Published in Science on May 01, 2003
Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia. J Virol (2005) 9.13
Bats: important reservoir hosts of emerging viruses. Clin Microbiol Rev (2006) 8.77
Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. MBio (2012) 8.54
Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci U S A (2005) 8.52
Viral discovery and sequence recovery using DNA microarrays. PLoS Biol (2003) 5.95
A previously undescribed coronavirus associated with respiratory disease in humans. Proc Natl Acad Sci U S A (2004) 5.76
Identification of anthrax toxin genes in a Bacillus cereus associated with an illness resembling inhalation anthrax. Proc Natl Acad Sci U S A (2004) 4.73
Prevalence and genetic diversity of coronaviruses in bats from China. J Virol (2006) 3.37
Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human. Proc Natl Acad Sci U S A (2005) 3.37
Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus. Microbiol Mol Biol Rev (2005) 3.18
Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J (2005) 3.14
Comparative analysis of twelve genomes of three novel group 2c and group 2d coronaviruses reveals unique group and subgroup features. J Virol (2006) 3.07
pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J Virol (2004) 3.04
The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor. Proc Natl Acad Sci U S A (2003) 3.02
A comprehensive assessment of N-terminal signal peptides prediction methods. BMC Bioinformatics (2009) 2.85
Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A (2003) 2.82
Evaluation of reverse transcription-PCR assays for rapid diagnosis of severe acute respiratory syndrome associated with a novel coronavirus. J Clin Microbiol (2003) 2.77
Severe acute respiratory syndrome coronavirus phylogeny: toward consensus. J Virol (2004) 2.61
Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission. J Virol (2009) 2.60
Tracking the evolution of the SARS coronavirus using high-throughput, high-density resequencing arrays. Genome Res (2004) 2.47
Epidemiology, transmission dynamics and control of SARS: the 2002-2003 epidemic. Philos Trans R Soc Lond B Biol Sci (2004) 2.45
Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus. J Clin Microbiol (2004) 2.45
Coronavirus HKU1 and other coronavirus infections in Hong Kong. J Clin Microbiol (2006) 2.44
Severe acute respiratory syndrome coronavirus spike protein expressed by attenuated vaccinia virus protectively immunizes mice. Proc Natl Acad Sci U S A (2004) 2.38
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci U S A (2004) 2.38
Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins. J Virol (2004) 2.38
Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. J Virol (2004) 2.29
A novel pancoronavirus RT-PCR assay: frequent detection of human coronavirus NL63 in children hospitalized with respiratory tract infections in Belgium. BMC Infect Dis (2005) 2.28
The spike protein of SARS-CoV--a target for vaccine and therapeutic development. Nat Rev Microbiol (2009) 2.23
Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice. J Virol (2005) 2.22
Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci U S A (2005) 2.21
Plasma inflammatory cytokines and chemokines in severe acute respiratory syndrome. Clin Exp Immunol (2004) 2.21
Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex. J Virol (2006) 2.20
Evolutionary insights into the ecology of coronaviruses. J Virol (2007) 2.16
BioTorrents: a file sharing service for scientific data. PLoS One (2010) 2.15
Molecular phylogenetics: principles and practice. Nat Rev Genet (2012) 2.08
Regulation of IRF-3-dependent innate immunity by the papain-like protease domain of the severe acute respiratory syndrome coronavirus. J Biol Chem (2007) 2.07
Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus. J Virol (2008) 2.06
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. J Virol (2005) 2.05
Arbovirus evolution in vivo is constrained by host alternation. Proc Natl Acad Sci U S A (2008) 2.04
Identification of severe acute respiratory syndrome coronavirus replicase products and characterization of papain-like protease activity. J Virol (2004) 1.97
Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms. J Virol (2005) 1.93
Health and economic benefits of an accelerated program of research to combat global infectious diseases. CMAJ (2004) 1.93
Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions. J Virol (2006) 1.91
Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1. J Virol (2006) 1.87
Characterization of the RNA components of a putative molecular switch in the 3' untranslated region of the murine coronavirus genome. J Virol (2004) 1.85
Diagnosis of severe acute respiratory syndrome (SARS) by detection of SARS coronavirus nucleocapsid antibodies in an antigen-capturing enzyme-linked immunosorbent assay. J Clin Microbiol (2003) 1.85
Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection. Proc Natl Acad Sci U S A (2005) 1.85
Modern clinical microbiology: new challenges and solutions. Nat Rev Microbiol (2013) 1.81
Improving gene annotation of complete viral genomes. Nucleic Acids Res (2003) 1.80
SARS coronavirus: a new challenge for prevention and therapy. J Clin Invest (2003) 1.80
S protein of severe acute respiratory syndrome-associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients. J Virol (2004) 1.80
Sockeye: a 3D environment for comparative genomics. Genome Res (2004) 1.80
Coronavirus non-structural protein 1 is a major pathogenicity factor: implications for the rational design of coronavirus vaccines. PLoS Pathog (2007) 1.78
Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia. J Clin Microbiol (2004) 1.78
Ultrastructural characterization of SARS coronavirus. Emerg Infect Dis (2004) 1.76
Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain. J Virol (2007) 1.75
Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc Natl Acad Sci U S A (2005) 1.75
Engineering H5N1 avian influenza viruses to study human adaptation. Nature (2012) 1.74
Design of wide-spectrum inhibitors targeting coronavirus main proteases. PLoS Biol (2005) 1.73
Modelling strategies for controlling SARS outbreaks. Proc Biol Sci (2004) 1.71
Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity. Proc Natl Acad Sci U S A (2004) 1.69
The nucleoprotein is required for efficient coronavirus genome replication. J Virol (2004) 1.68
Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin Microbiol Rev (2007) 1.68
MAVS-mediated apoptosis and its inhibition by viral proteins. PLoS One (2009) 1.67
Characterization of severe acute respiratory syndrome coronavirus genomes in Taiwan: molecular epidemiology and genome evolution. Proc Natl Acad Sci U S A (2004) 1.66
Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein. J Virol (2005) 1.64
Coronavirus genomics and bioinformatics analysis. Viruses (2010) 1.63
Identification of a severe acute respiratory syndrome coronavirus-like virus in a leaf-nosed bat in Nigeria. MBio (2010) 1.62
SEED servers: high-performance access to the SEED genomes, annotations, and metabolic models. PLoS One (2012) 1.62
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A (2004) 1.61
Mosaic evolution of the severe acute respiratory syndrome coronavirus. J Virol (2004) 1.61
Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome. BMC Immunol (2005) 1.61
Multiple organ infection and the pathogenesis of SARS. J Exp Med (2005) 1.58
Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis. J Virol (2006) 1.57
Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan. Emerg Infect Dis (2003) 1.55
ZCURVE_V: a new self-training system for recognizing protein-coding genes in viral and phage genomes. BMC Bioinformatics (2006) 1.54
Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants. J Virol (2005) 1.54
Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. J Virol (2010) 1.53
A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis. J Virol (2004) 1.53
Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium. J Virol (2007) 1.52
A severe acute respiratory syndrome coronavirus that lacks the E gene is attenuated in vitro and in vivo. J Virol (2006) 1.51
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience. CMAJ (2004) 1.50
Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism. J Virol (2013) 1.47
SARS coronavirus and innate immunity. Virus Res (2007) 1.44
Detection of a novel and highly divergent coronavirus from asian leopard cats and Chinese ferret badgers in Southern China. J Virol (2007) 1.44
Viral evolution and the emergence of SARS coronavirus. Philos Trans R Soc Lond B Biol Sci (2004) 1.44
Chloroquine is a potent inhibitor of SARS coronavirus infection and spread. Virol J (2005) 1.43
Viral proteomics. Microbiol Mol Biol Rev (2007) 1.43
Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome. PLoS One (2007) 1.42
Sensitive and specific monoclonal antibody-based capture enzyme immunoassay for detection of nucleocapsid antigen in sera from patients with severe acute respiratory syndrome. J Clin Microbiol (2004) 1.42
Characterization of the expression, intracellular localization, and replication complex association of the putative mouse hepatitis virus RNA-dependent RNA polymerase. J Virol (2003) 1.41
Macaque model for severe acute respiratory syndrome. J Virol (2004) 1.41
Discovery of novel human and animal cells infected by the severe acute respiratory syndrome coronavirus by replication-specific multiplex reverse transcription-PCR. J Clin Microbiol (2004) 1.41
A SARS DNA vaccine induces neutralizing antibody and cellular immune responses in healthy adults in a Phase I clinical trial. Vaccine (2008) 1.39
Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits. J Virol (2012) 1.39
Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS). J Clin Pathol (2004) 1.39
Review of bats and SARS. Emerg Infect Dis (2006) 1.38
The changing face of pathogen discovery and surveillance. Nat Rev Microbiol (2013) 1.37
Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04
ABySS: a parallel assembler for short read sequence data. Genome Res (2009) 43.20
Integrating common and rare genetic variation in diverse human populations. Nature (2010) 32.30
Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature (2004) 24.40
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Assembling millions of short DNA sequences using SSAKE. Bioinformatics (2006) 18.71
Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature (2009) 18.08
Evolutionary and biomedical insights from the rhesus macaque genome. Science (2007) 16.21
Scope and impact of financial conflicts of interest in biomedical research: a systematic review. JAMA (2003) 16.08
Identification of severe acute respiratory syndrome in Canada. N Engl J Med (2003) 14.29
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
Slider--maximum use of probability information for alignment of short sequence reads and SNP detection. Bioinformatics (2008) 14.04
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med (2010) 13.07
A systematic survey of loss-of-function variants in human protein-coding genes. Science (2012) 12.25
The clonal and mutational evolution spectrum of primary triple-negative breast cancers. Nature (2012) 11.91
mRNA-Seq whole-transcriptome analysis of a single cell. Nat Methods (2009) 11.71
Common regulatory variation impacts gene expression in a cell type-dependent manner. Science (2009) 11.28
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet (2010) 10.97
Genome-wide association study of 107 phenotypes in Arabidopsis thaliana inbred lines. Nature (2010) 10.66
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus. Nature (2007) 10.40
Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res (2008) 10.18
Profiling the HeLa S3 transcriptome using randomly primed cDNA and massively parallel short-read sequencing. Biotechniques (2008) 10.02
Dengue: a continuing global threat. Nat Rev Microbiol (2010) 9.96
Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature (2010) 9.81
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature (2011) 9.71
De novo assembly and analysis of RNA-seq data. Nat Methods (2010) 9.69
A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Science (2002) 9.59
Comparative genome and proteome analysis of Anopheles gambiae and Drosophila melanogaster. Science (2002) 9.43
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res (2004) 9.18
Transcriptome and genome sequencing uncovers functional variation in humans. Nature (2013) 8.89
De novo transcriptome assembly with ABySS. Bioinformatics (2009) 8.38
The genome sequence of taurine cattle: a window to ruminant biology and evolution. Science (2009) 8.23
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature (2007) 7.91
Modelling schizophrenia using human induced pluripotent stem cells. Nature (2011) 7.41
Whole-genome sequencing and social-network analysis of a tuberculosis outbreak. N Engl J Med (2011) 7.35
Analyses of deep mammalian sequence alignments and constraint predictions for 1% of the human genome. Genome Res (2007) 7.05
Mapping cis- and trans-regulatory effects across multiple tissues in twins. Nat Genet (2012) 6.97
Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses. Nat Med (2005) 6.77
FindPeaks 3.1: a tool for identifying areas of enrichment from massively parallel short-read sequencing technology. Bioinformatics (2008) 6.53
Next-generation tag sequencing for cancer gene expression profiling. Genome Res (2009) 6.50
A distinct lineage of influenza A virus from bats. Proc Natl Acad Sci U S A (2012) 6.27
Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus. Nature (2004) 6.11
The architecture of gene regulatory variation across multiple human tissues: the MuTHER study. PLoS Genet (2011) 5.95
Dynamic remodeling of individual nucleosomes across a eukaryotic genome in response to transcriptional perturbation. PLoS Biol (2008) 5.88
The new paradigm of flow cell sequencing. Genome Res (2008) 5.81
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Trends in survival after in-hospital cardiac arrest. N Engl J Med (2012) 5.67
Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis (2002) 5.64
Mutation of FOXL2 in granulosa-cell tumors of the ovary. N Engl J Med (2009) 5.63
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma. Genome Res (2011) 5.58
Network theory and SARS: predicting outbreak diversity. J Theor Biol (2005) 5.52
Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning. Nat Med (2003) 5.45
Patterns of cis regulatory variation in diverse human populations. PLoS Genet (2012) 5.28
Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet (2007) 5.21