Published in J Neurochem on January 09, 2006
Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment. Free Radic Biol Med (2007) 2.08
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res (2007) 1.62
Rapid cell death is preceded by amyloid plaque-mediated oxidative stress. Proc Natl Acad Sci U S A (2013) 1.61
Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment. J Alzheimers Dis (2010) 1.54
University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Curr Alzheimer Res (2012) 1.52
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Copper in the brain and Alzheimer's disease. J Biol Inorg Chem (2009) 1.40
Recent advances in our understanding of neurodegeneration. J Neural Transm (Vienna) (2009) 1.27
Mitochondrial DNA, base excision repair and neurodegeneration. DNA Repair (Amst) (2008) 1.27
DNA damage responses in neural cells: Focus on the telomere. Neuroscience (2007) 1.23
Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension. Hum Mol Genet (2012) 1.22
Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxid Redox Signal (2013) 1.20
Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med (2008) 1.19
Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: implications for early intervention and therapeutics. Biochim Biophys Acta (2011) 1.16
Effect of aging on 5-hydroxymethylcytosine in brain mitochondria. Neurobiol Aging (2012) 1.15
Basic mechanisms of neurodegeneration: a critical update. J Cell Mol Med (2010) 1.13
Increased levels of 4-hydroxynonenal and acrolein in the brain in preclinical Alzheimer disease. Free Radic Biol Med (2010) 1.11
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic Biol Med (2008) 1.10
The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons. J Neuropathol Exp Neurol (2012) 1.09
Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease. Neurobiol Dis (2009) 1.06
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. Nucleic Acids Res (2007) 1.06
Oxidatively modified RNA in mild cognitive impairment. Neurobiol Dis (2007) 1.05
Oxidatively modified, mitochondria-relevant brain proteins in subjects with Alzheimer disease and mild cognitive impairment. J Bioenerg Biomembr (2009) 1.05
Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease. Antioxid Redox Signal (2010) 1.04
Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation. Am J Med Genet A (2011) 1.02
Oxidatively modified nucleic acids in preclinical Alzheimer's disease (PCAD) brain. Mech Ageing Dev (2011) 0.98
Epigenetic changes in the progression of Alzheimer's disease. Mech Ageing Dev (2013) 0.97
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes. Nucleic Acids Res (2014) 0.96
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. Int J Cell Biol (2012) 0.96
Mitochondrial DNA: A Blind Spot in Neuroepigenetics. Biomol Concepts (2012) 0.95
Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits. J Neurochem (2009) 0.92
Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci (2015) 0.92
Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity. Free Radic Biol Med (2006) 0.92
Cognitive impairment in humanized APP×PS1 mice is linked to Aβ(1-42) and NOX activation. Neurobiol Dis (2011) 0.91
Elevated 4-hydroxyhexenal in Alzheimer's disease (AD) progression. Neurobiol Aging (2010) 0.90
Genomic integrity and the ageing brain. Nat Rev Neurosci (2015) 0.88
Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption. Am J Physiol Gastrointest Liver Physiol (2012) 0.88
Nucleic acid oxidation: an early feature of Alzheimer's disease. J Neurochem (2013) 0.88
Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PLoS One (2014) 0.85
The Response to Oxidative DNA Damage in Neurons: Mechanisms and Disease. Neural Plast (2016) 0.83
Novel post-synthetic generation, isomeric resolution, and characterization of Fapy-dG within oligodeoxynucleotides: differential anomeric impacts on DNA duplex properties. Nucleic Acids Res (2011) 0.83
Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis. Electrophoresis (2013) 0.81
Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients. Aging (Albany NY) (2015) 0.80
A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort. Neuropathol Appl Neurobiol (2015) 0.80
Roles of PTEN with DNA Repair in Parkinson's Disease. Int J Mol Sci (2016) 0.79
Lymphocytes of patients with Alzheimer's disease display different DNA damage repair kinetics and expression profiles of DNA repair and stress response genes. Int J Mol Sci (2013) 0.79
Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease. Acta Neuropathol (2015) 0.79
Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. Am J Epidemiol (2010) 0.79
Dietary antioxidant intake and its association with cognitive function in an ethnically diverse sample of US adults. Psychosom Med (2015) 0.78
Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proc Natl Acad Sci U S A (2011) 0.78
Alzheimer's disease-associated polymorphisms in human OGG1 alter catalytic activity and sensitize cells to DNA damage. Free Radic Biol Med (2013) 0.78
Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer-type pathology. Neuropathol Appl Neurobiol (2015) 0.76
Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair. Neuroscience (2013) 0.76
DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease. Aging Cell (2016) 0.76
Genome instability in Alzheimer disease. Mech Ageing Dev (2016) 0.75
Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease. J Neurochem (2016) 0.75
Mitochondrial DNA mutations increase in early stage Alzheimer disease and are inconsistent with oxidative damage. Ann Neurol (2016) 0.75
Altered DNA base excision repair profile in brain tissue and blood in Alzheimer's disease. Mol Brain (2016) 0.75
Suppression of synaptic plasticity by fullerenol in rat hippocampus in vitro. Int J Nanomedicine (2016) 0.75
Effect of coffee (caffeine) against human cataract blindness. Clin Ophthalmol (2016) 0.75
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses. Proc Natl Acad Sci U S A (2004) 5.65
Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease. Neurobiol Aging (2009) 4.36
Cerebrovascular pathology and dementia in autopsied Honolulu-Asia Aging Study participants. Ann N Y Acad Sci (2002) 3.11
TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. J Neuropathol Exp Neurol (2007) 2.97
Neuropathology and cognitive impairment in Alzheimer disease: a complex but coherent relationship. J Neuropathol Exp Neurol (2009) 2.87
Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: findings from the Nun Study. Ann Neurol (2002) 2.68
Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity. J Neuropathol Exp Neurol (2007) 2.65
Modeling the association between 43 different clinical and pathological variables and the severity of cognitive impairment in a large autopsy cohort of elderly persons. Brain Pathol (2008) 2.44
Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. J Neuropathol Exp Neurol (2006) 2.43
Failure of resolution of portal fibrosis during omega-3 fatty acid lipid emulsion therapy in two patients with irreversible intestinal failure. J Pediatr (2010) 2.31
Association of olfactory dysfunction with incidental Lewy bodies. Mov Disord (2006) 2.26
Age and gender effects on human brain anatomy: a voxel-based morphometric study in healthy elderly. Neurobiol Aging (2006) 2.23
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic Biol Med (2002) 2.10
Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med (2002) 2.08
Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol Dis (2006) 2.04
Methodological Considerations in Studying Centenarians: Lessons Learned From the Georgia Centenarian Studies. Annu Rev Gerontol Geriatr (2007) 1.85
Ribosome dysfunction is an early event in Alzheimer's disease. J Neurosci (2005) 1.80
Head circumference, education and risk of dementia: findings from the Nun Study. J Clin Exp Neuropsychol (2003) 1.73
Low sensitivity in clinical diagnoses of dementia with Lewy bodies. J Neurol (2009) 1.73
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71. J Neurochem (2002) 1.73
Proteomic identification of nitrated proteins in Alzheimer's disease brain. J Neurochem (2003) 1.70
Early life linguistic ability, late life cognitive function, and neuropathology: findings from the Nun Study. Neurobiol Aging (2005) 1.66
Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease. J Neuropathol Exp Neurol (2009) 1.66
Feeding dysfunction in children with eosinophilic gastrointestinal diseases. Pediatrics (2010) 1.62
Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease. Nucleic Acids Res (2007) 1.62
Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. Clin Cancer Res (2006) 1.61
Increased levels of 4-hydroxynonenal and acrolein, neurotoxic markers of lipid peroxidation, in the brain in Mild Cognitive Impairment and early Alzheimer's disease. Neurobiol Aging (2005) 1.60
Identification of nitrated proteins in Alzheimer's disease brain using a redox proteomics approach. Neurobiol Dis (2005) 1.58
Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Exp Neurol (2008) 1.58
Oxidative damage in mild cognitive impairment and early Alzheimer's disease. J Neurosci Res (2007) 1.54
University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology. Curr Alzheimer Res (2012) 1.52
Redox proteomics identification of oxidized proteins in Alzheimer's disease hippocampus and cerebellum: an approach to understand pathological and biochemical alterations in AD. Neurobiol Aging (2005) 1.52
Oxidative modification and down-regulation of Pin1 in Alzheimer's disease hippocampus: A redox proteomics analysis. Neurobiol Aging (2005) 1.50
Lipid peroxidation is an early event in the brain in amnestic mild cognitive impairment. Ann Neurol (2005) 1.49
Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment. Nucleic Acids Res (2007) 1.48
Recurrent inflammatory pseudotumors in children. J Pediatr Surg (2003) 1.46
Human cerebral neuropathology of Type 2 diabetes mellitus. Biochim Biophys Acta (2008) 1.46
Abeta solubility and deposition during AD progression and in APPxPS-1 knock-in mice. Neurobiol Dis (2007) 1.40
Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease. Neurobiol Dis (2008) 1.38
DNA oxidation in Alzheimer's disease. Antioxid Redox Signal (2006) 1.31
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease. Am J Pathol (2006) 1.28
Designing a large prevention trial: statistical issues. Stat Med (2004) 1.24
White matter diffusion alterations in normal women at risk of Alzheimer's disease. Neurobiol Aging (2008) 1.22
NOX activity is increased in mild cognitive impairment. Antioxid Redox Signal (2010) 1.22
Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. Brain Res (2009) 1.22
Elevated levels of 3-nitrotyrosine in brain from subjects with amnestic mild cognitive impairment: implications for the role of nitration in the progression of Alzheimer's disease. Brain Res (2007) 1.21
Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease. Neurochem Res (2006) 1.21
Proteasome inhibition induces reversible impairments in protein synthesis. FASEB J (2006) 1.20
Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med (2008) 1.19
Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging (2010) 1.16
Alzheimer's-type neuropathology in the precuneus is not increased relative to other areas of neocortex across a range of cognitive impairment. Neurosci Lett (2008) 1.15
Development of a method for quantification of acrolein-deoxyguanosine adducts in DNA using isotope dilution-capillary LC/MS/MS and its application to human brain tissue. Anal Chem (2005) 1.14
Kalirin is under-expressed in Alzheimer's disease hippocampus. J Alzheimers Dis (2007) 1.14
Oxidative stress in head trauma in aging. Free Radic Biol Med (2006) 1.13
Mechanisms of disease: Inborn errors of bile acid synthesis. Nat Clin Pract Gastroenterol Hepatol (2008) 1.13
Toll-like receptor 4-dependent Kupffer cell activation and liver injury in a novel mouse model of parenteral nutrition and intestinal injury. Hepatology (2012) 1.13
Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development. Neuromolecular Med (2003) 1.11
Molecular genetic analysis of a small bowel primitive neuroectodermal tumor. Pediatr Dev Pathol (2002) 1.10
Altered 8-oxoguanine glycosylase in mild cognitive impairment and late-stage Alzheimer's disease brain. Free Radic Biol Med (2008) 1.10
Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol (2007) 1.10
Healthy ageing in the Nun Study: definition and neuropathologic correlates. Age Ageing (2007) 1.09
Comparison of recruitment efforts targeted at primary care physicians versus the community at large for participation in Alzheimer disease clinical trials. Alzheimer Dis Assoc Disord (2010) 1.07
Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Mol Neurodegener (2009) 1.06
Identification and characterization of OGG1 mutations in patients with Alzheimer's disease. Nucleic Acids Res (2007) 1.06
Association between male gender and cortical Lewy body pathology in large autopsy series. J Neurol (2010) 1.06
Oxidatively modified RNA in mild cognitive impairment. Neurobiol Dis (2007) 1.05
Thymoma in children: report of 2 cases and review of the literature. Pediatr Dev Pathol (2010) 1.05
Succinyl-CoA ligase deficiency: a mitochondrial hepatoencephalomyopathy. Pediatr Res (2010) 1.05
F2-isoprostanes in Alzheimer and other neurodegenerative diseases. Antioxid Redox Signal (2005) 1.04
Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age. Free Radic Biol Med (2008) 1.02
Detection and quantification of endogenous cyclic DNA adducts derived from trans-4-hydroxy-2-nonenal in human brain tissue by isotope dilution capillary liquid chromatography nanoelectrospray tandem mass spectrometry. Chem Res Toxicol (2006) 1.02
Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiol Aging (2008) 1.02
Omega-3 fatty acids: potential role in the management of early Alzheimer's disease. Clin Interv Aging (2010) 1.01
Effects of short-term Western diet on cerebral oxidative stress and diabetes related factors in APP x PS1 knock-in mice. J Neurochem (2008) 1.00
Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule. J Cell Mol Med (2008) 1.00
APOE is a potential modifier gene in an autosomal dominant form of frontotemporal dementia (IBMPFD). Genet Med (2007) 0.99
Danon disease presenting with dilated cardiomyopathy and a complex phenotype. J Hum Genet (2007) 0.98
Use of bomb pulse carbon-14 to age senile plaques and neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging (2002) 0.97
Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks. Neurobiol Aging (2010) 0.96
Torsion of an indirect hernia sac causing acute scrotum. J Pediatr Surg (2004) 0.96
Primary pancreatic neuroblastoma: an unusual tumor in infancy. J Pediatr Surg (2010) 0.96
4-Hydroxynonenal oxidatively modifies histones: implications for Alzheimer's disease. Neurosci Lett (2004) 0.95
Under-expression of Kalirin-7 Increases iNOS activity in cultured cells and correlates to elevated iNOS activity in Alzheimer's disease hippocampus. J Alzheimers Dis (2007) 0.95
Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB. J Alzheimers Dis (2009) 0.94
Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. Brain Pathol (2009) 0.94
Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics. Neurobiol Dis (2010) 0.93
Case report: infantile hemangioendothelioma. Curr Opin Pediatr (2002) 0.93
Acute hemorrhagic leukoencephalitis: a critical entity for forensic pathologists to recognize. Am J Forensic Med Pathol (2010) 0.93
Proteomic analysis of human ventricular cerebrospinal fluid from neurologically normal, elderly subjects using two-dimensional LC-MS/MS. J Proteome Res (2004) 0.93
Bilateral lymphangiomatous polyps of the palatine tonsils. Int J Pediatr Otorhinolaryngol (2009) 0.92
Infantile cardiomyopathy caused by the T14709C mutation in the mitochondrial tRNA glutamic acid gene. Eur J Pediatr (2007) 0.92
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide (2002) 0.91