of acute lung injury. Respir Physiol Neurobiol (2012) 0.85
Contrasts between the effects of zinc-α2-glycoprotein, a putative β3/2-adrenoceptor agonist and the β3/2-adrenoceptor agonist BRL35135 in C57Bl/6 (ob/ob) mice. J Endocrinol (2013) 0.85
Fatty acids and hypoxia stimulate the expression and secretion of the adipokine ANGPTL4 (angiopoietin-like protein 4/ fasting-induced adipose factor) by human adipocytes. J Nutrigenet Nutrigenomics (2011) 0.84
Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes. Pflugers Arch (2006) 0.84
Accuracy and precision of calibrated arterial pulse contour analysis in patients with subarachnoid hemorrhage requiring high-dose vasopressor therapy: a prospective observational clinical trial. Crit Care (2014) 0.83
Correlations between platelet-derived microvesicles and thrombin generation in patients with coronary artery disease. Platelets (2008) 0.83
ADAMTS13 activity is decreased in a septic porcine model. Significance for glomerular thrombus deposition. Thromb Haemost (2010) 0.83
Neurological outcome after experimental lung injury. Respir Physiol Neurobiol (2011) 0.82
Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise. Br J Nutr (2011) 0.82
Effect of Drotrecogin alfa (activated) on platelet receptor expression in vitro. Platelets (2007) 0.81
The adipokine zinc-α2-glycoprotein activates AMP kinase in human primary skeletal muscle cells. Arch Physiol Biochem (2011) 0.81
Soluble Heparan Sulfate in Serum of Septic Shock Patients Induces Mitochondrial Dysfunction in Murine Cardiomyocytes. Shock (2015) 0.80
Impact of stable PGI₂ analog iloprost on early graft viability after liver transplantation: a pilot study. Clin Transplant (2011) 0.80
Psychoacoustic analysis of noise and the application of earplugs in an ICU: A randomised controlled clinical trial. Eur J Anaesthesiol (2016) 0.80
Stimulation of inflammatory gene expression in human preadipocytes by macrophage-conditioned medium: upregulation of IL-6 production by macrophage-derived IL-1β. Mol Cell Endocrinol (2011) 0.80
Alterations in zinc binding capacity, free zinc levels and total serum zinc in a porcine model of sepsis. Biometals (2015) 0.80
Resistin and RELM-alpha gene expression in white adipose tissue of lactating mice. Biochem Biophys Res Commun (2002) 0.79
Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification. Front Physiol (2013) 0.79
Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2. Am J Physiol Endocrinol Metab (2005) 0.79
Circulating Histone Concentrations Differentially Affect the Predominance of Left or Right Ventricular Dysfunction in Critical Illness. Crit Care Med (2016) 0.78
Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalpha. Pflugers Arch (2010) 0.78
Circulating soluble advanced glycation end product is inversely associated with the significant risk of developing cancer: evidence from a meta-analysis. Tumour Biol (2014) 0.78
Continuous monitoring of central venous oxygen saturation in neonates and small infants: in vitro evaluation of two different oximetry catheters. Paediatr Anaesth (2006) 0.78
Fluid-induced coagulopathy: does the type of fluid make a difference? Crit Care (2010) 0.77
Nutritional genomics - "Nutrigenomics". Br J Nutr (2003) 0.77
Hydrocortisone does not affect major platelet receptors in inflammation in vitro. Steroids (2007) 0.77
The effects of physiological and pharmacological weight loss on adiponectin and leptin mRNA levels in the rat epididymal adipose tissue. Eur J Pharmacol (2007) 0.77
Obesity -- what role now for nutritional science? Br J Nutr (2005) 0.77
Evidence-based fluid management in the ICU. Curr Opin Anaesthesiol (2016) 0.77
Successful treatment of an aggressive non-Hodgkin's lymphoma associated with acute respiratory insufficiency using extracorporeal membrane oxygenation. Interact Cardiovasc Thorac Surg (2007) 0.77
Dextran-70 to modulate inflammatory response after cardiopulmonary bypass: potential for a novel approach? Crit Care (2007) 0.77
Novel Synthetic, Host-defense Peptide Protects Against Organ Injury/Dysfunction in a Rat Model of Severe Hemorrhagic Shock. Ann Surg (2017) 0.77
Response to delivery stress is not mediated by beta-endorphin (1-31). Eur J Obstet Gynecol Reprod Biol (2007) 0.76
HIF-1alpha protein rather than mRNA as a marker of hypoxia in adipose tissue in obesity: focus on "inflammation is associated with a decrease of lipogenic factors in omental fat in women," by Poulain-Godefroy et al. Am J Physiol Regul Integr Comp Physiol (2008) 0.76
Adipose tissue. Editorial. Arch Physiol Biochem (2011) 0.76
Crystalloid and colloid preload for maintaining cardiac output in elderly patients undergoing total hip replacement under spinal anesthesia. J Biomed Res (2011) 0.76
[Is there any indication for perioperative use of the pulmonary artery catheter?]. Anasthesiol Intensivmed Notfallmed Schmerzther (2012) 0.76