Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
1
|
Identification of severe acute respiratory syndrome in Canada.
|
N Engl J Med
|
2003
|
14.29
|
2
|
Outpatient gatifloxacin therapy and dysglycemia in older adults.
|
N Engl J Med
|
2006
|
7.01
|
3
|
Resistance to levofloxacin and failure of treatment of pneumococcal pneumonia.
|
N Engl J Med
|
2002
|
6.22
|
4
|
Antiviral therapy and outcomes of influenza requiring hospitalization in Ontario, Canada.
|
Clin Infect Dis
|
2007
|
5.39
|
5
|
Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada.
|
JAMA
|
2013
|
4.69
|
6
|
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections.
|
Nat Med
|
2002
|
3.39
|
7
|
Empirical validation of guidelines for the management of pharyngitis in children and adults.
|
JAMA
|
2004
|
3.14
|
8
|
Triple reassortant H3N2 influenza A viruses, Canada, 2005.
|
Emerg Infect Dis
|
2006
|
3.05
|
9
|
West Nile virus infection in 2002: morbidity and mortality among patients admitted to hospital in southcentral Ontario.
|
CMAJ
|
2003
|
3.03
|
10
|
At the threshold: defining clinically meaningful resistance thresholds for antibiotic choice in community-acquired pneumonia.
|
Clin Infect Dis
|
2008
|
2.71
|
11
|
Evolutionary pathway to increased virulence and epidemic group A Streptococcus disease derived from 3,615 genome sequences.
|
Proc Natl Acad Sci U S A
|
2014
|
2.63
|
12
|
Predicting antimicrobial resistance in invasive pneumococcal infections.
|
Clin Infect Dis
|
2005
|
2.59
|
13
|
Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics.
|
Proc Natl Acad Sci U S A
|
2010
|
2.43
|
14
|
Managing skin and soft tissue infections: expert panel recommendations on key decision points.
|
J Antimicrob Chemother
|
2003
|
2.41
|
15
|
Genome-wide molecular dissection of serotype M3 group A Streptococcus strains causing two epidemics of invasive infections.
|
Proc Natl Acad Sci U S A
|
2004
|
2.32
|
16
|
Genetic variability of human respiratory syncytial virus A strains circulating in Ontario: a novel genotype with a 72 nucleotide G gene duplication.
|
PLoS One
|
2012
|
2.21
|
17
|
Detection of airborne severe acute respiratory syndrome (SARS) coronavirus and environmental contamination in SARS outbreak units.
|
J Infect Dis
|
2005
|
2.03
|
18
|
Invasive M1T1 group A Streptococcus undergoes a phase-shift in vivo to prevent proteolytic degradation of multiple virulence factors by SpeB.
|
Mol Microbiol
|
2004
|
1.99
|
19
|
Outcomes assessment of the surgical management of esophageal cancer in younger and older patients.
|
Ann Thorac Surg
|
2012
|
1.96
|
20
|
Severe group a streptococcal soft-tissue infections in Ontario: 1992-1996.
|
Clin Infect Dis
|
2002
|
1.93
|
21
|
Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes.
|
J Bacteriol
|
2005
|
1.90
|
22
|
New Delhi metallo-beta-lactamase, Ontario, Canada.
|
Emerg Infect Dis
|
2011
|
1.81
|
23
|
Phylogenetic analysis reveals a cryptic species Blastomyces gilchristii, sp. nov. within the human pathogenic fungus Blastomyces dermatitidis.
|
PLoS One
|
2013
|
1.79
|
24
|
Integrated analysis of FOCUS 1 and FOCUS 2: randomized, doubled-blinded, multicenter phase 3 trials of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in patients with community-acquired pneumonia.
|
Clin Infect Dis
|
2010
|
1.78
|
25
|
Successful management of severe group A streptococcal soft tissue infections using an aggressive medical regimen including intravenous polyspecific immunoglobulin together with a conservative surgical approach.
|
Scand J Infect Dis
|
2005
|
1.75
|
26
|
Clostridium difficile infection in hospitals: a brewing storm.
|
CMAJ
|
2004
|
1.74
|
27
|
New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection.
|
CMAJ
|
2011
|
1.73
|
28
|
Modulation of bacterial growth by tumor necrosis factor-alpha in vitro and in vivo.
|
Am J Respir Crit Care Med
|
2003
|
1.70
|
29
|
Treatment of Barrett's esophagus with early neoplasia: a comparison of endoscopic therapy and esophagectomy.
|
Gastrointest Endosc
|
2008
|
1.69
|
30
|
Clinical and epidemiologic features of group a streptococcal pneumonia in Ontario, Canada.
|
Arch Intern Med
|
2003
|
1.67
|
31
|
FOCUS 1: a randomized, double-blinded, multicentre, Phase III trial of the efficacy and safety of ceftaroline fosamil versus ceftriaxone in community-acquired pneumonia.
|
J Antimicrob Chemother
|
2011
|
1.66
|
32
|
Risk factors for resistance to antimicrobial agents among nursing home residents.
|
Am J Epidemiol
|
2003
|
1.62
|
33
|
Canadian guidelines for the management of acute exacerbations of chronic bronchitis: executive summary.
|
Can Respir J
|
2003
|
1.58
|
34
|
Volume-outcome relationship in surgery for esophageal malignancy: systematic review and meta-analysis 2000-2011.
|
J Gastrointest Surg
|
2011
|
1.57
|
35
|
The society of thoracic surgeons guidelines on the diagnosis and staging of patients with esophageal cancer.
|
Ann Thorac Surg
|
2013
|
1.56
|
36
|
Severe acute respiratory syndrome (SARS): a year in review.
|
Annu Rev Med
|
2005
|
1.55
|
37
|
Identification of a streptolysin S-associated gene cluster and its role in the pathogenesis of Streptococcus iniae disease.
|
Infect Immun
|
2002
|
1.52
|
38
|
Interpretation of diagnostic laboratory tests for severe acute respiratory syndrome: the Toronto experience.
|
CMAJ
|
2004
|
1.50
|
39
|
A review of Streptococcus pneumoniae infection treatment failures associated with fluoroquinolone resistance.
|
Clin Infect Dis
|
2005
|
1.49
|
40
|
Proton pump inhibitors and hospitalization for Clostridium difficile-associated disease: a population-based study.
|
Clin Infect Dis
|
2006
|
1.48
|
41
|
Genome-wide dissection of globally emergent multi-drug resistant serotype 19A Streptococcus pneumoniae.
|
BMC Genomics
|
2009
|
1.47
|
42
|
Decreased necrotizing fasciitis capacity caused by a single nucleotide mutation that alters a multiple gene virulence axis.
|
Proc Natl Acad Sci U S A
|
2010
|
1.47
|
43
|
Methicillin-resistant Staphylococcus aureus colonization in veterinary personnel.
|
Emerg Infect Dis
|
2006
|
1.46
|
44
|
Molecular analysis of antimicrobial resistance mechanisms in Neisseria gonorrhoeae isolates from Ontario, Canada.
|
Antimicrob Agents Chemother
|
2010
|
1.45
|
45
|
Possible SARS coronavirus transmission during cardiopulmonary resuscitation.
|
Emerg Infect Dis
|
2004
|
1.45
|
46
|
Viable group A streptococci in macrophages during acute soft tissue infection.
|
PLoS Med
|
2006
|
1.43
|
47
|
Pulmonary pathology of severe acute respiratory syndrome in Toronto.
|
Mod Pathol
|
2005
|
1.41
|
48
|
Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations.
|
Proc Natl Acad Sci U S A
|
2011
|
1.39
|
49
|
Community-associated methicillin-resistant Staphylococcus aureus in horses and humans who work with horses.
|
J Am Vet Med Assoc
|
2005
|
1.37
|
50
|
Is surveillance for multidrug-resistant enterobacteriaceae an effective infection control strategy in the absence of an outbreak?
|
J Infect Dis
|
2002
|
1.37
|
51
|
Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing.
|
MBio
|
2012
|
1.36
|
52
|
Outbreak of carbapenem-resistant enterobacteriaceae containing blaNDM-1, Ontario, Canada.
|
Clin Infect Dis
|
2012
|
1.36
|
53
|
New Delhi metallo-β-lactamase-1 in Enterobacteriaceae: emerging resistance.
|
CMAJ
|
2011
|
1.33
|
54
|
Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus.
|
Am J Pathol
|
2012
|
1.32
|
55
|
Group A Streptococcus emm gene types in pharyngeal isolates, Ontario, Canada, 2002-2010.
|
Emerg Infect Dis
|
2011
|
1.32
|
56
|
In vitro antimicrobial susceptibilities of Streptococcus pneumoniae clinical isolates obtained in Canada in 2002.
|
Antimicrob Agents Chemother
|
2004
|
1.30
|
57
|
The impact of empirical management of acute cystitis on unnecessary antibiotic use.
|
Arch Intern Med
|
2002
|
1.29
|
58
|
Antimicrobial susceptibility breakpoints and first-step parC mutations in Streptococcus pneumoniae: redefining fluoroquinolone resistance.
|
Emerg Infect Dis
|
2003
|
1.28
|
59
|
rmtD2, a new allele of a 16S rRNA methylase gene, has been present in Enterobacteriaceae isolates from Argentina for more than a decade.
|
Antimicrob Agents Chemother
|
2010
|
1.23
|
60
|
Severe acute respiratory syndrome.
|
Clin Infect Dis
|
2004
|
1.23
|
61
|
Multiplex PCR tests sentinel the appearance of pandemic influenza viruses including H1N1 swine influenza.
|
J Clin Virol
|
2009
|
1.23
|
62
|
Detection and species identification of Leishmania DNA from filter paper lesion impressions for patients with American cutaneous leishmaniasis.
|
Clin Infect Dis
|
2010
|
1.22
|
63
|
Comparative evaluation of a chromogenic agar medium, the modified Hodge test, and a battery of meropenem-inhibitor discs for detection of carbapenemase activity in Enterobacteriaceae.
|
J Clin Microbiol
|
2011
|
1.21
|
64
|
Cathelicidin LL-37 in severe Streptococcus pyogenes soft tissue infections in humans.
|
Infect Immun
|
2008
|
1.21
|
65
|
Antimicrobial susceptibility among organisms from the Asia/Pacific Rim, Europe and Latin and North America collected as part of TEST and the in vitro activity of tigecycline.
|
J Antimicrob Chemother
|
2007
|
1.20
|
66
|
Outbreak of vancomycin-susceptible Enterococcus faecium containing the wild-type vanA gene.
|
J Clin Microbiol
|
2014
|
1.20
|
67
|
Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007-2009 study.
|
Diagn Microbiol Infect Dis
|
2011
|
1.20
|
68
|
Fatal severe acute respiratory syndrome is associated with multiorgan involvement by coronavirus.
|
J Infect Dis
|
2004
|
1.18
|
69
|
Severe acute respiratory syndrome-associated coronavirus in lung tissue.
|
Emerg Infect Dis
|
2004
|
1.16
|
70
|
Characterization of an influenza A and influenza B co-infection of a patient in a long-term care facility with co-circulating influenza A and influenza B.
|
Int J Infect Dis
|
2008
|
1.14
|
71
|
Postgenomic analysis of four novel antigens of group a streptococcus: growth phase-dependent gene transcription and human serologic response.
|
J Bacteriol
|
2002
|
1.14
|
72
|
Getting under the skin: the immunopathogenesis of Streptococcus pyogenes deep tissue infections.
|
Clin Infect Dis
|
2010
|
1.13
|
73
|
MupB, a new high-level mupirocin resistance mechanism in Staphylococcus aureus.
|
Antimicrob Agents Chemother
|
2012
|
1.13
|
74
|
Evaluation and verification of the Seeplex Diarrhea-V ACE assay for simultaneous detection of adenovirus, rotavirus, and norovirus genogroups I and II in clinical stool specimens.
|
J Clin Microbiol
|
2011
|
1.11
|
75
|
Use of self-expandable metallic stents in benign GI diseases.
|
Gastrointest Endosc
|
2003
|
1.11
|
76
|
Canadian guidelines for the management of acute exacerbations of chronic bronchitis.
|
Can Respir J
|
2003
|
1.11
|
77
|
Necrotizing pneumonia and septic shock: suspecting CA-MRSA in patients presenting to Canadian emergency departments.
|
CJEM
|
2007
|
1.10
|
78
|
Effect on antibiotic prescribing of repeated clinical prompts to use a sore throat score: lessons from a failed community intervention study.
|
J Fam Pract
|
2002
|
1.08
|
79
|
Evolving management strategies in esophageal perforation: surgeons using nonoperative techniques to improve outcomes.
|
J Am Coll Surg
|
2011
|
1.07
|
80
|
Evaluation of a microculture method for isolation of Leishmania parasites from cutaneous lesions of patients in Peru.
|
J Clin Microbiol
|
2007
|
1.07
|
81
|
Phylogenetic incongruence in E. coli O104: understanding the evolutionary relationships of emerging pathogens in the face of homologous recombination.
|
PLoS One
|
2012
|
1.06
|
82
|
Outcomes and health-related quality of life after esophagectomy for high-grade dysplasia and intramucosal cancer.
|
Arch Surg
|
2006
|
1.06
|
83
|
Treatment of acute bacterial conjunctivitis: 1% fusidic acid viscous drops vs. 0.3% tobramycin drops.
|
Can J Ophthalmol
|
2002
|
1.06
|
84
|
Epidemic of group A Streptococcus M/emm59 causing invasive disease in Canada.
|
Clin Infect Dis
|
2010
|
1.06
|
85
|
Extensive genomic variation within clonal complexes of Neisseria meningitidis.
|
Genome Biol Evol
|
2011
|
1.06
|
86
|
Laboratory diagnosis of amoebic keratitis: comparison of four diagnostic methods for different types of clinical specimens.
|
J Clin Microbiol
|
2009
|
1.06
|
87
|
Complete sequence of pOZ176, a 500-kilobase IncP-2 plasmid encoding IMP-9-mediated carbapenem resistance, from outbreak isolate Pseudomonas aeruginosa 96.
|
Antimicrob Agents Chemother
|
2013
|
1.05
|
88
|
New endemic Legionella pneumophila serogroup I clones, Ontario, Canada.
|
Emerg Infect Dis
|
2010
|
1.05
|
89
|
Distribution of antiseptic resistance genes qacA, qacB, and smr in methicillin-resistant Staphylococcus aureus isolated in Toronto, Canada, from 2005 to 2009.
|
Antimicrob Agents Chemother
|
2011
|
1.05
|
90
|
Advances in the management of esophageal perforation.
|
Thorac Surg Clin
|
2011
|
1.05
|
91
|
The battle against emerging antibiotic resistance: should fluoroquinolones be used to treat children?
|
Clin Infect Dis
|
2002
|
1.04
|
92
|
Emergence of macrolide resistance in throat culture isolates of group a streptococci in Ontario, Canada, in 2001.
|
Antimicrob Agents Chemother
|
2003
|
1.04
|
93
|
Can routine laboratory tests discriminate between severe acute respiratory syndrome and other causes of community-acquired pneumonia?
|
Clin Infect Dis
|
2005
|
1.04
|
94
|
Polymorphisms in regulator of protease B (RopB) alter disease phenotype and strain virulence of serotype M3 group A Streptococcus.
|
J Infect Dis
|
2012
|
1.02
|
95
|
Rhinovirus outbreaks in long-term care facilities, Ontario, Canada.
|
Emerg Infect Dis
|
2010
|
1.02
|
96
|
Novel mutations in a patient isolate of Streptococcus agalactiae with reduced penicillin susceptibility emerging after long-term oral suppressive therapy.
|
Antimicrob Agents Chemother
|
2011
|
1.02
|
97
|
Diagnostic performance of filter paper lesion impression PCR for secondarily infected ulcers and nonulcerative lesions caused by cutaneous leishmaniasis.
|
J Clin Microbiol
|
2010
|
1.01
|
98
|
Physiology, not chronology, dictates outcomes after esophagectomy for esophageal cancer: outcomes in patients 80 years and older.
|
Ann Surg Oncol
|
2012
|
1.00
|
99
|
Combining clinical and epidemiologic features for early recognition of SARS.
|
Emerg Infect Dis
|
2004
|
1.00
|
100
|
Analytical and clinical validation of novel real-time reverse transcriptase-polymerase chain reaction assays for the clinical detection of swine-origin H1N1 influenza viruses.
|
Diagn Microbiol Infect Dis
|
2011
|
1.00
|
101
|
Vancomycin-variable Enterococcus faecium: in vivo emergence of vancomycin resistance in a vancomycin-susceptible isolate.
|
J Clin Microbiol
|
2014
|
1.00
|
102
|
Accordion severity grading system: assessment of relationship between costs, length of hospital stay, and survival in patients with complications after esophagectomy for cancer.
|
J Am Coll Surg
|
2012
|
0.99
|
103
|
Characterization of invasive group B streptococcus strains from the greater Toronto area, Canada.
|
J Clin Microbiol
|
2014
|
0.99
|
104
|
Surveillance for hospital outbreaks of invasive group a streptococcal infections in Ontario, Canada, 1992 to 2000.
|
Ann Intern Med
|
2007
|
0.99
|
105
|
The impact of influenza on the Canadian First Nations.
|
Can J Public Health
|
2011
|
0.99
|
106
|
Macrolide-resistant Mycoplasma pneumoniae in humans, Ontario, Canada, 2010-2011.
|
Emerg Infect Dis
|
2013
|
0.98
|
107
|
Assessment of short-term clinical outcomes following salvage esophagectomy for the treatment of esophageal malignancy: systematic review and pooled analysis.
|
Ann Surg Oncol
|
2013
|
0.98
|
108
|
Near-total esophagectomy: the influence of standardized multimodal management and intraoperative fluid restriction.
|
Reg Anesth Pain Med
|
2003
|
0.97
|
109
|
Morbidity and mortality of patients with invasive group A streptococcal infections admitted to the ICU.
|
Chest
|
2006
|
0.97
|
110
|
Going with the flow: legionellosis risk in Toronto, Canada is strongly associated with local watershed hydrology.
|
Ecohealth
|
2009
|
0.97
|
111
|
Comparative Genomics Reveal That Host-Innate Immune Responses Influence the Clinical Prevalence of Legionella pneumophila Serogroups.
|
PLoS One
|
2013
|
0.97
|
112
|
Is primary prevention of Clostridium difficile infection possible with specific probiotics?
|
Int J Infect Dis
|
2012
|
0.97
|
113
|
Type II topoisomerase mutations in Bacillus anthracis associated with high-level fluoroquinolone resistance.
|
J Antimicrob Chemother
|
2004
|
0.97
|
114
|
Screening for asymptomatic bacteriuria in pregnancy.
|
J Obstet Gynaecol Can
|
2005
|
0.96
|
115
|
Community-acquired antibiotic resistance in urinary isolates from adult women in Canada.
|
Can J Infect Dis Med Microbiol
|
2006
|
0.96
|
116
|
Useful benchmarks to evaluate outcomes after esophagectomy and pancreaticoduodenectomy.
|
Am J Surg
|
2004
|
0.96
|
117
|
Severe human rhinovirus outbreak associated with fatalities in a long-term care facility in Ontario, Canada.
|
J Am Geriatr Soc
|
2010
|
0.96
|
118
|
Launching of the CAN-R Web site -The official Web site of the Canadian Antimicrobial Resistance Alliance.
|
Can J Infect Dis Med Microbiol
|
2007
|
0.95
|
119
|
Homologous recombination drives both sequence diversity and gene content variation in Neisseria meningitidis.
|
Genome Biol Evol
|
2013
|
0.95
|
120
|
Optimization of microculture and evaluation of miniculture for the isolation of Leishmania parasites from cutaneous lesions in Peru.
|
Am J Trop Med Hyg
|
2008
|
0.95
|
121
|
Multidrug-resistant pandemic (H1N1) 2009 infection in immunocompetent child.
|
Emerg Infect Dis
|
2011
|
0.94
|
122
|
Susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada.
|
Antimicrob Agents Chemother
|
2011
|
0.94
|
123
|
Biofilms: the stronghold of Legionella pneumophila.
|
Int J Mol Sci
|
2013
|
0.93
|
124
|
Pertussis resurgence in Toronto, Canada: a population-based study including test-incidence feedback modeling.
|
BMC Public Health
|
2011
|
0.93
|
125
|
Whole-genome sequence of Streptococcus pseudopneumoniae isolate IS7493.
|
J Bacteriol
|
2011
|
0.93
|
126
|
Pneumococcal vaccination programs and the burden of invasive pneumococcal disease in Ontario, Canada, 1995-2011.
|
Vaccine
|
2013
|
0.91
|
127
|
Trends in antibiotic resistance over time among pathogens from Canadian hospitals: results of the CANWARD study 2007-11.
|
J Antimicrob Chemother
|
2013
|
0.91
|
128
|
Clinical and demographic stratification of test performance: a pooled analysis of five laboratory diagnostic methods for American cutaneous leishmaniasis.
|
Am J Trop Med Hyg
|
2010
|
0.90
|
129
|
Non-invasive cytology brush PCR diagnostic testing in mucosal leishmaniasis: superior performance to conventional biopsy with histopathology.
|
PLoS One
|
2011
|
0.90
|
130
|
Repair of giant paraesophageal hernias routinely produces improvement in respiratory function.
|
J Thorac Cardiovasc Surg
|
2011
|
0.90
|
131
|
Streptococcus pneumoniae infection: a Canadian perspective.
|
Expert Rev Anti Infect Ther
|
2013
|
0.90
|
132
|
Modified multiple-locus variable-number tandem-repeat analysis for rapid identification and typing of Clostridium difficile during institutional outbreaks.
|
J Clin Microbiol
|
2011
|
0.90
|
133
|
Laboratory-based evaluation of legionellosis epidemiology in Ontario, Canada, 1978 to 2006.
|
BMC Infect Dis
|
2009
|
0.89
|
134
|
Gastric ulceration following oesophageal stent migration complicating surgical management of oesophageal cancer.
|
Interact Cardiovasc Thorac Surg
|
2012
|
0.89
|
135
|
Assessment of criteria and clinical significance of circumferential resection margins in esophageal cancer.
|
Arch Surg
|
2009
|
0.89
|
136
|
Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome.
|
Clin Infect Dis
|
2011
|
0.88
|
137
|
Treatment of community-acquired pneumonia.
|
CMAJ
|
2008
|
0.88
|
138
|
Spontaneous intramural rupture of the esophagus: clinical presentation and endoscopic findings.
|
Gastrointest Endosc
|
2002
|
0.88
|
139
|
High-level telithromycin resistance in a clinical isolate of Streptococcus pneumoniae.
|
Antimicrob Agents Chemother
|
2007
|
0.88
|
140
|
Treatment and vaccines for severe acute respiratory syndrome.
|
Lancet Infect Dis
|
2005
|
0.88
|
141
|
The clinical and economic costs of delirium after surgical resection for esophageal malignancy.
|
Ann Surg
|
2013
|
0.88
|
142
|
Clinical ramifications of giant paraesophageal hernias are underappreciated: making the case for routine surgical repair.
|
Ann Thorac Surg
|
2012
|
0.87
|
143
|
Surveillance data on outbreaks of Clostridium difficile infection in Ontario, Canada, in 2008-2009.
|
Clin Infect Dis
|
2010
|
0.87
|
144
|
Is resistance futile?
|
Nat Med
|
2003
|
0.87
|
145
|
Evaluation of CLSI agar dilution method and Trek Sensititre broth microdilution panel for determining antimicrobial susceptibility of Streptococcus pneumoniae.
|
J Clin Microbiol
|
2010
|
0.87
|
146
|
Is It Time to Centralize High-risk Cancer Care in the United States? Comparison of Outcomes of Esophagectomy Between England and the United States.
|
Ann Surg
|
2015
|
0.86
|
147
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