Substrate rigidity regulates the formation and maintenance of tissues.

PubWeight™: 3.08‹?› | Rank: Top 1%

🔗 View Article (PMC 1386800)

Published in Biophys J on December 30, 2005

Authors

Wei-hui Guo1, Margo T Frey, Nancy A Burnham, Yu-li Wang

Author Affiliations

1: Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.

Articles citing this

(truncated to the top 100)

Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell (2009) 5.43

Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell (2012) 2.87

Cell-ECM traction force modulates endogenous tension at cell-cell contacts. Proc Natl Acad Sci U S A (2011) 2.67

Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes. Biophys J (2008) 2.61

Rigidity-driven growth and migration of epithelial cells on microstructured anisotropic substrates. Proc Natl Acad Sci U S A (2007) 2.47

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol (2012) 2.33

Extracellular matrix rigidity promotes invadopodia activity. Curr Biol (2008) 2.31

Cell-cell mechanical communication through compliant substrates. Biophys J (2008) 2.31

Microtubule function in fibroblast spreading is modulated according to the tension state of cell-matrix interactions. Proc Natl Acad Sci U S A (2007) 1.80

Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase. Arch Biochem Biophys (2006) 1.76

Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro. Biomaterials (2010) 1.71

Focal adhesion kinase as a regulator of cell tension in the progression of cancer. Semin Cancer Biol (2007) 1.64

Cellular responses to substrate topography: role of myosin II and focal adhesion kinase. Biophys J (2006) 1.58

Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact. Cell Mol Bioeng (2010) 1.55

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices. Biomaterials (2010) 1.54

Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Mol Biol Cell (2009) 1.47

Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods Cell Biol (2007) 1.43

Focal adhesion size uniquely predicts cell migration. FASEB J (2012) 1.40

Tuning supramolecular rigidity of peptide fibers through molecular structure. J Am Chem Soc (2010) 1.38

Mechanical forces induced by the transendothelial migration of human neutrophils. Biophys J (2008) 1.28

Phase transitions of the coupled membrane-cytoskeleton modify cellular shape. Biophys J (2007) 1.26

Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals. Mol Biol Cell (2007) 1.25

Matrix stiffening sensitizes epithelial cells to EGF and enables the loss of contact inhibition of proliferation. J Cell Sci (2011) 1.24

Strategies and applications for incorporating physical and chemical signal gradients in tissue engineering. Tissue Eng Part B Rev (2008) 1.24

Distinct ECM mechanosensing pathways regulate microtubule dynamics to control endothelial cell branching morphogenesis. J Cell Biol (2011) 1.24

Matrix stiffness reverses the effect of actomyosin tension on cell proliferation. J Cell Sci (2012) 1.23

Tuning three-dimensional collagen matrix stiffness independently of collagen concentration modulates endothelial cell behavior. Acta Biomater (2012) 1.22

A photo-modulatable material for probing cellular responses to substrate rigidity. Soft Matter (2009) 1.22

Polyelectrolyte multilayer films of controlled stiffness modulate myoblast cells differentiation. Adv Funct Mater (2008) 1.20

Softening of the actin cytoskeleton by inhibition of myosin II. Pflugers Arch (2008) 1.18

α-catenin cytomechanics--role in cadherin-dependent adhesion and mechanotransduction. J Cell Sci (2014) 1.17

Guiding cell migration by tugging. Curr Opin Cell Biol (2013) 1.14

Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proc Natl Acad Sci U S A (2012) 1.13

Regulation of cancer invasiveness by the physical extracellular matrix environment. Cell Adh Migr (2009) 1.09

Extracellular matrix ligand and stiffness modulate immature nucleus pulposus cell-cell interactions. PLoS One (2011) 1.09

An in vitro correlation of mechanical forces and metastatic capacity. Phys Biol (2011) 1.07

Stressing the limits of focal adhesion mechanosensitivity. Curr Opin Cell Biol (2014) 1.05

Investigating the role of substrate stiffness in the persistence of valvular interstitial cell activation. J Biomed Mater Res A (2012) 1.04

Matrix compliance regulates Rac1b localization, NADPH oxidase assembly, and epithelial-mesenchymal transition. Mol Biol Cell (2012) 1.04

Mechanosensing of substrate thickness. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 1.04

Stereolithographic bone scaffold design parameters: osteogenic differentiation and signal expression. Tissue Eng Part B Rev (2010) 1.03

Multi-scale mechanics from molecules to morphogenesis. Int J Biochem Cell Biol (2009) 1.03

Mechanical force affects expression of an in vitro metastasis-like phenotype in HCT-8 cells. Biophys J (2010) 1.00

Soft substrate up-regulates the interaction of STIM1 with store-operated Ca2+ channels that lead to normal epithelial cell apoptosis. Mol Biol Cell (2008) 0.99

Polycystins, focal adhesions and extracellular matrix interactions. Biochim Biophys Acta (2011) 0.98

Cellular response to substrate rigidity is governed by either stress or strain. Biophys J (2013) 0.97

High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One (2011) 0.97

Extracellular matrix density regulates the rate of neovessel growth and branching in sprouting angiogenesis. PLoS One (2014) 0.95

Assembly of Human Umbilical Vein Endothelial Cells on Compliant Hydrogels. Cell Mol Bioeng (2010) 0.95

How matrix properties control the self-assembly and maintenance of tissues. Ann Biomed Eng (2011) 0.95

Cell-cell interactions mediate the response of vascular smooth muscle cells to substrate stiffness. Biophys J (2011) 0.95

Endothelial cell responses to micropillar substrates of varying dimensions and stiffness. J Biomed Mater Res A (2012) 0.94

Extracellular matrix fibronectin stimulates the self-assembly of microtissues on native collagen gels. Tissue Eng Part A (2010) 0.93

Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis. Exp Cell Res (2009) 0.93

E-cadherin-dependent stimulation of traction force at focal adhesions via the Src and PI3K signaling pathways. Biophys J (2012) 0.92

Intercellular mechanotransduction during multicellular morphodynamics. J R Soc Interface (2010) 0.92

Fibroblast cluster formation on 3D collagen matrices requires cell contraction dependent fibronectin matrix organization. Exp Cell Res (2012) 0.92

Natural variation in embryo mechanics: gastrulation in Xenopus laevis is highly robust to variation in tissue stiffness. Dev Dyn (2009) 0.91

Multicellular sprouting in vitro. Biophys J (2008) 0.91

Bi-directional signaling: extracellular matrix and integrin regulation of breast tumor progression. Crit Rev Eukaryot Gene Expr (2013) 0.90

Tissue-tissue interaction-triggered calcium elevation is required for cell polarization during Xenopus gastrulation. PLoS One (2010) 0.89

A biocompatible endothelial cell delivery system for in vitro tissue engineering. Cell Transplant (2009) 0.89

Biochemical and mechanical extracellular matrix properties dictate mammary epithelial cell motility and assembly. Biotechnol J (2011) 0.89

Entering the era of nanoscience: time to be so small. J Biomed Nanotechnol (2013) 0.89

Effects of supported lipid monolayer fluidity on the adhesion of hematopoietic progenitor cell lines to fibronectin-derived peptide ligands for alpha5beta1 and alpha4beta1 integrins. Langmuir (2009) 0.88

A mathematical model of the coupled mechanisms of cell adhesion, contraction and spreading. J Math Biol (2013) 0.87

TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion. Mol Biol Cell (2014) 0.87

Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. J Muscle Res Cell Motil (2009) 0.87

Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation. Tissue Eng Part A (2014) 0.87

Regional fibronectin and collagen fibril co-assembly directs cell proliferation and microtissue morphology. PLoS One (2013) 0.86

The role of extracellular matrix elasticity and composition in regulating the nucleus pulposus cell phenotype in the intervertebral disc: a narrative review. J Biomech Eng (2014) 0.86

The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration. J Cell Sci (2008) 0.85

Is arterial wall-strain stiffening an additional process responsible for atherosclerosis in coronary bifurcations?: an in vivo study based on dynamic CT and MRI. Am J Physiol Heart Circ Physiol (2011) 0.85

Control of surface chemistry, substrate stiffness, and cell function in a novel terpolymer methacrylate library. Langmuir (2011) 0.85

Fibroblast morphogenesis on 3D collagen matrices: the balance between cell clustering and cell migration. Exp Cell Res (2013) 0.84

Substrate Stiffness Affects Human Keratinocyte Colony Formation. Cell Mol Bioeng (2015) 0.84

Variations in rigidity and ligand density influence neuronal response in methylcellulose-laminin hydrogels. Acta Biomater (2011) 0.84

Surface chemistry and polymer film thickness effects on endothelial cell adhesion and proliferation. J Biomed Mater Res A (2010) 0.83

Reprogramming cellular phenotype by soft collagen gels. Soft Matter (2014) 0.83

Functionalized nanostructures with application in regenerative medicine. Int J Mol Sci (2012) 0.83

Scaffold stiffness influences cell behavior: opportunities for skeletal tissue engineering. Open Orthop J (2008) 0.83

The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces. J Cell Sci (2016) 0.83

Micro- and nanoengineering approaches to control stem cell-biomaterial interactions. J Funct Biomater (2011) 0.82

Early differentiation patterning of mouse embryonic stem cells in response to variations in alginate substrate stiffness. J Biol Eng (2013) 0.82

The mechanobiology of mitral valve function, degeneration, and repair. J Vet Cardiol (2012) 0.82

Focal adhesions in osteoneogenesis. Proc Inst Mech Eng H (2010) 0.82

Dissecting Collective Cell Behavior in Polarization and Alignment on Micropatterned Substrates. Biophys J (2015) 0.82

Localized application of mechanical and biochemical stimuli in 3-D culture. Dev Dyn (2008) 0.82

Regulation of epithelial cell organization by tuning cell-substrate adhesion. Integr Biol (Camb) (2015) 0.81

Rectified cell migration on saw-like micro-elastically patterned hydrogels with asymmetric gradient ratchet teeth. PLoS One (2013) 0.81

Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation. Chin Med (2009) 0.81

A biomechanical model for fluidization of cells under dynamic strain. Biophys J (2015) 0.81

Liquid drops attract or repel by the inverted Cheerios effect. Proc Natl Acad Sci U S A (2016) 0.80

Magnetic approaches to study collective three-dimensional cell mechanics in long-term cultures (invited). J Appl Phys (2014) 0.80

Role of differential adhesion in cell cluster evolution: from vasculogenesis to cancer metastasis. Comput Methods Biomech Biomed Engin (2013) 0.80

Directed stem cell differentiation: the role of physical forces. Cell Commun Adhes (2010) 0.79

Green tea polyphenol tailors cell adhesivity of RGD displaying surfaces: multicomponent models monitored optically. Sci Rep (2017) 0.77

Scanning probe recognition microscopy investigation of tissue scaffold properties. Int J Nanomedicine (2007) 0.77

Evaluation of PHBHHx and PHBV/PLA fibers used as medical sutures. J Mater Sci Mater Med (2013) 0.77

Silk Hydrogels of Tunable Structure and Viscoelastic Properties Using Different Chronological Orders of Genipin and Physical Cross-Linking. ACS Appl Mater Interfaces (2015) 0.76

Articles cited by this

Cell locomotion and focal adhesions are regulated by substrate flexibility. Proc Natl Acad Sci U S A (1997) 19.46

Tensional homeostasis and the malignant phenotype. Cancer Cell (2005) 19.30

Wound healing--aiming for perfect skin regeneration. Science (1997) 16.08

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88

Mechanotransduction across the cell surface and through the cytoskeleton. Science (1993) 14.01

Cell movement is guided by the rigidity of the substrate. Biophys J (2000) 13.84

Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (2003) 12.41

Stresses at the cell-to-substrate interface during locomotion of fibroblasts. Biophys J (1999) 10.71

Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell (1997) 10.22

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motil Cytoskeleton (2005) 10.20

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism. J Cell Biol (2001) 9.73

Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer (2004) 9.68

Integrins: emerging paradigms of signal transduction. Annu Rev Cell Dev Biol (1995) 8.88

Cell migration: Rho GTPases lead the way. Dev Biol (2004) 8.20

Signal transduction from the extracellular matrix. J Cell Biol (1993) 7.64

Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. J Cell Biol (2004) 7.38

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science (1999) 7.12

Substrate compliance versus ligand density in cell on gel responses. Biophys J (2004) 6.71

Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. J Cell Biol (2001) 6.32

A cell's sense of direction. Science (1999) 6.00

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix. J Cell Biol (1989) 4.85

ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix. J Cell Biol (2003) 4.24

Preparation of a flexible, porous polyacrylamide substrate for mechanical studies of cultured cells. Methods Enzymol (1998) 4.03

Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts. Biophys J (2001) 4.01

Substrate flexibility regulates growth and apoptosis of normal but not transformed cells. Am J Physiol Cell Physiol (2000) 3.97

Neurite branching on deformable substrates. Neuroreport (2002) 3.73

High resolution detection of mechanical forces exerted by locomoting fibroblasts on the substrate. Mol Biol Cell (1999) 3.46

Focal adhesion kinase is involved in mechanosensing during fibroblast migration. Proc Natl Acad Sci U S A (2001) 3.41

Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem (2004) 3.31

Surface tensions of embryonic tissues predict their mutual envelopment behavior. Development (1996) 3.06

Haptotaxis and the mechanism of cell motility. Nature (1967) 3.04

Nonmuscle myosin IIb is involved in the guidance of fibroblast migration. Mol Biol Cell (2003) 3.02

Quantitative analysis of the viscoelastic properties of thin regions of fibroblasts using atomic force microscopy. Biophys J (2004) 2.89

A mechanical function of myosin II in cell motility. J Cell Sci (1995) 2.74

Signaling pathways controlling cell polarity and chemotaxis. Trends Biochem Sci (2001) 2.58

Alteration of collagen-dependent adhesion, motility, and morphogenesis by the expression of antisense alpha 2 integrin mRNA in mammary cells. J Cell Sci (1995) 2.39

Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis. Curr Opin Oncol (1994) 2.21

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells. Proc Natl Acad Sci U S A (2002) 2.01

Chemotaxis: signalling modules join hands at front and tail. EMBO Rep (2004) 1.61

Articles by these authors

The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis. Curr Biol (2002) 2.68

Fc-receptor-mediated phagocytosis is regulated by mechanical properties of the target. J Cell Sci (2002) 2.54

Responses of fibroblasts to anchorage of dorsal extracellular matrix receptors. Proc Natl Acad Sci U S A (2004) 2.18

Exploring the control circuit of cell migration by mathematical modeling. Biophys J (2008) 1.44

Biomedical research publication system. Science (2004) 1.39

Retrograde fluxes of focal adhesion proteins in response to cell migration and mechanical signals. Mol Biol Cell (2007) 1.25

Guidance of cell migration by substrate dimension. Biophys J (2013) 1.15

Carbon nanotubes reorganize actin structures in cells and ex vivo. ACS Nano (2010) 1.15

Measuring the mechanical properties of living cells using atomic force microscopy. J Vis Exp (2013) 1.02

Microtubule depolymerization induces traction force increase through two distinct pathways. J Cell Sci (2011) 0.93

Atomic force microscopy study of the role of LPS O-antigen on adhesion of E. coli. J Mol Recognit (2009) 0.91

Relating the physical properties of Pseudomonas aeruginosa lipopolysaccharides to virulence by atomic force microscopy. J Bacteriol (2010) 0.88

A three-component mechanism for fibroblast migration with a contractile cell body that couples a myosin II-independent propulsive anterior to a myosin II-dependent resistive tail. Mol Biol Cell (2012) 0.87

Assessing the spatial resolution of cellular rigidity sensing using a micropatterned hydrogel-photoresist composite. Lab Chip (2011) 0.85

Double-hydrogel substrate as a model system for three-dimensional cell culture. Methods Mol Biol (2007) 0.80

Effect of electrode roughness on the capacitive behavior of self-assembled monolayers. Anal Chem (2008) 0.78

[A multicenter study on treatment of autonomous nerve-mediated syncope in children with beta-receptor blocker]. Zhonghua Er Ke Za Zhi (2007) 0.77

[A study on atrioventricular annular movement in healthy children by tissue Doppler imaging]. Zhonghua Er Ke Za Zhi (2006) 0.77

Regulation of cell cycle by the anaphase spindle midzone. BMC Cell Biol (2004) 0.75

[Hemodynamic changes during head-up tilt test and predictive value thereof in predicting the efficacy of metoprolol therapy in children with vasovagal syncope]. Zhonghua Yi Xue Za Zhi (2007) 0.75

A multi-center study of hemodynamic characteristics exhibited by children with unexplained syncope. Chin Med J (Engl) (2006) 0.75

Shape-independent lateral force calibration. ACS Appl Mater Interfaces (2011) 0.75

[Up-regulation of costimulatory molecules by sodium butyrate in acute leukemia cells and its molecular mechanism]. Zhonghua Xue Ye Xue Za Zhi (2005) 0.75

[Effect of selective alpha1 receptor agonist in the treatment of children with postural orthostatic tachycardia syndrome]. Zhonghua Er Ke Za Zhi (2008) 0.75