PubRank

Paul R Ortiz de Montellano

Author PubWeight™ 82.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase. J Biol Chem 2002 2.04
2 Pyrrolidine carboxamides as a novel class of inhibitors of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis. J Med Chem 2006 1.28
3 2.3 A X-ray structure of the heme-bound GAF domain of sensory histidine kinase DosT of Mycobacterium tuberculosis. Biochemistry 2008 1.26
4 Caenorhabditis elegans and human dual oxidase 1 (DUOX1) "peroxidase" domains: insights into heme binding and catalytic activity. J Biol Chem 2009 1.25
5 Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3. Chem Res Toxicol 2006 1.21
6 Comparison of the heme-free and -bound crystal structures of human heme oxygenase-1. J Biol Chem 2002 1.20
7 Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes. J Med Chem 2004 1.18
8 Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses. J Biol Chem 2010 1.17
9 The Mycobacterium tuberculosis cytochrome P450 system. Arch Biochem Biophys 2009 1.16
10 Reaction of Mycobacterium tuberculosis cytochrome P450 enzymes with nitric oxide. Biochemistry 2009 1.13
11 Biochemical and structural characterization of CYP124: a methyl-branched lipid omega-hydroxylase from Mycobacterium tuberculosis. Proc Natl Acad Sci U S A 2009 1.13
12 Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. FEBS Lett 2004 1.10
13 The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties. J Biol Chem 2005 1.08
14 Cyclopropyl containing fatty acids as mechanistic probes for cytochromes P450. J Org Chem 2005 1.05
15 Cytochrome P450(cin) (CYP176A), isolation, expression, and characterization. J Biol Chem 2002 1.05
16 EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme. Biochemistry 2004 1.04
17 Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor. Proc Natl Acad Sci U S A 2004 1.03
18 The crystal structure of Mycobacterium tuberculosis alkylhydroperoxidase AhpD, a potential target for antitubercular drug design. J Biol Chem 2002 1.03
19 The mechanism of Mycobacterium tuberculosis alkylhydroperoxidase AhpD as defined by mutagenesis, crystallography, and kinetics. J Biol Chem 2003 1.02
20 Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. J Biol Chem 2003 1.02
21 Autocatalytic radical reactions in physiological prosthetic heme modification. Chem Rev 2003 1.01
22 Structural control of cytochrome P450-catalyzed ω-hydroxylation. Arch Biochem Biophys 2010 1.01
23 Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications. J Mol Biol 2003 1.01
24 Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes. Biochemistry 2006 1.01
25 Nitric-oxide synthase (NOS) reductase domain models suggest a new control element in endothelial NOS that attenuates calmodulin-dependent activity. J Biol Chem 2003 0.99
26 DevS oxy complex stability identifies this heme protein as a gas sensor in Mycobacterium tuberculosis dormancy. Biochemistry 2009 0.98
27 Enhanced electron transfer and lauric acid hydroxylation by site-directed mutagenesis of CYP119. J Am Chem Soc 2002 0.97
28 Crystal structure of human heme oxygenase-1 in a complex with biliverdin. Biochemistry 2004 0.96
29 Role of the Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG) as revealed by KatG(M255I). Biochemistry 2005 0.96
30 The Sulfolobus solfataricus electron donor partners of thermophilic CYP119: an unusual non-NAD(P)H-dependent cytochrome P450 system. Arch Biochem Biophys 2005 0.95
31 Alteration of the regiospecificity of human heme oxygenase-1 by unseating of the heme but not disruption of the distal hydrogen bonding network. Biochemistry 2006 0.95
32 Correlation between isoniazid resistance and superoxide reactivity in mycobacterium tuberculosis KatG. J Am Chem Soc 2005 0.94
33 Bioactivation of antituberculosis thioamide and thiourea prodrugs by bacterial and mammalian flavin monooxygenases. Chem Biol Interact 2010 0.92
34 Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. J Pharmacol Exp Ther 2003 0.92
35 Interaction of nitric oxide with human heme oxygenase-1. J Biol Chem 2002 0.92
36 Oxidation of carboxylic acids by horseradish peroxidase results in prosthetic heme modification and inactivation. J Am Chem Soc 2004 0.92
37 Role of cysteine residues in heme binding to human heme oxygenase-2 elucidated by two-dimensional NMR spectroscopy. J Biol Chem 2012 0.92
38 The diagnostic substrate bicyclohexane reveals a radical mechanism for bacterial cytochrome P450 in whole cells. Angew Chem Int Ed Engl 2006 0.91
39 Prosthetic heme modification during halide ion oxidation. Demonstration of chloride oxidation by horseradish peroxidase. J Am Chem Soc 2005 0.90
40 Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides. Bioorg Med Chem 2007 0.90
41 Autoreduction of ferryl myoglobin: discrimination among the three tyrosine and two tryptophan residues as electron donors. Biochemistry 2004 0.90
42 Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis. Biochemistry 2011 0.90
43 Perturbed heme binding is responsible for the blistering phenotype associated with mutations in the Caenorhabditis elegans dual oxidase 1 (DUOX1) peroxidase domain. J Biol Chem 2010 0.89
44 Role of heme-protein covalent bonds in mammalian peroxidases. Protection of the heme by a single engineered heme-protein link in horseradish peroxidase. J Biol Chem 2006 0.89
45 Ligand-induced conformational heterogeneity of cytochrome P450 CYP119 identified by 2D NMR spectroscopy with the unnatural amino acid (13)C-p-methoxyphenylalanine. J Am Chem Soc 2008 0.89
46 Autocatalytic modification of the prosthetic heme of horseradish but not lactoperoxidase by thiocyanate oxidation products. A role for heme-protein covalent cross-linking. J Am Chem Soc 2005 0.87
47 Functional expression and characterization of cytochrome P450 52A21 from Candida albicans. Arch Biochem Biophys 2007 0.87
48 Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage. J Inorg Biochem 2004 0.87
49 Asp-225 and glu-375 in autocatalytic attachment of the prosthetic heme group of lactoperoxidase. J Biol Chem 2001 0.86
50 Reverse type I inhibitor of Mycobacterium tuberculosis CYP125A1. Bioorg Med Chem Lett 2010 0.85
51 Conserved cysteine residues provide a protein-protein interaction surface in dual oxidase (DUOX) proteins. J Biol Chem 2013 0.85
52 Selenolate complexes of CYP101 and the heme-bound hHO-1/H25A proximal cavity mutant. Inorg Chem 2008 0.85
53 A highly conserved mycobacterial cholesterol catabolic pathway. Environ Microbiol 2013 0.85
54 Thermophilic cytochrome P450 enzymes. Biochem Biophys Res Commun 2005 0.85
55 Alpha- and beta-thujone radical rearrangements and isomerizations. A new radical clock. J Org Chem 2004 0.85
56 Aromatic stacking as a determinant of the thermal stability of CYP119 from Sulfolobus solfataricus. Arch Biochem Biophys 2003 0.85
57 Intra- and intermolecular transfers of protein radicals in the reactions of sperm whale myoglobin with hydrogen peroxide. J Biol Chem 2003 0.85
58 Autocatalytic mechanism and consequences of covalent heme attachment in the cytochrome P4504A family. J Biol Chem 2002 0.85
59 Tryptophan-14 is the preferred site of DBNBS spin trapping in the self-peroxidation reaction of sperm whale metmyoglobin with a single equivalent of hydrogen peroxide. Chem Res Toxicol 2003 0.85
60 Steady-state kinetic investigation of cytochrome P450cam: interaction with redox partners and reaction with molecular oxygen. Biochemistry 2004 0.84
61 Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. Biochemistry 2002 0.84
62 A novel intermediate in the reaction of seleno CYP119 with m-chloroperbenzoic acid. Biochemistry 2011 0.84
63 Covalent attachment of heme to the protein moiety in an insect E75 nitric oxide sensor. Biochemistry 2012 0.84
64 Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain. Arch Biochem Biophys 2011 0.84
65 Regiospecificity determinants of human heme oxygenase: differential NADPH- and ascorbate-dependent heme cleavage by the R183E mutant. J Biol Chem 2004 0.83
66 Reductive heme-dependent activation of the n-oxide prodrug AQ4N by nitric oxide synthase. J Med Chem 2008 0.83
67 Solution NMR study of environmental effects on substrate seating in human heme oxygenase: influence of polypeptide truncation, substrate modification and axial ligand. J Inorg Biochem 2005 0.83
68 Heme-protein covalent bonds in peroxidases and resistance to heme modification during halide oxidation. Arch Biochem Biophys 2005 0.82
69 Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1. Bioorg Med Chem 2012 0.82
70 Calculated and experimental spin state of seleno cytochrome P450. Angew Chem Int Ed Engl 2009 0.82
71 Covalent heme attachment to the protein in human heme oxygenase-1 with selenocysteine replacing the His25 proximal iron ligand. J Inorg Biochem 2008 0.82
72 CYP119 plus a Sulfolobus tokodaii strain 7 ferredoxin and 2-oxoacid:ferredoxin oxidoreductase constitute a high-temperature cytochrome P450 catalytic system. J Am Chem Soc 2002 0.82
73 The orbital ground state of the azide-substrate complex of human heme oxygenase is an indicator of distal H-bonding: implications for the enzyme mechanism. Biochemistry 2009 0.81
74 Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion. J Am Chem Soc 2012 0.81
75 Ultrafast ligand dynamics in the heme-based GAF sensor domains of the histidine kinases DosS and DosT from Mycobacterium tuberculosis. Biochemistry 2011 0.80
76 Inhibition of Mycobacterium tuberculosis AhpD, an element of the peroxiredoxin defense against oxidative stress. Antimicrob Agents Chemother 2004 0.80
77 Cyclopropyl fatty acids implicate a radical but not a cation as an intermediate in P450BM3-catalysed hydroxylations. Chem Commun (Camb) 2004 0.80
78 Specificity determinants of CYP1B1 estradiol hydroxylation. Mol Pharmacol 2013 0.80
79 Cooperative effects on radical recombination in CYP3A4-catalyzed oxidation of the radical clock beta-thujone. Chembiochem 2009 0.80
80 Coupling of the distal hydrogen bond network to the exogenous ligand in substrate-bound, resting state human heme oxygenase. Biochemistry 2009 0.79
81 The P450cam G248E mutant covalently binds its prosthetic heme group. Biochemistry 2005 0.79
82 Isocyanides inhibit human heme oxygenases at the verdoheme stage. Biochemistry 2009 0.78
83 Influence of the distal his in imparting imidazolate character to the proximal his in heme peroxidase: (1)h NMR spectroscopic study of cyanide-inhibited his42-->ala horseradish peroxidase. J Am Chem Soc 2002 0.78
84 Tricistronic overexpression of cytochrome P450cam, putidaredoxin, and putidaredoxin reductase provides a useful cell-based catalytic system. Biotechnol Lett 2009 0.78
85 Superoxide reactivity of KatG: insights into isoniazid resistance pathways in TB. J Am Chem Soc 2004 0.78
86 Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae. Protein Expr Purif 2003 0.78
87 Carbon-carbon bond cleavage in activation of the prodrug nabumetone. Drug Metab Dispos 2014 0.77
88 Efficient catalytic turnover of cytochrome P450(cam) is supported by a T252N mutation. Arch Biochem Biophys 2008 0.75
89 Arthromyces ramosus peroxidase produces two chlorinating species. Biochem Biophys Res Commun 2007 0.75
90 Electron supply and catalytic oxidation of nitrogen by cytochrome P450 and nitric oxide synthase. Drug Metab Rev 2002 0.75