Clinicopathologic correlations in a large Alzheimer disease center autopsy cohort: neuritic plaques and neurofibrillary tangles "do count" when staging disease severity.

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Published in J Neuropathol Exp Neurol on December 01, 2007

Authors

Peter T Nelson1, Gregory A Jicha, Frederick A Schmitt, Huaichen Liu, Daron G Davis, Marta S Mendiondo, Erin L Abner, William R Markesbery

Author Affiliations

1: Department of Pathology and Division of Neuropathology, University of Kentucky, Lexington, Kentucky 40536-0230, USA. pnel2@email.uky.edu

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Decreased RNA, and increased RNA oxidation, in ribosomes from early Alzheimer's disease. Neurochem Res (2006) 1.21

Proteasome inhibition induces reversible impairments in protein synthesis. FASEB J (2006) 1.20

Improving dementia care: the role of screening and detection of cognitive impairment. Alzheimers Dement (2013) 1.19

Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. Free Radic Biol Med (2008) 1.19

Should older adults be screened for dementia? Alzheimers Dement (2006) 1.17

PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathol (2015) 1.17

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging (2010) 1.16