Published in Leuk Res on January 04, 2006
Cardiac glycosides in cancer therapy: from preclinical investigations towards clinical trials. Invest New Drugs (2013) 1.04
Ex vivo activity of cardiac glycosides in acute leukaemia. PLoS One (2011) 0.81
Real-time analysis of the effects of toxic, therapeutic and sub-therapeutic concentrations of digitoxin on lung cancer cells. Biosens Bioelectron (2014) 0.79
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood (2004) 1.65
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. J Nat Prod (2005) 1.42
The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res (2005) 1.35
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. Proc Natl Acad Sci U S A (2012) 1.29
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer Res (2008) 1.13
NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem (2008) 1.04
Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity. Cancer Chemother Pharmacol (2003) 0.98
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents. Int J Environ Res Public Health (2012) 0.97
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat Prod (2007) 0.96
Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death. Pharmacol Rep (2012) 0.96
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair. Nucleic Acids Res (2013) 0.95
The role of topoisomerase II in the excision of DNA loop domains during apoptosis. J Biol Chem (2002) 0.93
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod (2011) 0.93
Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer. Mol Cancer Ther (2003) 0.93
Curcumin as a DNA topoisomerase II poison. J Enzyme Inhib Med Chem (2003) 0.92
Roles of DNA topoisomerases in chromosome segregation and mitosis. Mutat Res (2003) 0.89
A comparative study of genotoxic effects of anti-topoisomerase II drugs ICRF-193 and bufalin in Chinese hamster ovary cells. Mutat Res (2002) 0.89
Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. Mutagenesis (2011) 0.89
Toward a comprehensive model for induced endoreduplication. Life Sci (2004) 0.88
Induction of endoreduplication by topoisomerase II catalytic inhibitors. Mutagenesis (2003) 0.88
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open (2012) 0.88
Evaluation of genotoxic effects of heavy metals and arsenic in wild nestling white storks (Ciconia ciconia) and black kites (Milvus migrans) from southwestern Spain after a mining accident. Environ Toxicol Chem (2006) 0.87
Anti-tumour activity of Digitalis purpurea L. subsp. heywoodii. Planta Med (2003) 0.86
Cells lacking DNA topoisomerase II beta are resistant to genistein. J Nat Prod (2007) 0.86
Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance. Mol Pharmacol (2005) 0.86
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells. Mutat Res (2009) 0.85
Bufalin influences the repair of X-ray-induced DNA breaks in Chinese hamster cells. DNA Repair (Amst) (2003) 0.85
The coffee constituent chlorogenic acid induces cellular DNA damage and formation of topoisomerase I- and II-DNA complexes in cells. J Agric Food Chem (2012) 0.85
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents. Proc Natl Acad Sci U S A (2003) 0.85
Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide. J Nucleic Acids (2010) 0.84
Cytotoxic effect of Plantago spp. on cancer cell lines. J Ethnopharmacol (2003) 0.84
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. Mutagenesis (2010) 0.83
Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. Nucleus (2011) 0.82
DNA demethylation protects from cleavable complex stabilization and DNA strand breakage induced by the topoisomerase type I inhibitor camptothecin. Mutagenesis (2009) 0.82
Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance. FEBS Lett (2003) 0.81
Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells. Biochem Pharmacol (2002) 0.81
Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability. Nucleic Acids Res (2002) 0.80
The impact of the human DNA topoisomerase II C-terminal domain on activity. PLoS One (2008) 0.80
Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells. Mutat Res (2008) 0.80
Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. BMC Genomics (2013) 0.80
Genotoxicity detected in wild mice living in a highly polluted wetland area in south western Spain. Environ Pollut (2007) 0.80
Cisplatin-induced endoreduplication in CHO cells: DNA damage and inhibition of topoisomerase II. Mutat Res (2006) 0.80
The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells. Mutat Res (2005) 0.79
Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death. Toxicol Lett (2013) 0.79
Salicylate, a catalytic inhibitor of topoisomerase II, inhibits DNA cleavage and is selective for the α isoform. Mol Pharmacol (2013) 0.79
A 4 year follow-up analysis of genotoxic damage in birds of the Doñana area (south west Spain) in the wake of the 1998 mining waste spill. Mutagenesis (2004) 0.79
Modulation of radiation response by inhibiting topoisomerase II catalytic activity. Mutat Res (2006) 0.78
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. Genes Chromosomes Cancer (2013) 0.78
mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity. Nucleic Acids Res (2006) 0.78
High yield of endoreduplication induced by ICRF-193: a topoisomerase II catalytic inhibitor. Mutat Res (2002) 0.77
The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA. PLoS One (2011) 0.77
Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin. Mutat Res (2007) 0.77
Endoreduplication induced in cultured Chinese hamster cells by different anti-topoisomerase II chemicals. Evidence for the essential contribution of the enzyme to chromosome segregation. Mutat Res (2005) 0.76
Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells (2015) 0.76
Effect of phenazine compounds XR11576 and XR5944 on DNA topoisomerases. Cancer Chemother Pharmacol (2008) 0.76
The role of the DNA hypermethylating agent Budesonide in the decatenating activity of DNA topoisomerase II. Mutat Res (2010) 0.76
Differential selection of acridine resistance mutations in human DNA topoisomerase IIbeta is dependent on the acridine structure. Mol Pharmacol (2007) 0.76
Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells. Int J Cancer (2008) 0.76
Do transcription factories and TOP2B provide a recipe for chromosome translocations in therapy-related leukemia? Cell Cycle (2012) 0.75
The nature of DNA plays a role in chromosome segregation: endoreduplication in halogen-substituted chromosomes. DNA Repair (Amst) (2003) 0.75
Halogen substitution of DNA protects from poisoning of topoisomerase II that results in DNA double-strand breaks. DNA Repair (Amst) (2006) 0.75
The high rate of endoreduplication in the repair deficient CHO mutant EM9 parallels a reduced level of methylated deoxycytidine in DNA. Mutat Res (2008) 0.75
Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues. Bioorg Med Chem (2003) 0.75
The mycotoxin ochratoxin A inhibits DNA topoisomerase II and induces polyploidy in cultured CHO cells. Toxicol In Vitro (2009) 0.75
Cytotoxicity and mitotic alterations induced by non-genotoxic lithium salts in CHO cells in vitro. Toxicol In Vitro (2009) 0.75
The DNA topoisomerase II catalytic inhibitor merbarone is genotoxic and induces endoreduplication. Mutat Res (2012) 0.75
DNA topoisomerase activities in Chinese hamster radiosensitive mutants after X-ray treatment. Cell Biol Int (2002) 0.75