PubRank

Mohamed A Marahiel

Author PubWeight™ 161.91‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep 2013 5.38
2 Siderophore-based iron acquisition and pathogen control. Microbiol Mol Biol Rev 2007 4.87
3 Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics. Chem Rev 2005 4.64
4 Biosynthesis of nonribosomal peptides1. Annu Rev Microbiol 2004 3.64
5 Nonribosomal peptides: from genes to products. Nat Prod Rep 2003 2.73
6 Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc Natl Acad Sci U S A 2002 2.51
7 Crystal structure of the termination module of a nonribosomal peptide synthetase. Science 2008 2.02
8 Dissection of the mechanism for the stringent factor RelA. Mol Cell 2002 1.98
9 Ways of assembling complex natural products on modular nonribosomal peptide synthetases. Chembiochem 2002 1.85
10 Nonribosomal peptide synthetases: structures and dynamics. Curr Opin Struct Biol 2010 1.83
11 Mechanistic and structural basis of stereospecific Cbeta-hydroxylation in calcium-dependent antibiotic, a daptomycin-type lipopeptide. ACS Chem Biol 2007 1.77
12 Insights into the biosynthesis and stability of the lasso peptide capistruin. Chem Biol 2009 1.75
13 Functional dissection of surfactin synthetase initiation module reveals insights into the mechanism of lipoinitiation. Chem Biol 2010 1.72
14 Structural basis for the selectivity of the external thioesterase of the surfactin synthetase. Nature 2008 1.66
15 Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases. Proc Natl Acad Sci U S A 2002 1.64
16 Inhibition of aryl acid adenylation domains involved in bacterial siderophore synthesis. FEBS J 2006 1.61
17 Conformational switches modulate protein interactions in peptide antibiotic synthetases. Science 2006 1.61
18 Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J Biol Chem 2008 1.50
19 Evidence for a monomeric structure of nonribosomal Peptide synthetases. Chem Biol 2002 1.49
20 Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure 2002 1.49
21 Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264. J Am Chem Soc 2008 1.47
22 Chemoenzymatic and template-directed synthesis of bioactive macrocyclic peptides. Microbiol Mol Biol Rev 2006 1.41
23 Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis. J Bacteriol 2010 1.40
24 Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase. Structure 2007 1.40
25 The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A. Nat Chem Biol 2012 1.39
26 Macrocyclization strategies in polyketide and nonribosomal peptide biosynthesis. Nat Prod Rep 2007 1.38
27 Bacterial cold shock responses. Sci Prog 2003 1.37
28 Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J Biol Chem 2003 1.36
29 Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis. Appl Environ Microbiol 2006 1.33
30 Exploitation of the selectivity-conferring code of nonribosomal peptide synthetases for the rational design of novel peptide antibiotics. Biochemistry 2002 1.33
31 Genomewide transcriptional analysis of the cold shock response in Bacillus subtilis. J Bacteriol 2002 1.32
32 Cloning and characterization of the biosynthetic gene cluster for kutznerides. Proc Natl Acad Sci U S A 2007 1.31
33 Cold-induced putative DEAD box RNA helicases CshA and CshB are essential for cold adaptation and interact with cold shock protein B in Bacillus subtilis. J Bacteriol 2006 1.30
34 Inhibition of the D-alanine:D-alanyl carrier protein ligase from Bacillus subtilis increases the bacterium's susceptibility to antibiotics that target the cell wall. FEBS J 2005 1.21
35 Ferri-bacillibactin uptake and hydrolysis in Bacillus subtilis. Mol Microbiol 2006 1.21
36 Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases. Methods Enzymol 2004 1.20
37 The Bacillus subtilis transition state regulator AbrB binds to the -35 promoter region of comK. FEMS Microbiol Lett 2003 1.20
38 Mutational analysis of the C-domain in nonribosomal peptide synthesis. Eur J Biochem 2002 1.18
39 The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide. J Mol Biol 2006 1.16
40 A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis. Mol Microbiol 2007 1.12
41 Daptomycin, a bacterial lipopeptide synthesized by a nonribosomal machinery. J Biol Chem 2010 1.11
42 Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J Biol Chem 2002 1.10
43 Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst. Biochemistry 2003 1.09
44 Rational design of a bimodular model system for the investigation of heterocyclization in nonribosomal peptide biosynthesis. Chem Biol 2004 1.07
45 Functional characterization of 4'-phosphopantetheinyl transferase genes of bacterial and fungal origin by complementation of Saccharomyces cerevisiae lys5. FEMS Microbiol Lett 2002 1.07
46 Aminoacyl adenylate substrate analogues for the inhibition of adenylation domains of nonribosomal peptide synthetases. Chembiochem 2003 1.06
47 Identification and characterization of the lysobactin biosynthetic gene cluster reveals mechanistic insights into an unusual termination module architecture. Chem Biol 2011 1.04
48 Two [4Fe-4S] clusters containing radical SAM enzyme SkfB catalyze thioether bond formation during the maturation of the sporulation killing factor. J Am Chem Soc 2013 1.03
49 Loading peptidyl-coenzyme A onto peptidyl carrier proteins: a novel approach in characterizing macrocyclization by thioesterase domains. J Am Chem Soc 2003 1.03
50 Coping with the cold: the cold shock response in the Gram-positive soil bacterium Bacillus subtilis. Philos Trans R Soc Lond B Biol Sci 2002 1.02
51 Structure-based mutational analysis of the 4'-phosphopantetheinyl transferases Sfp from Bacillus subtilis: carrier protein recognition and reaction mechanism. Biochemistry 2004 1.01
52 The structural diversity of acidic lipopeptide antibiotics. Chembiochem 2009 1.01
53 Learning from nature's drug factories: nonribosomal synthesis of macrocyclic peptides. J Bacteriol 2003 1.00
54 Recognition of hybrid peptidyl carrier proteins/acyl carrier proteins in nonribosomal peptide synthetase modules by the 4'-phosphopantetheinyl transferases AcpS and Sfp. J Biol Chem 2002 1.00
55 The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains. J Biol Chem 2003 1.00
56 Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics. J Am Chem Soc 2004 1.00
57 Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem Biol 2009 1.00
58 The iterative gramicidin s thioesterase catalyzes peptide ligation and cyclization. Chem Biol 2007 0.98
59 Peptide macrocyclization: the reductase of the nostocyclopeptide synthetase triggers the self-assembly of a macrocyclic imine. J Am Chem Soc 2006 0.97
60 Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis. Eur J Biochem 2004 0.97
61 Stereospecific enzymatic transformation of alpha-ketoglutarate to (2S,3R)-3-methyl glutamate during acidic lipopeptide biosynthesis. J Am Chem Soc 2007 0.97
62 Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry. Biopolymers 2013 0.97
63 Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase. Biochemistry 2002 0.96
64 Dissecting the maturation steps of the lasso peptide microcin J25 in vitro. Chembiochem 2012 0.96
65 Copper acquisition is mediated by YcnJ and regulated by YcnK and CsoR in Bacillus subtilis. J Bacteriol 2009 0.95
66 Sigma L is important for cold shock adaptation of Bacillus subtilis. J Bacteriol 2006 0.94
67 The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides. FEBS Lett 2009 0.94
68 Structural basis for the erythro-stereospecificity of the L-arginine oxygenase VioC in viomycin biosynthesis. FEBS J 2009 0.93
69 Caulosegnins I-III: a highly diverse group of lasso peptides derived from a single biosynthetic gene cluster. J Am Chem Soc 2012 0.92
70 SufU is an essential iron-sulfur cluster scaffold protein in Bacillus subtilis. J Bacteriol 2010 0.92
71 How to tailor non-ribosomal peptide products--new clues about the structures and mechanisms of modifying enzymes. Mol Biosyst 2008 0.92
72 Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis. Mol Microbiol 2009 0.92
73 Chemo- and regioselective peptide cyclization triggered by the N-terminal fatty acid chain length: the recombinant cyclase of the calcium-dependent antibiotic from Streptomyces coelicolor. Biochemistry 2004 0.92
74 Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis. J Bacteriol 2006 0.92
75 Characterization of a mutation in the acetolactate synthase of Bacillus subtilis that causes a cold-sensitive phenotype. FEMS Microbiol Lett 2007 0.91
76 Where chemistry meets biology: the chemoenzymatic synthesis of nonribosomal peptides and polyketides. Curr Opin Biotechnol 2007 0.91
77 The siderophore-interacting protein YqjH acts as a ferric reductase in different iron assimilation pathways of Escherichia coli. Biochemistry 2011 0.90
78 Mutational analysis of peptidyl carrier protein and acyl carrier protein synthase unveils residues involved in protein-protein recognition. Biochemistry 2004 0.90
79 Stereospecific synthesis of threo- and erythro-beta-hydroxyglutamic acid during kutzneride biosynthesis. J Am Chem Soc 2009 0.90
80 Xanthomonins I-III: a new class of lasso peptides with a seven-residue macrolactam ring. Angew Chem Int Ed Engl 2014 0.90
81 Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B. Biochemistry 2002 0.90
82 Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist. Angew Chem Int Ed Engl 2011 0.90
83 Radical S-adenosylmethionine enzyme catalyzed thioether bond formation in sactipeptide biosynthesis. Curr Opin Chem Biol 2013 0.89
84 Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes. J Am Chem Soc 2002 0.89
85 The antibacterial threaded-lasso peptide capistruin inhibits bacterial RNA polymerase. J Mol Biol 2011 0.89
86 A tRNA-dependent two-enzyme pathway for the generation of singly and doubly methylated ditryptophan 2,5-diketopiperazines. Biochemistry 2013 0.89
87 Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes. J Am Chem Soc 2008 0.89
88 Biosynthesis of the siderophore rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococcus jostii RHA1. J Am Chem Soc 2011 0.89
89 The Synechocystis sp. PCC6803 Sfp-type phosphopantetheinyl transferase does not possess characteristic broad-range activity. Chembiochem 2009 0.89
90 The astexin-1 lasso peptides: biosynthesis, stability, and structural studies. Chem Biol 2013 0.89
91 Role of DptE and DptF in the lipidation reaction of daptomycin. FEBS J 2008 0.88
92 The major facilitator superfamily-type transporter YmfE and the multidrug-efflux activator Mta mediate bacillibactin secretion in Bacillus subtilis. J Bacteriol 2008 0.88
93 Insights into the generation of structural diversity in a tRNA-dependent pathway for highly modified bioactive cyclic dipeptides. Chem Biol 2013 0.88
94 Structural basis and stereochemistry of triscatecholate siderophore binding by FeuA. Angew Chem Int Ed Engl 2009 0.88
95 Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template. Biochemistry 2003 0.88
96 Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis. PLoS One 2011 0.88
97 Topoisomer differentiation of molecular knots by FTICR MS: lessons from class II lasso peptides. J Am Soc Mass Spectrom 2011 0.86
98 Use of biotin derivatives to probe conformational changes in proteins. J Biol Chem 2007 0.86
99 Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains. FEBS Lett 2007 0.86
100 TioS T-TE--a prototypical thioesterase responsible for cyclodimerization of the quinoline- and quinoxaline-type class of chromodepsipeptides. FEBS J 2009 0.86
101 Impact of epimerization domains on the intermodular transfer of enzyme-bound intermediates in nonribosomal peptide synthesis. Chembiochem 2006 0.85
102 A four-enzyme pathway for 3,5-dihydroxy-4-methylanthranilic acid formation and incorporation into the antitumor antibiotic sibiromycin. Biochemistry 2011 0.85
103 Peptidyl thiophenols as substrates for nonribosomal peptide cyclases. Angew Chem Int Ed Engl 2004 0.85
104 The siderophore binding protein FeuA shows limited promiscuity toward exogenous triscatecholates. Chem Biol 2011 0.85
105 The Bacillus subtilis EfeUOB transporter is essential for high-affinity acquisition of ferrous and ferric iron. Biochim Biophys Acta 2013 0.85
106 Formylation domain: an essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. J Am Chem Soc 2006 0.84
107 Delta-amino group hydroxylation of L-ornithine during coelichelin biosynthesis. Org Biomol Chem 2008 0.84
108 Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH. Nucleic Acids Res 2003 0.83
109 Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum. J Nat Prod 2012 0.83
110 CSDBase: an interactive database for cold shock domain-containing proteins and the bacterial cold shock response. Nucleic Acids Res 2002 0.83
111 Structure-function relationship and regulation of two Bacillus subtilis DNA-binding proteins, HBsu and AbrB. J Mol Microbiol Biotechnol 2002 0.83
112 Chemoenzymatic design of acidic lipopeptide hybrids: new insights into the structure-activity relationship of daptomycin and A54145. Biochemistry 2006 0.83
113 Construction of hybrid peptide synthetases for the production of alpha-l-aspartyl-l-phenylalanine, a precursor for the high-intensity sweetener aspartame. Eur J Biochem 2003 0.83
114 Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity. FEBS Lett 2012 0.83
115 Consecutive enzymatic modification of ornithine generates the hydroxamate moieties of the siderophore erythrochelin. Biochemistry 2011 0.83
116 Exploring the mechanism of lipid transfer during biosynthesis of the acidic lipopeptide antibiotic CDA. FEBS Lett 2012 0.83
117 Ion mobility-mass spectrometry of lasso peptides: signature of a rotaxane topology. Anal Chem 2014 0.83
118 Rational improvement of the affinity and selectivity of integrin binding of grafted lasso peptides. J Med Chem 2014 0.83
119 Non-heme hydroxylase engineering for simple enzymatic synthesis of L-threo-hydroxyaspartic acid. Chembiochem 2008 0.82
120 The frataxin homologue Fra plays a key role in intracellular iron channeling in Bacillus subtilis. Chembiochem 2011 0.81
121 NMR as an effective tool for the structure determination of lasso peptides. Chembiochem 2012 0.81
122 The reversible macrocyclization of Tyrocidine A aldehyde: a hemiaminal reminiscent of the tetrahedral intermediate of macrolactamization. Org Biomol Chem 2009 0.81
123 Erythrochelin--a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea. FEBS J 2009 0.81
124 Mechanistic characterization of sulfur transfer from cysteine desulfurase SufS to the iron-sulfur scaffold SufU in Bacillus subtilis. FEBS Lett 2011 0.80
125 Genetic evidence for the temperature-sensing ability of the membrane domain of the Bacillus subtilis histidine kinase DesK. FEMS Microbiol Lett 2004 0.80
126 The entropy balance of nostocyclopeptide macrocyclization analysed by NMR spectroscopy. Chembiochem 2008 0.80
127 Chemoenzymatic approach to enantiopure streptogramin B variants: characterization of stereoselective pristinamycin I cyclase from Streptomyces pristinaespiralis. J Am Chem Soc 2005 0.80
128 The ring residue proline 8 is crucial for the thermal stability of the lasso peptide caulosegnin II. Mol Biosyst 2016 0.80
129 Utility of epimerization domains for the redesign of nonribosomal peptide synthetases. FEBS J 2005 0.79
130 An enzymatic pathway for the biosynthesis of the formylhydroxyornithine required for rhodochelin iron coordination. Biochemistry 2012 0.79
131 Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles. J Am Chem Soc 2006 0.79
132 Fluorescence resonance energy transfer as a probe of peptide cyclization catalyzed by nonribosomal thioesterase domains. Chem Biol 2005 0.79
133 Enzymatic cyclisation of peptidomimetics with incorporated (E)-alkene dipeptide isosteres. Chembiochem 2004 0.79
134 Structural characterization of the heterobactin siderophores from Rhodococcus erythropolis PR4 and elucidation of their biosynthetic machinery. J Nat Prod 2013 0.78
135 Post-translational modification and folding of a lasso-type gene-encoded antimicrobial peptide require two enzymes only in Escherichia coli. Adv Exp Med Biol 2009 0.78
136 Uptake of xenosiderophores in Bacillus subtilis occurs with high affinity and enhances the folding stabilities of substrate binding proteins. FEBS Lett 2012 0.77
137 Photoreduction of the folate cofactor in members of the photolyase family. J Biol Chem 2009 0.77
138 Detection of nonribosomal peptide synthetase genes in Xylaria sp. BCC1067 and cloning of XyNRPSA. FEMS Microbiol Lett 2007 0.77
139 Synthesis of linear gramicidin requires the cooperation of two independent reductases. Biochemistry 2005 0.76
140 Determination of peptide topology through time-resolved double-resonance under electron capture dissociation conditions. Anal Chem 2012 0.76
141 Identification and characterization of a novel-type ferric siderophore reductase from a gram-positive extremophile. J Biol Chem 2010 0.76
142 Heterologous expression of nonribosomal peptide synthetases in B. subtilis: construction of a bi-functional B subtilis/E coli shuttle vector system. FEMS Microbiol Lett 2002 0.76
143 Direct identification of a siderophore import protein using synthetic petrobactin ligands. Angew Chem Int Ed Engl 2010 0.76
144 A synthetic adenylation-domain-based tRNA-aminoacylation catalyst. Angew Chem Int Ed Engl 2015 0.75
145 Solvent engineering substantially enhances the chemoenzymatic production of surfactin. Chembiochem 2006 0.75