Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.

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Published in Am J Hum Genet on October 28, 2005

Authors

M Daniele Fallin1, Virginia K Lasseter, Dimitrios Avramopoulos, Kristin K Nicodemus, Paula S Wolyniec, John A McGrath, Gary Steel, Gerald Nestadt, Kung-Yee Liang, Richard L Huganir, David Valle, Ann E Pulver

Author Affiliations

1: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21231, USA.

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Regulation of AMPA receptor trafficking and synaptic plasticity. Curr Opin Neurobiol (2012) 2.61

Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry (2007) 2.53

Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron (2005) 2.50

Prevalence and correlates of personality disorders in a community sample. Br J Psychiatry (2002) 2.49

Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation. Nat Neurosci (2009) 2.47

Lipoid proteinosis maps to 1q21 and is caused by mutations in the extracellular matrix protein 1 gene (ECM1). Hum Mol Genet (2002) 2.41

Microdeletions of 3q29 confer high risk for schizophrenia. Am J Hum Genet (2010) 2.38

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nat Med (2009) 2.37

Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science (2003) 2.36

Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci Lett (2004) 2.36

Prediction of real-world functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. Am J Psychiatry (2010) 2.35

Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J Neurosci (2002) 2.31

Recurrent DNA inversion rearrangements in the human genome. Proc Natl Acad Sci U S A (2007) 2.29

DNA methylation regulates MicroRNA expression. Cancer Biol Ther (2007) 2.21

Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites. Neuron (2005) 2.16

Prevalence and correlates of hoarding behavior in a community-based sample. Behav Res Ther (2008) 2.16

Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci (2004) 2.15

Regulation of thalamocortical patterning and synaptic maturation by NeuroD2. Neuron (2006) 2.15

Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons. J Neurosci (2003) 2.14

PhenoDB: a new web-based tool for the collection, storage, and analysis of phenotypic features. Hum Mutat (2013) 2.13

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons. Proc Natl Acad Sci U S A (2006) 2.11

Peroxisome biogenesis disorders. Annu Rev Genomics Hum Genet (2003) 2.09

Population-based study of first onset and chronicity in major depressive disorder. Arch Gen Psychiatry (2008) 2.01

Agoraphobia in adults: incidence and longitudinal relationship with panic. Br J Psychiatry (2006) 2.01

Imaging of receptor trafficking by using alpha-bungarotoxin-binding-site-tagged receptors. Proc Natl Acad Sci U S A (2004) 2.00

The identification of OCD-related subgroups based on comorbidity. Biol Psychiatry (2003) 2.00

Stabilization of Ca2+-permeable AMPA receptors at perisynaptic sites by GluR1-S845 phosphorylation. Proc Natl Acad Sci U S A (2009) 2.00

Regulation of AMPA receptor function by the human memory-associated gene KIBRA. Neuron (2011) 2.00

The molecular basis of lipoid proteinosis: mutations in extracellular matrix protein 1. Exp Dermatol (2007) 1.98

Recurrent mutations in kindlin-1, a novel keratinocyte focal contact protein, in the autosomal recessive skin fragility and photosensitivity disorder, Kindler syndrome. J Invest Dermatol (2004) 1.95

Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Am J Hum Genet (2003) 1.94

A systematic review of vitamin D receptor gene polymorphisms and prostate cancer risk. J Urol (2006) 1.86

Homeostatic regulation of AMPA receptor expression at single hippocampal synapses. Proc Natl Acad Sci U S A (2008) 1.85

Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses. Hum Mol Genet (2006) 1.84

PICK1 and phosphorylation of the glutamate receptor 2 (GluR2) AMPA receptor subunit regulates GluR2 recycling after NMDA receptor-induced internalization. J Neurosci (2007) 1.84

Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron (2009) 1.81

Neuropsychological functioning in bipolar disorder and schizophrenia. Biol Psychiatry (2006) 1.80

Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of hippocampus. J Neurophysiol (2009) 1.78

Reevaluating the role of LTD in cerebellar motor learning. Neuron (2011) 1.76

Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature (2009) 1.75

S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron (2005) 1.73

The role of synaptic GTPase-activating protein in neuronal development and synaptic plasticity. J Neurosci (2003) 1.71

Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. PLoS Genet (2013) 1.68

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A (2005) 1.68